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31.发明申请公开(公告)号：US20200273692A1
公开(公告)日：2020-08-27
申请号：US16647237
申请日：2018-08-06
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Masahiro KOTANI , Takayuki OHMURA
Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, a conductive layer provided on at least the first surface, and a matrix provided in the plurality of through holes; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; and a third step of ionizing a component of the sample that is mixed with the matrix and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser light while a voltage is applied to the conductive layer.
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公开(公告)号：US20200273691A1
公开(公告)日：2020-08-27
申请号：US16762971
申请日：2018-10-05
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Yasuhide NAITO , Takayuki OHMURA , Masahiro KOTANI
Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of introducing a sample and a solvent having refractoriness in a vacuum into the plurality of through holes; and a third step of ionizing a component of the sample by irradiating the first surface with laser beam while applying a voltage to the conductive layer.
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33.发明申请公开(公告)号：US20200258730A1
公开(公告)日：2020-08-13
申请号：US16864919
申请日：2020-05-01
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Yasuhide NAITO , Masahiro KOTANI , Takayuki OHMURA
Abstract: A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support (2) having a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided and a conductive layer (23) that covers at least the one surface (21a); a second process of placing a sample (10) on a sample stage (1) and arranging the sample support (2) on the sample (10) such that the other surface (21b) faces the sample (10); and a third process of applying a laser beam (L) to the one surface (21a) and ionizing the sample (10) moved from the other surface (21b) side to the one surface (21a) side via the through-holes (S) due to a capillary phenomenon.
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公开(公告)号：US20200219712A1
公开(公告)日：2020-07-09
申请号：US16647497
申请日：2018-08-03
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Takayuki OHMURA , Masahiro KOTANI
Abstract: Provided is a sample support body that includes a substrate and an ionization substrate. The ionization substrate has a measurement region for dropping a sample on a second surface. A plurality of through-holes that open in a first surface and the second surface are formed in at least the measurement region of the ionization substrate. A conductive layer is provided on peripheral edges of the through-holes on at least the second surface. At least a part of the substrate which is adjacent to the ionization substrate is formed to enable the sample to move to the inside of the substrate.
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公开(公告)号：US20130256539A1
公开(公告)日：2013-10-03
申请号：US13902084
申请日：2013-05-24
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Masahiro KOTANI , Takayuki OHMURA , Motohiro SUYAMA , Hiroshi KOBAYASHI
IPC: G01T1/20
CPC classification number: G01T1/2006 , G01T1/185 , G01T1/28
Abstract: An ion detector for detecting positive ions and negative ions, includes a housing provided with an ion entrance to make the positive ions and the negative ions enter, a conversion dynode which is disposed in the housing and to which a negative potential is applied, a scintillator which is disposed in the housing and has an electron incident surface which is opposed to the conversion dynode and into which secondary electrons emitted from the conversion dynode are made incident, a conductive layer which is formed on the electron incident surface and to which a positive potential is applied, and a photodetector which detects light emitted by the scintillator in response to incidence of the secondary electrons.
Abstract translation: 用于检测正离子和负离子的离子检测器包括设置有离子入口以使正离子和负离子进入的壳体，设置在壳体中并且施加负电位的转换倍增电极，闪烁体 其设置在壳体中并且具有与转换倍增电极相对的电子入射表面，并且从转换倍增极发射的二次电子入射到其中;形成在电子入射表面上并且具有正电位的导电层 以及光电检测器，其响应于二次电子的入射而检测由闪烁体发射的光。
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Patent Agency Ranking
公开(公告)号：US20230253196A1
公开(公告)日：2023-08-10
申请号：US18015804
申请日：2021-05-10
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Akira TASHIRO , Takayuki OHMURA , Masahiro KOTANI , Takamasa IKEDA
IPC: H01J49/04
CPC classification number: H01J49/0418
Abstract: A sample support used for sample component ionization includes: a substrate having a first surface and a plurality of holes opening to the first surface; and a conductive layer provided on the first surface so as not to block the hole, in which the conductive layer is configured by a plurality of nanoparticles and has a thickness of 30 nm or more.
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公开(公告)号：US20230131548A1
公开(公告)日：2023-04-27
申请号：US17913211
申请日：2021-01-14
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Akira TASHIRO , Masahiro KOTANI , Takayuki OHMURA
Abstract: A sample support includes: a substrate having a plurality of through-holes opening on a first surface and on a second surface; a first member having a plurality of first openings and disposed on the first surface; a second member having a plurality of second openings and disposed on the second surface, and; a bonding member disposed between the first member and the second member; and a conductive layer integrally provided on a region of the second surface corresponding to each of the plurality of second openings. The plurality of through-holes include a plurality of first through-holes located between each of the plurality of first openings and each of the plurality of second openings, and a plurality of second through-holes located between the first member and the second member. Each of the plurality of second openings communicate with each of the plurality of first openings through the plurality of first through-holes.
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公开(公告)号：US20230095349A1
公开(公告)日：2023-03-30
申请号：US17795964
申请日：2020-12-01
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Akira TASHIRO , Masahiro KOTANI , Takayuki OHMURA
IPC: H01J49/04
Abstract: A sample support body includes: an insulating substrate having a measurement region formed with a plurality of through holes; a frame formed with an opening part opening to a first face and a second face to correspond to the measurement region, and formed on the first surface such that the opening part overlaps the measurement region when viewed from a thickness direction of the substrate; an adhesive layer to bond the substrate and the frame and having a protruding portion protruding from an inner surface of the opening part toward the measurement region; and a conductive layer having a first portion provided along the inner surface of the opening part, a second portion provided along the first surface of the measurement region, and a third portion provided along a surface of the protruding portion so as to connect the first portion and the second portion.
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公开(公告)号：US20220157587A1
公开(公告)日：2022-05-19
申请号：US17439029
申请日：2019-12-11
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Masahiro KOTANI , Takayuki OHMURA , Akira TASHIRO
Abstract: The sample support is used for ionization of a sample contained in a sample solution dropped using a pipette tip. The sample support includes a substrate formed with a plurality of through holes opened in a first surface and a second surface, and a frame that is formed with a through hole penetrating in a thickness direction of the substrate so as to overlap a measurement region when viewed from the thickness direction and that is bonded to the first surface of the substrate. The through hole of the frame includes a narrow portion having a width smaller than the outer diameter of a tip of the pipette tip.
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公开(公告)号：US20220102126A1
公开(公告)日：2022-03-31
申请号：US17549113
申请日：2021-12-13
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Masahiro KOTANI , Takayuki OHMURA , Takamasa IKEDA
IPC: H01J49/04
Abstract: A sample support body is a sample support body for ionizing a sample, including: a substrate having an irregular porous structure formed to communicate a first surface and a second surface opposite to each other; and a conductive layer provided at least on the first surface.
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