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公开(公告)号：US09176099B2
公开(公告)日：2015-11-03
申请号：US13466285
申请日：2012-05-08
IPC分类号： G01N29/26 , G01N29/22 , G01N29/265
CPC分类号： G01N29/265 , G01N29/221 , G01N29/225 , G01N2291/0231 , G01N2291/2638
摘要： Method and apparatus for enabling ultrasonic inspection of a changing, insufficiently defined or unknown shape (e.g., a variable radius or a noncircular radius caused by the use of soft tooling) at a rate that meets production requirements. The apparatus comprises a linear ultrasonic array (i.e., sensor) incorporated in a toppler, which in turn is slidably supported by an oscillating sensor mechanism carried by a traveling trailer vehicle. As a result of this arrangement, the sensor can undergo a back-and-forth sweeping motion coupled with motion along the spar radius. The sensor is further able to displace radially relative to a sweep pivot axis and rotate (hereinafter “topple”) about a topple pivot axis. In this manner, the orientation of the sensor can adjust to the contour of the inspected surface as the sensor scans.
摘要翻译： 能够以满足生产要求的速率超声波检查改变的，不充分限定的或未知的形状（例如，由使用软工具引起的可变半径或非圆形半径）的方法和装置。 该装置包括结合在倾倒机中的线性超声波阵列（即，传感器），其又由由行驶的拖车车辆承载的振动传感器机构可滑动地支撑。 作为这种布置的结果，传感器可以经受与沿着翼梁半径的运动耦合的往复扫掠运动。 传感器还能够相对于扫掠枢转轴线径向移位，并且围绕俯仰枢转轴线旋转（以下称为“倾倒”）。 以这种方式，当传感器扫描时，传感器的方向可以调整到被检查表面的轮廓。
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公开(公告)号：US08943892B2
公开(公告)日：2015-02-03
申请号：US13470125
申请日：2012-05-11
CPC分类号： G01N29/225 , G01N2291/0231 , G01N2291/106 , G01N2291/2636 , G01N2291/2694
摘要： A computer-controlled robotic platform with a collapsible lifting arm that positions a non-destructive inspection (NDI) sensor for scanning inside tunnel regions of a composite structure such as an integrally stiffened wing box. The lifting arm of a modified scissor lift mechanism can be collapsed to a very low height to pass through narrow sections of the integrally stiffened wing box, and also extended by more than a factor of three to reach the maximum height of the wing box tunnels. The system performs a vertical position sensing and control process that uses inverse kinematics to enable position control using data from a standard rotational encoder on the motor to determine vertical position. The system produces simulated encoder pulses that represent unit vertical displacements of a distal portion of a modified scissor lift mechanism using a forward kinematics equation in which the rotation angle of a lead screw is an input variable.
摘要翻译： 具有可折叠提升臂的计算机控制的机器人平台，其定位用于在复合结构（例如整体加强的翼盒）的隧道区域内扫描的非破坏性检查（NDI）传感器。 改进的剪刀提升机构的提升臂可以折叠到非常低的高度以穿过整体加固的翼盒的狭窄部分，并且还延伸超过三倍以达到翼盒隧道的最大高度。 系统执行垂直位置检测和控制过程，该过程使用反向运动学来使用来自马达上的标准旋转编码器的数据来进行位置控制，以确定垂直位置。 该系统产生模拟编码器脉冲，其表示改进的剪式提升机构的远端部分的单元垂直位移，其使用前导运动学方程，其中导螺杆的旋转角度是输入变量。
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公开(公告)号：US08650958B2
公开(公告)日：2014-02-18
申请号：US11345905
申请日：2006-02-02
IPC分类号： G01N29/28
CPC分类号： G01N29/28 , B33Y80/00 , G01N29/223 , G01N29/24 , G01N2291/101
摘要： An ultrasonic probe for examining an item. The probe includes a body having a contact surface adapted for contacting the item when being examined and an ultrasonic transducer attached to the body and spaced from the contact surface. The probe further includes a spacer positioned in the body between the transducer and the contact surface for spacing the transducer from the item when being examined. The spacer includes a coupling surface facing the item when being examined and a transducer surface facing the transducer. The probe also includes a fluid outlet positioned adjacent the coupling surface of the spacer for delivering coupling fluid to the coupling surface as a film so that the coupling fluid tends to maintain contact with the spacer due to surface tension after the fluid is delivered through the outlet.
摘要翻译： 用于检查物品的超声波探头。 探针包括具有接触表面的主体，该接触表面适于在检查时接触物品，以及附接到主体并与接触表面间隔开的超声波换能器。 探头还包括位于换能器和接触表面之间的主体中的间隔件，用于在检测时将换能器与物品间隔开。 间隔件包括当检查时面向物品的联接表面和面向换能器的换能器表面。 探针还包括邻近间隔件的联接表面定位的流体出口，用于将耦合流体作为膜输送到耦合表面，使得耦合流体趋向于在流体通过出口输送流体之后由于表面张力而保持与间隔物的接触 。
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公开(公告)号：US07561753B2
公开(公告)日：2009-07-14
申请号：US11018840
申请日：2004-12-21
申请人： Michael C. Hutchinson , Michael D. Horky , Mark A. Lee , William D. Meade , James C. Kennedy , Thomas E. Riechers , Michael J. Duncan
发明人： Michael C. Hutchinson , Michael D. Horky , Mark A. Lee , William D. Meade , James C. Kennedy , Thomas E. Riechers , Michael J. Duncan
CPC分类号： G06T5/50 , G06T5/009 , G06T7/001 , G06T2200/24 , G06T2207/10116 , G06T2207/30136 , G06T2207/30164
摘要： Methodologies and systems to compare images with different levels of contrast are provided. Contrast is normalized between the images with different contrast levels and brightness is set. When normalizing contrast a derivative of gray level is determined for a first digital image having a first contrast level, and a derivative of gray level is determined for a second digital image having a second contrast level that is greater than the first contrast level. A ratio of the derivative of gray level for the first digital image to the derivative of gray level for the second digital image is determined, and the derivative of gray level for the first digital image is equalized with the derivative of gray level for the second digital image. Brightness of at least one image may be set automatically, such as by calculating an average pixel value excluding background and text, or manually.
摘要翻译： 提供了比较不同对比度图像的方法和系统。 对比度在具有不同对比度水平的图像和亮度之间进行归一化。 当归一化对比度时，确定具有第一对比度级别的第一数字图像的灰度级的导数，并且对于具有大于第一对比度级别的第二对比度级别的第二数字图像来确定灰度级的导数。 确定第一数字图像的灰度级的导数与第二数字图像的灰度级的导数的比率，并且第一数字图像的灰度级的导数与第二数字图像的灰度级的导数相等 图片。 可以自动设置至少一个图像的亮度，例如通过计算除了背景和文本之外的平均像素值，或者手动地。
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35.发明申请公开(公告)号：US20080148854A1
公开(公告)日：2008-06-26
申请号：US11643112
申请日：2006-12-21
申请人： Gary E. Georgeson , Joseph Hafenrichter , David A. Lilienthal , James C. Kennedy , Walter J. Harris
发明人： Gary E. Georgeson , Joseph Hafenrichter , David A. Lilienthal , James C. Kennedy , Walter J. Harris
IPC分类号： G01N9/24
CPC分类号： G01N29/30 , G01N29/11 , G01N2291/0289 , Y10T29/49004
摘要： Ultrasonic measurements of porosity in manufactured parts or materials are calibrated using reference standards in which parallel holes are drilled in the backside of a body of material. The holes simulate voids in a part which attenuate incident ultrasonic energy. The number, size and location of the holes determine the simulated level of porosity that may be used to calibrate an ultrasonic tester. Multiple reference standards representing different levels of porosity can be produced in the form of individual coupons, or in a single body having multiple groups of holes.
摘要翻译： 使用参考标准校准制造的零件或材料中的孔隙度的超声波测量，其中在材料体的背面钻出平行的孔。 这些孔模拟衰减入射超声波能量的部分中的空隙。 孔的数量，尺寸和位置确定了可用于校准超声波测试仪的模拟孔隙度水平。 代表不同孔隙度水平的多个参考标准可以以单个试样的形式产生，或者在具有多个孔组的单个体中。
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36.发明授权Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins 失效使用5-氨基乙酰丙酸和其他内源卟啉前体的光化学疗法公开(公告)号：US06710066B2
公开(公告)日：2004-03-23
申请号：US09816329
申请日：2001-03-26
申请人： James C. Kennedy , Roy H. Pottier
发明人： James C. Kennedy , Roy H. Pottier
IPC分类号： A61K3140
CPC分类号： A61K31/195 , A61K31/555 , A61K41/0057 , A61K41/0061 , A61K41/0071 , Y02A50/411
摘要： Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or precursor thereof is administered to the patient, or contacted to the exogenous cells, in an amount sufficient to induce synthesis fluorescence and/or photosensitizing concentrations of a protoporphyrin IX in the exogenous cells, followed by exposure of the exogenous cells to light of photoactivating wavelengths.
摘要翻译： 检测和治疗快速生长的外源细胞例如Protista或寄生虫的方法，其优先地积累可光活化的卟啉，其中5-氨基乙酰丙酸或其前体向患者施用或接触外源细胞，其量足以 诱导外源细胞中原卟啉IX的合成荧光和/或光敏化浓度，随后将外源细胞暴露于光活化波长的光。
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公开(公告)号：US5618790A
公开(公告)日：1997-04-08
申请号：US213897
申请日：1994-03-16
申请人： James C. Kennedy , Michel Ringuet , Roy H. Pottier
发明人： James C. Kennedy , Michel Ringuet , Roy H. Pottier
IPC分类号： A61K41/00 , C07D487/22 , A61K38/27 , A61K38/00 , C07K14/00
CPC分类号： C07D487/22 , A61K41/0071
摘要： Lipophilic and amphiphilic therapeutic or diagnostic agents having water solubilizing groups attached thereto by bonds that can be cleaved readily by one or more of the various proteases that are active in the extracellular fluid or on the surfaces of cells in many types of malignant tissue may accumulate selectively in such malignant tissues. Protease mediated removal of the water solubilizing groups converts such drugs into lipophilic or amphiphilic forms which are more soluble in plasma membrane lipids and which therefore enter cells more readily. Since the extracellular fluid in most non-malignant tissues under normal circumstances has little such protease activity, removal of the water solubilizing groups takes place primarily within malignant tissues, with consequent preferential accumulation of the lipophilic or amphiphilic forms of the drug within malignant tissues. Certain lipophilic and amphiphilic porphyrins and chlorins may be modified by the addition of water solubilizing groups, such as alcohols, which are attached by short polypeptide chains, that are stable while in the circulation but are cleaved by proteases in malignant tissue to provide novel compounds useful for the photodynamic therapy of cancer.
摘要翻译： 亲水性和两亲性的治疗或诊断剂，其具有通过可由可在细胞外液中活化的多种蛋白酶或许多类型的恶性组织中的细胞表面上的一种或多种蛋白酶易于切割的键连接在其上的水溶性基团， 在这样的恶性组织中。 蛋白酶介导的水溶性基团的去除将这些药物转化为亲脂性或两亲性形式，其更易溶于质膜脂质，因此更容易进入细胞。 由于大多数非恶性组织中的细胞外液在正常情况下几乎没有此类蛋白酶活性，所以水溶性基团的去除主要发生在恶性组织内，因此在恶性组织中亲和或两亲形式的药物优先积累。 某些亲脂性和两亲性卟啉和二氢卟酚可以通过添加水溶性基团来修饰，例如通过短多肽链连接的醇，其在循环中是稳定的，但在恶性组织中被蛋白酶切割以提供有用的新化合物 用于癌症的光动力治疗。
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公开(公告)号：US5219878A
公开(公告)日：1993-06-15
申请号：US807341
申请日：1991-12-16
IPC分类号： A61K41/00 , C07D487/22
CPC分类号： C07D487/22 , A61K41/0071
摘要： This invention relates to new preparations which are valuable for photodetection and photochemotherapy of tumors and malignant tissues. The active compounds of these therapeutic preparations are mono-, di- or polyamides of an amino alcohol and a cyclic tetrapyrrole containing at least one carboxyl group. The general structure of these active compounds is(ZNHCO).sub.n Xwherein Z is the amino alcohol molecule less the amino group, X is the tetrapyrrole molecule less a carboxyl group, and "n" is an integer from 1 to 8.
摘要翻译： 本发明涉及对肿瘤和恶性组织的光电探测和光化学治疗有价值的新制剂。 这些治疗制剂的活性化合物是含有至少一个羧基的氨基醇和环状四吡咯的单酰胺，二酰胺或聚酰胺。 这些活性化合物的一般结构是（ZNHCO）nX，其中Z是氨基醇分子少于氨基，X是四吡咯分子少羧基，“n”是1至8的整数。
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39.发明授权Method of detection of malignant and non-malignant lesions by photochemotherapy of protoporphyrin IX percursors 失效通过原卟啉IX光刻法光化学治疗检测恶性和非恶性病变的方法
公开(公告)号：US5211938A
公开(公告)日：1993-05-18
申请号：US783750
申请日：1991-10-28
申请人： James C. Kennedy , Roy H. Pottier , Robert L. Reid
发明人： James C. Kennedy , Roy H. Pottier , Robert L. Reid
IPC分类号： A61B10/00 , A61K31/195 , A61K31/555 , A61K39/395 , A61K41/00 , A61K49/00 , A61N5/06 , A61P35/00 , A61P43/00
CPC分类号： A61K31/195 , A61K31/555 , A61K41/0061
摘要： A method of detecting and treating malignant and nonmalignant tissue abnormalities and lesions of the skin, conjunctives, respiratory, digestive and vaginal mucosa; endometrium and urothelium in which 5-aminolevulinic acid is administered to the patient in an amount sufficient to induce synthesis of protoporphyrin IX in the lesions, followed by exposure of the treated lesion to a photoactivating light in the range 350-640 nm.
摘要翻译： 一种检测和治疗恶性和非恶性组织异常和皮肤，结膜，呼吸，消化和阴道粘膜损伤的方法; 子宫内膜和尿路上皮，其中5-氨基乙酰丙酸以足以诱导病变中原卟啉IX合成的量施用于患者，随后将经处理的病变暴露于350-640nm范围内的光活化光。
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40.发明授权Channel selection in a switching system having clustered remote switching modules 失效具有集群远程交换模块的交换系统中的信道选择
公开(公告)号：US4566094A
公开(公告)日：1986-01-21
申请号：US493741
申请日：1983-05-11
CPC分类号： H04Q11/0407 , H04Q2213/13107 , H04Q2213/13213 , H04Q2213/13292
摘要： An arrangement comprising a host switching system and a number of remote switching modules which are directly interconnected such that voice and data traffic as well as control information can be conveyed between modules without being routed through the host system network. The arrangement allows the integrated stand-alone operation of the remote switching modules and advantageously reduces traffic through the host system network during normal operation. For each pair of remote switching modules, one of the modules selects the channels of the direct interconnection which are used for conveying information between the modules.
摘要翻译： 一种包括主机交换系统和多个直接互连的远程交换模块的布置，使得语音和数据业务以及控制信息可以在模块之间传送，而不通过主机系统网络路由。 该布置允许远程交换模块的集成独立操作，并且有利地在正常操作期间减少通过主机系统网络的业务。 对于每对远程交换模块，其中一个模块选择用于在模块之间传送信息的直接互连通道。
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