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公开(公告)号：US08288407B2
公开(公告)日：2012-10-16
申请号：US13046322
申请日：2011-03-11
IPC分类号： C07D471/14 , A61K31/437 , A61P35/00
CPC分类号： C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/14
摘要： The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer. Compounds disclosed herein have the following chemical structure:
摘要翻译： 本发明提供抑制Akt活性的取代的萘啶化合物。 特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。 本文公开的化合物具有以下化学结构：
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公开(公告)号：US20120077810A1
公开(公告)日：2012-03-29
申请号：US13262096
申请日：2010-03-29
申请人： Qi Chen , Mingxiang Cui , Bin Hu , Shuangxi Hu , Zhifa Pu , Philip E. Sanderson , Richard Soll , Xue Tang , Jiabing Wang , Yongjin Yan , Jinfeng Yao , Hongjie Zhang
发明人： Qi Chen , Mingxiang Cui , Bin Hu , Shuangxi Hu , Zhifa Pu , Philip E. Sanderson , Richard Soll , Xue Tang , Jiabing Wang , Yongjin Yan , Jinfeng Yao , Hongjie Zhang
IPC分类号： A61K31/5377 , A61K31/519 , A61P35/00 , C07D487/04
CPC分类号： A61K31/44 , C07D487/04
摘要： The instant invention provides for substituted fused pyrimidine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译： 本发明提供抑制Akt活性的取代的稠合嘧啶化合物。 特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。
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公开(公告)号：US20110319443A1
公开(公告)日：2011-12-29
申请号：US13255757
申请日：2010-03-03
IPC分类号： A61K31/4375 , A61P35/00 , C07D471/04
CPC分类号： A61K31/4375 , C07D471/04
摘要： The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
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公开(公告)号：US20110160183A1
公开(公告)日：2011-06-30
申请号：US13046322
申请日：2011-03-11
IPC分类号： A61K31/397 , C07D471/14 , A61K31/4985 , A61K31/4375 , A61K31/506 , A61K31/501 , C07D413/14 , A61K31/5377 , C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/14
摘要： The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译： 本发明提供抑制Akt活性的取代的萘啶化合物。 特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。
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公开(公告)号：US20090253734A1
公开(公告)日：2009-10-08
申请号：US12482095
申请日：2009-06-10
IPC分类号： A61K31/4375 , C07D471/14
CPC分类号： C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/14
摘要： The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译： 本发明提供抑制Akt活性的取代的萘啶化合物。 特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。
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公开(公告)号：US07589068B2
公开(公告)日：2009-09-15
申请号：US11795156
申请日：2006-02-10
申请人： Nicholas D. P. Cosford , Mark E. Layton , Jun Liang , Craig W. Lindsley , Philip E. Sanderson , Zhijian Zhao
发明人： Nicholas D. P. Cosford , Mark E. Layton , Jun Liang , Craig W. Lindsley , Philip E. Sanderson , Zhijian Zhao
IPC分类号： A01N43/04 , A01N43/58 , A01N43/42 , A61K31/70 , A61K31/50 , A61K31/495 , A61K31/52 , A61K31/47 , C07D487/00 , C07D491/00 , C07H15/00 , C07H17/00 , C07H17/02 , C09B25/00
CPC分类号： C07D471/04
摘要： The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译： 本发明提供抑制Akt活性的化合物。 特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。
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公开(公告)号：US5744486A
公开(公告)日：1998-04-28
申请号：US829406
申请日：1997-03-31
申请人： Philip E. Sanderson , Adel M. Naylor-Olsen , Dona L. Dyer , Joseph P. Vacca , Richard C. A. Isaacs , Bruce D. Dorsey , Mark E. Fraley
发明人： Philip E. Sanderson , Adel M. Naylor-Olsen , Dona L. Dyer , Joseph P. Vacca , Richard C. A. Isaacs , Bruce D. Dorsey , Mark E. Fraley
IPC分类号： A61K38/00 , C07K5/078 , A61K31/445 , C07D211/06
CPC分类号： C07K5/06139 , A61K38/00
摘要： Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and have the following structure: ##STR1## for example: ##STR2##
摘要翻译： 本发明的化合物可用于抑制凝血酶和相关的血栓闭塞，并具有以下结构：
例如：
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