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公开(公告)号：US08519328B2
公开(公告)日：2013-08-27
申请号：US13435877
申请日：2012-03-30
IPC分类号： H01J49/26
CPC分类号： H01J49/427 , H01J49/4235
摘要： An ion guide or ion trap is disclosed having an entrance electrode and an exit electrode. The potential of the exit electrode is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap via an aperture in the exit electrode. The period of time that the potential of the exit electrode is dropped for is progressively increased and ions emerge from the ion guide or ion trap in a mass to charge ratio dependent manner. The ion guide or ion trap may be operated as a mass separator or low resolution mass analyzer.
摘要翻译： 公开了一种具有入口电极和出射电极的离子导向器或离子阱。 出口电极的电位周期性地下降相当短的时间段，允许一些离子通过出射电极的孔离开离子导向器或离子阱。 出口电极的电位下降的时间段逐渐增加，并且离子导向器或离子阱以质荷比依赖的方式出现离子。 离子导向器或离子阱可以作为质量分离器或低分辨率质量分析器来操作。
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公开(公告)号：US08440968B2
公开(公告)日：2013-05-14
申请号：US13166882
申请日：2011-06-23
申请人： Kevin Giles
发明人： Kevin Giles
IPC分类号： H01J49/00
CPC分类号： G01N27/624
摘要： An ion-mobility analyser is disclosed comprising a plurality of axially segmented upper electrodes, a plurality of axially segmented lower electrodes, a first plurality of axially segmented intermediate electrodes and a second plurality of axially segmented intermediate electrodes which together define an ion pathway. An asymmetric voltage waveform is applied to the upper electrodes and a DC compensating voltage is applied to the lower electrodes in order to separate ions in a vertical radial direction according to their rate of change of ion mobility with electric field strength. At the same time, a DC axial voltage gradient is maintained along the axial length of the analyser in order to separate ions axially according to their ion mobility.
摘要翻译： 公开了一种离子迁移率分析仪，其包括多个轴向分段的上电极，多个轴向分段的下电极，第一多个轴向分段的中间电极和第二多个轴向分段的中间电极，这两个中间电极共同限定离子通路。 对上部电极施加非对称电压波形，并且向下部电极施加直流补偿电压，以便根据其离子迁移率随电场强度的变化率在垂直方向上分离离子。 同时，沿着分析仪的轴向长度保持直流轴向电压梯度，以便根据离子迁移率轴向分离离子。
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公开(公告)号：US08426802B2
公开(公告)日：2013-04-23
申请号：US12518291
申请日：2007-12-12
CPC分类号： G01N27/622 , G01N27/624 , H01J49/062 , H01J49/4235
摘要： A mass spectrometer is disclosed comprising a device which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device is also operable in a second mode of operation wherein ions are separated temporally according to the their mass to charge ratio by pulsing an applied axial electric field ON and OFF.
摘要翻译： 公开了一种质谱仪，其包括可在第一操作模式中操作的装置，其通过施加连续的轴向电场根据其离子迁移率暂时分离离子。 该装置还可在第二操作模式中操作，其中通过脉冲施加的轴向电场ON和OFF，离子根据其质荷比暂时分离。
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公开(公告)号：US20120018631A1
公开(公告)日：2012-01-26
申请号：US13166882
申请日：2011-06-23
申请人： Kevin Giles
发明人： Kevin Giles
IPC分类号： H01J49/40
CPC分类号： G01N27/624
摘要： An ion-mobility analyser is disclosed comprising a plurality of axially segmented upper electrodes 12a-12g, a plurality of axially segmented lower electrodes 13a-13g, a first plurality of axially segmented intermediate electrodes and a second plurality of axially segmented intermediate electrodes which together define an ion pathway. An asymmetric voltage waveform is applied to the upper electrodes 12a-12g and a DC compensating voltage is applied to the lower electrodes 13a-13g in order to separate ions in a vertical radial direction according to their rate of change of ion mobility with electric field strength. At the same time, a DC axial voltage gradient is maintained along the axial length of the analyser in order to separate ions axially according to their ion mobility.
摘要翻译： 公开了一种离子迁移率分析仪，其包括多个轴向分段的上电极12a-12g，多个轴向分段的下电极13a-13g，第一多个轴向分段的中间电极和第二多个轴向分段的中间电极， 离子途径。 将不对称电压波形施加到上电极12a-12g，并且向下电极13a-13g施加DC补偿电压，以便根据其离子迁移率随电场强度的变化率在垂直方向上分离离子 。 同时，沿着分析仪的轴向长度保持直流轴向电压梯度，以便根据离子迁移率轴向分离离子。
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公开(公告)号：US20110042565A1
公开(公告)日：2011-02-24
申请号：US12917720
申请日：2010-11-02
IPC分类号： H01J49/40
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator 4 and an ion guide 6 arranged downstream of the ion mobility spectrometer or separator 4. A plurality of axial potential wells are created in the ion guide 6 so that ions received from the ion mobility spectrometer or separator 4 become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator 4. The potential wells are translated along the length of the ion guide 6.
摘要翻译： 公开了一种质谱仪，其包括离子迁移谱仪或分离器4和布置在离子迁移谱仪或分离器4下游的离子导向器6.在离子导向器6中产生多个轴向势阱，使得从离子迁移率 光谱仪或分离器4被限制在单独的轴向势阱中。 势阱保持从离子迁移谱仪或分离器4接收的离子的保真度和/或组成。势阱沿离子导向器6的长度平移。
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公开(公告)号：US07829841B2
公开(公告)日：2010-11-09
申请号：US11718213
申请日：2005-11-03
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (4) and an ion guide (6) arranged downstream of the ion mobility spectrometer or separator (4). A plurality of axial potential wells are created in the ion guide (6) so that ions received from the ion mobility spectrometer or separator (4) become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator (4). The potential wells are translated along the length of the ion guide (6).
摘要翻译： 公开了一种质谱仪，其包括离子迁移谱仪或分离器（4）和布置在离子迁移谱仪或分离器（4）的下游的离子导向器（6）。 在离子导向器（6）中产生多个轴向势阱，使得从离子迁移谱仪或分离器（4）接收的离子被限制在单独的轴向势阱中。 潜在的孔维持从离子迁移谱仪或分离器（4）接收的离子的保真度和/或组成。 潜在的井沿离子导向件（6）的长度平移。
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公开(公告)号：US20100065737A1
公开(公告)日：2010-03-18
申请号：US11721260
申请日：2005-12-08
申请人： Robert Harold Bateman , Kevin Giles , Jeffrey Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Jeffrey Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： B01D59/44
CPC分类号： H01J49/062 , H01J49/004
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyser (4) arranged upstream of an ion guide (6). Ions are scanned out of the mass selective ion trap or mass analyser (4) and are received in one or more axial potential wells created or formed within the ion guide (6). One or more transient DC voltages or potentials are preferably applied to the ion guide (6) in order to create a plurality of axial potential wells which are translated along the length of the ion guide (6). Ions are released in packets from the exit of the ion guide (6) and are orthogonally accelerated into a drift or flight region of an orthogonal acceleration Time of Flight mass analyser (13) with a relatively high duty cycle.
摘要翻译： 公开了一种质谱仪，其包括布置在离子导向器（6）上游的质量选择性离子阱或质量分析器（4）。 从质量选择性离子阱或质量分析器（4）中扫描离子，并将其接收在离子导向器（6）内产生或形成的一个或多个轴向势阱中。 优选地将一个或多个瞬态DC电压或电位施加到离子导向器（6），以便产生沿离子导向件（6）的长度平移的多个轴向势阱。 从离子导向器（6）的出口以分组的形式释放离子，并以相对较高的占空比正交加速到正交加速时间飞行质量分析器（13）的漂移或飞行区域。
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公开(公告)号：US20090272891A1
公开(公告)日：2009-11-05
申请号：US11721729
申请日：2005-12-16
申请人： Kevin Giles
发明人： Kevin Giles
CPC分类号： H01J49/062 , Y10T29/49165
摘要： A mass spectrometer is disclosed comprising an ion guide. The ion guide comprises a hollow tubular conductor (1) having a wall. One or more electrodes are provided in the wall of the tubular conductor (1). An exit aperture (3) is provided in the wall of the tubular conductor (1) downstream of the one or more electrodes (2). An AC or RF voltage is applied to the one or more electrodes (2) and a DC potential difference is maintained between the wall of the tubular conductor (1) and the one or more electrodes (2). The combination of a DC voltage gradient and applying an AC or RF voltage to the electrodes (2) is that ions are confined radially to a region which is preferably close to the one or more electrodes (2). Ions are preferably extracted from the ion guide via the exit aperture (3) by maintaining a pressure gradient between the inside of the tubular conductor (1) and the outside of the tubular conductor (1) and/or by maintaining a DC electric field which acts to extract ions through the exit aperture (3).
摘要翻译： 公开了包括离子导向器的质谱仪。 离子导向器包括具有壁的中空管状导体（1）。 一个或多个电极设置在管状导体（1）的壁中。 在一个或多个电极（2）的下游，在管状导体（1）的壁上设置出口孔（3）。 对一个或多个电极（2）施加AC或RF电压，并且在管状导体（1）的壁和一个或多个电极（2）之间保持DC电位差。 直流电压梯度和向电极（2）施加AC或RF电压的组合是离子被限制在优选地接近一个或多个电极（2）的区域。 离子优选通过出口孔（3）从管状导体（1）的内部和管状导体（1）的外部之间保持压力梯度和/或通过维持DC电场而从离子导向器中提取出来， 用于通过出口孔（3）提取离子。
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公开(公告)号：US20090121123A1
公开(公告)日：2009-05-14
申请号：US11916438
申请日：2006-06-05
CPC分类号： H01J49/427 , H01J49/4235
摘要： An ion guide or ion trap (1) is disclosed having an entrance electrode (2) and an exit electrode (3). The potential of the exit electrode (3) is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap (1) via an aperture in the exit electrode (3). The period of time that the potential of the exit electrode (3) is dropped for is progressively increased and ions emerge from the ion guide or ion trap (1) in a mass to charge ratio dependent manner. The ion guide or ion trap (1) may be operated as a mass separator or low resolution mass analyser.
摘要翻译： 公开了一种具有入口电极（2）和出口电极（3）的离子导向器或离子阱（1）。 出口电极（3）的电位周期性地下降相当短的时间段，允许一些离子通过出射电极（3）中的孔从离子导向器或离子阱（1）逸出。 退出电极（3）的电位下降的时间段逐渐增加，并且离子导向器或离子阱（1）以质荷比依赖的方式出现离子。 离子导向器或离子阱（1）可以作为质量分离器或低分辨率质量分析器来操作。
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公开(公告)号：US20080135746A1
公开(公告)日：2008-06-12
申请号：US11574554
申请日：2005-09-14
IPC分类号： B01D59/44
CPC分类号： H01J49/005
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (3) arranged upstream of a collision or fragmentation cell (5). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (3). The kinetic energy of the ions exiting the ion mobility spectrometer or separator (3) is increased substantially linearly with time in order to optimise the fragmentation energy of ions as they enter the collision or fragmentation cell (5).
摘要翻译： 公开了一种质谱仪，其包括设置在碰撞或破碎电池（5）的上游的离子迁移谱仪或分离器（3）。 离子在离子迁移谱仪或分离器（3）内根据其离子迁移率分离。 离子离子迁移谱仪或分离器（3）离子的动能随时间呈线性增加，以优化离子进入碰撞或破碎电池（5）时的碎裂能。
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