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公开(公告)号:US20060189677A1
公开(公告)日:2006-08-24
申请号:US11342270
申请日:2006-01-27
申请人: Gregory Beatch , Bertrand Plouvier , Tao Sheng , Michael Walker , Richard Wall , Sandro Yong , Jeff Zhu , Alexander Zolotoy
发明人: Gregory Beatch , Bertrand Plouvier , Tao Sheng , Michael Walker , Richard Wall , Sandro Yong , Jeff Zhu , Alexander Zolotoy
IPC分类号: A61K31/4015 , A61K9/68
CPC分类号: A61K31/40 , A61K9/0019 , A61K31/4015 , C07D207/12 , C07D209/36
摘要: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号:US20050020481A1
公开(公告)日:2005-01-27
申请号:US10674684
申请日:2003-09-29
申请人: Allan Bain , Gregory Beatch , Cindy Longley , Bertrand Plouvier , Tao Sheng , Michael Walker , Richard Wall , Sandro Yong , Jeff Zhu , Alexander Zolotoy
发明人: Allan Bain , Gregory Beatch , Cindy Longley , Bertrand Plouvier , Tao Sheng , Michael Walker , Richard Wall , Sandro Yong , Jeff Zhu , Alexander Zolotoy
IPC分类号: C07D295/08 , A61K20060101 , A61K31/13 , A61K31/133 , A61K31/135 , A61K31/40 , A61K31/4015 , A61K31/407 , A61K31/41 , A61K31/4162 , A61K31/426 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P3/10 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P15/00 , A61P15/10 , A61P17/14 , A61P21/00 , A61P21/04 , A61P23/00 , A61P25/00 , A61P25/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/06 , C07C20060101 , C07C217/52 , C07D20060101 , C07D207/04 , C07D207/12 , C07D207/24 , C07D207/26 , C07D207/27 , C07D277/04 , C07D295/096 , C07D295/15 , C07D295/18 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10 , C07D491/113 , A61K31/00
CPC分类号: C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号:US20100111955A1
公开(公告)日:2010-05-06
申请号:US12448655
申请日:2007-11-09
申请人: Jingwu Xie , Tao Sheng , Xiaoli Zhang
发明人: Jingwu Xie , Tao Sheng , Xiaoli Zhang
IPC分类号: A61K39/395 , C12Q1/68 , G01N33/53 , G01N33/00 , C12N5/02 , A61K31/7088 , A61P35/04
CPC分类号: C07K14/4702 , A61K48/00
摘要: The present invention discloses a component in the hedgehog signaling pathway that can be useful in the treatment and diagnosis of hedgehog signaling pathway associated disorders. In this regard, the present invention discloses that RanBPM regulated the stability of hedgehog signaling molecule, smoothened (SMO) and that inactivation of RanBPM by siRNA prevented growth and metastasis of cancer cells.
摘要翻译: 本发明公开了一种刺猬蛋白信号通路中可用于治疗和诊断刺猬蛋白信号通路相关病症的成分。 在这方面,本发明公开了RanBPM调节刺猬蛋白信号分子的稳定性,平滑化(SMO),并且通过siRNA的RanBPM的失活阻止了癌细胞的生长和转移。
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公开(公告)号:US20090306107A1
公开(公告)日:2009-12-10
申请号:US11908913
申请日:2006-03-17
申请人: Lawrence Blas Perez , Tao Sheng
发明人: Lawrence Blas Perez , Tao Sheng
IPC分类号: A61K31/519 , C07D471/04 , A61P35/00
CPC分类号: C07D471/14 , C07D487/04
摘要: The present invention relates to compounds that are useful to inhibit, regulate and/or modulate tyrosine and serine/threonine kinase and kinase-like proteins, such as RAF kinase, a serine/threonine kinase that functions in the MAP kinase signaling pathway. The application is also concerned with compositions which contain these compounds, and methods of using them to treat tyrosine and serine/threonine kinase and kinase-like dependent diseases, such as angiogenesis, cancer and cardiac hypertrophy, and with other subject matter.
摘要翻译: 本发明涉及可用于抑制,调节和/或调节酪氨酸和丝氨酸/苏氨酸激酶和激酶样蛋白质的化合物,例如在MAP激酶信号通路中起作用的丝氨酸/苏氨酸激酶的RAF激酶。 该应用还涉及含有这些化合物的组合物,以及使用它们治疗酪氨酸和丝氨酸/苏氨酸激酶和激酶样依赖性疾病如血管生成,癌症和心脏肥大以及其它主题的方法。
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公开(公告)号:US20070190156A1
公开(公告)日:2007-08-16
申请号:US11619136
申请日:2007-01-02
申请人: Gregory Beatch , Bertrand Plouvier , Tao Sheng , Michael Walker , Richard Wall , Sandro Yong , Jeff Zhu , Alexander Zolotoy
发明人: Gregory Beatch , Bertrand Plouvier , Tao Sheng , Michael Walker , Richard Wall , Sandro Yong , Jeff Zhu , Alexander Zolotoy
IPC分类号: A61K31/4015 , A61K9/14 , A61K9/48 , A61K9/68
CPC分类号: A61K31/40 , A61K9/0019 , A61K31/4015 , C07D207/12 , C07D209/36
摘要: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译: 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途,包括治疗心律失常和产生镇痛和局部麻醉。
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