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公开(公告)号：US08785397B2
公开(公告)日：2014-07-22
申请号：US12602246
申请日：2008-06-20
Applicant: Dominique Bernard , Isabelle Castiel , Lucie Simonetti
Inventor： Dominique Bernard , Isabelle Castiel , Lucie Simonetti
CPC classification number: G01N33/92 , A61K8/64 , A61K38/1709 , A61Q17/00 , A61Q19/08 , C07K14/775 , G01N2500/04 , G01N2500/10
Abstract: The subject of the present invention is the use, in particular the cosmetic and/or therapeutic use, of the apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of an agent modulating the activity or of the expression of such a polypeptide, in particular for stimulating terminal epithelial differentiation.The invention also relates to the use of the protein apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide as a marker for evaluating the state of the epidermis.
Abstract translation: 本发明的主题是使用来自该蛋白质或其类似物的多肽的载脂蛋白D的化妆品和/或治疗用途，编码这种多肽的核酸序列或调节 活性或这种多肽的表达，特别是用于刺激末端上皮分化。 本发明还涉及来自该蛋白质或其类似物的多肽的蛋白质载脂蛋白D或编码这种多肽的核酸序列作为评估表皮状态的标记物的用途。
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公开(公告)号：US20100129324A1
公开(公告)日：2010-05-27
申请号：US12513631
申请日：2007-11-06
Applicant: Vanessa Crespy , Isabelle Castiel , Rachid Bel-Rhlid , Nicolas Page , Thomas Raab
Inventor： Vanessa Crespy , Isabelle Castiel , Rachid Bel-Rhlid , Nicolas Page , Thomas Raab
CPC classification number: A61K35/747 , A23L5/00 , A23L7/00 , A23L31/00 , A23L33/10 , A23L33/105 , A23L33/125 , A23L33/135 , A23L33/14 , A23V2002/00 , A61K31/216 , A61K35/745 , A61K36/53 , A61K38/465 , A61K2300/00 , A23V2250/2132 , A23V2200/3204 , A23V2250/21
Abstract: The present invention relates to compositions of rosmarinic acid or its derivatives and to the use of a hydrolytic enzyme or of microorganism containing or producing hydrolytic enzymes in these compositions. The invention also pertains to methods for improving the biological effects of the rosemary extracts and for administering such compositions to a human or animal subject for improving the skin, coat, hair or health of the subject.
Abstract translation: 本发明涉及迷迭香酸或其衍生物的组合物以及在这些组合物中含有或产生水解酶的水解酶或微生物的用途。 本发明还涉及用于改善迷迭香提取物的生物学作用并将这些组合物给予人或动物受试者以改善受试者的皮肤，外套，毛发或健康的方法。
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33.发明申请Reconstructed epidermis/skin equivalent comprising a ceramide 7 and/or 5.5 and lipid lamellar vesicular compositions comprising ceramide 7 and/or 5.5 compounds 审中-公开包含神经酰胺7和/或5.5的重建表皮/皮肤等同物和包含神经酰胺7和/或5.5化合物的脂质层状水泡组合物公开(公告)号：US20070148771A1
公开(公告)日：2007-06-28
申请号：US11634078
申请日：2006-12-06
Applicant: Melanie Chopart , Isabelle Castiel , Jean-Thierry Simonnet
Inventor： Melanie Chopart , Isabelle Castiel , Jean-Thierry Simonnet
IPC: C12N5/08
CPC classification number: A61K8/68 , A61K8/14 , A61Q19/005 , C12N5/0698 , C12N2500/36 , C12N2500/38 , C12N2502/094 , C12N2502/1323 , Y10S514/943
Abstract: A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the barrier function of dry skin and of reconstructed skin or skin equivalents, is prepared by introducing the at least one ceramide 7 and/or 5.5 compound into the culture medium of such reconstructed epidermis/skin equivalent and/or topically applying onto the face surface of such reconstructed epidermis/skin equivalent a composition which comprises lipid lamellar vesicles incorporating at least one ceramide 7 and/or 5.5 compound.
Abstract translation: 补充有至少一种神经酰胺7和/或5.5化合物的重建表皮/皮肤当量，其适于增强正常人表皮的屏障功能并改善干性皮肤和重建的皮肤或皮肤等同物的屏障功能，通过引入 所述至少一种神经酰胺7和/或5.5化合物进入这种重建的表皮/皮肤等效的培养基中和/或局部施用于这种重建的表皮/皮肤等效物的表面上，该组合物包含掺入至少一种神经酰胺的脂质层状囊泡 7和/或5.5化合物。
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34.发明授权Reconstructed epidermis/skin equivalent comprising a ceramide 7 and /or 5.5 and lipid lamellar vesicular compositions comprising ceramide 7 and/or 5.5 compounds 失效包含神经酰胺7和/或5.5的重建表皮/皮肤等同物和包含神经酰胺7和/或5.5化合物的脂质层状水泡组合物公开(公告)号：US07169382B2
公开(公告)日：2007-01-30
申请号：US10766016
申请日：2004-01-29
Applicant: Mélanie Chopart , Isabelle Castiel , Jean-Thierry Simonnet
Inventor： Mélanie Chopart , Isabelle Castiel , Jean-Thierry Simonnet
CPC classification number: A61K8/68 , A61K8/14 , A61Q19/005 , C12N5/0698 , C12N2500/36 , C12N2500/38 , C12N2502/094 , C12N2502/1323 , Y10S514/943
Abstract: A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the barrier function of dry skin and of reconstructed skin or skin equivalents, is prepared by introducing the at least one ceramide 7 and/or 5.5 compound into the culture medium of such reconstructed epidermis/skin equivalent and/or topically applying onto the face surface of such reconstructed epidermis/skin equivalent a composition which comprises lipid lamellar vesicles incorporating at least one ceramide 7 and/or 5.5 compound.
Abstract translation: 补充有至少一种神经酰胺7和/或5.5化合物的重建表皮/皮肤当量，其适于增强正常人表皮的屏障功能并改善干性皮肤和重建的皮肤或皮肤等同物的屏障功能，通过引入 所述至少一种神经酰胺7和/或5.5化合物进入这种重建的表皮/皮肤等效的培养基中和/或局部施用于这种重建的表皮/皮肤等效物的表面上，该组合物包含掺入至少一种神经酰胺的脂质层状囊泡 7和/或5.5化合物。
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