公开(公告)号：US20170095514A1

公开(公告)日：2017-04-06

申请号：US15379718

申请日：2016-12-15

Applicant: Massachusetts Institute of Technology ,  The Children's Medical Center Corporation

Inventor： Minglin Ma ,  Daniel G. Anderson ,  Robert S. Langer ,  Omid Veiseh ,  Arturo Jose Vegas ,  Joshua Charles Doloff ,  Delai Chen ,  Christian J. Kastrup

IPC: A61K35/39 ,  A61K9/00 ,  B01J13/04 ,  A61K9/50

CPC classification number: A61K9/0024 ,  A61K9/4833 ,  A61K9/4866 ,  A61K9/5036 ,  A61K9/5078 ,  A61K9/5089 ,  A61K35/39 ,  A61K45/06 ,  A61K2035/126 ,  A61K2035/128 ,  B01J13/046

Abstract: Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

公开(公告)号：US20160324793A1

公开(公告)日：2016-11-10

申请号：US15208192

申请日：2016-07-12

Applicant: Massachusetts Institute of Technology

Inventor： Arturo J. Vegas ,  Minglin Ma ,  Kaitlin M. Bratlie ,  Daniel G. Anderson ,  Robert S. Langer

IPC: A61K9/50 ,  A61K9/00 ,  C08B37/00 ,  A61K35/39

CPC classification number: A61K9/5036 ,  A61K9/0024 ,  A61K9/5161 ,  A61K35/39 ,  A61K45/06 ,  C08B37/0084

Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.

Abstract translation: 本文公开了具有增强的生物相容性和定制的理化性质的共价改性的藻酸盐聚合物，以及其制备和使用方法。 共价修饰的藻酸盐可用作细胞的包封和移植的基质。 还公开了用于表征改性藻酸盐聚合物的生物相容性和物理化学性质的高通量方法。

公开(公告)号：US20160137785A1

公开(公告)日：2016-05-19

申请号：US14941384

申请日：2015-11-13

Applicant: Massachusetts Institute of Technology

Inventor： Minglin Ma ,  Wendy F. Liu ,  Robert S. Langer ,  Daniel Griffith Anderson

IPC: C08G73/02 ,  A61K47/48 ,  A61L31/10 ,  A61K31/7088 ,  A61K47/34 ,  A61K9/127

CPC classification number: C08G73/0206 ,  A61K9/1273 ,  A61K31/7088 ,  A61K47/34 ,  A61K47/59 ,  A61L31/10 ,  C08G59/22 ,  C08G59/306 ,  C08G59/50 ,  C08G73/02 ,  C09D5/1637 ,  C09D179/02 ,  Y10T428/31725

Abstract: A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.