公开(公告)号：US07332164B2

公开(公告)日：2008-02-19

申请号：US10394393

申请日：2003-03-21

申请人： Richard B. Greenwald ,  Hong Zhao

发明人： Richard B. Greenwald ,  Hong Zhao

IPC分类号： A61K47/48 ,  A61K38/00

CPC分类号： A61K49/0041 ,  A61K47/60 ,  A61K49/0047

摘要： Heterobifunctional polymeric prodrug platforms for delivering biologically active compounds, including proteins, monoclonal antibodies and the like are disclosed. One preferred compound is Methods of making and using the compounds and conjugates described herein are also provided.

摘要翻译： 公开了用于递送生物活性化合物（包括蛋白质，单克隆抗体等）的异双功能聚合物前药平台。 一种优选的化合物是还提供制备和使用本文所述的化合物和缀合物的方法。

公开(公告)号：US20070197575A1

公开(公告)日：2007-08-23

申请号：US11704607

申请日：2007-02-09

申请人： Hong Zhao ,  Maria Rubio ,  Dechun Wu ,  Puja Sapra

发明人： Hong Zhao ,  Maria Rubio ,  Dechun Wu ,  Puja Sapra

IPC分类号： A61K31/4745

CPC分类号： A61K31/121 ,  A61K31/4745 ,  A61K47/55 ,  A61K47/60 ,  C07D491/22 ,  C07D519/00

摘要： A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.

摘要翻译： 公开了四臂聚乙二醇-7-乙基-10-羟基喜树碱缀合物。 还公开了制备缀合物的方法和使用其的治疗哺乳动物的方法。

公开(公告)号：US20070173615A1

公开(公告)日：2007-07-26

申请号：US11328662

申请日：2006-01-10

申请人： Hong Zhao ,  Anthony Martinez

发明人： Hong Zhao ,  Anthony Martinez

IPC分类号： C08G65/337

CPC分类号： C08G65/329 ,  C08G65/3322

摘要： A new method of preparing a tertiary alkyl ester of a polyalkylene oxide is provided. The new method employs milder conditions that avoid the back reaction to the starting polyalkylene oxide. The tertiary alkyl ester of a polyalkylene oxide is then reacted with a suitable acid to produce a polyalkylene oxide acid.

摘要翻译： 提供了一种制备聚环氧烷的叔烷基酯的新方法。 新方法采用较轻的条件，避免了起始聚环氧烷的反应。 然后使聚环氧烷的叔烷基酯与合适的酸反应以产生聚环氧烷酸。

公开(公告)号：US07073140B1

公开(公告)日：2006-07-04

申请号：US10651617

申请日：2003-08-29

申请人： Jun Li ,  Athanasius Spyrou ,  Hong Zhao ,  Hsien-Yen Chiu

发明人： Jun Li ,  Athanasius Spyrou ,  Hong Zhao ,  Hsien-Yen Chiu

IPC分类号： G06F17/90

CPC分类号： G06F17/5036

摘要： Disclosed is an improved approach for performing crosstalk and signal integrity analysis in which multiple variables are taken into account when analyzing the effects of on-chip crosstalk, such as for example coupled wire length, ration of coupling capacitance, and aggressor and victim driver types. Rather than performing a full-chip simulation, the potential crosstalk effects can be pre-characterized by performing simulation/modeling over specific net portions by systematically changing the values of these multiple variables. A set of patterns characterized from the variables are formed from the modeling. During the analysis process, the IC design is checked of the presence of the patterns, from which is produced the expected delay impact for crosstalk in the design.

摘要翻译： 公开了一种用于执行串扰和信号完整性分析的改进方法，其中在分析片上串扰的影响时考虑多个变量，例如耦合的线长度，耦合电容的比例，侵略者和受害者驱动器类型。 通过系统地改变这些多个变量的值，可以通过对特定网络部分进行模拟/建模来预先表征潜在的串扰效应，而不是进行全芯片仿真。 从变量形成的一组模式由建模形成。 在分析过程中，检查IC设计是否存在图案，从而产生设计中串扰的预期延迟影响。

公开(公告)号：US20050278671A1

公开(公告)日：2005-12-15

申请号：US11014096

申请日：2004-12-15

申请人： Nishath Verghese ,  Hong Zhao

发明人： Nishath Verghese ,  Hong Zhao

IPC分类号： G06F17/50

CPC分类号： G06F17/5031

摘要： A system, method, and computer program accurately models circuit parameter variation for delay calculation. For any given circuit parameter value, a cell is characterized at just three values in the circuit parameter range. An interpolation process generates an equation to calculate delay using the characterization data from the three circuit parameter values. This delay equation calculates the delay for any value in the circuit parameter range. Similar methodology is used to model simultaneous variation of two circuit parameters. The cell is characterized at just six circuit parameter pairs to interpolate the delay equation for any circuit parameter pair in the characterized ranges. This methodology can be extended to accommodate variation of multiple circuit parameters using similar interpolation techniques.

摘要翻译： 系统，方法和计算机程序准确地对电路参数变化进行延迟计算。 对于任何给定的电路参数值，单元格仅在电路参数范围内的三个值进行表征。 插值过程使用来自三个电路参数值的表征数据产生计算延迟的方程式。 该延迟方程计算电路参数范围内任何值的延迟。 类似的方法用于模拟两个电路参数的同时变化。 该单元的特征在于仅仅六个电路参数对，以在特征化范围内插值任何电路参数对的延迟方程。 可以使用类似的内插技术来扩展该方法以适应多个电路参数的变化。

公开(公告)号：US06775270B1

公开(公告)日：2004-08-10

申请号：US09628980

申请日：2000-02-11

申请人： Jeffrey Rhodes ,  Hong Zhao

发明人： Jeffrey Rhodes ,  Hong Zhao

IPC分类号： H04L1266

CPC分类号： H04W88/181 ,  H04W4/00 ,  H04W4/16 ,  H04W76/20

摘要： A method for improving the sound quality of voice signals transmitted during a call between two digital wireless telephones by diverting the call from a circuit switched network to a data network is disclosed. In accordance with the present invention, a call setup procedure using the circuit switched network is modified so that the calling party may determine the following information: 1) whether the called party's digital wireless telephone is able to support one of the voice compression algorithms supported by the calling party's digital wireless telephone and 2) whether both wireless telephones have access to the same data network. If the called party's digital wireless telephone is able to support one of the voice compression algorithms supported by the calling party's digital wireless telephone and both wireless telephones have access to the same data network, the circuit switched network call setup procedure is abandoned before the called party answers the call and the call is completed using the data network. Completing the call by encoding voice signals using a common voice compression algorithm executed by the digital wireless telephones and by sending the encoded voice signals through a data network eliminates the drawbacks associated with the additional intermediate encoding which would have been required if the call had been completed using the circuit switched network.

摘要翻译： 公开了一种通过将呼叫从电路交换网络转移到数据网络来改善在两个数字无线电话之间的呼叫期间发送的语音信号的声音质量的方法。 根据本发明，对使用电路交换网络的呼叫建立过程进行修改，以便呼叫方可以确定以下信息：1）被叫方的数字无线电话是否能够支持由 主叫方的数字无线电话和2）无线电话是否可以访问相同的数据网络。 如果被叫方的数字无线电话能够支持呼叫方的数字无线电话支持的语音压缩算法之一，并且两个无线电话都可以访问相同的数据网络，则在被叫方之前放弃电路交换网络呼叫建立过程 应答呼叫，使用数据网络完成呼叫。 通过使用由数字无线电话执行的公共语音压缩算法编码语音信号并通过数据网络发送编码的语音信号来完成呼叫消除了与如果呼叫已经完成所需的附加中间编码相关联的缺点 使用电路交换网络。

公开(公告)号：US06624142B2

公开(公告)日：2003-09-23

申请号：US09852335

申请日：2001-05-09

申请人： Richard B. Greenwald ,  Hong Zhao

发明人： Richard B. Greenwald ,  Hong Zhao

IPC分类号： A61K31222

CPC分类号： C07C237/22 ,  A61K47/60 ,  C07B2200/11 ,  C07C271/16 ,  C07C271/22 ,  C07C271/48

摘要： The invention is directed primarily to compounds of Formula I: wherein: R1 is a polymeric residue; L1 is a bifunctional linking group; Y1 and Y2 are independently O, S or NR7; R2-7 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls, C1-6 alkoxy, phenoxy and C1-6 heteroalkoxy; D is a moiety that is a leaving group or a residue of a compound to be delivered into a cell; Z is selected from the group consisting of: a moiety that is actively transported into a target cell, a hydrophobic moiety, and combinations thereof; Ar is a moiety which when included in Formula (I) forms a multi-substituted aromatic hydrocarbon or a multi-substituted heterocyclic group; and (y) is a positive integer greater than or equal to 1. Methods of making and using the same are also disclosed.

摘要翻译： 本发明主要针对式I化合物：其中：R1是无规残基; L1是双官能连接基团; Y 1和Y 2独立地是O，S或NR 7; R 2-7独立地选自氢，C1 C6烷基，C3-12支链烷基，C3-8环烷基，C1-6取代烷基，C3-8取代环烷基，芳基，取代芳基，芳烷基，C1-6杂烷基，取代C1-6杂烷基，C1-6烷氧基， 苯氧基和C 1-6杂烷氧基; D是作为离开基团或待递送至细胞中的化合物的残基的部分; Z选自：主动转运入靶细胞的部分， 疏水部分及其组合; Ar是当式（I）中包含时形成多取代芳族烃或多取代杂环基的部分; 和（y）是大于或等于1的正整数。还公开了制造和使用它们的方法。

公开(公告)号：US06453308B1

公开(公告)日：2002-09-17

申请号：US09160128

申请日：1998-09-24

申请人： Hong Zhao ,  Guillermo Sentoni ,  John P. Guiver

发明人： Hong Zhao ,  Guillermo Sentoni ,  John P. Guiver

IPC分类号： G06N302

CPC分类号： G05B13/048 ,  G05B17/02

摘要： A non-linear dynamic predictive device (60) is disclosed which operates either in a configuration mode or in one of three runtime modes: prediction mode, horizon mode, or reverse horizon mode. An external device controller (50) sets the mode and determines the data source and the frequency of data. In prediction mode, the input data are such as might be received from a distributed control system (DCS) (10) as found in a manufacturing process; the device controller ensures that a contiguous stream of data from the DCS is provided to the predictive device at a synchronous discrete base sample time. In prediction mode, the device controller operates the predictive device once per base sample time and receives the output from the predictive device through path (14). In horizon mode and reverse horizon mode, the device controller operates the predictive device additionally many times during base sample time interval. In horizon mode, additional data is provided through path (52). In reverse horizon mode data is passed in a reverse direction through the device, utilizing information stored during horizon mode, and returned to the device controller through path (66). In the forward modes, the data are passed to a series of preprocessing units (20) which convert each input variable (18) from engineering units to normalized units. Each preprocessing unit feeds a delay unit (22) that time-aligns the input to take into account dead time effects such as pipeline transport delay. The output of each delay unit is passed to a dynamic filter unit (24). Each dynamic filter unit internally utilizes one or more feedback paths that are essential for representing the dynamic information in the process. The filter units themselves are configured into loosely coupled subfilters which are automatically set up during the configuration mode and allow the capability of practical operator override of the automatic configuration settings. The outputs (28) of the dynamic filter units are passed to a non-linear analyzer (26) which outputs a value in normalized units. The output of the analyzer is passed to a post-processing unit (32) that converts the output to engineering units. This output represents a prediction of the output of the modeled process. In reverse horizon mode, a value of 1 is presented at the output of the predictive device and data is passed through the device in a reverse flow to produce a set of outputs (64) at the input of the predictive device. These are returned to the device controller through path (66). The purpose of the reverse horizon mode is to provide essential information for process control and optimization. The precise operation of the predictive device is configured by a set of parameters. that are determined during the configuration mode and stored in a storage device (30). The configuration mode makes use of one or more files of training data (48) collected from the DCS during standard operation of the process, or through structured plant testing. The predictive device is trained in four phases (40, 42, 44, and 46) corresponding respectively to components 20/32, 22, 24 and 26. The importance of this predictive device is that it is shown to approximate a large class of non-linear dynamic processes. The structure of the predictive device allows it to be incorporated into a practical multivariable non-linear Model Predictive Control scheme, or used to estimate process properties.

公开(公告)号：US6031880A

公开(公告)日：2000-02-29

申请号：US674725

申请日：1996-07-02

申请人： Yong Li ,  Adnan Abu-Dayya ,  Hong Zhao ,  Rui Wang ,  Iouri Trofimov ,  Alexandre Chloma ,  Mikhail Bakouline ,  Vitali Kreindeline

发明人： Yong Li ,  Adnan Abu-Dayya ,  Hong Zhao ,  Rui Wang ,  Iouri Trofimov ,  Alexandre Chloma ,  Mikhail Bakouline ,  Vitali Kreindeline

IPC分类号： H04L27/227 ,  H04L7/00 ,  H04L7/04 ,  H04L27/00 ,  H04L27/22 ,  H04L27/233 ,  H04L27/38 ,  H04L27/14

CPC分类号： H04L27/2332 ,  H04L2027/003 ,  H04L2027/0046 ,  H04L7/042

摘要： A method of carrier recovery in a wireless communications system using a known synchronization word, for example an IS-54 TDMA system, operates in two stages to produce an estimate of carrier phase. In the first stage, a complex fading factor, embodying carrier phase information, is estimated from the synchronization word in the received signal using a least square criterion. In the second stage, the carrier phase is estimated from this complex fading factor by averaging. The averaging can provide a recursive average or a moving average, or can be implemented using Kalman filtering which also provides an estimated amplitude factor and frequency shift. The method and apparatus provide a substantial improvement over phase locked loop carrier recovery.

摘要翻译： 使用已知同步字的无线通信系统中的载波恢复方法，例如IS-54 TDMA系统，在两个阶段中工作，以产生载波相位的估计。 在第一阶段，使用最小二乘准则从接收信号中的同步字估计体现载波相位信息的复数衰落因子。 在第二阶段，通过平均从该复数衰落因子估计载波相位。 平均可以提供递归平均或移动平均，或者可以使用卡尔曼滤波来实现，其也提供估计的振幅因子和频移。 该方法和装置提供了相对于锁相环载波恢复的实质性改进。

公开(公告)号：US5965566A

公开(公告)日：1999-10-12

申请号：US914927

申请日：1997-08-20

申请人： Richard B. Greenwald ,  Annapurna Pendri ,  Hong Zhao

发明人： Richard B. Greenwald ,  Annapurna Pendri ,  Hong Zhao

IPC分类号： A61K31/335 ,  A61K47/48 ,  C07D305/14 ,  C07D491/22 ,  C08G65/329 ,  A61K31/44

CPC分类号： A61K47/48215 ,  A61K31/335 ,  C07D305/14 ,  C08G65/329

摘要： The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of biologically active moiety;X is an electron withdrawing group;Y and Y' are independently O or S;(n) is zero (0) or a positive integer, preferably from 1 to about 12;wherein: R.sub.1 and R.sub.2 are independently selected from the group consisting of H, C.sub.1-6 alkyls, aryls, substituted aryls, aralkyls, heteroalkyls, substituted heteroalkyls and substituted C.sub.1-6 alkyls;wherein: R.sub.3 is a substantially non-antigenic polymer, C.sub.1-12 straight or branched alkyl or substituted allyl, C.sub.5-8 cycloalkyl or substituted cycloalkyl, carboxyalkyl, carboalkoxy alkyl, dialkylaminoalkyl, phenylalkyl, phenylaryl or ##STR2## wherein: R.sub.4 and R.sub.5 are independently selected from the group consisting of H, C.sub.1-6 alkyls, aryls, substituted aryls, aralkyls, heteroalkyls, substituted heteroalkyls, and substituted C.sub.1-6 alkyls or jointly form a cyclic C.sub.5 -C.sub.7 ring. In preferred embodiments, the prodrugs contain a polyethylene glycol having a molecular weight of at least about 20,000.

摘要翻译： 本发明涉及下式的组合物：其中：D是生物活性部分的残基; X是吸电子基团; Y和Y'独立地为O或S; （n）为零（0）或正整数，优选1至约12; 其中：R 1和R 2独立地选自H，C 1-6烷基，芳基，取代的芳基，芳烷基，杂烷基，取代的杂烷基和取代的C 1-6烷基; 其中：R3是基本上非抗原性的聚合物，C1-12直链或支链烷基或取代的烯丙基，C5-8环烷基或取代的环烷基，羧基烷基，烷氧基烷基，二烷基氨基烷基，苯基烷基，苯基芳基或其中：R4和R5独立地选自 由H，C 1-6烷基，芳基，取代的芳基，芳烷基，杂烷基，取代的杂烷基和取代的C 1-6烷基组成的基团或共同形成环状C 5 -C 7环。 在优选的实施方案中，前药包含分子量为至少约20,000的聚乙二醇。