公开(公告)号：US10925932B2

公开(公告)日：2021-02-23

申请号：US15611296

申请日：2017-06-01

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs ,  Karyn O'Neil ,  Thomas Rutkoski

IPC: C07K14/78 ,  A61K38/39 ,  A61K47/54 ,  C07K16/18 ,  C07K16/40 ,  A61K39/00

Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.

公开(公告)号：US20200325210A1

公开(公告)日：2020-10-15

申请号：US16840479

申请日：2020-04-06

Applicant: Janssen Biotech, Inc.

Inventor： Mark Anderson ,  Ricardo Attar ,  Michael Diem ,  Shalom Goldberg ,  Linus Hyun ,  Steven Jacobs ,  Alastair King ,  Donna Klein ,  Sheri Moores ,  Karyn O'Neil ,  Kristen Picha

IPC: C07K14/78 ,  C07K14/71 ,  C12N15/64 ,  C12N15/09 ,  C12N15/63 ,  C07K19/00

Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.

公开(公告)号：US20180162929A1

公开(公告)日：2018-06-14

申请号：US15840303

申请日：2017-12-13

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  C07K14/705 ,  C12N15/85 ,  A61P35/00

Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US20170348397A1

公开(公告)日：2017-12-07

申请号：US15611296

申请日：2017-06-01

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs ,  Karyn O'Neil ,  Thomas Rutkoski

IPC: A61K38/39 ,  C07K16/40 ,  C07K14/78 ,  C07K16/18

CPC classification number: A61K38/39 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/78 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/94 ,  C07K2318/20 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/70

Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.

公开(公告)号：US20160041182A1

公开(公告)日：2016-02-11

申请号：US14822335

申请日：2015-08-10

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs

IPC: G01N33/68

CPC classification number: G01N33/6845 ,  C12N15/1044 ,  C40B30/04 ,  C40B40/08 ,  C40B50/06 ,  G01N2333/78

Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US20140155325A1

公开(公告)日：2014-06-05

申请号：US14085340

申请日：2013-11-20

Applicant: Janssen Biotech, Inc.

Inventor： Anderson Mark ,  Ricardo Attar ,  Michael Diem ,  Linus Hyun ,  Steven Jacobs ,  Alastair King ,  Donna Klein ,  Sheri Moores ,  Karyn O'Neil ,  Kristen Picha

IPC: C07K14/78 ,  A61K45/06 ,  A61K38/39

CPC classification number: C07K14/78 ,  A61K38/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/70

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.