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    Neurodegenerative Protein Aggregation Inhibition Methods and Compounds
    35.
    发明申请
    Neurodegenerative Protein Aggregation Inhibition Methods and Compounds 审中-公开
    神经变性蛋白聚集抑制方法和化合物

    公开(公告)号：US20110160246A1

    公开(公告)日：2011-06-30

    申请号：US12944558

    申请日：2010-11-11

    申请人： Isabella A. Graef ,  Gerald R. Crabtree ,  Jason E. Gestwicki

    发明人： Isabella A. Graef ,  Gerald R. Crabtree ,  Jason E. Gestwicki

    IPC分类号： A61K31/445 ,  C07D211/60 ,  C12P21/00 ,  A61P25/00 ,  A61P25/28 ,  A61P25/16

    CPC分类号： A61K31/4745 ,  A61K31/5415 ,  A61K31/655 ,  A61K31/7076 ,  A61K47/54

    摘要： Methods and compositions are provided for reducing aggregation of neurodegenerative proteins associated with neurotoxicity or other proteins. The compounds comprise a first domain or targeting element for binding to the target proteins linked to a second domain or recruiting element that binds to an aggregation inhibiting protein, e.g. a prolyl isomerase. By associating the aggregating forming proteins or neuronal cells under conditions where aggregating proteins are produced with the compound and the aggregation inhibiting protein, aggregation is reduced. The subject agents can be used in assays, investigating the etiology of the neuronal diseases and for prophylaxis and therapy.

    摘要翻译： 提供了用于减少与神经毒性相关的神经变性蛋白质的聚集或其它蛋白质的方法和组合物。 所述化合物包含用于结合靶向蛋白质的第一结构域或靶向元件，所述靶蛋白与结合至聚集抑制蛋白质的第二结构域或募集元件连接。 脯氨酰异构酶。 通过在与化合物和聚集抑制蛋白质产生聚集蛋白质的条件下缔合形成蛋白质或神经元细胞，聚集减少。 主题试剂可用于测定，研究神经元疾病的病因以及预防和治疗。

    Bifunctional molecules and their use in the disruption of protein-protein interactions
    36.
    发明授权
    Bifunctional molecules and their use in the disruption of protein-protein interactions 有权
    双功能分子及其在蛋白质 - 蛋白质相互作用破坏中的应用

    公开(公告)号：US07220552B1

    公开(公告)日：2007-05-22

    申请号：US09716054

    申请日：2000-11-17

    申请人： Gerald R. Crabtree ,  Kryn Stankunas ,  Roger Briesewitz ,  Thomas J. Wandless

    发明人： Gerald R. Crabtree ,  Kryn Stankunas ,  Roger Briesewitz ,  Thomas J. Wandless

    IPC分类号： G01N33/53 ,  A61K39/00

    CPC分类号： G01N33/6845 ,  G01N33/542

    摘要： Bifunctional inhibitor molecules and methods for their use in the inhibition of protein—protein interactions are provided. The subject bifunctional inhibitor molecules are conjugates of a target protein ligand and a blocking protein ligand, where these two moieties are optionally joined by a linking group. In the subject methods, an effective amount of the bifunctional inhibitor molecule is administered to a host in which the inhibition of a protein—protein interaction is desired. The bifunctional inhibitor molecule simultaneously binds to its corresponding target and blocking proteins to produce a tripartite complex that inhibits the target protein—protein interaction. The subject methods and compositions find use in a variety of applications, including therapeutic applications.

    摘要翻译： 提供了双功能抑制剂分子及其用于抑制蛋白质 - 蛋白质相互作用的方法。 受试者双功能抑制剂分子是靶蛋白配体和阻断蛋白配体的缀合物，其中这两个部分任选地通过连接基团连接。 在本方法中，将有效量的双功能抑制剂分子施用于需要抑制蛋白质 - 蛋白质相互作用的宿主。 双功能抑制剂分子同时结合其相应的靶标和阻断蛋白质以产生抑制靶蛋白 - 蛋白质相互作用的三方复合物。 主题方法和组合物可用于各种应用，包括治疗应用。

    Neurodegenerative protein aggregation inhibition methods and compounds
    40.
    发明授权
    Neurodegenerative protein aggregation inhibition methods and compounds 失效
    神经变性蛋白聚集抑制方法和化合物

    公开(公告)号：US07923230B2

    公开(公告)日：2011-04-12

    申请号：US12050017

    申请日：2008-03-17

    申请人： Isabella A. Graef ,  Gerald R. Crabtree ,  Jason E. Gestwicki

    发明人： Isabella A. Graef ,  Gerald R. Crabtree ,  Jason E. Gestwicki

    IPC分类号： C12N9/00 ,  C07D498/18 ,  C07D417/02 ,  C07D211/60

    CPC分类号： A61K31/4745 ,  A61K31/5415 ,  A61K31/655 ,  A61K31/7076 ,  A61K47/54

    摘要： Methods and compositions are provided for reducing aggregation of neurodegenerative proteins associated with neurotoxicity or other proteins. The compounds comprise a first domain or targeting element for binding to the target proteins linked to a second domain or recruiting element that binds to an aggregation inhibiting protein, e.g. a prolyl isomerase. By associating the aggregating forming proteins or neuronal cells under conditions where aggregating proteins are produced with the compound and the aggregation inhibiting protein, aggregation is reduced. The subject agents can be used in assays, investigating the etiology of the neuronal diseases and for prophylaxis and therapy.

    摘要翻译： 提供了用于减少与神经毒性相关的神经变性蛋白质的聚集或其它蛋白质的方法和组合物。 所述化合物包含用于结合靶向蛋白质的第一结构域或靶向元件，所述靶蛋白与结合至聚集抑制蛋白质的第二结构域或募集元件连接。 脯氨酰异构酶。 通过在与化合物和聚集抑制蛋白质产生聚集蛋白质的条件下缔合形成蛋白质或神经元细胞，聚集减少。 主题试剂可用于测定，研究神经元疾病的病因以及预防和治疗。