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公开(公告)号：US20240293481A1
公开(公告)日：2024-09-05
申请号：US18656397
申请日：2024-05-06
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Melody Smith , Marcel Van Den Brink , Anqi Dai , Sean Devlin , Marco Ruella , Andrea Facciabene
IPC分类号： A61K35/742 , A61K35/17 , A61K35/745 , A61K35/747 , A61K39/00 , A61K45/06 , C12Q1/06 , C12Q1/689
CPC分类号： A61K35/742 , A61K35/17 , A61K35/745 , A61K35/747 , A61K39/4611 , A61K39/4631 , A61K39/464412 , A61K39/464417 , A61K45/06 , C12Q1/06 , C12Q1/689 , C12Q2600/106
摘要： The present disclosure relates to compositions and methods for predicting cancer survival or toxicity in a subject receiving a chimeric antigen receptor (CAR) T cell therapy. The present disclosure further discloses compositions, e.g., pharmaceutical compositions, and methods for treating said subject.
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公开(公告)号：US20240279601A1
公开(公告)日：2024-08-22
申请号：US18542134
申请日：2023-12-15
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES
发明人： Lorenz STUDER , Yujie Fan
IPC分类号： C12N5/0793 , A61K35/30
CPC分类号： C12N5/0619 , A61K35/30 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/19 , C12N2501/415 , C12N2506/45
摘要： The present disclosure relates to methods for generating sacral neural crest lineage cells and enteric neurons. Also provided are sacral neural crest lineage cells and enteric neurons generated by the presently disclosed methods and compositions comprising such cells. The present disclosure further provides uses of the sacral neural crest lineage cells and enteric neurons for preventing, modeling, and/or treating of enteric nervous system disorders.
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3.发明公开公开(公告)号：US20240254564A1
公开(公告)日：2024-08-01
申请号：US18565767
申请日：2022-06-01
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
IPC分类号： C12Q1/6886 , A61K45/06
CPC分类号： C12Q1/6886 , A61K45/06 , C12Q2600/106 , C12Q2600/156
摘要： The present disclosure relates to methods for detecting chemoresistant SCLC tumors in a patient and/or methods for determining whether a patient diagnosed with small cell lung cancer (SCLC) will benefit from treatment with chemotherapy. These methods are based on screening a SCLC patient for elevated XP01 expression. The present technology also provides methods for sensitizing SCLC patients to chemotherapy using an inhibitor of XP01.
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公开(公告)号：US20240197879A1
公开(公告)日：2024-06-20
申请号：US18591191
申请日：2024-02-29
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC.
IPC分类号： A61K39/00 , A61P35/02 , C07K14/705 , C07K14/725 , C07K14/73 , C07K16/28 , C12N5/0783
CPC分类号： A61K39/464411 , A61K39/4611 , A61K39/4631 , A61P35/02 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70517 , C07K14/70521 , C07K14/70532 , C07K14/70578 , C07K16/2803 , C12N5/0636 , C07K2317/622 , C07K2319/02 , C07K2319/03
摘要： The presently disclosed subject matter provides for antigen-recognizing receptors that specifically target CD33 and cells comprising such CD33-targeted antigen-recognizing receptors. The presently disclosed subject matter further provides uses of the CD33-targeted antigen-recognizing receptors for treatment.
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公开(公告)号：US20240131070A1
公开(公告)日：2024-04-25
申请号：US18535469
申请日：2023-12-11
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC.
发明人： Scott W. Lowe , Michel Sadelain , Corina Amor Vegas , Paul Balderes , Ivo C. Lorenz , Zeda Zhang
CPC分类号： A61K35/17 , A61K39/4611 , A61K39/4631 , A61K39/464429 , C07K16/2896 , A61K2239/21 , A61K2239/22 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The presently disclosed subject matter provides for antigen-recognizing receptors that specifically target uPAR and cells comprising such uPAR-targeted antigen-recognizing receptors. The presently disclosed subject matter further provides uses of the uPAR-targeted antigen-recognizing receptors for treatment.
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公开(公告)号：US20230381315A1
公开(公告)日：2023-11-30
申请号：US18306890
申请日：2023-04-25
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES
CPC分类号： A61K39/4631 , A61K39/4621 , A61P37/02 , A61K39/464429
摘要： The presently disclosed subject matter provides cells, compositions and methods for enhancing immune responses toward tumor antigens. It relates to cells comprising: an antigen-recognizing receptor (e.g., a chimeric antigen receptor, a TCR, or a TCR like fusion molecule); and a gene disruption of a CD70 locus. The gene disruption of the CD70 locus can improve the activity and/or efficiency of the cells.
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公开(公告)号：US20240319174A1
公开(公告)日：2024-09-26
申请号：US18732216
申请日：2024-06-03
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES
发明人： Karuna Ganesh
IPC分类号： G01N33/50 , C12N1/20 , C12N5/0783 , C12N5/09 , C12Q1/02
CPC分类号： G01N33/5088 , C12N1/20 , C12N5/0636 , C12N5/0693 , C12Q1/025 , C12N2501/11 , C12N2501/415 , C12N2501/998 , C12N2503/02
摘要： The present disclosure provides organoid co-cultures and methods of using such co-cultures. In particular, the present disclosure provides organoid-immune cell and organoid-bacterial cell co-cultures. The present disclosure further provides methods for testing therapeutic agents using the disclosed organoid co-cultures.
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公开(公告)号：US20240262910A1
公开(公告)日：2024-08-08
申请号：US18592427
申请日：2024-02-29
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC.
CPC分类号： C07K16/2803 , A61K47/6849 , G01N33/58 , G01N33/6854 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N2333/70596
摘要： The presently disclosed subject matter provides antibodies or antigen-binding fragments thereof that bind to CD33 and methods of using such antibodies or antigen-binding fragments thereof same.
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公开(公告)号：US20240252640A1
公开(公告)日：2024-08-01
申请号：US18591403
申请日：2024-02-29
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES
IPC分类号： A61K39/00 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/18 , C12N5/0783
CPC分类号： A61K39/4631 , A61K39/4611 , A61K39/4643 , A61P35/00 , C07K14/7051 , C07K14/70521 , C07K16/18 , C12N5/0636 , A61K2039/572 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C12N2510/00
摘要： The presently disclosed subject matter provides for antigen-recognizing receptors that specifically target DLL3 and cells comprising such DLL3-targeted antigen-recognizing receptors. The presently disclosed subject matter further provides uses of the DLL3-targeted antigen-recognizing receptors for treatment.
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公开(公告)号：US20240219403A1
公开(公告)日：2024-07-04
申请号：US18554176
申请日：2022-04-08
申请人： Memorial Sloan-Kettering Cancer Center , Memorial Hospital for Cancer and Allied Diseases , Sloan-Kettering Institute for Cancer Research
发明人： Piro LITO
IPC分类号： G01N33/68 , A61K45/06 , C12Q1/6886
CPC分类号： G01N33/6893 , A61K45/06 , C12Q1/6886 , G01N33/6854 , C12Q2600/158 , G01N2800/52
摘要： The present disclosure relates to methods for determining whether a cancer patient harboring a constitutively active KRAS mutation will be responsive to treatment with a KRASG12C inhibitor that selectively targets the inactive state of KRAS. These methods are based on assaying regulators of G-protein signaling (RGS) expression in the cancer patient.
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