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公开(公告)号：US5725535A
公开(公告)日：1998-03-10
申请号：US717299
申请日：1996-09-20
CPC分类号： A61F2/958 , A61M25/1011 , A61M2025/1013
摘要： A multiple balloon catheter for use in a vessel of a patient and for use with an inflation/deflation device. A flexible elongate tubular member with proximal and distal extremities has a distal balloon mounted on the distal extremity of the flexible elongate tubular member. Coaxial inner and outer balloons are mounted on the distal extremity of the flexible elongate member proximal of the distal balloon. The flexible elongate tubular member has balloon inflation lumens therein in communication with the interiors of the distal balloon and the inner and outer coaxial balloons. A manifold is secured to the proximal extremity of the flexible elongate tubular member in communication with the inflation lumens and is adjusted to be coupled to the inflation/deflation device. Valves are carried by the inflation/deflation manifold for inflating the distal balloon in the inner and outer coaxial balloons one at a time or in unison without removal of the inflation/deflation device from the manifold.
摘要翻译： 一种用于患者血管并用于充气/放气装置的多气囊导管。 具有近端和远端的柔性细长管状构件具有安装在柔性细长管状构件的远端上的远端球囊。 同轴的内外球囊安装在远端球囊近端的柔性细长构件的远端上。 柔性细长管状构件具有与远侧气囊和内外同轴气囊的内部连通的球囊充气腔。 歧管固定到与膨胀腔连通的柔性细长管状构件的近端，并且被调节以联接到充气/放气装置。 阀通过充气/放气歧管携带，用于一次一个地或一致地充气内外同轴气囊中的远端球囊，而不从歧管中移除充气/放气装置。
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32.发明授权Probe assembly for mapping and ablating pulmonary vein tissue and method of using same 失效用于测绘和消融肺静脉组织的探针组件及其使用方法公开(公告)号：US06640120B1
公开(公告)日：2003-10-28
申请号：US09684559
申请日：2000-10-05
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2018/00065 , A61B2018/00214 , A61B2018/00238 , A61B2018/00267 , A61B2018/00375 , A61B2018/00839
摘要： The present invention relates to a probe assembly for mapping and ablating pulmonary vein tissue and method of using the same. The probe assembly includes an expandable and collapsible basket assembly having multiple splines. One or more of the splines carry one or more electrodes adapted to sense electrical activity in the pulmonary vein tissue. The basket assembly defines an interior, and a microporous expandable and collapsible body is disposed in the interior of the basket assembly and defines an interior adapted to receive a medium containing ions. An internal electrode is disposed within the interior of the body and is adapted to transmit electrical energy to the medium containing ions. The body includes at least one microporous region having a plurality of micropores therein sized to pass ions contained in the medium without substantial medium perfusion therethrough, enabling ionic transport of electrical energy from the internal electrode, through ion-containing medium to an exterior of the body to ablate pulmonary vein tissue. In other aspects of the invention, the microporous body may be replaced by a non-porous expandable and collapsible body that receives a fluid medium for expanding the non-porous body to exclude blood from the electrodes on the splines, or the probe assembly may not include any expandable and collapsible body in the basket assembly interior (one or more electrodes on splines sense electrical activity in the pulmonary vein tissue and ablate the pulmonary vein tissue).
摘要翻译： 本发明涉及用于测定和消融肺静脉组织的探针组件及其使用方法。 探针组件包括具有多个花键的可膨胀和可折叠的篮组件。 一个或多个花键携带一个或多个适于感测肺静脉组织中的电活动的电极。 筐组件限定内部，并且微孔可膨胀和可折叠主体设置在筐组件的内部并且限定适于接收含有离子的介质的内部。 内部电极设置在身体的内部，并且适于将电能传递到包含离子的介质。 主体包括至少一个微孔区域，其中具有多个微孔，其尺寸适于通过包含在介质中的离子而不需要大量介质灌注，从而能够将电能从内部电极通过含离子的介质离子输送到体外 消融肺静脉组织。 在本发明的其它方面，微孔体可以被接收用于膨胀无孔体的流体介质以排除来自花键上的电极的血液的无孔可扩张和可折叠体，或者探针组件可以不 在篮组件内部包括任何可膨胀和可折叠的主体（花键上的一个或多个电极感测肺静脉组织中的电活动并消融肺静脉组织）。
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33.发明授权Sheath with expandable distal extremity and balloon catheters and stents for use therewith and method 失效具有可扩展的远端末端和气囊导管和与其一起使用的支架的护套和方法
公开(公告)号：US5766203A
公开(公告)日：1998-06-16
申请号：US728769
申请日：1996-10-10
CPC分类号： A61F2/958 , A61M2025/0063 , A61M2025/1086 , A61M25/005 , A61M25/0053 , A61M25/0668
摘要： A sheath for advancement into a vessel of a patient having a stenosis therein which at least partially occludes the flow of blood in the vessel. A flexible elongate tubular member has proximal and distal extremities with a lumen extending from the proximal extremity to the distal extremity. A portion of the distal extremity of the flexible elongate tubular member is radially expandable. The expandable portion carries stiffening elements that impart pushability and column strength to the expandable portion.
摘要翻译： 用于进入其中具有狭窄的患者的血管的护套，其至少部分地封闭血管中的血液流。 柔性细长管状构件具有近端和远端，其末端具有从近端延伸到远端的内腔。 柔性细长管状构件的远端的一部分是可径向扩张的。 可膨胀部分承载加强元件，其赋予可膨胀部分的推压性和柱强度。
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公开(公告)号：US08588884B2
公开(公告)日：2013-11-19
申请号：US12790619
申请日：2010-05-28
IPC分类号： A61B5/0408 , A61B5/0416 , A61B5/0478 , A61B5/0492 , A61N1/04
CPC分类号： A61B5/0478 , A61B5/0408 , A61B5/0492
摘要： In certain variations, methods, systems and/or devices for enhancing conductivity of an electrical signal through a subject's skin using one or more microneedle electrodes are provided. A microneedle electrode may be applied to the subject's skin by placing the microneedle electrode in direct contact with the subject's skin. The microneedles of the microneedle electrode may be inserted into the skin such that the microneedles pierce stratum corneum of the skin up to or through dermis of the skin. An electrical signal passes or is conducted through or across the microneedle electrode and the subject's skin, where impedance of the microneedle electrode is minimal and greatly reduced compared to existing technologies.
摘要翻译： 在一些变型中，提供了通过使用一个或多个微针电极来增强通过受试者的皮肤的电信号的导电性的方法，系统和/或装置。 可以通过将微针电极与受试者的皮肤直接接触来将微针电极施加到受试者的皮肤。 微针电极的微针可以插入皮肤中，使得微针刺穿皮肤的角质层直到皮肤或通过真皮皮肤。 电信号通过或穿过微针电极和受试者的皮肤，其中微针电极的阻抗最小并且与现有技术相比大大降低。
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公开(公告)号：US20080132749A1
公开(公告)日：2008-06-05
申请号：US11748410
申请日：2007-05-14
申请人： Anant V. Hegde , Halil I. Karabey
发明人： Anant V. Hegde , Halil I. Karabey
IPC分类号： A61M1/10
CPC分类号： A61M1/122 , A61B5/0215 , A61B5/042 , A61B5/0452 , A61B5/4836 , A61B5/6876 , A61B2017/00871 , A61M1/1053 , A61M1/1058 , A61M1/106 , A61M1/1067 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/0283 , A61M2205/33 , A61M2205/3303 , A61M2205/8243 , H01L41/27
摘要： Several electroactive polymer (EAP) actuated vascular assist devices are provided that can be readily implanted within the body of a patient without coming in direct blood contact. The devices are also readily repositioned and/or removed from contact with the internal vasculature or may even be turned OFF remotely. In addition, there is provided a method of fabrication and a method of implanting such devices. There are also provided methods for the augmentation of a body lumen through the use of hemodynamic signals such as pressure or ECG signals to synchronize EAP actuation in the vascular assist system.
摘要翻译： 提供了几种电活性聚合物（EAP）致动的血管辅助装置，其可以容易地植入患者的身体内而不会直接接触血液。 这些装置也容易地重新定位和/或从与内部脉管系统的接触中去除或者甚至可以远程关闭。 此外，提供了一种制造方法和一种植入这种装置的方法。 还提供了通过使用诸如压力或ECG信号之类的血液动力学信号来增加体腔的方法来同步血管辅助系统中的EAP致动。
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公开(公告)号：US06231543B1
公开(公告)日：2001-05-15
申请号：US09292545
申请日：1999-04-15
申请人： Anant V. Hegde , Arlene L. Errazo
发明人： Anant V. Hegde , Arlene L. Errazo
IPC分类号： A61M2900
CPC分类号： A61M25/10 , A61M25/0075 , A61M2025/0018 , A61M2025/0079 , A61M2025/09125 , A61M2025/1063
摘要： A dilation catheter having a catheter shaft with an inner lumen for receiving a guidewire and an inflatable balloon member located at the distal portion of the shaft in fluid communication with the inner lumen. The catheter includes a distal seal disposed within the inner lumen of the shaft. The distal seal allows for movement of the guidewire relative to the inner lumen, while also providing for a fluid tight seal around the guidewire, independent of fluid pressure within the lumen, thereby both restricting a patient's blood from passing into the inner lumen and restricting media from the inner lumen from passing into the patient's bloodstream. A valve is located along the catheter shaft and adapted to engage the guidewire and provide for a fluid tight seal around the guidewire when fluid under pressure is applied to the interior of the balloon member. The valve can be surrounded by a perforated rigid sleeve connected to the shaft to provide additional structural support for the shaft at the valve location. As fluid pressure builds in the balloon, the valve is activated against the guidewire to form an additional fluid tight seal around the guidewire.
摘要翻译： 一种具有导管轴的扩张导管，其具有用于容纳导丝的内腔和位于所述轴的远端部分处的与所述内腔流体连通的可膨胀气囊构件。 导管包括设置在轴的内腔内的远侧密封件。 远侧密封件允许导丝相对于内腔的运动，同时还提供围绕导丝的流体密封密封，独立于内腔内的流体压力，从而限制患者的血液进入内腔并限制介质 从内腔流入患者的血液。 当导管轴上的流体被施加到球囊构件的内部时，阀沿着导管轴定位并且适于接合导丝并且在导丝周围提供流体密封的密封。 阀可以被连接到轴的穿孔刚性套筒包围，以在阀位置处为轴提供额外的结构支撑。 当流体压力建立在球囊中时，阀门相对于导丝线被启动，以在引导线周围形成额外的流体密封。
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公开(公告)号：US5788708A
公开(公告)日：1998-08-04
申请号：US949726
申请日：1997-10-14
CPC分类号： A61F2/958 , A61M25/1011 , A61M2025/1013
摘要： A multiple balloon catheter for use in a vessel of a patient and for use with an inflation/deflation device. A flexible elongate tubular member with proximal and distal extremities has a distal balloon mounted on the distal extremity of the flexible elongate tubular member. Coaxial inner and outer balloons are mounted on the distal extremity of the flexible elongate member proximal of the distal balloon. The flexible elongate tubular member has balloon inflation lumens therein in communication with the interiors of the distal balloon and the inner and outer coaxial balloons. A manifold is secured to the proximal extremity of the flexible elongate tubular member in communication with the inflation lumens and is adjusted to be coupled to the inflation/deflation device. Valves are carried by the inflation/deflation manifold for inflating the distal balloon in the inner and outer coaxial balloons one at a time or in unison without removal of the inflation/deflation device from the manifold.
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38.发明授权Surgical probe for supporting inflatable therapeutic devices in contact with tissue in or around body orifice and within tumors 有权手术探针，用于支撑与身体孔内和周围的肿瘤内的组织接触的可充气治疗装置公开(公告)号：US08795271B2
公开(公告)日：2014-08-05
申请号：US12175433
申请日：2008-07-17
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/0422 , A61B2018/00065 , A61B2018/00083 , A61B2018/00095 , A61B2018/00214 , A61B2018/0022 , A61B2018/00238 , A61B2018/00577 , A61B2018/00839 , A61B2090/065 , A61B2218/002
摘要： A probe that facilitates the creation of lesions in bodily tissue. The probe includes a relatively short shaft and an inflatable therapeutic element.
摘要翻译： 有助于在身体组织中产生损伤的探针。 探针包括相对短的轴和可膨胀的治疗元件。
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公开(公告)号：US08613283B2
公开(公告)日：2013-12-24
申请号：US13227727
申请日：2011-09-08
申请人： Anant V. Hegde , Kasey K. Li
发明人： Anant V. Hegde , Kasey K. Li
CPC分类号： A61F5/566
摘要： A mandibular advancement appliance is described which is secured to a subject's dentition. The appliance may adjust a position of the subject's lower dentition relative to the upper dentition while maintaining a distance between the upper and lower dentition. The appliance may also allow for the free rotation of the lower dentition relative to the upper dentition for increased comfort. Additionally, the appliance may also be utilized with a tongue retention assembly for maintaining a position of the subject's tongue relative to the device for treating sleep disordered breathing.
摘要翻译： 描述了下颌前进器具，其被固定到受试者的牙列。 器具可以调节受试者的下牙列相对于上牙列的位置，同时保持上牙齿和下牙列之间的距离。 该器具还可以允许下齿列相对于上牙列的自由旋转以增加舒适度。 此外，该器具还可以与舌保持组件一起使用，以保持被检者的舌头相对于该装置的位置，以治疗睡眠呼吸紊乱。
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公开(公告)号：US08425527B2
公开(公告)日：2013-04-23
申请号：US12168825
申请日：2008-07-07
IPC分类号： A61F2/00
CPC分类号： A61F5/566
摘要： A system for inserting an implant into a cavity in a periostrum region of patient's palate including a sheath and a pusher. The sheath has a substantially flat portion, a distal end, and a proximal end. The sheath has a hollow collar on the proximal end, an insertion depth mark near the distal end, and a slit on the distal end. The slit is in fluid communication with the hollow collar. The substantially rigid pusher configured to be disposed within and in slidable engagement with the sheath. The pusher has a distal end and a proximal end. The pusher has a rigid body having an outside diameter for slidably engaging with the hollow collar of the sheath, a tip on the distal end, and a lumen extending from said proximal end to said distal end of the rigid body and configured for fluid communication with a syringe and the sheath.
摘要翻译： 一种用于将植入物插入病人口蹄血管区域中的空腔中的系统，包括护套和推动器。 护套具有基本平坦的部分，远端和近端。 护套在近端具有中空的环，在远端附近具有插入深度标记，在远端具有狭缝。 狭缝与空心轴环流体连通。 基本刚性的推动器构造成设置在护套内并与护套滑动接合。 推动器具有远端和近端。 推动器具有刚体，其具有外径，用于可滑动地接合护套的空心环，远端上的尖端以及从刚体的所述近端延伸到所述远端的内腔，并且构造成用于与 注射器和护套。
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