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公开(公告)号:US20080131421A1
公开(公告)日:2008-06-05
申请号:US10864684
申请日:2004-06-08
摘要: The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译: 本发明提供脑膜炎奈瑟菌(A&B)菌株和来自淋病奈瑟氏球菌的蛋白质,包括氨基酸序列,相应的核苷酸序列,表达数据和血清学数据。 蛋白质是疫苗,免疫原性组合物和/或诊断的有用的抗原。
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公开(公告)号:US09067987B2
公开(公告)日:2015-06-30
申请号:US13405213
申请日:2012-02-24
申请人: Cesira Galeotti , Guido Grandi , Vega Masignani , Marirosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人: Cesira Galeotti , Guido Grandi , Vega Masignani , Marirosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号: C07K14/22 , A61K39/095 , A61K39/00 , A61K48/00
CPC分类号: A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要: This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
摘要翻译: 本发明尤其提供衍生自脑膜炎奈瑟氏球菌B细菌的蛋白质,多肽和其片段。还提供编码这种蛋白质,多肽和/或片段的核酸,以及与其互补的核酸,例如, 反义核酸)。 另外,本发明提供了结合蛋白质,多肽和/或片段的抗体。 本发明进一步提供了可用于制备蛋白质,多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。 本发明还提供用作疫苗,诊断试剂,免疫原性组合物等的蛋白质,多肽,片段和/或核酸的组合物。 还提供了用组合物制备组合物和处理方法的方法。 本发明还提供了检测蛋白质,多肽,片段和/或核酸的方法。
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公开(公告)号:US20120276129A1
公开(公告)日:2012-11-01
申请号:US13405213
申请日:2012-02-24
申请人: Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人: Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号: A61K39/095 , A61P37/04 , C07K14/22
CPC分类号: A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要: This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
摘要翻译: 本发明尤其提供衍生自脑膜炎奈瑟氏球菌B细菌的蛋白质,多肽和其片段。还提供编码这种蛋白质,多肽和/或片段的核酸,以及与其互补的核酸,例如, 反义核酸)。 另外,本发明提供了结合蛋白质,多肽和/或片段的抗体。 本发明进一步提供了可用于制备蛋白质,多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。 本发明还提供用作疫苗,诊断试剂,免疫原性组合物等的蛋白质,多肽,片段和/或核酸的组合物。 还提供了用组合物制备组合物和处理方法的方法。 本发明还提供了检测蛋白质,多肽,片段和/或核酸的方法。
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公开(公告)号:US20120219578A1
公开(公告)日:2012-08-30
申请号:US13405162
申请日:2012-02-24
申请人: Cesira GALEOTTI , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人: Cesira GALEOTTI , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号: A61K39/095 , A61P31/04 , A61P37/04 , C07K14/22
CPC分类号: A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要: This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
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公开(公告)号:US20100272725A1
公开(公告)日:2010-10-28
申请号:US12653954
申请日:2009-12-18
摘要: The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
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公开(公告)号:US20130064846A1
公开(公告)日:2013-03-14
申请号:US13593464
申请日:2012-08-23
IPC分类号: A61K39/095 , A61P31/04 , A61P37/04 , C07K14/22
摘要: The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译: 本发明提供脑膜炎奈瑟菌(A&B)菌株和来自淋病奈瑟氏球菌的蛋白质,包括氨基酸序列,相应的核苷酸序列,表达数据和血清学数据。 蛋白质是疫苗,免疫原性组合物和/或诊断的有用的抗原。
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公开(公告)号:US07655245B2
公开(公告)日:2010-02-02
申请号:US10864684
申请日:2004-06-08
IPC分类号: A61K39/095 , C07K14/195 , C12P21/04 , C07H21/04
摘要: The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译: 本发明提供脑膜炎奈瑟菌(A&B)菌株和来自淋病奈瑟氏球菌的蛋白质,包括氨基酸序列,相应的核苷酸序列,表达数据和血清学数据。 蛋白质是疫苗,免疫原性组合物和/或诊断的有用的抗原。
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公开(公告)号:US08293251B2
公开(公告)日:2012-10-23
申请号:US12653954
申请日:2009-12-18
IPC分类号: A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
摘要: The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译: 本发明提供脑膜炎奈瑟菌(A&B)菌株和来自淋病奈瑟氏球菌的蛋白质,包括氨基酸序列,相应的核苷酸序列,表达数据和血清学数据。 蛋白质是疫苗,免疫原性组合物和/或诊断的有用的抗原。
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公开(公告)号:US07988979B2
公开(公告)日:2011-08-02
申请号:US12013047
申请日:2008-01-11
申请人: Claire M. Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Maria Rosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulo Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , Craig Venter
发明人: Claire M. Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Maria Rosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulo Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , Craig Venter
IPC分类号: A61K39/095 , A61K39/02 , A61K39/00 , A61K38/00 , C07K14/00
CPC分类号: C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
摘要翻译: 本发明提供脑膜炎奈瑟氏球菌的蛋白质,包括氨基酸序列和相应的核苷酸序列。 蛋白质被预测为用于疫苗和/或诊断的有用的抗原。
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公开(公告)号:US06709660B1
公开(公告)日:2004-03-23
申请号:US09302626
申请日:1999-04-30
IPC分类号: A61K39095
摘要: The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译: 本发明提供来自脑膜炎奈瑟菌(A&B)菌株的蛋白质,包括氨基酸序列,相应的核苷酸序列,表达数据和血清学数据。 蛋白质是疫苗,免疫原性组合物和/或诊断的有用的抗原。
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