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    INSULIN SECRETION INDUCER, AND ACCELERATOR FOR INCREASING THE NUMBER OF PANCREATIC BETA-CELLS
    31.
    发明申请
    INSULIN SECRETION INDUCER, AND ACCELERATOR FOR INCREASING THE NUMBER OF PANCREATIC BETA-CELLS 有权
    胰岛素分泌诱导剂和加速胰蛋白酶细胞数量的加速器

    公开(公告)号：US20100168026A1

    公开(公告)日：2010-07-01

    申请号：US12669324

    申请日：2007-07-20

    申请人： Hideo Toyoshima ,  Tomotaka Yokoo ,  Nobuhiro Yamada

    发明人： Hideo Toyoshima ,  Tomotaka Yokoo ,  Nobuhiro Yamada

    IPC分类号： A61K38/17 ,  C07K14/435 ,  C12N15/63

    CPC分类号： C07K14/705 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0325 ,  A01K2267/0362 ,  A61K38/00 ,  A61K48/00 ,  C12N15/8509 ,  C12N2799/022

    摘要： Disclosed are: an insulin secretion inducer; an insulin secretion-inducing composition; a process for the production of the composition; an accelerator for increasing the number of pancreatic β-cells; a composition for increasing the number of pancreatic β-cells; a process for the production of the composition; and a viral vector for gene therapy. The insulin secretion inducer or the accelerator for increasing the number of pancreatic β-cells comprises a polypeptide having an amino acid sequence encoded by DNA that is known to encode a membrane protein Tm4sf20 (transmembrane 4 L six family member 20) or the like or a fragment of the polypeptide as an active ingredient.

    摘要翻译： 公开的是：胰岛素分泌诱导剂; 胰岛素分泌诱导组合物; 一种生产该组合物的方法; 用于增加胰腺细胞数量的促进剂; 用于增加胰腺细胞数量的组合物; 一种生产该组合物的方法; 和用于基因治疗的病毒载体。 用于增加胰腺细胞数量的胰岛素分泌诱导剂或促进剂包括具有已知编码膜蛋白Tm4sf20（跨膜4L六个家族成员20）等的由DNA编码的氨基酸序列的多肽，或 多肽作为活性成分的片段。

    Method of screening methods prediabetic state and screening reagent
    32.
    发明授权
    Method of screening methods prediabetic state and screening reagent 有权
    筛选方法前驱糖尿病状态和筛选试剂方法

    公开(公告)号：US07198905B2

    公开(公告)日：2007-04-03

    申请号：US10471823

    申请日：2002-03-01

    申请人： Hiroyuki Ebinuma ,  Kazunori Saito ,  Hirohito Sone ,  Nobuhiro Yamada

    发明人： Hiroyuki Ebinuma ,  Kazunori Saito ,  Hirohito Sone ,  Nobuhiro Yamada

    IPC分类号： C12Q1/32

    CPC分类号： G01N33/66

    摘要： The present invention provides a screening method by which a prediabetic state can be more accurately determined and many test samples can be treated without physical burden on patients, and a diagnostic reagent used for it. By measuring a D-mannose concentration, preferably a D-mannose concentration and a glucose concentration, in a body fluid collected from a subject, and comparing them with their respective standard values, a patient in a prediabetic state can be detected. Further, the measurement of the mannose concentration is conducted by allowing an enzyme having an oxidizing activity on mannose by dehydrogenation to react on the mannose in a sample in the presence of an electron acceptor, and quantitatively determining the formed reductant of the electron acceptor.

    摘要翻译： 本发明提供了一种筛选方法，通过该方法能够更准确地确定前列腺状态，并且可以对患者进行治疗而不会对身体造成负担的许多测试样品以及用于其的诊断试剂。 通过在从受试者收集的体液中测量D-甘露糖浓度，优选D-甘露糖浓度和葡萄糖浓度，并将其与它们各自的标准值进行比较，可以检测患有糖尿病状态的患者。 此外，甘露糖浓度的测定是通过在电子受体的存在下，使通过脱氢使对甘露糖具有氧化活性的酶在样品中与甘露糖反应，并定量测定形成的电子受体的还原剂来进行的。

    Game device and method for implementing a screen-displayed card game
    33.
    发明授权
    Game device and method for implementing a screen-displayed card game 有权
    用于实现屏幕显示纸牌游戏的游戏装置和方法

    公开(公告)号：US06398651B1

    公开(公告)日：2002-06-04

    申请号：US09528104

    申请日：2000-03-17

    申请人： Nobuhiro Yamada

    发明人： Nobuhiro Yamada

    IPC分类号： G06F1730

    CPC分类号： A63F13/822 ,  A63F1/00 ,  A63F13/12 ,  A63F13/92 ,  A63F13/95 ,  A63F2001/008 ,  A63F2300/201 ,  A63F2300/204 ,  A63F2300/206 ,  A63F2300/65 ,  A63F2300/807

    摘要： In a storage medium storing a program, a storage device and a game device, a card game having rich variety can be implemented by determining win or loss on the basis of various judgement criteria. The cards used in the card game are divided into a plurality of groups which have continuous, cyclical strength differential relationships between the respective groups. The card game does not depend solely on the capability index of each card. Moreover, a variation of the card game can be increased by preparing trap cards which impart various functions and actions on the opponent's cards. Moreover, by including field card representing competition environments and causing the capability indices creature cards to vary according to the competition environment, a more interesting card game can be enjoyed by the game device.

    摘要翻译： 在存储程序，存储装置和游戏装置的存储介质中，可以通过基于各种判断标准确定胜利或者失败来实现具有丰富多样性的纸牌游戏。 在卡片游戏中使用的卡片被划分为在各个组之间具有连续的，周期性的强度差异关系的多个组。 纸牌游戏不仅仅取决于每张牌的能力指数。 此外，通过制备向对手的卡片赋予各种功能和动作的陷阱卡，可以增加纸牌游戏的变化。 此外，通过包括表示竞争环境的现场卡，并且使能力指标生物牌根据竞争环境而变化，游戏装置可以享受更有趣的纸牌游戏。