专利检索 ap:("MEMORIAL SLOAN-KETTERING CANCER CENTER" OR "THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES") AND inv:"Michel Sadelain" 第 4 页

31.

发明授权
Mesothelin-targeted chimeric antigen receptors and methods of making them 有权

公开(公告)号：US10538588B2

公开(公告)日：2020-01-21

申请号：US15981142

申请日：2018-05-16

申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , The U.S.A. as Represented by the Secretary, Department Of Health and Human Services

发明人： Prasad S. Adusumilli , Michel Sadelain , Dimiter S. Dimitrov , Yang Feng

IPC分类号： C07K16/28 , C07K14/725 , C07K16/30 , C07K14/705 , C07K14/47 , A61K39/00 , A61K38/00 , A61K35/00

摘要： The presently disclosed subject matter provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to chimeric antigen receptors (CARs) that specifically target human mesothelin, and immunoresponsive cells comprising such CARs. The presently disclosed mesothelin-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.

32.

发明授权
Effective generation of tumor-targeted T cells derived from pluripotent stem cells 有权

公开(公告)号：US10370452B2

公开(公告)日：2019-08-06

申请号：US14873836

申请日：2015-10-02

申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER

发明人： Maria Themeli , Michel Sadelain , Christopher C. Kloss

IPC分类号： A61K35/12 , A61K35/17 , A61K39/00 , C07K14/47 , C07K16/28 , C07K16/30 , C07K14/705 , C07K14/725 , C12N5/0783

摘要： The present invention relates to the field of adoptive immunotherapy. The invention provides methods for generating phenotypically defined, functional, and/or expandable T cells from pluripotent stem cells engineered through safe genetic modifications. The engineered cells may provide one or more of: 1) targeting a specific predetermined antigen expressed on the cell surface of a target cell in an HLA independent manner, 2) enhanced survival and functional potential 3) “off-the-shelf” T cells for administration to multiple recipients, eventually across immunogenic barriers, and/or 4) cytotoxic potential and anti-tumor activity.

33.

发明申请
CANCER ANTIGEN TARGETS AND USES THEREOF 审中-公开

公开(公告)号：US20180348227A1

公开(公告)日：2018-12-06

申请号：US15966992

申请日：2018-04-30

申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER

发明人： Michel Sadelain , Fabiana Perna

IPC分类号： G01N33/574 , G06F19/12 , G06F19/22 , G06F19/18 , G06K9/00 , A61P35/00 , G01N33/566 , G01N33/68 , C07K16/28 , A61K35/17

CPC分类号： A61K35/17 , A61K39/00 , A61K48/00 , A61P35/02 , C07K14/00

摘要： The presently disclosed subject matter provides methods and compositions for treating myeloid disorders (e.g., acute myeloid leukemia (AML)). It relates to immunoresponsive cells bearing antigen recognizing receptors (e.g., chimeric antigen receptors (CARs)) targeting AML-specific antigens.

34.

发明申请
ANTIGEN-BINDING PROTEINS TARGETING CD56 AND USES THEREOF 审中-公开

公开(公告)号：US20180230214A1

公开(公告)日：2018-08-16

申请号：US15884608

申请日：2018-01-31

申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HE

发明人： Michel Sadelain , Reuben Benjamin , Dimiter S. Dimitrov , Yang Feng

IPC分类号： C07K16/28 , C07K14/705 , C07K14/725 , A61K35/17 , A61P35/00

摘要： The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., multiple myeloma). It relates to anti-CD56 antibodies, chimeric antigen receptors (CARs) that specifically target human CD56, and immunoresponsive cells comprising such CARs. The presently disclosed CD56-specific CARs have enhanced immune-activating properties, including anti-tumor activity.

35.

发明申请
METHOD AND COMPOSITION TO INCREASE RADIATION-INDUCED TUMOR THERAPEUTIC EFFECTS 审中-公开

公开(公告)号：US20180015184A1

公开(公告)日：2018-01-18

申请号：US15208335

申请日：2016-07-12

申请人： Memorial Sloan-Kettering Cancer Center , Vascular Biogenics, Ltd.

发明人： Richard N. Kolesnick , Branka Stancevic , Michel Sadelain , Zvi Fuks , Nira Varda-Bloom , Dror Harats

IPC分类号： A61K48/00 , A61K38/46

CPC分类号： A61K48/0066 , A61K38/46 , A61K48/0058 , C12N2710/10343

摘要： Disclosed herein are methods and compositions for treating cancer by increasing radiation-induced damage to cancer without increasing radiation-induced side effects by increasing secretory ASMase levels specifically in tumor endothelium, and inducing apoptosis of tumor endothelial cells by treating the tumor with radiation. ASMase levels are increased in tumor endothelium by administration of a recombinant DNA construct comprising a region coding for a functional ASMase linked to particular transcriptional regulatory sequences that confer tissue-specific expression of ASMase.

36.

发明申请
METHODS FOR OFF-THE-SHELF-TUMOR IMMUNOTHERAPY USING ALLOGENEIC T-CELL PRECURSORS 审中-公开
标题翻译：使用特异性T细胞前体免疫球蛋白免疫治疗的方法

公开(公告)号：US20170049818A1

公开(公告)日：2017-02-23

申请号：US15048550

申请日：2016-02-19

申请人： Memorial Sloan-Kettering Cancer Center

发明人： Johannes L. Zakrzewski , Marcel R.m. Van Den Brink , Michel Sadelain

IPC分类号： A61K35/17

CPC分类号： A61K35/17

摘要： The inventive subject matter relates to methods for treating a T-cell deficiency in a subject in need thereof, comprising administering to said subject a T-cell precursor isolated from an allogeneic donor, provided that said allogeneic donor is not MHC-matched to said subject. The inventive methods can be further enhanced by genetic engineering for targeted immunotherapy.

摘要翻译： 本发明主题涉及用于治疗有需要的受试者的T细胞缺陷的方法，其包括向所述受试者施用从同种异体供体分离的T细胞前体，条件是所述同种异体供体不与所述受试者MHC匹配。通过用于靶向免疫治疗的遗传工程可以进一步增强本发明的方法。

37.

发明申请
METHOD AND COMPOSITION TO INCREASE RADIATION-INDUCED TUMOR THERAPEUTIC EFFECTS 审中-公开
标题翻译：增加辐射诱导的肿瘤治疗效果的方法和组合

公开(公告)号：US20170007718A1

公开(公告)日：2017-01-12

申请号：US14846513

申请日：2015-09-04

申请人： Memorial Sloan-Kettering Cancer Center

发明人： Richard N. Kolesnick , Branka Stancevic , Michel Sadelain , Zvi Fuks , Nira Varda-Bloom , Dror Harats

IPC分类号： A61K48/00 , C12N15/86 , C12N9/16 , A61K45/06

CPC分类号： A61K48/005 , A61K35/761 , A61K38/00 , A61K45/06 , A61N2005/1098 , C12N9/16 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/85

摘要： Disclosed herein are methods and compositions for treating cancer by increasing radiation-induced damage to cancer without increasing radiation-induced side effects by increasing secretory ASMase levels specifically in tumor endothelium, and inducing apoptosis of tumor endothelial cells by treating the tumor with radiation. ASMase levels are increased in tumor endothelium by administration of a recombinant DNA construct comprising a region coding for a functional ASMase linked to particular transcriptional regulatory sequences that confer tissue-specific expression of ASMase.

摘要翻译： 本文公开了通过增加辐射诱导的癌症损伤而不增加辐射诱导的副作用的方法和组合物，通过在肿瘤内皮中特异性增加分泌型ASMase水平，并通过用辐射治疗肿瘤来诱导肿瘤内皮细胞的凋亡。通过施用重组DNA构建体，ASMase水平增加，所述重组DNA构建体包含与赋予ASMase的组织特异性表达的特定转录调控序列连接的功能性ASMase的区域。