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97 条记录 (耗时 0.072 秒)

    MONOCLONAL ANTIBODIES AGAINST TISSUE FACTOR PATHWAY INHIBITOR (TFPI)
    31.
    发明申请
    MONOCLONAL ANTIBODIES AGAINST TISSUE FACTOR PATHWAY INHIBITOR (TFPI) 审中-公开
    组织因子途径抑制剂（TFPI）的单克隆抗体

    公开(公告)号：US20140294832A1

    公开(公告)日：2014-10-02

    申请号：US14009334

    申请日：2012-03-30

    申请人： Zhuozhi Wang ,  John Murphy ,  Tobias Marquardt ,  Dieter Moosmayer

    发明人： Zhuozhi Wang ,  John Murphy ,  Tobias Marquardt ,  Dieter Moosmayer

    IPC分类号： C07K16/38

    摘要： Isolated monoclonal antibodies that bind to specific epitopes of human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided.

    摘要翻译： 提供了结合人组织因子途径抑制剂（TFPI）的特异性表位的分离的单克隆抗体和编码它们的分离的核酸分子。 还提供了包含抗TFPI单克隆抗体的药物组合物和通过施用抗体治疗缺血或凝血缺陷的方法。

    Interspinous Internal Fixation/Distraction Device
    35.
    发明申请
    Interspinous Internal Fixation/Distraction Device 有权
    棘突内固定/牵引装置

    公开(公告)号：US20120245639A1

    公开(公告)日：2012-09-27

    申请号：US13493630

    申请日：2012-06-11

    申请人： James W. Dwyer ,  John Murphy

    发明人： James W. Dwyer ,  John Murphy

    IPC分类号： A61B17/70

    CPC分类号： A61B17/7067 ,  A61B17/7062 ,  A61B17/7068

    摘要： Disclosed are an apparatus for an interspinous fixation and/or distraction of vertebrae and a methodology for minimally invasive implantation of the apparatus in the spine of a patient. The apparatus corresponds to a pair of teardrop shaped lateral wing elements spaced apart by a central core element that may be selectively sized during the implantation process. The wings and central core are held together by a single threaded bolt and locking nut configuration resulting in a simple structure that may be easily implanted with minimal patient discomfort.

    摘要翻译： 公开了一种用于椎间棘突固定和/或牵引椎体的装置以及用于在患者脊柱中微创植入该装置的方法。 该装置对应于由中心芯元件间隔开的一对泪滴形侧翼元件，其可以在植入过程期间选择性地定尺寸。 翼和中心芯通过单个螺栓和锁定螺母构造保持在一起，导致简单的结构，其可以容易地植入，患者的不适最小。

    Electric fence energiser
    37.
    发明授权
    Electric fence energiser 有权
    电动扶梯

    公开(公告)号：US07893521B2

    公开(公告)日：2011-02-22

    申请号：US11242724

    申请日：2005-10-03

    申请人： Pieter Cornelis Lunenburg ,  Robert Charles Bryan Woodhead ,  John Murphy

    发明人： Pieter Cornelis Lunenburg ,  Robert Charles Bryan Woodhead ,  John Murphy

    IPC分类号： H01L27/06 ,  H02M3/18

    CPC分类号： H05C1/04

    摘要： An energiser for an electric fence. The energiser includes, at least, one energy storage capacitor (14), a charging circuit (13) to enable the or each storage capacitor (14) to be charged from an energy source (10), semiconductor switching means (16), and control circuit means (15) to facilitate controlled turning -on and -off of the semiconductor switching means (16) to control the duration of the discharge from the energy storage means (14). In one form of the energiser a first semi-conductor switching means is arranged to connect in parallel the energy storage capacitors (14) to be charged and second semi-conductor switching means to connect two or more of the charged energy storage capacitors (14) in series to create an output pulse.

    摘要翻译： 电动围栏的活力。 能量器至少包括一个储能电容器（14），一个充电电路（13），用于使能量或每个存储电容器（14）从能量源（10），半导体开关装置（16）和 控制电路装置（15），以便于控制半导体开关装置（16）的导通和关断，以控制从能量存储装置（14）的放电持续时间。 在激励器的一种形式中，第一半导体开关装置被布置为并联连接待充电的储能电容器（14）和第二半导体开关装置，以连接两个或更多个充电的能量存储电容器（14） 串联产生输出脉冲。

    Interspinous Internal Fixation/Distraction Device
    38.
    发明申请
    Interspinous Internal Fixation/Distraction Device 有权
    棘突内固定/牵引装置

    公开(公告)号：US20100241166A1

    公开(公告)日：2010-09-23

    申请号：US11461610

    申请日：2006-08-01

    申请人： James W. Dwyer ,  John Murphy

    发明人： James W. Dwyer ,  John Murphy

    IPC分类号： A61B17/70

    CPC分类号： A61B17/7067 ,  A61B17/7062 ,  A61B17/7068

    摘要： Disclosed are an apparatus for an interspinous fixation and/or distraction of vertebrae and a methodology for minimally invasive implantation of the apparatus in the spine of a patient. The apparatus corresponds to a pair of teardrop shaped lateral wing elements spaced apart by a central core element that may be selectively sized during the implantation process. The wings and central core are held together by a single threaded bolt and locking nut configuration resulting in a simple structure that may be easily implanted with minimal patient discomfort.

    摘要翻译： 公开了一种用于椎间棘突固定和/或牵引椎体的装置以及用于在患者脊柱中微创植入该装置的方法。 该装置对应于由中心芯元件间隔开的一对泪滴形侧翼元件，其可以在植入过程期间选择性地定尺寸。 翼和中心芯通过单个螺栓和锁定螺母构造保持在一起，导致简单的结构，其可以容易地植入，患者的不适最小。

    Internet provider subscriber communications system
    40.
    发明申请
    Internet provider subscriber communications system 有权
    互联网提供商用户通信系统

    公开(公告)号：US20080082686A1

    公开(公告)日：2008-04-03

    申请号：US11895623

    申请日：2007-08-24

    申请人： Jonathan Schmidt ,  Henry Donzis ,  Lewis Donzis ,  Rodney Erey ,  John Murphy

    发明人： Jonathan Schmidt ,  Henry Donzis ,  Lewis Donzis ,  Rodney Erey ,  John Murphy

    IPC分类号： G06F15/173

    CPC分类号： H04L65/60 ,  H04L29/06 ,  H04L67/02 ,  H04L67/22 ,  H04L67/2814 ,  H04L67/2819 ,  H04L67/2871 ,  H04L69/329

    摘要： A system, method, and computer readable medium for communicating at least one real-time specially-composed bulletin message to at least one subscriber of a provider of Internet services, comprising a first device, and a second device communicably coupled to the first device, wherein the first device: accesses only subscriber upstream traffic to a destination web site requested by the subscriber, wherein the first device inter-connects between the at least one subscriber and the destination web site, identifies the at least one subscriber's unique identification based on the accessed subscriber upstream traffic automatically provided by the subscriber, and provides the unique subscriber identification to the second device located at the provider of Internet services providing data services and management control to the first device, wherein the second device determines the subscriber associated with the unique subscriber identification, and if the specially-composed bulletin message for the subscriber is desired to be communicated: the second device sends policy information related to the data services and management control, to the first device, wherein the policy information includes an IP address of the subscriber's device, and at least one of: the specially-composed bulletin message, a modification of the message to be performed for the IP address, a reference to the message, and a redirection to the message, the first device examines the accessed upstream traffic to determine if it is possible to send a redirection, wherein the examining occurs without modifying the accessed upstream traffic, and the first device sends the redirection if it is possible to do so.

    摘要翻译： 一种系统，方法和计算机可读介质，用于将包括第一设备和可通信地耦合到第一设备的第二设备的因特网服务提供商的至少一个用户传送至少一个实时专用公告消息， 其中所述第一设备：仅将订户上游流量访问到由所述订户请求的目的地网站，其中所述第一设备在所述至少一个用户与所述目的地网站之间进行互连，基于所述至少一个用户的唯一标识识别所述至少一个用户的唯一标识 由用户自动提供的访问用户上行流量，并且向位于提供数据服务和管理控制的因特网服务提供商处的第二设备向第一设备提供唯一的用户标识，其中第二设备确定与唯一用户相关联的用户 识别，如果是专门的公告信息 希望通信用户：第二设备向第一设备发送与数据业务和管理控制有关的策略信息，其中策略信息包括用户设备的IP地址，以及以下至少一个： 组合公告消息，要对IP地址执行的消息的修改，对消息的引用以及对消息的重定向，第一设备检查所访问的上行流量以确定是否可能发送重定向，其中 在不修改所访问的上游流量的情况下进行检查，并且如果可以这样做，则第一设备发送重定向。