利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

44 条记录 (耗时 0.038 秒)

    DIPHENYL-HETEROARYL DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES
    34.
    发明申请
    DIPHENYL-HETEROARYL DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES 审中-公开
    二苯醚衍生物及其用于结合和成像淀粉样物质的用途

    公开(公告)号：US20110158907A1

    公开(公告)日：2011-06-30

    申请号：US12595131

    申请日：2008-04-18

    申请人： Hank F. Kung ,  Mei-Ping Kung ,  Wenchao Qu

    发明人： Hank F. Kung ,  Mei-Ping Kung ,  Wenchao Qu

    IPC分类号： A61K51/00 ,  C07D249/06 ,  C07F13/00 ,  A61K31/4192 ,  A61P25/28

    CPC分类号： C07D249/06

    摘要： This invention relates to a method of imaging amyloid deposits and to diphenyl-heteroaryl compounds, and methods of making radiolabeled diphenyl-heteroaryl compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

    摘要翻译： 本发明涉及淀粉样蛋白沉积物和二苯基 - 杂芳基化合物的成像方法，以及制备用于成像淀粉样沉积物的放射性标记的二苯基 - 杂芳基化合物的方法。 本发明还涉及化合物和制备用于抑制淀粉样蛋白聚集以形成淀粉样沉积物的化合物的方法，以及将治疗剂递送至淀粉样沉积物的方法。

    Styrylpyridine Derivatives and Their Use for Binding and Imaging Amyloid Plaques
    35.
    发明申请
    Styrylpyridine Derivatives and Their Use for Binding and Imaging Amyloid Plaques 有权
    苯乙烯基吡啶衍生物及其用于结合和成像淀粉样斑块的用途

    公开(公告)号：US20090123369A1

    公开(公告)日：2009-05-14

    申请号：US12186072

    申请日：2008-08-05

    申请人： Hank F. Kung ,  Mei Ping Kung

    发明人： Hank F. Kung ,  Mei Ping Kung

    IPC分类号： A61K51/04 ,  C07D213/64 ,  C07F13/00

    CPC分类号： C07D211/94 ,  A61K51/0455 ,  C07D213/16

    摘要： This invention relates to a method of imaging amyloid deposits and to styrylpyridine compounds, and methods of making radiolabeled styrylpyridine compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

    摘要翻译： 本发明涉及淀粉样蛋白沉积物和苯乙烯基吡啶化合物的成像方法，以及制备用于成像淀粉样沉积物的放射性标记的苯乙烯基吡啶化合物的方法。 本发明还涉及化合物和制备用于抑制淀粉样蛋白聚集以形成淀粉样沉积物的化合物的方法，以及将治疗剂递送至淀粉样沉积物的方法。

    Serotonin reuptake inhibitors for S.P.E.C.T. imaging
    40.
    发明授权
    Serotonin reuptake inhibitors for S.P.E.C.T. imaging 失效
    血清素再摄取抑制剂S.P.E.C.T. 成像

    公开(公告)号：US5320825A

    公开(公告)日：1994-06-14

    申请号：US694346

    申请日：1991-05-01

    申请人： Hank F. Kung

    发明人： Hank F. Kung

    IPC分类号： A61K51/04 ,  C07B59/00 ,  C07C217/48 ,  A61K49/02 ,  C07C93/08

    CPC分类号： C07C217/48 ,  A61K51/0406 ,  C07B59/001 ,  A61K2123/00

    摘要： Disclosed are novel compounds for CNS neurotransmitter systems, especially for the neurotransmitter serotonin, which have the formula ##STR1## where each of U, V, W, X, Y and Z is independently selected from the group consisting of hydrogen; halogen; C.sub.1 -C.sub.4 alkyl; C.sub.1 -C.sub.4 alkyl substituted with one or more moieties selected from halogen atoms and hydroxy groups; C.sub.1 -C.sub.4 alkoxy; C.sub.1 -C.sub.4 alkoxy substituted with one or more moieties selected from halogen atoms and hydroxy groups; C.sub.1 -C.sub.6 heterocycles; C.sub.1 -C.sub.4 thioalkyl; NR.sub.3 R.sub.4 ; --R.sub.5 --A --R.sub.6 ; and --A--R.sub.7 ; CN; SO.sub.2 R.sub.8 ; --NHCONH.sub.2 ; and C(O)NR.sub.3 R.sub.4 ;each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is independently selected from the group consisting of hydrogen and C.sub.1 -C.sub.4 alkyl;each of R.sub.5 and R.sub.6 is independently a C.sub.1 -C.sub.6 alkyl;R.sub.7 is selected from the group consisting of H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 heterocycles or --A--R.sub.5 ;R.sub.8 is selected from the group consisting of C.sub.1 -C.sub.4 alkyl and NR.sub.3 R.sub.4 ;A is selected from the group consisting of S, N and O;provided that at least one of U, V, W, X, Y and Z is a halogen atom;and pharmaceutically acceptable salts thereof.

    摘要翻译： 公开了用于CNS神经递质系统的新化合物，特别是用于神经递质5-羟色胺的新化合物，其具有式“IMAGE”，其中U，V，W，X，Y和Z各自独立地选自氢; 卤素; C 1 -C 4烷基; 被一个或多个选自卤素原子和羟基的部分取代的C 1 -C 4烷基; C1-C4烷氧基; 被一个或多个选自卤素原子和羟基的部分取代的C 1 -C 4烷氧基; C1-C6杂环; C 1 -C 4硫代烷基; NR3R4; -R5 -A -R6; 和-A-R7; CN; SO2R8; -NHCONH 2; 和C（O）NR 3 R 4; R 1，R 2，R 3和R 4各自独立地选自氢和C 1 -C 4烷基; R 5和R 6各自独立地为C 1 -C 6烷基; R 7选自H，C 1 -C 6烷基，C 1 -C 6杂环或-A-R 5; R8选自C1-C4烷基和NR3R4; A选自S，N和O; U，V，W，X，Y和Z中的至少一个为卤原子; 及其药学上可接受的盐。