公开(公告)号：US07013273B2

公开(公告)日：2006-03-14

申请号：US09820401

申请日：2001-03-29

申请人： Michael Kahn

发明人： Michael Kahn

IPC分类号： G01L15/26 ,  G01L15/06 ,  G01L15/14

CPC分类号： G10L15/26 ,  G10L2015/025

摘要： A system and associated method of converting audio data from a television signal into textual data for display as a closed caption on an display device is provided. The audio data is decoded and audio speech signals are filtered from the audio data. The audio speech signals are parsed into phonemes in accordance by a speech recognition module. The parsed phonemes are grouped into words and sentences responsive to a database of words corresponding to the grouped phonemes. The words are converted into text data which is formatted for presentation on the display device as closed captioned textual data.

公开(公告)号：US20050001931A1

公开(公告)日：2005-01-06

申请号：US10457251

申请日：2003-06-09

申请人： Michael Kahn

发明人： Michael Kahn

IPC分类号： H04N5/66 ,  G09G5/00 ,  H04N5/44 ,  H04N5/46

CPC分类号： H04N7/0122

摘要： A method, system, and apparatus for configuring a signal processing device for use with a display device having a display size is disclosed. The signal processing device is configured by determining the display size of the display device and configuring the signal processing device for use with the display device based on the determined display size.

摘要翻译： 公开了一种用于配置与具有显示尺寸的显示装置一起使用的信号处理装置的方法，系统和装置。 信号处理装置通过基于所确定的显示尺寸确定显示装置的显示尺寸并配置与显示装置一起使用的信号处理装置来配置。

公开(公告)号：US5710245A

公开(公告)日：1998-01-20

申请号：US453006

申请日：1995-05-30

申请人： Michael Kahn

发明人： Michael Kahn

IPC分类号： C07K1/107 ,  C07K5/078 ,  C07K14/575 ,  A61K38/00 ,  C07K7/00 ,  C07K7/10

CPC分类号： C07K5/06139 ,  C07K1/1075 ,  C07K14/57545

摘要： There are disclosed alpha-helix mimetics and methods relating to the same for imparting or stabilizing alpha-helicity to a peptide or protein. In one aspect, the alpha-helix mimetics contain six- or seven-membered rings covalently attached at the end or within the length of the peptide or protein. The alpha-helix mimetics render the resulting peptide or protein more stable with regard to thermal stability, as well as making the peptide or protein more resistant to proteolytic degredation. In addition, the alpha-helix mimetics may be used in standard peptide synthesis protocols.

公开(公告)号：US08604018B2

公开(公告)日：2013-12-10

申请号：US13073176

申请日：2011-03-28

申请人： Michael Kahn ,  Masakatsu Eguchi

发明人： Michael Kahn ,  Masakatsu Eguchi

IPC分类号： A61K31/553 ,  A61K31/554 ,  A61K31/519

CPC分类号： C07K7/56

摘要： The invention provides α-helix mimetic structures and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising the compounds, and methods of the invention using the compounds, relate to the treatment of diseases including fibrosis, such as pulmonary fibrosis.

摘要翻译： 本发明提供α-螺旋模拟结构和与其相关的化学文库。 包含该化合物的化合物，药物组合物和使用该化合物的本发明的方法涉及治疗包括纤维化在内的疾病，例如肺纤维化。

公开(公告)号：US20110039333A1

公开(公告)日：2011-02-17

申请号：US12855578

申请日：2010-08-12

申请人： Michael Kahn ,  Kouichi Hasegawa ,  Jia-Ling Teo ,  Michael McMillan

发明人： Michael Kahn ,  Kouichi Hasegawa ,  Jia-Ling Teo ,  Michael McMillan

IPC分类号： C12N5/0735

CPC分类号： C12N5/0606 ,  C12N5/0696 ,  C12N2500/25 ,  C12N2500/90 ,  C12N2500/98 ,  C12N2501/115 ,  C12N2501/415 ,  C12N2533/52

摘要： The invention relates to human pluripotent cells. More specifically, the invention provides a chemically defined xeno-free culture system that allows for long term expansion of human pluripotent cells. This culture system allows for human pluripotent cell lines to be maintained in the pluripotent state for an extended time while maintaining a normal karyotype and the ability to differentiate into all three germ layers.

摘要翻译： 本发明涉及人多能细胞。 更具体地，本发明提供了一种化学上定义的不含异种植物的培养系统，其允许人类多能细胞的长期扩增。 该培养系统允许人类多能细胞系在多能状态下保持延长的时间，同时保持正常的核型和分化成所有三个胚层的能力。

公开(公告)号：US07662960B2

公开(公告)日：2010-02-16

申请号：US10449822

申请日：2003-05-30

申请人： Michael Kahn ,  Masakatsu Eguchi ,  Sung Hwan Moon ,  Jae Uk Chung

发明人： Michael Kahn ,  Masakatsu Eguchi ,  Sung Hwan Moon ,  Jae Uk Chung

IPC分类号： C07F9/02

CPC分类号： C07D487/04

摘要： Conformationally constrained compounds of structure: which mimic the secondary structure of β-strand regions of biologically active peptides and proteins are disclosed. Such β-strand mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents that inhibit protease, kinase and the like. Libraries containing the β-strand mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members.

摘要翻译： 公开了构型化的结构化合物：其模拟生物活性肽和蛋白质的β-链区域的二级结构。 这种β-链模拟结构在广泛的领域中具有实用性，包括用作抑制蛋白酶，激酶等的诊断和治疗剂。 还公开了含有本发明的β-链模拟结构的文库以及筛选该文库以鉴定生物活性成员的方法。

公开(公告)号：US07585862B2

公开(公告)日：2009-09-08

申请号：US11242653

申请日：2005-10-04

申请人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

发明人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

IPC分类号： C07D487/04 ,  A61K31/53

CPC分类号： C07D487/04

摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

公开(公告)号：US07566711B2

公开(公告)日：2009-07-28

申请号：US11108164

申请日：2005-04-15

申请人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen ,  Soo Jin Lee

发明人： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen ,  Soo Jin Lee

IPC分类号： C07D487/04 ,  A61K31/53 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/53 ,  A61K31/555 ,  A61K45/06 ,  A61K2300/00

摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

摘要翻译： 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。 还公开了包含本发明的反转模拟结构的文库以及用于筛选其的方法以鉴定生物活性成员。 本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄 ，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。

公开(公告)号：US20070129353A1

公开(公告)日：2007-06-07

申请号：US11594576

申请日：2006-11-08

申请人： Michael Kahn

发明人： Michael Kahn

IPC分类号： A61K31/551 ,  C07D487/04

CPC分类号： A61K31/551 ,  C07D487/04 ,  C07K5/06139 ,  C07K5/06191

摘要： The invention provides α-mimetic structures and a chemical library relating thereto. Additionally, the invention provides methods wherein a-mimetic compounds are used to treat cancer stem cells.

摘要翻译： 本发明提供α-模拟结构和与其相关的化学文献。 另外，本发明提供了其中使用α-模拟化合物来治疗癌症干细胞的方法。

公开(公告)号：US20070021425A1

公开(公告)日：2007-01-25

申请号：US10826972

申请日：2004-04-16

申请人： Sung Moon ,  Jae Chung ,  Sung Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Jeong ,  Cu Nguyen

发明人： Sung Moon ,  Jae Chung ,  Sung Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Jeong ,  Cu Nguyen

IPC分类号： A61K31/53 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/4985 ,  Y02A50/467

摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

摘要翻译： 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。 还公开了含有本发明的反转模拟结构的文库以及筛选该文库以鉴定生物活性成员的方法。 本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄 ，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。