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93 条记录 (耗时 0.033 秒)

    Antimycotic diaryloxy-imidazolyl-O,N-acetals
    33.
    发明授权
    Antimycotic diaryloxy-imidazolyl-O,N-acetals 失效
    抗真菌的二芳氧基 - 咪唑基-O，N-缩醛

    公开(公告)号：US4239767A

    公开(公告)日：1980-12-16

    申请号：US629215

    申请日：1975-11-06

    申请人： Karl H. Buchel ,  Wolfgang Kramer ,  Manfred Plempel

    发明人： Karl H. Buchel ,  Wolfgang Kramer ,  Manfred Plempel

    IPC分类号： A01N43/50 ,  A01P3/00 ,  C07D233/60 ,  C07D521/00 ,  A61K31/415

    CPC分类号： C07D231/12 ,  C07C317/00 ,  C07D233/56 ,  C07D249/08

    摘要： Diaryloxy-imidazolyl-O,N-acetals of the formula ##STR1## or pharmaceutically-acceptable, nontoxic salts thereof wherein X and Y are each halo, alkyl, alkoxy, haloalkylthio, nitro, amino, alkylamino or dialkylamino;Z is a direct bond, methylene, oxygen, sulphur, sulphonyl, alkoxymethylene or a keto moiety;A is a keto moiety or a moiety of the formula C(OH)R, wherein R is hydrogen or alkyl; anda and b are each integers from 0 to 3;are useful for their antimycotic activity and their sporocidal action.

    摘要翻译： 式（I）的二芳氧基 - 咪唑基-O，N-缩醛或其药学上可接受的无毒盐，其中X和Y各自为卤素，烷基，烷氧基，卤代烷硫基，硝基，氨基，烷基氨基或二烷基氨基; Z是直接键，亚甲基，氧，硫，磺酰基，烷氧基亚甲基或酮基部分; A是酮基部分或式C（OH）R的部分，其中R是氢或烷基; a和b各自为0至3的整数; 对于它们的抗真菌活性及其杀孢子作用是有用的。

    Acylated imidazolyl-O,N-acetals, their pharmaceutically acceptable salts and metal complexes
    35.
    发明授权
    Acylated imidazolyl-O,N-acetals, their pharmaceutically acceptable salts and metal complexes 失效
    酰化咪唑基-O，N-缩醛，其药学上可接受的盐和金属络合物

    公开(公告)号：US4153708A

    公开(公告)日：1979-05-08

    申请号：US764830

    申请日：1977-02-02

    申请人： Wolfgang Kramer ,  Karl H. Buchel ,  Manfred Plempel

    发明人： Wolfgang Kramer ,  Karl H. Buchel ,  Manfred Plempel

    IPC分类号： C07D233/60 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Acylated imidazolyl-O,N-acetals of the formula ##STR1## and their pharmaceutically acceptable salts and metal complexes wherein R is alkyl, alkenyl, alkinyl, cycloalkyl, halogenoalkyl, optionally substituted phenyl, optionally substituted phenoxyalkyl, alkylamino, dialkylamino or optionally substituted phenylamino;X is halogen, alkyl, cycloalkyl, alkoxy, halogenoalkyl, alkylthio, alkoxycarbonyl, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl, amino, cyano or nitro; andN is 0 or an integer of from 1 to 5; are useful as antimicrobial agents, particularly for their use in treating mycotic infectins in humans and animals.

    摘要翻译： 具有式（I）的酰化咪唑基-O，N-缩醛及其药学上可接受的盐和金属络合物，其中R是烷基，烯基，炔基，环烷基，卤代烷基，任选取代的苯基，任选取代的苯氧基烷基，烷基氨基，二烷基氨基或 任选取代的苯基氨基; X是卤素，烷基，环烷基，烷氧基，卤代烷基，烷硫基，烷氧基羰基，任选取代的苯基，任选取代的苯氧基，任选取代的苯基烷基，氨基，氰基或硝基; 和N是0或1到5的整数; 有用的抗微生物剂，特别是用于治疗人类和动物中的MYCOTIC感染。

    Disubstituted triphenylmethylmidazoles for treating mycotic infections
    36.
    发明授权
    Disubstituted triphenylmethylmidazoles for treating mycotic infections 失效
    用于治疗肌肉感染的三甲基甲酰胺

    公开(公告)号：US4117142A

    公开(公告)日：1978-09-26

    申请号：US726568

    申请日：1976-09-27

    申请人： Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

    发明人： Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

    IPC分类号： C07D521/00 ,  A61K31/415

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Imidazoles of the formula ##STR1## and pharmaceutically acceptable nontoxic salts thereof, wherein X is methyl or chloro,Y is methyl or chloro, or, when Z is methyl or chloro, Y is hydrogen, andZ is methyl or chloro, or, when Y is methyl or chloro, Z is hydrogen,Are useful as antimycotics for the treatment of mycotic infections in humans and animals. The imidazoles may be produced by reacting the corresponding triphenylmethylcarbinol with a brominating or chlorinating agent and thereafter reacting the resultant triphenylmethyl halide, either with or without isolation, with imidazole in the presence or absence of an acid-binding agent, or they may be prepared by reacting a triphenylmethyl halide with imidazole, either in the presence or absence of an acid-binding agent.

    1-Propyl-triazolyl antimycotic compositions and methods of treating mycoses
    37.
    发明授权
    1-Propyl-triazolyl antimycotic compositions and methods of treating mycoses 失效
    1-丙基 - 三唑基抗真菌组合物和治疗真菌病的方法

    公开(公告)号：US4079142A

    公开(公告)日：1978-03-14

    申请号：US638754

    申请日：1975-12-08

    申请人： Karl Heinz Buchel ,  Wolfgang Kramer ,  Manfred Plempel

    发明人： Karl Heinz Buchel ,  Wolfgang Kramer ,  Manfred Plempel

    IPC分类号： C07D249/08 ,  A61K31/41

    CPC分类号： C07D249/08

    摘要： Pharmaceutical compositions are produced which comprise an antimycotically effective amount of a compound of the formula ##STR1## or a pharmaceutically acceptable non-toxic salt thereof wherein R.sup.1 is an unsubstituted or substituted aryl moiety,R.sup.2 is hydrogen, alkyl, alkenyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl, andR.sup.3 is hydrogen, alkyl or cycloalkyl,Provided that when R.sup.3 is hydrogen, R.sup.2 cannot be hydrogen, in combination with a pharmaceutically acceptable non-toxic inert diluent or carrier.

    摘要翻译： 制备药物组合物，其包含抗真菌有效量的下式化合物或其药学上可接受的无毒盐，其中R 1是未取代或取代的芳基部分，R 2是氢，烷基，烯基，环烷基，未取代的或未取代的 取代的芳基或未取代或取代的芳烷基，并且R 3是氢，烷基或环烷基，当R3是氢时，R2不能是氢，与药学上可接受的无毒惰性稀释剂或载体组合。