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公开(公告)号：US20240393608A1
公开(公告)日：2024-11-28
申请号：US18670935
申请日：2024-05-22
Applicant: ILLUMINA, INC.
Inventor： Steven Boege , Stanley Hong
Abstract: An apparatus includes a sample stage region, an optical assembly, and a camera assembly. The optical assembly includes an objective element, a tube lens, a first dichroic element, and a compensating element. The objective element provides a field of view including the object plane. The tube lens is configured to receive light transmitted through the objective element. The optical assembly is configured to transmit light in at least a first color channel, a second color channel, a third color channel, and a fourth color channel from the tube lens toward the first dichroic element. The first dichroic element is configured to transmit light of the first and third color channels while reflecting light of the second and fourth color channels. The compensating element is configured to induce an astigmatism in the first and third color channels offsetting an astigmatism induced by the dichroic element.
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公开(公告)号：US11590505B2
公开(公告)日：2023-02-28
申请号：US17254462
申请日：2020-05-26
Applicant: ILLUMINA, INC.
Inventor： Merek Siu , Ali Agah , Stanley Hong , Tarun Khurana , Aathavan Karunakaran , Craig Ciesla , Amirali Kia
Abstract: Devices, systems, and methods for non-volatile storage include a well activation device operable to modify one or more wells from a plurality of wells of a flow cell to provide a set of readable wells. Readable wells are configured to allow exposure of a well to substances from nucleotide sequencing fluids, and prevent exposure to other substances and fluids, such as nucleotide synthesizing fluids. The well activation device may also modify wells to provide a set of writeable wells. This set of wells is configured to allow exposure to the nucleotide synthesizing fluids and substances; and prevent exposure to the nucleotide sequencing fluids and substances. There may also be provisions made for risk mitigation for data errors such as generating commands to write specified data to a nucleotide sequence associated with a particular location in a storage device, reading the nucleotide sequence and performing a comparison.
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公开(公告)号：US11453003B2
公开(公告)日：2022-09-27
申请号：US17550063
申请日：2021-12-14
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC: B01L3/00 , G11C13/02 , B01J19/00 , C12Q1/6874 , C12N15/09
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
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公开(公告)号：US11229909B2
公开(公告)日：2022-01-25
申请号：US17254469
申请日：2020-05-26
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
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公开(公告)号：US11867672B2
公开(公告)日：2024-01-09
申请号：US18107752
申请日：2023-02-09
Applicant: ILLUMINA, INC.
Inventor： Tarun Khurana , Ali Agah , Aathavan Karunakaran , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC: G01N30/74 , C12Q1/6874
CPC classification number: G01N30/74 , C12Q1/6874 , G01N2030/746
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.
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Patent Agency Ranking
公开(公告)号：US20230184725A1
公开(公告)日：2023-06-15
申请号：US18107752
申请日：2023-02-09
Applicant: ILLUMINA, INC.
Inventor： Tarun Khurana , Ali Agah , Aathavan Karunakaran , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC: G01N30/74 , C12Q1/6874
CPC classification number: G01N30/74 , C12Q1/6874 , G01N2030/746
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.
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公开(公告)号：US11604175B2
公开(公告)日：2023-03-14
申请号：US17846538
申请日：2022-06-22
Applicant: ILLUMINA, INC.
Inventor： Tarun Khurana , Ali Agah , Aathavan Karunakaran , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC: G01N30/74 , C12Q1/6874
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.
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公开(公告)号：US20230076689A1
公开(公告)日：2023-03-09
申请号：US17896176
申请日：2022-08-26
Applicant: ILLUMINA, INC.
Inventor： Mohsen Rezaei , Craig Hetherington , Arvin Emadi , Stanley Hong
IPC: G01N15/14 , G02B5/20 , H01L27/146
Abstract: An apparatus includes a flow cell body with an array of reaction sites positioned along a floor of a channel. An optical filter layer is positioned under the floor of the channel and includes at least a portion spanning uninterruptedly along a length corresponding to the length of the array of reaction sites. Imaging regions are positioned under the optical filter layer. Each imaging region is positioned directly under a corresponding reaction site. The optical filter layer is configured to permit one or more selected wavelengths of light to pass from each reaction site to the imaging region forming a sensing pair with the reaction site. The optical filter layer is configured to reduce transmission of excitation light directed toward the reaction sites; and to reduce transmission of light emitted from each reaction site to imaging regions not forming a sensing pair with the reaction site.
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公开(公告)号：US11282588B2
公开(公告)日：2022-03-22
申请号：US17254459
申请日：2020-05-26
Applicant: ILLUMINA, INC.
Inventor： Craig Ciesla , Ali Agah , Stanley Hong , Tarun Khurana , Aathavan Karunakaran , Arvin Emadi , Merek Siu
IPC: G16B50/30 , G06F3/06 , G16B30/10 , C12Q1/6869 , G11C13/02 , B01L3/00 , C12Q1/6874
Abstract: A system writes input data to a storage device as machine-written polynucleotides; and reads machine written polynucleotides from the storage device as output data. The storage device includes a flow cell including a plurality of storage wells in which machine written polynucleotides may be stored. The storage device may include a set of electrodes corresponding to the storage wells that allow for selective interactions with wells across the surface of a flow cell. Operation of the storage device may include receiving a read request associated with a particular location in the storage device, creating a copy of a nucleotide sequence located at the particular location in the storage device, transferring the copy of the nucleotide sequence to a read location, and reading the copy of the nucleotide sequence at the read location.
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公开(公告)号：US12287490B2
公开(公告)日：2025-04-29
申请号：US17981206
申请日：2022-11-04
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Dakota Watson , Andrew Carson , Vincent Hsieh , Steven Boege , Changqin Ding , Stanley Hong
Abstract: Apparatus and methods for controlling heating of an objective in a linescanning sequencing system to improve resolution are disclosed. In accordance with a first implementation, an apparatus includes or comprises a beam source for providing input radiation and a beam shaping group including or comprising one or more optical elements positioned to receive the input radiation from the beam source, and to perform beam shaping on the input radiation to form a shaped beam. The apparatus further including or comprising an objective positioned to receive the shaped beam and to transform the shaped beam into a probe beam and configured to provide the probe beam to a focal plane of the objective for optically probing a sample. The beam shaping group is configured to adjust one or more properties of the shaped beam over time to generally uniformly heat the objective over a region of incidence for the shaped beam.
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