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37 条记录 (耗时 0.046 秒)

    Human virus causing respiratory tract infection and uses thereof
    31.
    发明授权
    Human virus causing respiratory tract infection and uses thereof 有权
    引起呼吸道感染的人类病毒及其用途

    公开(公告)号：US08092994B2

    公开(公告)日：2012-01-10

    申请号：US12476019

    申请日：2009-06-01

    申请人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan ,  Lit Man Poon ,  Joseph Sriyal Malik Peiris ,  Yi Guan

    发明人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan ,  Lit Man Poon ,  Joseph Sriyal Malik Peiris ,  Yi Guan

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/56983 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022

    摘要： The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen, China. The virus belongs to the order Nidovirales of the family Coronavirdae, being a single-stranded RNA virus of positive polarity. The invention also provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.

    摘要翻译： 本发明提供了一种新型人冠状病毒的完整基因组序列，其创造为冠状病毒HKU1（“CoV-HKU1”），在香港从最近访问中国的深圳的病人中分离出来。 该病毒属于Coronavirdae家族的Nidovirales，为正极性的单链RNA病毒。 本发明还提供了CoV-HKU1的完整基因组的推导的氨基酸序列。 CoV-HKU1的核苷酸序列和推导的氨基酸序列可用于预防，诊断和/或治疗CoV-HKU1感染。 此外，本发明基于CoV-HKU1的核苷酸序列和推定的氨基酸序列，提供使用重组和嵌合形式以及CoV-HKU1的亚基的免疫原性和疫苗制剂。

    Baicalin as a treatment for SARS infection
    34.
    发明授权
    Baicalin as a treatment for SARS infection 有权
    黄芩苷作为治疗SARS感染

    公开(公告)号：US07605135B2

    公开(公告)日：2009-10-20

    申请号：US10983985

    申请日：2004-11-08

    申请人： Kwok Yung Yuen ,  Feng Chen ,  Kwok Hung Chan ,  Yi Tsun Kao ,  Yi Guan ,  Leo Lit Man Poon ,  JSM Peiris

    发明人： Kwok Yung Yuen ,  Feng Chen ,  Kwok Hung Chan ,  Yi Tsun Kao ,  Yi Guan ,  Leo Lit Man Poon ,  JSM Peiris

    IPC分类号： A01N43/04

    CPC分类号： A61K31/382 ,  A61K31/7048

    摘要： The present invention relates to a pharmaceutical composition useful for the treatment of diseases associated with viruses of the order Nidovirales of the family Coronaviradae, such as Severe Acute Respiratory Syndrome (SARS) viruses in humans and other animals. In particular, this invention relates to a naturally occurring compound, namely, baicalin, extracted and purified from the Chinese medicinal plant Scutellaria baicalensis Georgi (Chinese name: Huang Qin), that exhibits potent antiviral activity against members of the order Nidovirales of the family Coronaviradae that infects humans and other animals; in particular, SARS viruses in humans (“hSARS virus”). The invention also relates to a therapeutic method, using pharmaceutical compositions comprising baicalin compounds, for the treatment, amelioration, management or prevention of diseases associated with members of the order Nidovirales of the family Coronaviradae, such as hSARS.

    摘要翻译： 本发明涉及可用于治疗与冠状病毒家族的病毒相关的疾病的药物组合物，例如人和其他动物中的严重急性呼吸综合征（SARS）病毒。 特别地，本发明涉及一种天然存在的化合物，即黄芩苷，其从中国药用植物黄芩（中文名：黄琴）中提取和纯化，其对抗冠状病毒家族的冠状病毒 感染人类和其他动物; 特别是人类中的SARS病毒（“hSARS病毒”）。 本发明还涉及使用包含黄芩苷化合物的药物组合物用于治疗，改善，管理或预防与冠状病毒家族（Norovirales）家族成员有关的疾病如hSARS的治疗方法。

    High-throughput diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS)
    35.
    发明授权
    High-throughput diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS) 有权
    导致严重急性呼吸综合征（SARS）的人类病毒的高通量诊断测定

    公开(公告)号：US07547512B2

    公开(公告)日：2009-06-16

    申请号：US10807807

    申请日：2004-03-24

    申请人： Joseph S. M. Peiris ,  Kwok Yung Yuen ,  Lit Man Poon ,  Yi Guan ,  Kwok Hung Chan ,  John M. Nicholls ,  Frederick C. Leung

    发明人： Joseph S. M. Peiris ,  Kwok Yung Yuen ,  Lit Man Poon ,  Yi Guan ,  Kwok Hung Chan ,  John M. Nicholls ,  Frederick C. Leung

    IPC分类号： C12Q1/68 ,  C12Q1/00

    CPC分类号： C12Q1/701 ,  C12Q1/6844 ,  Y02A50/451

    摘要： The present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product.

    摘要翻译： 本发明涉及用于引起人类严重急性呼吸综合征（SARS）的病毒（“hSARS病毒”）的高通量诊断测定。 特别地，本发明涉及SARS相关冠状病毒（SARS-CoV）的高通量逆转录PCR诊断试验。 本试验是一种快速，可靠的测定法，可用于诊断和监测SARS的扩散，并且基于hSARS病毒的N（核衣壳）基因的核苷酸序列。 本方法消除假阴性结果并提供增加的检测灵敏度。 本发明还公开了hSARS病毒的S（尖峰）基因。 本发明还涉及hSARS病毒的N-基因和S-基因产物的推断氨基酸序列以及在诊断方法中使用N-基因和S-基因产物。 本发明还包括诊断测定和试剂盒，其包含针对N-基因或S-基因产物产生的抗体。

    System and methods for determining semantic similarity of sentences
    37.
    发明授权
    System and methods for determining semantic similarity of sentences 失效
    用于确定句子的语义相似性的系统和方法

    公开(公告)号：US06810376B1

    公开(公告)日：2004-10-26

    申请号：US09614465

    申请日：2000-07-11

    申请人： Yi Guan ,  Pascale Fung

    发明人： Yi Guan ,  Pascale Fung

    IPC分类号： G06F1727

    CPC分类号： G06F17/2775 ,  G06F17/2785

    摘要： A system and associated methods determine the semantic similarity of different sentences to one another. A particularly appropriate application of the present invention is to automatic processing of Chinese-language text, for example, for document retrieval. A method for computing the similarity between a first and a second set of words comprises identifying a word of the second set of words as being most similar to a word of the first set of words, wherein the word of the second set of words need not be identical to the word of the first set of words; and computing a score of the similarity between the first and second set of words based at least in part on the word of the second set of words.

    摘要翻译： 系统和相关联的方法确定不同句子彼此的语义相似性。 本发明的特别合适的应用是例如用于文档检索的中文文本的自动处理。 一种用于计算第一和第二组词之间的相似度的方法包括将第二组词的单词识别为与第一组单词最相似的单词，其中第二组单词的单词不需要 与第一组单词相同; 以及至少部分地基于所述第二组词的单词计算所述第一和第二组词之间的相似度的得分。