公开(公告)号：US06271415B1

公开(公告)日：2001-08-07

申请号：US09529917

申请日：2000-04-19

Applicant: Friedrich-Wilhelm Ullrich ,  Helmut Fiege ,  Wolfgang Eymann

Inventor： Friedrich-Wilhelm Ullrich ,  Helmut Fiege ,  Wolfgang Eymann

IPC: C07C38100

CPC classification number: C07C319/06 ,  C07C381/02 ,  C07C321/26

Abstract: The invention relates to novel S-(4-biphenyl)-thiosulfuric acids and their salts, to a method for producing them from S-(4-biphenyl)-thiosulfinic acids and their salts, and to a method for producing 4-mercaptobiphenyls from the S-(4-biphenyl)-thiosulfuric acids and their salts.

Abstract translation: 本发明涉及新型S-（4-联苯基） - 硫代硫酸及其盐，涉及由S-（4-联苯基） - 硫代亚磺酸及其盐制备它们的方法，以及由4- S-（4-联苯基） - 硫代硫酸及其盐。

公开(公告)号：US5847236A

公开(公告)日：1998-12-08

申请号：US710990

申请日：1996-09-25

Applicant: Franz-Josef Mais ,  Helmut Fiege

Inventor： Franz-Josef Mais ,  Helmut Fiege

IPC: B01J31/02 ,  C07C37/62 ,  C07C39/28

CPC classification number: B01J31/0218 ,  B01J31/26 ,  B01J31/30 ,  C07C37/62

Abstract: 2-Chloro-4-methylphenol is prepared by reacting 4-methylphenol with a chlorinating agent in the presence of a catalyst system of one or more Lewis acids in a total amount of 0.1-10% by weight and one or more diaryl sulphides in a total amount of 0.1-10% by weight, all based on the amount of 4-methylphenol. The reaction temperature is 0.degree.-100.degree. C. The chlorinating agent is used in an amount of 0.5-1.5 mol per mole of 4-methylphenol. The reaction can be carried out until virtually complete consumption of the 4-methylphenol, high isomeric selectivity and high stage selectivity being observed.

Abstract translation: 2-氯-4-甲基苯酚是通过使4-甲基苯酚与氯化剂在总量为0.1-10重量％的一种或多种路易斯酸的催化剂体系存在下反应来制备的，一种或多种二芳基硫化物在 总量为0.1-10重量％，均基于4-甲基苯酚的量。 反应温度为0℃-100℃。氯化剂的用量为每摩尔4-甲基苯酚0.5-1.5摩尔。 反应可以进行直到几乎完全消耗4-甲基苯酚，高异构选择性和高阶段选择性被观察到。

公开(公告)号：US5741936A

公开(公告)日：1998-04-21

申请号：US710474

申请日：1996-09-18

Applicant: Klaus-Christian Paetz ,  Helmut Fiege ,  Wolfram Kissener

Inventor： Klaus-Christian Paetz ,  Helmut Fiege ,  Wolfram Kissener

IPC: C07C201/08 ,  C07C205/45 ,  C07C45/61

CPC classification number: C07C201/08

Abstract: 3-Chloro-3'-nitro-4'-methoxybenzophenone with substantially lower contents of dinitro derivatives than hitherto is obtained if 3-chloro-4'-methoxybenzophenone is nitrated in from 65 to 85% strength by weight sulfuric acid with nitric acid at temperatures in the range from -20.degree. to +60.degree. C.

Abstract translation: 迄今为止，如果将3-氯-4'-甲氧基二苯甲酮硝酸化为65-85％的硫酸与硝酸的强度，则得到3-二氯硝基-4'-甲氧基二苯甲酮，其中二硝基衍生物的含量基本较低 温度范围为-20°C至+60°C

公开(公告)号：US5672708A

公开(公告)日：1997-09-30

申请号：US521941

申请日：1995-08-31

Applicant: Gunter Rauchschwalbe ,  Bernhard Beitzke ,  Wolfgang Eymann ,  Helmut Fiege

Inventor： Gunter Rauchschwalbe ,  Bernhard Beitzke ,  Wolfgang Eymann ,  Helmut Fiege

IPC: C07D317/48 ,  C07C227/06 ,  C07C227/10 ,  C07C229/34 ,  C07D213/61 ,  C07D213/74 ,  C07D215/56 ,  C07D319/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D471/04 ,  C07D491/044 ,  C07D491/056 ,  C07D491/14 ,  C07D491/22 ,  C07D491/02 ,  C07C205/00 ,  C07C229/00 ,  C07D307/00

CPC classification number: C07D215/56 ,  C07C227/10 ,  C07C229/34

Abstract: N-arylaminoacrylic acid derivatives are obtained in good yields and in high purities when benzoylacetic acid derivatives are reacted with N-arylimino ethers. The products thus prepared are used, in particular, for the preparation of 4-quinolone-3-carboxylic acid derivatives, which have an outstanding bactericidal action.

Abstract translation: 当苯甲酰乙酸衍生物与N-芳基亚氨基醚反应时，得到N-芳基氨基丙烯酸衍生物，产率高，纯度高。 这样制备的产品特别用于制备具有优异杀菌作用的4-喹诺酮-3-羧酸衍生物。

公开(公告)号：US5591869A

公开(公告)日：1997-01-07

申请号：US568050

申请日：1995-12-06

Applicant: Helmut Fiege ,  Ferdinand Hagedorn

Inventor： Helmut Fiege ,  Ferdinand Hagedorn

IPC: C07B31/00 ,  C07C1/32 ,  C07C17/35 ,  C07D307/38 ,  C07D333/08 ,  C07D333/12

CPC classification number: C07D307/38 ,  C07B31/00 ,  C07D333/08 ,  C07D333/12

Abstract: Methylene compounds are preferably prepared by reducing an aluminum halide complex of the formula ##STR1## in which R.sup.1 represents a C.sub.6 -C.sub.10 -aryl radical which is optionally substituted by 1 to 4 C.sub.1 -C.sub.4 -alkyl radicals, 1 to 4 fluorine, chlorine and/or bromine atoms, one C.sub.1 -C.sub.8 -alkoxy group and/or one acetoxy group, or represents a heteroaryl radical which is optionally substituted by one C.sub.1 -C.sub.4 -alkyl radical and/or one fluorine, chlorine or bromine atom and contains 5 to 10 C atoms and one O or S atom andR.sup.2 represents a C.sub.1 -C.sub.12 -alkyl radical which is optionally substituted by 1 to 5 fluorine, chlorine and/or bromine atoms, independently of R.sup.1 represents a radical as defined for R.sup.1 and, in the case where R.sup.1 =a C.sub.6 -C.sub.10 -aryl radical which is substituted by 1 to 4 fluorine, chlorine and/or bromine atoms, also represents a furyl or thienyl radical,Y represents fluorine, chlorine or bromine,with an amineborane of the formula ##STR2## in which R.sup.3 represents C.sub.1 -C.sub.4 -alkyl andR.sup.4 represents hydrogen or C.sub.1 -C.sub.4 -alkyl and/orwith sodium borohydride and/or with potassium borohydride.2-(2,4-Dichloro-5-fluorobenzyl)thiophene is obtainable in this way for the first time.

Abstract translation: 亚甲基化合物优选通过还原任选被1至4个C 1 -C 4烷基，1至4个氟，氯和/或溴原子，一个C 1 -C 8 - 烷氧基取代的式偕基的卤化铝配合物 和/或一个乙酰氧基，或表示任选被一个C 1 -C 4 - 烷基和/或一个氟，氯或溴原子取代且含有5至10个C原子和一个O或S原子且R 2表示 任选被1至5个氟，氯和/或溴原子取代的C1-C12-烷基，独立于R1表示对R1定义的基团，并且在R1 = C6-C10芳基的情况下，其中 被1至4个氟，氯和/或溴原子取代，也代表呋喃基或噻吩基，Y代表氟，氯或溴，与式（III）的胺硼烷反应，其中R 3表示C 1 -C 4 - 烷基和R 4表示氢或C 1 -C 4烷基和/或与硼氢化钠 ydride和/或用硼氢化钾。 2-（2,4-二氯-5-氟苄基）噻吩可以首次以这种方式获得。

公开(公告)号：US5502256A

公开(公告)日：1996-03-26

申请号：US350552

申请日：1994-12-07

Applicant: Ferdinand Hagedorn ,  Helmut Fiege ,  Robert So/ llner ,  Rudolf Helm

Inventor： Ferdinand Hagedorn ,  Helmut Fiege ,  Robert So/ llner ,  Rudolf Helm

IPC: C07C319/22 ,  C07C323/09

CPC classification number: C07C319/22

Abstract: 2,2'-Dinitrodiphenyl disulphide is obtained in particularly good yields and purities in a simple manner by reacting 2-chloronitrobenzene with an aqueous alkali metal disulphide solution in the presence of phase transfer catalysts and an organic solvent.

Abstract translation: 在相转移催化剂和有机溶剂的存在下，2-氯硝基苯与碱金属二硫化物水溶液反应，以简单的方式获得了特别好的收率和纯度的2,2'-二硝基二苯基二硫化物。

公开(公告)号：US5475142A

公开(公告)日：1995-12-12

申请号：US288632

申请日：1994-08-10

Applicant: Stefan Antons ,  Helmut Fiege ,  Werner Bussmann ,  Hartmut Richter

Inventor： Stefan Antons ,  Helmut Fiege ,  Werner Bussmann ,  Hartmut Richter

IPC: B01J27/128 ,  C07B61/00 ,  C07C315/04 ,  C07C317/14

CPC classification number: C07C315/04

Abstract: Alkyl-(3-chlorophenyl)-sulphones are particularly advantageously obtained by chlorination of alkylphenylsulphones if alkylphenylsulphones are chlorinated in molten form with elemental chlorine in the presence of iron(III) chloride and optionally iodine and/or sulphur.

Abstract translation: 如果烷基苯基砜在氯化铁（III）和任选的碘和/或硫的存在下，用元素氯以熔融形式氯化，则烷基 - （3-氯苯基） - 砜特别有利地通过氯化烷基苯基砜获得。

公开(公告)号：US5436377A

公开(公告)日：1995-07-25

申请号：US300614

申请日：1994-09-02

Applicant: Michael Pies ,  Kai Rohlk ,  Helmut Lahr ,  Helmut Fiege

Inventor： Michael Pies ,  Kai Rohlk ,  Helmut Lahr ,  Helmut Fiege

IPC: C07C17/392 ,  C07C25/08

CPC classification number: C07C17/392

Abstract: In a particularly advantageous process for isolating m-dichlorobenzene from mixtures of dichlorobenzene isomers by crystallization as eutectic crystals using a processing aid, the processing aid used is a compound of the formula (I) ##STR1## in which R.sup.1 to R.sup.6 are, independently of one another, hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, hydroxyl, NH.sub.2 or R--CO-- having R=C.sub.1 -C.sub.4 -alkyl,with 1-bromo-4-chlorobenzene and 1,4-dibromobenzene being excepted.

Abstract translation: 在使用加工助剂通过结晶作为共晶晶体从二氯苯异构体的混合物中分离间二氯苯的特别有利的方法中，所用的加工助剂是式（I）化合物，其中R 1至R 6为 独立地是具有R = C 1 -C 4 - 烷基的氢，卤素，C 1 -C 4 - 烷基，羟基，NH 2或R-CO-，除了1-溴-4-氯苯和1,4-二溴苯外。

公开(公告)号：US5315049A

公开(公告)日：1994-05-24

申请号：US108367

申请日：1993-08-18

Applicant: Heinrich Schrage ,  Helmut Fiege

Inventor： Heinrich Schrage ,  Helmut Fiege

IPC: B01J31/28 ,  B01J31/02 ,  B01J31/30 ,  C07B61/00 ,  C07C17/12 ,  C07C25/02 ,  C07C25/18 ,  C07C25/00

CPC classification number: B01J31/0204 ,  B01J31/068 ,  B01J31/30 ,  C07C17/12 ,  B01J2231/40

Abstract: Alkylaromatics are subjected to nuclear chlorination in the liquid phase in the presence of Friedel-Crafts catalyst mixtures comprising compounds of iron and antimony and cocatalysts of the formula (II) ##STR1## wherein the substituents have the meaning given in the description.

Abstract translation: 在包含铁和锑化合物的Friedel-Crafts催化剂混合物和式（II）的助催化剂（II）的存在下，将烷基芳族化合物在液相中进行核氯化，其中取代基具有在说明书中给出的含义。

公开(公告)号：US5010193A

公开(公告)日：1991-04-23

申请号：US282712

申请日：1988-12-09

Applicant: Fritz Maurer ,  Reinhard Lantzsch ,  Helmut Fiege ,  Albert Schnatterer

Inventor： Fritz Maurer ,  Reinhard Lantzsch ,  Helmut Fiege ,  Albert Schnatterer

IPC: C07D239/06 ,  C07D239/10 ,  C07D239/14 ,  C07D239/36 ,  C07D239/46 ,  C07D239/47 ,  C07D239/52 ,  C07F9/6512

CPC classification number: C07D239/06 ,  C07D239/14 ,  C07D239/36 ,  C07D239/46 ,  C07F9/65125

Abstract: A process for the preparation of a compound of the formula ##STR1## in which R is hydrogen, alkoxy, alkylamino, dialkylamino or an optionally substituted radical from the group consisting of alkyl, cycloalkyl, aralkyl and aryl,R.sup.1 is an optionally substituted radical from the group consisting of alkyl, alkoxy, alkylthio, mono- or dialkylamino and phenyl,R.sup.2 is optionally substituted alkyl, andY is oxygen or sulphur,comprising(a1) reacting a compound of the formula ##STR2## with ##STR3## or withR.sup.5 COOHin whichR.sup.5 is R except for hydrogen, or equivalent, to produce ##STR4## oxidizing that compound or its salt to ##STR5## and phosphorylating. Several of the intermediates are new.

Abstract translation: 制备式（I）化合物的方法，其中R是氢，烷氧基，烷基氨基，二烷基氨基或任选取代的基团，其由烷基，环烷基，芳烷基和芳基组成的组中，R 1是任选的 取代基由烷基，烷氧基，烷硫基，一烷基或二烷基氨基和苯基组成的组中，R 2为任选取代的烷基，Y为氧或硫，包括（a1）使式（IIa）化合物与 （III）或其中R5为R的R5 COOH，或氢等价物，以产生氧化该化合物或其盐至（V）并进行磷酸化的（VIa）（Ⅳa）。 几个中间体是新的。