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156 条记录 (耗时 0.028 秒)

    Repuncturable self-sealing sample container with internal collapsible bag
    1.
    发明授权
    Repuncturable self-sealing sample container with internal collapsible bag 失效
    具有内部可折叠袋的可重复自密封样品容器

    公开(公告)号：US06805842B1

    公开(公告)日：2004-10-19

    申请号：US09976628

    申请日：2001-10-12

    申请人： Kevin S. Bodner ,  Tyler A. Palmer ,  Pejman Ghanouni

    发明人： Kevin S. Bodner ,  Tyler A. Palmer ,  Pejman Ghanouni

    IPC分类号： B01L300

    CPC分类号： B01L3/505 ,  B01L3/0217 ,  B01L3/50825 ,  B01L3/5085 ,  B01L2200/142 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0854 ,  B01L2400/0478

    摘要： A sample container for minimizing evaporation of a contained volume of sample includes a container housing, a repuncturable self-sealing membrane, and a collapsible sample bag. The container housing includes an open end and a hollow interior region. The repuncturable self-sealing membrane configured to self-seal after repeated punctures is engaged in the open end of the container housing and includes an exterior surface exposed to the external environment and an interior surface oriented toward the hollow interior region of the container housing. The collapsible sample bag includes a proximate end that is permanently attached to the interior surface of the repuncturable self-sealing membrane.

    摘要翻译： 用于最小化容纳体积的样品的蒸发的样品容器包括容器壳体，可重复的自密封膜和可折叠样品袋。 容器壳体包括开口端和中空的内部区域。 构造为在重复穿刺之后自密封的可重复使用的自密封膜被接合在容器壳体的开口端中，并且包括暴露于外部环境的外表面和朝向容器壳体的中空内部区域定向的内表面。 可折叠的样品袋包括永久地附着到可再次自密封膜的内表面的近端。

    Micromachined device for receiving and retaining at least one liquid droplet, method of making the device and method of using the device
    3.
    发明授权
    Micromachined device for receiving and retaining at least one liquid droplet, method of making the device and method of using the device 有权
    用于接收和保持至少一个液滴的微加工装置，制造该装置的方法和使用该装置的方法

    公开(公告)号：US06764652B2

    公开(公告)日：2004-07-20

    申请号：US09768950

    申请日：2001-01-24

    申请人： Robert W. Hower ,  Richard B. Brown

    发明人： Robert W. Hower ,  Richard B. Brown

    IPC分类号： B01L300

    CPC分类号： B01L3/5085 ,  G01N2035/1037 ,  Y10T436/25

    摘要： A micromachined device such as a solid-state liquid chemical sensor for receiving and retaining a plurality of separate liquid droplets at desired sites, a method of making the device and a method of using the device are provided. The technique works for both aqueous and solvent-based solutions. The device includes a substrate having an upper surface, and a first set of three-dimensional, thin film well rings patterned at the upper surface of the substrate. Each of the wells is capable of receiving and retaining a known quantity of liquid at one of the desired sites through surface tension. A method for patterning a membrane/solvent solution results in reproducibly-sized, uniformly-thick membranes. The patterning precision of this method allows one to place the membranes closer together, making the sensors smaller and less expensive, and the uniform film thickness imparts reproducibility to the sensors.

    摘要翻译： 提供了一种微机械装置，例如固态液体化学传感器，用于在期望的位置接收和保持多个分离的液滴，提供了制造该装置的方法和使用该装置的方法。 该技术适用于水溶剂和溶剂型溶液。 该器件包括具有上表面的衬底和在衬底的上表面上图案化的第一组三维薄膜阱环。 每个孔能够通过表面张力接收和保留在期望位置之一处的已知量的液体。 用于图案化膜/溶剂溶液的方法导致可再现尺寸的均匀厚的膜。 该方法的图案精度允许将膜更靠近在一起，使得传感器更小和更便宜，并且均匀的膜厚赋予传感器再现性。

    Container for holding biologic fluid for analysis
    5.
    发明授权
    Container for holding biologic fluid for analysis 有权
    用于容纳生物液体的容器用于分析

    公开(公告)号：US06723290B1

    公开(公告)日：2004-04-20

    申请号：US09256486

    申请日：1999-02-23

    申请人： Stephen C. Wardlaw

    发明人： Stephen C. Wardlaw

    IPC分类号： B01L300

    CPC分类号： B01L3/50 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/545 ,  B01L9/50 ,  B01L2300/089 ,  B01L2400/0406 ,  B01L2400/0633 ,  B01L2400/086 ,  G01N35/00029 ,  G01N35/00732 ,  G01N2001/282 ,  G01N2035/00851

    摘要： A container for holding a biologic fluid sample for analysis is provided which includes a chamber and a label. The chamber includes a first wall, a transparent second wall, and at least one feature located at a known spatial location within the chamber. The transparent second wall permits a fluid sample quiescently residing within the chamber to be imaged through the second wall. The at least one feature is operable to enable the analysis of the biologic fluid. The label directly or indirectly contains information regarding the features and the spatial location of the features within the chamber. The sample is analyzed by an analytical device that utilizes the information communicated through the label.

    摘要翻译： 提供用于容纳用于分析的生物流体样品的容器，其包括室和标签。 该腔室包括第一壁，透明第二壁和位于室内的已知空间位置的至少一个特征。 透明的第二壁允许静止在腔室内的流体样品通过第二壁成像。 所述至少一个特征可操作以使得能够分析生物流体。 标签直接或间接包含关于室内特征和空间位置的信息。 样品通过利用通过标签传递的信息的分析装置进行分析。

    Flow cell for chemical reactions
    6.
    发明授权
    Flow cell for chemical reactions 失效
    用于化学反应的流通池

    公开(公告)号：US06713023B2

    公开(公告)日：2004-03-30

    申请号：US09896596

    申请日：2001-06-29

    申请人： Jay K. Bass ,  John F. McEntee ,  Tim J. Lazaruk ,  Maryam Mobed-Miremadi

    发明人： Jay K. Bass ,  John F. McEntee ,  Tim J. Lazaruk ,  Maryam Mobed-Miremadi

    IPC分类号： B01L300

    CPC分类号： B82Y30/00 ,  B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00664 ,  B01J2219/00675 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B50/14 ,  Y10T436/11 ,  Y10T436/2575

    摘要： Devices and methods are disclosed for synthesizing compounds on the surface of supports. The devices are flow devices, which include a housing comprising a housing chamber. The housing has an opening adapted for insertion of a support into the housing chamber. A sealing member is movably mounted in the housing chamber and adapted to engage the support to form a reagent chamber between a surface of the support and a surface of the sealing member. A mechanism is included for moving the sealing member within the housing chamber. The device has both an inlet and an outlet, which are both in fluid communication with the reagent chamber. In the methods of the invention a support is placed into a chamber of a device such as described above. The mechanism adapted to engage the support on a surface opposite the surface engaged by the sealing member is activated to urge the support toward the sealing member. The pressure-activated mechanism is activated to urge the support against the aforesaid mechanism and against an interior wall of the housing chamber to form the reagent chamber. A fluid reagent for conducting the reaction step is introduced into the reagent chamber by means of the inlet. Thereafter, the fluid reagent is removed from the reagent chamber. The pressure-activated mechanism is deactivated and the support is removed from the housing chamber. In this way the reagent chamber is formed and un-formed in situ.

    摘要翻译： 公开了用于在载体表面上合成化合物的装置和方法。 装置是流动装置，其包括包括容纳室的壳体。 壳体具有适于将支撑件插入到容纳室中的开口。 密封构件可移动地安装在容纳室中并且适于接合支撑件以在支撑件的表面和密封构件的表面之间形成试剂室。 包括用于使密封构件在壳体室内移动的机构。 该装置具有入口和出口，它们都与试剂室流体连通。 在本发明的方法中，将支撑件放置在如上所述的装置的室中。 适于将支撑件接合在与由密封构件接合的表面相对的表面上的机构被启动以将支撑件推向密封构件。 压力启动机构被启动，以推动支撑件抵靠上述机构并抵靠壳体室的内壁以形成试剂室。 用于进行反应步骤的流体试剂通过入口引入试剂室。 此后，将流体试剂从试剂室中取出。 压力启动机构被停用，并且支撑件从壳体室移除。 以这种方式，试剂室在原位形成和未形成。

    Production of microcuvettes
    8.
    发明授权
    Production of microcuvettes 有权
    微生物的生产

    公开(公告)号：US06607701B1

    公开(公告)日：2003-08-19

    申请号：US09541894

    申请日：2000-04-03

    申请人： Lars Jansson ,  Per Olsson ,  Norbert Pogorzelski ,  Ingrid Hultgren

    发明人： Lars Jansson ,  Per Olsson ,  Norbert Pogorzelski ,  Ingrid Hultgren

    IPC分类号： B01L300

    CPC分类号： B01L3/502707 ,  B01F13/0059 ,  B01L2200/0684 ,  B01L2300/0825 ,  B01L2300/0887 ,  B29C51/10 ,  B29C2791/006 ,  G01N21/03 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/0357

    摘要： The invention concerns a method for continuous production of disposable capillary plastic microcuvettes including the steps of providing a first and a second sheet; providing at least one depression having a predetermined depth at a predetermined place in at least one of the sheets; introducing at least one additive or reagent in at least one depression; joining the first sheet and the second sheet for obtaining a body member including at least one cavity, the inner walls of which are defined by the at least one depression and a predetermined area of the opposite sheet and cutting out microcuvettes including at least one cavity and having a predetermined size and configuration from the body member, in such a way that at least one cavity of the microcuvette is communicating with the exterior atmosphere of the microcuvette through a capillary sample inlet opening. The invention also concerns a cuvette prepared according to the new method.

    摘要翻译： 本发明涉及连续生产一次性毛细管塑料微量玻璃的方法，包括提供第一和第二片材的步骤; 在至少一个所述片材中的预定位置处提供具有预定深度的至少一个凹部; 在至少一个凹陷中引入至少一种添加剂或试剂; 接合第一片和第二片以获得包括至少一个腔的主体构件，其内壁由至少一个凹部和相对片的预定区域限定，并且切除包括至少一个空腔的微型电池 具有来自本体构件的预定尺寸和构造，使得微型小瓶的至少一个空腔通过毛细管样品入口开口与微型小瓶的外部气氛连通。 本发明还涉及根据新方法制备的比色皿。

    Adapter for holding a sample container to facilitate sensing of liquid level in the sample container
    10.
    发明授权
    Adapter for holding a sample container to facilitate sensing of liquid level in the sample container 失效

    公开(公告)号：US06598474B2

    公开(公告)日：2003-07-29

    申请号：US10277521

    申请日：2002-10-21

    申请人： Paul E. Purpura ,  Thomas W. De Young

    发明人： Paul E. Purpura ,  Thomas W. De Young

    IPC分类号： B01L300

    CPC分类号： G01N35/026 ,  B01L9/06 ,  G01N2035/1025

    摘要： An adapter for holding a sample container includes a main body portion and a tapered body portion that forms a continuation of the main body portion. The tapered body portion includes a mouth opening that is of lesser diameter than the diameter of the main body portion. The mouth opening of the adapter is sized to provide direct support of a sample container which holds a liquid sample. During liquid level sensing ultrasonic waves from an ultrasound detector are reflected back to the sound detector as echoes from the lip flange of the sample container and from the liquid level within the sample container. The tapered surface of the adapter deflects sound echoes away from the sound detector. The adapter is thus invisible to the ultrasound detector. The echo from the liquid level is a variable duration echo and the echo from the lip flange of the sample container is a fixed duration echo that is always of lesser duration than the variable duration echo. Thus the sound detector can easily recognize the liquid level echo and convert the characteristics of the liquid level echo to a discernible liquid level.