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公开(公告)号：US12201985B2
公开(公告)日：2025-01-21
申请号：US18103625
申请日：2023-01-31
Applicant: ILLUMINA, INC.
Inventor： Merek Siu , Ali Agah , Stanley Hong , Tarun Khurana , Aathavan Karunakaran , Craig Ciesla , Amirali Kia
Abstract: Devices, systems, and methods for non-volatile storage include a well activation device operable to modify one or more wells from a plurality of wells of a flow cell to provide a set of readable wells. Readable wells are configured to allow exposure of a well to substances from nucleotide sequencing fluids, and prevent exposure to other substances and fluids, such as nucleotide synthesizing fluids. The well activation device may also modify wells to provide a set of writeable wells. This set of wells is configured to allow exposure to the nucleotide synthesizing fluids and substances; and prevent exposure to the nucleotide sequencing fluids and substances. There may also be provisions made for risk mitigation for data errors such as generating commands to write specified data to a nucleotide sequence associated with a particular location in a storage device, reading the nucleotide sequence and performing a comparison.
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公开(公告)号：US20230321651A1
公开(公告)日：2023-10-12
申请号：US18202461
申请日：2023-05-26
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
CPC classification number: B01L3/502715 , B01L3/502707 , B01L3/502738 , G11C13/02 , B01J19/0046 , C12Q1/6874
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
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公开(公告)号：US11691146B2
公开(公告)日：2023-07-04
申请号：US17898663
申请日：2022-08-30
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC: B01L3/00 , G11C13/02 , B01J19/00 , C12Q1/6874 , C12N15/09
CPC classification number: B01L3/502715 , B01J19/0046 , B01L3/502707 , B01L3/502738 , G11C13/02 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , B01L2200/026 , B01L2300/0645 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L2400/0622 , B01L2400/0655 , B01L2400/08 , C12N15/09 , C12Q1/6874
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
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公开(公告)号：US20220410154A1
公开(公告)日：2022-12-29
申请号：US17898663
申请日：2022-08-30
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
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公开(公告)号：US20220317100A1
公开(公告)日：2022-10-06
申请号：US17846538
申请日：2022-06-22
Applicant: ILLUMINA, INC.
Inventor： Tarun Khurana , Ali Agah , Aathavan Karunakaran , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC: G01N30/74 , C12Q1/6874
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.
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Patent Agency Ranking
公开(公告)号：US12111262B2
公开(公告)日：2024-10-08
申请号：US17419375
申请日：2020-06-25
Applicant: ILLUMINA, INC.
Inventor： Arvin Emadi , Arnaud Rival , Fabien Abeille , Ali Agah , Craig Ciesla , Aathavan Karunakaran
IPC: G01N21/64 , G01N15/1434 , G01N21/05 , G02B6/12 , G02B6/124 , H01L27/148
CPC classification number: G01N21/645 , G02B6/124 , H01L27/14825 , G01N15/1436 , G01N2021/058 , G01N2021/6482 , G01N2021/6484 , G02B2006/12107 , G02B2006/12138
Abstract: Provided herein include various examples of an apparatus, flow cells that include these examples of the apparatus, and methods of making these examples of the apparatus. The apparatus can include a molding layer over a substrate and covering sides of a light detection device. The molding layer comprises a first region and a second region, which, with the active surface of the light detection device, form a contiguous surface. A waveguide integration layer is between the contiguous surface and a waveguide. The waveguide integration layer comprises optical coupling structures over the first and second regions, to optically couple light waves from a light source to the waveguide. The waveguide utilizes the light waves to excite light sensitive materials in nanowells. A nanostructure layer over the waveguide comprises the nanowells. Each nanowell shares a vertical axis with a location on the active surface of the light detection device.
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公开(公告)号：US20230112203A1
公开(公告)日：2023-04-13
申请号：US17934175
申请日：2022-09-21
Applicant: ILLUMINA, INC. , ILLUMINA SINGAPORE PTE. LTD.
Inventor： Boyan Boyanov , Craig Ciesla , Anthony Flannery , Gerald Kreindl , Rean Silke Musa , Darren Segale
IPC: G01N33/487 , C12Q1/6869 , G01N27/414 , B01L3/00
Abstract: Devices for sequencing biopolymers and methods of using the devices are disclosed. In one example, such a device has a nanopore, a plurality of wells and fluidic tunnels to allow a biopolymer to translocate in the device. In some embodiments, the device may include integrated electronics or micro-electromechanical systems, such as valves, bubble generators/annihilators or pressure pulse generators, to actively control fluidic/ionic/electric flows in the device.
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公开(公告)号：US11590505B2
公开(公告)日：2023-02-28
申请号：US17254462
申请日：2020-05-26
Applicant: ILLUMINA, INC.
Inventor： Merek Siu , Ali Agah , Stanley Hong , Tarun Khurana , Aathavan Karunakaran , Craig Ciesla , Amirali Kia
Abstract: Devices, systems, and methods for non-volatile storage include a well activation device operable to modify one or more wells from a plurality of wells of a flow cell to provide a set of readable wells. Readable wells are configured to allow exposure of a well to substances from nucleotide sequencing fluids, and prevent exposure to other substances and fluids, such as nucleotide synthesizing fluids. The well activation device may also modify wells to provide a set of writeable wells. This set of wells is configured to allow exposure to the nucleotide synthesizing fluids and substances; and prevent exposure to the nucleotide sequencing fluids and substances. There may also be provisions made for risk mitigation for data errors such as generating commands to write specified data to a nucleotide sequence associated with a particular location in a storage device, reading the nucleotide sequence and performing a comparison.
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公开(公告)号：US11453003B2
公开(公告)日：2022-09-27
申请号：US17550063
申请日：2021-12-14
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC: B01L3/00 , G11C13/02 , B01J19/00 , C12Q1/6874 , C12N15/09
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
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公开(公告)号：US11229909B2
公开(公告)日：2022-01-25
申请号：US17254469
申请日：2020-05-26
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
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