公开(公告)号：US20110311410A1

公开(公告)日：2011-12-22

申请号：US13219823

申请日：2011-08-29

Applicant: David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

Inventor： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC: B01L3/02

CPC classification number: B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：US20090274587A1

公开(公告)日：2009-11-05

申请号：US12115005

申请日：2008-05-05

Applicant: David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

Inventor： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC: B01L3/02

CPC classification number: B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：US20080095671A1

公开(公告)日：2008-04-24

申请号：US11552384

申请日：2006-10-24

Applicant: Gregory Mathus ,  Terrence Kelley ,  Richard Cote

Inventor： Gregory Mathus ,  Terrence Kelley ,  Richard Cote

IPC: B01L3/02

CPC classification number: B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/087

Abstract: In one aspect, the invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes located above a stop member and a lower sealing section located below the stop member. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip, the tip locks onto the mounting shaft. The bore of the pipette tip includes a circumferential shelf or shoulder separating its upper collar from the tip sealing area which is located below the circumferential shelf. The tip collar preferably includes a locking ring located at or near the upper opening for the mounting shaft. The dimensions of the collar, and in particular the distance between its circumferential shelf and the locking ring, are selected to match the dimensions of the mounting shaft between the stop member and the upper end of the locking lobes, thus locking the pipette tip in a secure, reliable position and orientation while using ergonomic insertion and ejection forces. The locking lobes preferably include a ramp portion that gently flexes and distorts the pipette tip collar out of round as the mounting shaft is inserted in the pipette tip, rather than stretching the tip collar. The circumferential shelf on the pipette tip between the tip collar and the barrel isolates the sealing area at the upper end of the barrel from distortion, thus facilitating reliable sealing engagement between the lower sealing section of the mounting shaft and the sealing ring in the upper end of the barrel of the pipette tip.

Abstract translation: 一方面，本发明涉及移液器吸头安装轴构造和具有匹配构型的一次性吸头。 安装轴包括位于下密封部分上方的锁定部分。 锁定部分具有位于止动构件上方的向外延伸的锁定凸角和位于止动构件下方的下部密封部分。 当安装轴完全插入到匹配的一次性移液管尖端的轴环中时，尖端锁定在安装轴上。 移液管尖端的孔包括将其上部套环与位于周向架下方的顶部密封区域分开的圆周架或肩部。 尖端衣领优选地包括位于或靠近用于安装轴的上部开口的锁定环。 颈圈的尺寸，特别是其圆周架和锁定环之间的距离被选择成与止动构件和锁定瓣的上端之间的安装轴的尺寸相匹配，从而将移液管尖端锁定在 安全可靠的位置和方向，同时使用符合人体工程学的插拔力。 锁定凸耳优选地包括斜坡部分，当斜面部分安装在插管头中时，该倾斜部分使得移液管尖端套环温度弯曲并变形，而不是拉伸尖端套环。 吸头顶端的圆周架在顶端套环和筒体之间隔开了桶的上端的密封区域的变形，从而促进了安装轴的下密封部分与上端的密封环之间的可靠密封接合 的移液管尖端的桶。

公开(公告)号：USRE38214E1

公开(公告)日：2003-08-12

申请号：US09760250

申请日：2001-01-12

Applicant: William J. Lacey ,  Gregory Mathus ,  Paul M. Szlosek

Inventor： William J. Lacey ,  Gregory Mathus ,  Paul M. Szlosek

IPC: B01L300

CPC classification number: B01L3/5085 ,  B01L2300/0829 ,  B01L2300/12 ,  B29C45/1418 ,  B29C45/14344 ,  B29C45/14778 ,  G01N21/03 ,  G01N21/25 ,  G01N21/33

Abstract: Microplates and methods for manufacturing microplates. The microplate is designed to allow UV radiation to pass through the bottom wells of the microplate so that the microplate can be used for assaying samples by use of UV absorbance. In one embodiment, the microplate comprises at least first and second wells, each well having a UV permeable bottom. In another embodiment, the microplate comprises a frame having an upper portion and a lower portion contiguous with the upper portion and a sheet disposed between the upper portion and the lower portion and defining the bottom of at least one well of the microplate. One embodiment of the method includes steps of inserting a sheet of UV permeable material into a mold cavity that includes sections shaped to form the sidewalls of the plurality of wells, injecting molten plastic material into the mold cavity, and cooling the plastic material to form the microplate with the plastic material forming the sidewalls of each of the first and second wells and the sheet of UV permeable material forming the bottom of each of the first and second wells. Another embodiment of the method includes providing an upper plate defining sidewalls of at least one well, adhering an intermediate layer to the upper plate and adhering a sheet of UV permeable material to the intermediate layer. A further embodiment of the method includes inserting a sheet of material having at least one hole into a mold cavity, injecting a molten plastic material into the mold cavity and cooling the plastic material to form a microplate.

公开(公告)号：US5972694A

公开(公告)日：1999-10-26

申请号：US5542

申请日：1998-01-12

Applicant: Gregory Mathus

Inventor： Gregory Mathus

IPC: B01L3/00 ,  C12M3/00

CPC classification number: B01L3/50255 ,  C12M23/12 ,  C12M25/02

Abstract: The invention relates to an improved multiwell cluster plate. The wells of the plate each have an upper chamber and a lower chamber separated by a microporous membrane. Adjacent to each well is a corresponding access port. The access port is a separate opening in the tip surface of the plate which provides direct access to the lower chamber of the corresponding well, without disturbing the upper chamber or the membrane

Abstract translation: 本发明涉及一种改进的多孔聚集板。 板的孔各自具有由微孔膜分隔的上室和下室。 相邻的每个井都是相应的通道。 进入口是板的尖端表面中的独立的开口，其提供对相应井的下部腔室的直接通路，而不会干扰上部腔室或膜

公开(公告)号：US5856176A

公开(公告)日：1999-01-05

申请号：US625728

申请日：1996-03-29

Applicant: Gregory Mathus ,  Anthony M. Labriola

Inventor： Gregory Mathus ,  Anthony M. Labriola

IPC: C12M1/22 ,  C12M3/00

CPC classification number: C12M23/52 ,  C12M23/10

Abstract: A culture dish for growing cultures such as tissue cells, bacteria and the like. The culture dish includes a handle extending therefrom that can be easily grasped by a user when lifting or handling the culture dish. The culture dish can also include a lid that can be placed on a base of the dish to prevent contamination of the cultures and to control evaporation of liquid from the dish. The handle can extend from the base, the lid or both. If the handles are provided on both the base and the lid, they can be configured differently so that a user can readily distinguish between them.

Abstract translation: 用于培养诸如组织细胞，细菌等的培养物的培养皿。 培养皿包括从其上延伸的手柄，当提起或处理培养皿时，可以容易地被使用者掌握。 培养皿还可以包括可以放置在盘的底部上的盖，以防止培养物的污染并且控制来自盘的液体的蒸发。 手柄可以从基座，盖子或两者延伸。 如果把手提供在基座和盖子上，则它们可以被不同地配置，使得用户可以容易地区分它们。

公开(公告)号：US5272083A

公开(公告)日：1993-12-21

申请号：US705767

申请日：1991-05-28

Applicant: David Butz ,  George Lyman ,  David Root ,  Gregory Mathus

Inventor： David Butz ,  George Lyman ,  David Root ,  Gregory Mathus

IPC: C12M3/00 ,  C12M3/06 ,  C12N5/00 ,  C12N5/06

CPC classification number: C12M47/02 ,  C12M23/00 ,  C12M23/12 ,  C12M25/04

Abstract: A tissue or cell growth device is described for placement within a well of a cluster dish. The device has a cell or tissue retention element detachably attached to a hanger. The hanger preferably has openings allowing access to the well without removal of the member and is capable of positioning the cell or tissue retention element a preselected distance relative to the hanger. Also described are various embodiments of the device having differently shaped hangers and the combination of the device and a cluster dish.

Abstract translation: 描述了组织或细胞生长装置用于放置在簇盘的孔内。 该装置具有可拆卸地附接到衣架的细胞或组织保持元件。 衣架优选地具有允许进入井的开口，而不移除构件，并且能够将电池或组织保持元件相对于衣架定位成预选的距离。 还描述了具有不同形状的悬挂器以及装置和簇盘的组合的装置的各种实施例。

公开(公告)号：USD262752S

公开(公告)日：1982-01-26

申请号：US103052

申请日：1979-12-13

Applicant: Pasquale L. Pepicelli, Jr. ,  Alan Lowry ,  David Roche ,  Gregory Mathus

Designer： Pasquale L. Pepicelli, Jr. ,  Alan Lowry ,  David Roche ,  Gregory Mathus

公开(公告)号：US08518345B2

公开(公告)日：2013-08-27

申请号：US13411675

申请日：2012-03-05

Applicant: David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

Inventor： David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC: B01L3/00 ,  B01L3/02 ,  G01N1/14

CPC classification number: B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：USD599030S1

公开(公告)日：2009-08-25

申请号：US29284850

申请日：2007-09-17

Applicant: Richard Cote ,  David E. Roche ,  Samuel Millen ,  Christopher Labak ,  Laurence Keene ,  Stanley O. Thompson ,  Alex Therrien ,  Gary E. Nelson ,  Gregory Mathus ,  George Kalmakis

Designer： Richard Cote ,  David E. Roche ,  Samuel Millen ,  Christopher Labak ,  Laurence Keene ,  Stanley O. Thompson ,  Alex Therrien ,  Gary E. Nelson ,  Gregory Mathus ,  George Kalmakis