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31.发明授权
公开(公告)号：US5514810A
公开(公告)日：1996-05-07
申请号：US461007
申请日：1995-06-05
IPC分类号： C07C227/08 , C07C229/16 , C07C229/36 , C07D213/55 , C07D233/02 , C07C229/06
CPC分类号： C07C229/16 , C07C227/08 , C07C229/36 , C07D213/55
摘要： The invention relates to a process for the production of diethylenetriaminepentacarboxylic acid tetraesters of general formula I ##STR1## in which R.sup.1 and Z have different meanings.
摘要翻译： 本发明涉及一种制备通式Ⅰ的二亚乙基三胺四羧酸四酯的方法，其中R1和Z具有不同的含义。
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32.发明授权Synthesis of oxygen-substituted benzocycloheptenes as valuable intermediate products for the production of tissue-selective estrogens 失效合成氧取代的苯并环庚烯作为生产组织选择性雌激素的有价值的中间产物公开(公告)号：US07321044B2
公开(公告)日：2008-01-22
申请号：US10270080
申请日：2002-10-15
申请人： Johannes Platzek , Wolfgang Beckmann , Jens Geisler , Holger Kirstein , Ulrich Niedballa , Eckhard Ottow , Sigmar Radau , Claudia Schulz , Thomas Wessa
发明人： Johannes Platzek , Wolfgang Beckmann , Jens Geisler , Holger Kirstein , Ulrich Niedballa , Eckhard Ottow , Sigmar Radau , Claudia Schulz , Thomas Wessa
IPC分类号： C07D211/70 , C07D233/56
CPC分类号： C07D213/16 , C07C43/225 , C07C45/46 , C07C49/755 , C07C51/36 , C07C51/367 , C07C59/64 , C07C67/03 , C07C69/736 , C07C69/738 , C07C303/26 , C07C303/28 , C07C309/65 , C07C315/02 , C07C2602/12 , C07D213/30 , C07D213/50 , C07D213/55 , C07D333/16 , C07D333/22 , C07D333/24 , C07C317/18
摘要： The invention relates to intermediate products and a new process for the production of benzocycloheptene C. The process for the production of its new intermediate products according to the invention starts from economical starting materials, provides the intermediate stages in high yields and high purity, without chromatographic purification steps, and allows production on an industrial scale.
摘要翻译： 本发明涉及中间产物和用于生产苯并环庚烯C的新方法。根据本发明生产其新中间产物的方法从经济起始材料开始，提供高产率和高纯度的中间阶段，无色谱 净化步骤，并允许在工业规模生产。
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33.发明申请STENTS WITH A RADIOACTIVE SURFACE COATING, PROCESSES FOR THEIR PRODUCTION AND THEIR USE FOR RESTENOSIS PROPHYLAXIS 审中-公开具有放射性表面涂层的方法，其生产方法及其用于保护预防的用途公开(公告)号：US20070032694A1
公开(公告)日：2007-02-08
申请号：US10718580
申请日：2003-11-24
申请人： Ludger Dinkelborg , Friedhelm Blume , Christoph-Stephan Hilger , Dieter Heldmann , Johannes Platzek , Ulrich Niedballa , Heribert Miklautz , Ulrich Speck , Stephan Duda , Gunnar Tepe , Bernhard Noll , Heidemarie Goerner
发明人： Ludger Dinkelborg , Friedhelm Blume , Christoph-Stephan Hilger , Dieter Heldmann , Johannes Platzek , Ulrich Niedballa , Heribert Miklautz , Ulrich Speck , Stephan Duda , Gunnar Tepe , Bernhard Noll , Heidemarie Goerner
CPC分类号： A61K51/1282 , A61F2/82 , A61F2210/0095 , A61L31/082 , A61L31/14 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/44 , A61L2300/606 , A61N5/1002
摘要： The invention relates to radioactive stents, characterized in that the stent is coated on the surface with the radioactive isotope, as well as processes for their production.
摘要翻译： 本发明涉及放射性支架，其特征在于，用放射性同位素将支架涂覆在表面上，以及其生产方法。
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公开(公告)号：US07166740B2
公开(公告)日：2007-01-23
申请号：US10890521
申请日：2004-07-14
申请人： Heiko Schirmer , Ulrich Niedballa , Hannelore Niedballa , Johannes Platzek , Jose Luis Martin , Juan R. Harto , Jose Carretero
发明人： Heiko Schirmer , Ulrich Niedballa , Hannelore Niedballa , Johannes Platzek , Jose Luis Martin , Juan R. Harto , Jose Carretero
IPC分类号： C07C69/00 , C07C51/255
CPC分类号： C07C69/007 , C07C51/16 , C07C51/285 , C07C67/00 , C07C67/035 , C07C63/72 , C07C63/68 , C07C69/63
摘要： A new process for the production of triiodotrimesic acid that is used as an intermediate product for the synthesis of x-ray contrast media is described.
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公开(公告)号：US06677483B2
公开(公告)日：2004-01-13
申请号：US10056044
申请日：2002-01-28
申请人： Johannes Platzek , Ulrich Niedballa
发明人： Johannes Platzek , Ulrich Niedballa
IPC分类号： C07C22900
CPC分类号： C07C231/02 , C07C237/04
摘要： A new process for the preparation of diethylenetriaminepentaacetic-monoamides in which amines can be reacted with sensitive groups, a higher mono/diamide selectivity is achieved, a higher yield of monoamide is achieved and has a simple reaction scheme and working-up.
摘要翻译： 制备二胺三胺五乙酸单酰胺的新方法，其中胺可以与敏感基团反应，获得更高的单/二酰胺选择性，实现了更高的单酰胺产率，并且具有简单的反应方案和后处理。
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36.发明授权Process for the production of DTPA-monoamides of the central carboxylic acid and their use as pharmaceutical agents 失效制备中枢羧酸的DTPA-单酰胺的方法及其作为药剂的用途
公开(公告)号：US5679852A
公开(公告)日：1997-10-21
申请号：US460119
申请日：1995-06-02
IPC分类号： C07C231/02 , C07C237/06 , C07C237/08 , C07C237/10 , C07C237/14 , C07C237/20 , C07D295/185
CPC分类号： C07D295/185 , C07C231/02 , C07C237/06 , C07C237/08 , C07C237/10 , C07C237/14 , C07C237/20
摘要： A process for the production of of general formula I diethylenetriaminepentacarboxylic acid monoamide derivatives ##STR1## in which E.sup.1, E.sup.2 and Z have varying meanings.
摘要翻译： 制备通式I二亚乙基三胺三羧酸单酰胺衍生物（I）的方法，其中E1，E2和Z具有不同的含义。
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公开(公告)号：US20070093674A1
公开(公告)日：2007-04-26
申请号：US11607016
申请日：2006-12-01
申请人： Heiko Schirmer , Ulrich Niedballa , Hannelore Niedballa , Johannes Platzek , Jose Martin , Juan Harto , Jose Carretero
发明人： Heiko Schirmer , Ulrich Niedballa , Hannelore Niedballa , Johannes Platzek , Jose Martin , Juan Harto , Jose Carretero
IPC分类号： C07C51/255 , C07C69/035
CPC分类号： C07C69/007 , C07C51/16 , C07C51/285 , C07C67/00 , C07C67/035 , C07C63/72 , C07C63/68 , C07C69/63
摘要： A new process for the production of triiodotrimesic acid that is used as an intermediate product for the synthesis of x-ray contrast media is described.
摘要翻译： 描述了用作生产用于合成X射线造影剂的中间产物的三碘三次风酸的新方法。
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38.发明授权Stents with a radioactive surface coating, processes for their production and their use for restenosis prophylaxis 失效具有放射性表面涂层的支架，其生产过程及其用于再狭窄预防公开(公告)号：US06709693B1
公开(公告)日：2004-03-23
申请号：US09627321
申请日：2000-07-27
申请人： Ludger Dinkelborg , Friedhelm Blume , Christoph-Stephan Hilger , Dieter Heldmann , Johannes Platzek , Ulrich Niedballa , Heribert Miklautz , Ulrich Speck , Stephan Duda , Gunnar Tepe , Bernhard Noll , Heidemarie Goerner
发明人： Ludger Dinkelborg , Friedhelm Blume , Christoph-Stephan Hilger , Dieter Heldmann , Johannes Platzek , Ulrich Niedballa , Heribert Miklautz , Ulrich Speck , Stephan Duda , Gunnar Tepe , Bernhard Noll , Heidemarie Goerner
IPC分类号： A61L2700
CPC分类号： A61K51/1282 , A61F2/82 , A61F2210/0095 , A61L31/082 , A61L31/14 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/44 , A61L2300/606 , A61N5/1002
摘要： The invention relates to radioactive stents, characterized in that the stent is coated on the surface with the radioactive isotope, as well as processes for their production.
摘要翻译： 本发明涉及放射性支架，其特征在于，用放射性同位素将支架涂覆在表面上，以及其生产方法。
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![CALCIUM COMPLEX OF [[(4R)-4-[BIS{CARBOXY-.KAPPA.O)METHYL]AMINO-.KAPPA.N]-6,9-BIS[(CARBOXY.KAPPA.O)METHYL]-1-[(4,4-DIPHENYLCYCLOHEXYL)OXY]-1-HYDROXY-2-OXA-6,9-DIAZA-1-PHOSPHAUNDECAN-11-YLIC-ACID-.KAPPA.N6,.KAPPA.N9,.KAPPA.011]1-OXIDATO(6-)]-, HEXAHYDROGEN, ITS SALTS, PHARMACEUTICAL AGENTS THAT CONTAIN THESE COMPLEXES, THEIR USE IN TREATMENT AND AS ADDITIVES IN DIAGNOSIS, AS WELL AS PROCESSES FOR THE PRODUCTION OF THE COMPLEXES AND AGENTS](/abs-image/US/2003/05/06/US06559330B1/abs.jpg.150x150.jpg)
39.发明授权CALCIUM COMPLEX OF [[(4R)-4-[BIS{CARBOXY-.KAPPA.O)METHYL]AMINO-.KAPPA.N]-6,9-BIS[(CARBOXY.KAPPA.O)METHYL]-1-[(4,4-DIPHENYLCYCLOHEXYL)OXY]-1-HYDROXY-2-OXA-6,9-DIAZA-1-PHOSPHAUNDECAN-11-YLIC-ACID-.KAPPA.N6,.KAPPA.N9,.KAPPA.011]1-OXIDATO(6-)]-, HEXAHYDROGEN, ITS SALTS, PHARMACEUTICAL AGENTS THAT CONTAIN THESE COMPLEXES, THEIR USE IN TREATMENT AND AS ADDITIVES IN DIAGNOSIS, AS WELL AS PROCESSES FOR THE PRODUCTION OF THE COMPLEXES AND AGENTS 失效[[（4R）-4- [BIS（羧甲基）KAPPA.O）甲基]氨基] .KAPPA.N] -6,9-双（[（羧甲基）酮]甲基] -1- [ （4,4-二苯基环己基）氧基] -1-羟基-2-氧代-6,9-二氮杂-1-磷杂环丁烷-11-酰氯-KAPPA.N6，KAPPA.N9，KAPPA.011] 1 -OXIDATO（6 - ）] - ，十六氢萘，其盐，含有这些复合物的药物代理，其用于治疗和作为诊断中的添加剂，以及用于生产复合物和药剂的方法公开(公告)号：US06559330B1
公开(公告)日：2003-05-06
申请号：US09659554
申请日：2000-09-11
IPC分类号： C07F902
CPC分类号： A61K49/10 , A61K49/085 , C07F9/091 , C07F9/117
摘要： The invention relates to the calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.kappa. N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen(MS-325) and its salts, pharmaceutical agents that contain these complexes, for the production of agents for the reduction of effects that are caused by heavy metals as well as processes for their production.
摘要翻译： 本发明涉及[[（4R）-4- [双[（羧基 - .kappa.O）甲基]氨基 - .kappa.N] -6,9-双[（羧基 - .kappaO ）甲基] -1 - [（4,4-二苯基环己基）氧基] -1-羟基-2-氧杂-6,9-二氮杂-1-磷杂十一碳-7-烯酸-κκ6， N9，.kappa.011] 1-氧化物（6 - ）] - ，四氢（MS-325）及其盐，含有这些配合物的药剂，用于生产用于降低由重金属引起的作用的试剂 以及生产过程。
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公开(公告)号：US06545135B2
公开(公告)日：2003-04-08
申请号：US09801050
申请日：2001-03-08
IPC分类号： C07H1500
CPC分类号： C07H15/203
摘要： The invention relates to a process for the production of perbenzylated 1-O-glycosides of general formula I or salts thereof in which sugar1 is a monosaccharide that is functionalized in 1-OH-position, R represents benzyl, n means 2, 3 or 4, means —O—, —S—, —COO— or —NH— and L means a straight-chain, branched, saturated or unsaturated C1-C30 carbon chain, which optionally is interrupted or substituted by groups. The process according to the invention starts from economical starting materials, provides good yields and allows the production of perbenzylated saccharides with 1-O-functionalized side chains on an enlarged scale.
摘要翻译： 本发明涉及生产通式I的过苄氧基化的1-O-糖苷或其盐的方法，其中所述的1是在1-OH位官能化的单糖，R表示苄基，n表示2,3或4， -O - ， - S - ， - COO-或-NH-和L表示直链，支链，饱和或不饱和的C 1 -C 30碳链，其任选被基团中断或取代。根据本发明的方法从 经济的起始原料，提供良好的产率，并允许以1-O-官能化侧链的大范围生产过苄基化糖。
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