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    Cosmetic and therapeutic use of proteins of DJ-1 type for treating skin dryness
    1.
    发明授权
    Cosmetic and therapeutic use of proteins of DJ-1 type for treating skin dryness 有权
    DJ-1型蛋白质的化妆和治疗用途，用于治疗皮肤干燥

    公开(公告)号：US09295711B2

    公开(公告)日：2016-03-29

    申请号：US13130710

    申请日：2009-11-19

    申请人： Dominique Bernard ,  Lucie Simonetti ,  Isabelle Castiel

    发明人： Dominique Bernard ,  Lucie Simonetti ,  Isabelle Castiel

    IPC分类号： A61K38/00 ,  A61K38/17 ,  A61K8/64 ,  A61Q19/00

    CPC分类号： A61K38/1709 ,  A61K8/64 ,  A61Q19/007

    摘要： The present invention relates to the use, especially the cosmetic and/or therapeutic use, of the protein DJ-1, of polypeptides derived from this protein or of analogs thereof, of a nucleic acid sequence coding for such a polypeptide or of a modulator of the activity, stability or expression of such a polypeptide, especially for preventing and/or treating the signs of skin dryness. The invention also relates to the use of the protein DJ-1, of polypeptides derived from this protein or of analogs thereof or of a nucleic acid sequence coding for such a polypeptide, as a marker for evaluating the state of dryness of an epithelium.

    摘要翻译： 本发明涉及编码这种多肽或调节剂的核酸序列的衍生自该蛋白质或其类似物的多肽的蛋白质DJ-1的使用，特别是化妆品和/或治疗用途 这种多肽的活性，稳定性或表达，特别是用于预防和/或治疗皮肤干燥症状。 本发明还涉及蛋白质DJ-1来自该蛋白质或其类似物的多肽或编码这种多肽的核酸序列作为评价上皮干燥状态的标记物的用途。

    COSMETIC USE OF APOLIPOPROTEIN D TYPE PROTEINS
    2.
    发明申请
    COSMETIC USE OF APOLIPOPROTEIN D TYPE PROTEINS 有权
    化学应用APOLIPOPROTEIN D型蛋白质

    公开(公告)号：US20100216707A1

    公开(公告)日：2010-08-26

    申请号：US12602246

    申请日：2008-06-20

    申请人： Dominique Bernard ,  Isabelle Castiel ,  Lucie Simonetti

    发明人： Dominique Bernard ,  Isabelle Castiel ,  Lucie Simonetti

    IPC分类号： A61K8/64 ,  A61K8/60 ,  A61K8/63 ,  A61K8/36 ,  A61K8/49 ,  G01N33/68 ,  C12Q1/02 ,  A61Q19/00

    CPC分类号： G01N33/92 ,  A61K8/64 ,  A61K38/1709 ,  A61Q17/00 ,  A61Q19/08 ,  C07K14/775 ,  G01N2500/04 ,  G01N2500/10

    摘要： The subject of the present invention is the use, in particular the cosmetic and/or therapeutic use, of the apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of an agent modulating the activity or of the expression of such a polypeptide, in particular for stimulating terminal epithelial differentiation. The invention also relates to the use of the protein apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide as a marker for evaluating the state of the epidermis.

    摘要翻译： 本发明的主题是使用来自该蛋白质或其类似物的多肽的载脂蛋白D的化妆品和/或治疗用途，编码这种多肽的核酸序列或调节 活性或这种多肽的表达，特别是用于刺激末端上皮分化。 本发明还涉及来自该蛋白质或其类似物的多肽的蛋白质载脂蛋白D或编码这种多肽的核酸序列作为评估表皮状态的标记物的用途。

    COSMETIC USE OF ANNEXIN II-TYPE PROTEINS FOR TREATING DRYNESS OF THE SKIN
    3.
    发明申请
    COSMETIC USE OF ANNEXIN II-TYPE PROTEINS FOR TREATING DRYNESS OF THE SKIN 审中-公开
    用于治疗皮肤干燥的新型II型蛋白质的化妆品用途

    公开(公告)号：US20110098230A1

    公开(公告)日：2011-04-28

    申请号：US12936320

    申请日：2009-04-02

    申请人： Dominique Bernard ,  Lucie Simonetti ,  Isabelle Castiel

    发明人： Dominique Bernard ,  Lucie Simonetti ,  Isabelle Castiel

    IPC分类号： A61K38/16 ,  A61K38/08 ,  A61K38/10 ,  A61Q19/00

    CPC分类号： A61Q19/007 ,  A61K8/64

    摘要： The present invention relates to the use, in particular cosmetic and/or therapeutic use, of annexin II, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of a modulator of the activity, the stability or the expression of such a polypeptide, in particular for preventing and/or treating the signs of skin dryness.The invention also relates to the use of annexin II, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide, as a marker for evaluating a state of dryness of an epithelium.

    摘要翻译： 本发明涉及膜联蛋白II的用途，特别是化妆品和/或治疗用途，其衍生自该蛋白质或其类似物的多肽编码这种多肽或活性调节剂的核酸序列，其稳定性 或这种多肽的表达，特别是用于预防和/或治疗皮肤干燥症状。 本发明还涉及膜联蛋白II来自该蛋白质或其类似物的多肽或编码这种多肽的核酸序列作为评价上皮干燥状态的标记物的用途。

    COSMETIC USE OF ACID CERAMIDASE TYPE PROTEINS
    4.
    发明申请
    COSMETIC USE OF ACID CERAMIDASE TYPE PROTEINS 审中-公开
    酸性蛋白酶类型蛋白质的化学使用

    公开(公告)号：US20110091439A1

    公开(公告)日：2011-04-21

    申请号：US12809428

    申请日：2008-12-18

    申请人： Dominique Bernard ,  Lucie Simonetti ,  Isabelle Castiel

    发明人： Dominique Bernard ,  Lucie Simonetti ,  Isabelle Castiel

    IPC分类号： A61K38/46 ,  A61K38/00 ,  G01N33/53 ,  C12Q1/68 ,  C12N5/071 ,  A61Q19/00 ,  A61Q19/08

    CPC分类号： A61K38/50 ,  A61K8/64 ,  A61K8/66 ,  A61Q19/08

    摘要： A method for preventing and/or treating the signs of skin aging comprises administering as an agent into an individual in need thereof an effective amount of acid ceramidase, polypeptides derived from this protein or analogues thereof, a nucleic sequence encoding such a polypeptide, or an agent for modulating the expression or the biological or biochemical activity of such a polypeptide. A methods for characterizing a state of an epithelium comprises determining a content of acid ceramidase, polypeptides derived from this protein or analogues thereof, or a nucleic sequence encoding such a polypeptide in an epidermis sample.

    摘要翻译： 用于预防和/或治疗皮肤老化症状的方法包括将有效量的酸性神经酰胺酶，衍生自该蛋白质或其类似物的多肽，编码这种多肽的核酸序列，或 用于调节这种多肽的表达或生物或生物化学活性的试剂。 用于表征上皮状态的方法包括确定酸性神经酰胺酶的含量，源自该蛋白质的多肽或其类似物，或在表皮样品中编码这种多肽的核酸序列。

    Cosmetic use of apolipoprotein D type proteins
    6.
    发明授权
    Cosmetic use of apolipoprotein D type proteins 有权
    化妆品使用载脂蛋白D型蛋白

    公开(公告)号：US08785397B2

    公开(公告)日：2014-07-22

    申请号：US12602246

    申请日：2008-06-20

    申请人： Dominique Bernard ,  Isabelle Castiel ,  Lucie Simonetti

    发明人： Dominique Bernard ,  Isabelle Castiel ,  Lucie Simonetti

    IPC分类号： A61K38/16 ,  A61K8/64 ,  G01N33/68

    CPC分类号： G01N33/92 ,  A61K8/64 ,  A61K38/1709 ,  A61Q17/00 ,  A61Q19/08 ,  C07K14/775 ,  G01N2500/04 ,  G01N2500/10

    摘要： The subject of the present invention is the use, in particular the cosmetic and/or therapeutic use, of the apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of an agent modulating the activity or of the expression of such a polypeptide, in particular for stimulating terminal epithelial differentiation.The invention also relates to the use of the protein apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide as a marker for evaluating the state of the epidermis.

    摘要翻译： 本发明的主题是使用来自该蛋白质或其类似物的多肽的载脂蛋白D的化妆品和/或治疗用途，编码这种多肽的核酸序列或调节 活性或这种多肽的表达，特别是用于刺激末端上皮分化。 本发明还涉及来自该蛋白质或其类似物的多肽的蛋白质载脂蛋白D或编码这种多肽的核酸序列作为评估表皮状态的标记物的用途。

    Administration of urea compounds for combating signs of cutaneous aging
    7.
    发明授权
    Administration of urea compounds for combating signs of cutaneous aging 有权
    管理尿素化合物，防止皮肤老化迹象

    公开(公告)号：US08173144B2

    公开(公告)日：2012-05-08

    申请号：US11260139

    申请日：2005-10-28

    申请人： Dominique Bernard ,  Lucie Simonetti

    发明人： Dominique Bernard ,  Lucie Simonetti

    IPC分类号： A61K8/02

    CPC分类号： A61Q19/08 ,  A61K8/42

    摘要： Signs of aging of the skin and/or mucous membranes are prevented and/or reduced, and the activity of the proteolytic enzymes of the stratum corneum are stimulated as well, by administering to an individual in need of such treatment, a cosmetic/pharmaceutical composition which comprises a thus effective amount of at least one hydroxylated urea compound having the following formula (I): in which: the radicals R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a C1-C4 alkyl radical or a C2-C6 hydroxyalkyl radical which can contain from 1 to 5 hydroxyl groups, wherein at least one of the R1 to R4 radicals represents a hydroxyalkyl radical, or salt, solvate or isomer thereof, formulated into a physiologically acceptable medium therefor.

    摘要翻译： 防止和/或减少皮肤和/或粘膜老化的迹象，通过向需要这种治疗的个体施用化妆品/药物组合物来刺激角质层蛋白水解酶的活性 其包含如此有效量的至少一种具有下式（I）的羟基化脲化合物：其中：可以相同或不同的基团R 1，R 2，R 3和R 4各自为氢原子，C1- C4烷基或可含有1至5个羟基的C 2 -C 6羟烷基，其中至少一个R 1至R 4基团表示配制成其生理学上可接受的介质的羟烷基或其盐，溶剂化物或异构体 。