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公开(公告)号：US4239765A
公开(公告)日：1980-12-16
申请号：US92804
申请日：1979-11-09
申请人： Erik Regel , Karl Buchel , Ingo Haller , Manfred Plempel
发明人： Erik Regel , Karl Buchel , Ingo Haller , Manfred Plempel
IPC分类号： A61K31/40 , A61K31/41 , A61K31/415 , A61P31/04 , C07C29/40 , C07C49/813 , C07D233/60 , C07D249/08 , C07D521/00 , C07D249/12
CPC分类号： C07D231/12 , C07C29/40 , C07C49/813 , C07D249/08 , C07C2103/18
摘要： The invention relates to fluorenylazolylmethylcarbinols and methods for their preparation. Also included are compositions containing said fluorenylazolylmethyl-carbinols and methods for the use of said carbinols and compositions containing them as antimycotic agents.
摘要翻译： 本发明涉及芴基唑基甲基甲醇及其制备方法。 还包括含有所述芴基甲基 - 甲醇的组合物和使用所述甲醇的方法和含有它们的组合物作为抗真菌剂。
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2.发明授权
公开(公告)号：US4381306A
公开(公告)日：1983-04-26
申请号：US92805
申请日：1979-11-09
申请人： Erik Regel , Karl H. Buchel , Ingo Haller , Manfred Plempel
发明人： Erik Regel , Karl H. Buchel , Ingo Haller , Manfred Plempel
IPC分类号： A61K31/41 , A61P31/04 , C07C29/40 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07C29/40 , C07D249/08
摘要： The invention relates to hydroxypropyl-triazole compounds and methods for their preparation. Also included are compositions containing said hydroxypropyl-triazoles and methods for the use of the said active compounds and compositions, as antimycotic agents.
摘要翻译： 本发明涉及羟丙基三唑化合物及其制备方法。 还包括含有所述羟丙基三唑的组合物和使用所述活性化合物和组合物作为抗真菌剂的方法。
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公开(公告)号：US4301166A
公开(公告)日：1981-11-17
申请号：US92806
申请日：1979-11-09
申请人： Erik Regel , Karl H. Buchel , Ingo Haller , Manfred Plempel
发明人： Erik Regel , Karl H. Buchel , Ingo Haller , Manfred Plempel
IPC分类号： C07D249/04 , A61K31/40 , A61K31/41 , A61K31/415 , A61P31/04 , C07C29/40 , C07C45/46 , C07D233/60 , C07D249/08 , C07D521/00 , A01N43/50 , A01N43/82
CPC分类号： C07D231/12 , C07C29/40 , C07C45/46 , C07D249/08
摘要： The invention relates to hydroxyethyl-azole compounds and methods for their preparation. Also included in the invention are compositions containing said hydroxyethyl-azole compounds and methods for the use of said compounds and compositions as antimycotic agents.
摘要翻译： 本发明涉及羟乙基唑化合物及其制备方法。 本发明还包括含有所述羟乙基 - 唑类化合物的组合物和使用所述化合物和组合物作为抗真菌剂的方法。
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公开(公告)号：US4246274A
公开(公告)日：1981-01-20
申请号：US30799
申请日：1979-04-17
申请人： Erik Regel , Karl H. Buchel , Ingo Haller , Manfred Plempel
发明人： Erik Regel , Karl H. Buchel , Ingo Haller , Manfred Plempel
IPC分类号： C07D521/00 , A61K31/415 , C07D233/60
CPC分类号： C07D231/12 , C07D249/08
摘要： The invention includes as a series of 2-(substituted-phenyl)-1-aryl-3-(imidazol-1-yl)-propan-2-ols useful as antimicrobial agents. Also included in the invention are methods for the manufacture of the above-identified imidazol-1-yl-propan-2-ols, compositions containing said compounds and the use of said compounds and compositions for antimicrobial use.
摘要翻译： 本发明包括用作抗微生物剂的一系列2-（取代苯基）-1-芳基-3-（咪唑-1-基） - 丙-2-醇。 本发明还包括制备上述咪唑-1-基 - 丙-2-醇的方法，含有所述化合物的组合物以及所述化合物和组合物用于抗微生物使用的方法。
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公开(公告)号：US4238498A
公开(公告)日：1980-12-09
申请号：US8632
申请日：1979-02-01
申请人： Erik Regel , Karl H. Buchel , Wilfried Draber , Manfred Plempel , Ingo Haller
发明人： Erik Regel , Karl H. Buchel , Wilfried Draber , Manfred Plempel , Ingo Haller
IPC分类号： A61K31/415 , A61P31/04 , A61P31/10 , C07C33/34 , C07C45/46 , C07C49/792 , C07D233/56 , C07D233/58 , C07D521/00
CPC分类号： C07D231/12 , C07C33/34 , C07C45/46 , C07C49/792 , C07D233/56 , C07D249/08
摘要： The invention provides a series of substituted diphenyl-imidazolyl-methanes useful as antimycotic agents. Also included in the invention are pharmaceutical compositions containing said diphenyl-imidazolyl-methanes and methods for the use of said compounds and compositions. The invention additionally includes methods for the manufacture of the diphenyl-imidazolyl-methanes.
摘要翻译： 本发明提供一系列用作抗真菌剂的取代的二苯基 - 咪唑基 - 甲烷。 本发明还包括含有所述二苯基 - 咪唑基 - 甲烷的药物组合物和用于所述化合物和组合物的方法。 本发明另外包括制备二苯基 - 咪唑基 - 甲烷的方法。
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公开(公告)号：US4632932A
公开(公告)日：1986-12-30
申请号：US549868
申请日：1983-11-08
IPC分类号： A01N43/50 , A01N43/653 , A61K31/41 , A61P31/04 , C07C45/56 , C07D317/26 , C07D319/06 , C07D405/06 , C07D405/14 , C07D407/04 , C07D407/06 , C07D521/00
CPC分类号： C07D231/12 , C07C45/56 , C07D233/56 , C07D249/08 , C07D317/26 , C07D319/06 , C07D407/04 , C07D407/06
摘要： The invention concerns the provision of compound of Formula I as defined herein as well as compositions containing compound of Formula I. Said compounds and compositions are used as antimycotic agents and the invention includes such use.
摘要翻译： 本发明涉及提供如本文所定义的式I化合物以及含有式I化合物的组合物。所述化合物和组合物用作抗真菌剂，本发明包括此类用途。
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公开(公告)号：US4141981A
公开(公告)日：1979-02-27
申请号：US813055
申请日：1977-07-05
申请人： Wilfried Draber , Manfred Plempel , Karl H. Buchel , Erik Regel
发明人： Wilfried Draber , Manfred Plempel , Karl H. Buchel , Erik Regel
IPC分类号： C07D401/06 , A61K31/44 , A61K31/4427 , A61P17/00 , A61P31/04 , C07D213/30 , C07D521/00
CPC分类号： C07D213/30 , C07D231/12 , C07D233/56 , C07D249/08
摘要： Antimycotic compositions in topical or vaginal administration form are prepared wherein the active agent is imidazol-1-yl-(4-phenoxyphenyl)-(pyridin-2-yl)phenylmethane in combination with a pharmaceutically acceptable carrier suitable for topical application to the skin of a human or suitable for vaginal administration to humans. Such compositions are useful for treating mycoses in humans.
摘要翻译： 制备局部或阴道给药形式的抗真菌组合物，其中活性剂是咪唑-1-基 - （4-苯氧基苯基） - （吡啶-2-基）苯基甲烷与适用于局部施用于皮肤的药学上可接受的载体的组合 人类或适合于对人类进行阴道给药。 这样的组合物可用于治疗人类的真菌病。
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8.发明授权Substituted diazolylalkyl-carbinols, a process for their preparation and their use as antimycotic agents 失效取代的二唑基烷基 - 甲醇，其制备方法及其作为抗真菌剂的用途
公开(公告)号：US5011850A
公开(公告)日：1991-04-30
申请号：US915435
申请日：1986-10-06
IPC分类号： A61K31/41 , A61K31/415 , A61P31/04 , C07C45/63 , C07C49/00 , C07D20060101 , C07D233/60 , C07D249/08 , C07D403/06 , C07D405/06 , C07D521/00
CPC分类号： C07D231/12 , C07C45/63 , C07D233/56 , C07D249/08
摘要： The invention relates to compounds and their derivatives, said compounds being described herein as those of Formula (I). The compounds and compositions containing them are effective antimycotic agents and the invention includes methods for the use of said compounds and compositions.
摘要翻译： 本发明涉及化合物及其衍生物，所述化合物在本文中被描述为式（I）的化合物。 含有它们的化合物和组合物是有效的抗真菌剂，本发明包括使用所述化合物和组合物的方法。
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公开(公告)号：US4910213A
公开(公告)日：1990-03-20
申请号：US787833
申请日：1985-10-16
申请人： Erik Regel , Klaus Bockmann , Karl H. Buchel , Manfred Plempel
发明人： Erik Regel , Klaus Bockmann , Karl H. Buchel , Manfred Plempel
IPC分类号： C07D409/06 , A61K31/41 , A61K31/415 , A61P31/04 , C07D233/60 , C07D249/08 , C07D333/00 , C07D403/06 , C07D405/06 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： A method of combating mycoses which comprises administering to a patient in need thereof an antimycotic effective amount of an azolylcyclopropyl-azolylmethyl-carbinol derivative of the formula ##STR1## in which Ar is optionally substituted aryl or optionally substituted heteroaryl,R is hydrogen, alkyl, alkenyl, alkinyl, trialkylsilyl, optionally substituted phenylalkyl or the acyl radical,X is a nitrogen atom or the CH group, andY is a nitrogen atom or the CH group,or an acid addition salt thereof.
摘要翻译： 一种防治真菌病的方法，其包括向有需要的患者施用抗真菌有效量的式（I）的唑基环丙基 - 唑基甲基 - 甲醇衍生物，其中Ar为任选取代的芳基或任选取代的杂芳基，R为氢 烷基，烯基，炔基，三烷基甲硅烷基，任选取代的苯基烷基或酰基，X是氮原子或CH基团，Y是氮原子或CH基团，或其酸加成盐。
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公开(公告)号：US4117142A
公开(公告)日：1978-09-26
申请号：US726568
申请日：1976-09-27
申请人： Karl Heinz Buchel , Erik Regel , Manfred Plempel
发明人： Karl Heinz Buchel , Erik Regel , Manfred Plempel
IPC分类号： C07D521/00 , A61K31/415
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Imidazoles of the formula ##STR1## and pharmaceutically acceptable nontoxic salts thereof, wherein X is methyl or chloro,Y is methyl or chloro, or, when Z is methyl or chloro, Y is hydrogen, andZ is methyl or chloro, or, when Y is methyl or chloro, Z is hydrogen,Are useful as antimycotics for the treatment of mycotic infections in humans and animals. The imidazoles may be produced by reacting the corresponding triphenylmethylcarbinol with a brominating or chlorinating agent and thereafter reacting the resultant triphenylmethyl halide, either with or without isolation, with imidazole in the presence or absence of an acid-binding agent, or they may be prepared by reacting a triphenylmethyl halide with imidazole, either in the presence or absence of an acid-binding agent.
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