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公开(公告)号：US20220134334A1
公开(公告)日：2022-05-05
申请号：US17310790
申请日：2020-12-08
Applicant: Illumina, Inc. , Illumina Cambridge Limited
Inventor： Geraint Evans , Stanley Hong
Abstract: An analysis substrate comprises: a localization layer to be provided with a sample comprising a nucleotide provided with a fluorescent dye; and a sensor layer comprising an array of sensor pixels, the localization layer being on-chip relative to the sensor layer, one or more of the array of sensor pixels to receive a propagation of fluorescence from the fluorescent dye.
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公开(公告)号：US20220003728A1
公开(公告)日：2022-01-06
申请号：US17479342
申请日：2021-09-20
Applicant: Illumina, Inc.
Inventor： Tarun Khurana , Ali Agah , Aathavan Karunakaran , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC: G01N30/74 , C12Q1/6874
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.
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公开(公告)号：US11143638B2
公开(公告)日：2021-10-12
申请号：US17254466
申请日：2020-05-26
Applicant: ILLUMINA, INC.
Inventor： Tarun Khurana , Ali Agah , Aathavan Karunakaran , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC: G01N30/74 , C12Q1/6874
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.
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公开(公告)号：US20210151129A1
公开(公告)日：2021-05-20
申请号：US17254459
申请日：2020-05-26
Applicant: ILLUMINA, INC.
Inventor： Craig Ciesla , Ali Agah , Stanley Hong , Tarun Khurana , Aathavan Karunakaran , Arvin Emadi , Merek Siu
IPC: G16B50/30 , G06F3/06 , G16B30/10 , C12Q1/6869
Abstract: A system writes input data to a storage device as machine-written polynucleotides; and reads machine written polynucleotides from the storage device as output data. The storage device includes a flow cell including a plurality of storage wells in which machine written polynucleotides may be stored. The storage device may include a set of electrodes corresponding to the storage wells that allow for selective interactions with wells across the surface of a flow cell. Operation of the storage device may include receiving a read request associated with a particular location in the storage device, creating a copy of a nucleotide sequence located at the particular location in the storage device, transferring the copy of the nucleotide sequence to a read location, and reading the copy of the nucleotide sequence at the read location.
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