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公开(公告)号：US20050226851A1
公开(公告)日：2005-10-13
申请号：US11053982
申请日：2005-02-08
IPC分类号： C12N15/09 , A61K9/19 , A61K35/76 , A61P31/04 , C12N1/21 , C12N7/00 , C12N7/01 , C12N7/04 , A61K45/00
CPC分类号： C12N7/00 , A61K35/76 , C12N2795/10111 , C12N2795/10132 , C12N2795/10161 , Y02A50/475
摘要： The present invention features therapeutic bacteriophage deficient in the lysin protein (“Lys minus” phage). Lys minus bacteriophage are incapable of facilitating efficient lysis of the bacterial host since the enzymatic activity of the lysin of the phage is needed for breaking down the peptidoglycan layer of the bacterial cell wall. Lys minus bacteriophage retain activity in invasion of its appropriate bacterial host, destruction of the bacterial genome, and replication, which are sufficient to inhibit bacterial growth and replication. Therefore, the therapeutic Lys minus phage stops the spread of infection by the bacterial pathogen without lysis of the bacterium. This approach is attractive as it also prevents the release of the phage progeny, thus reducing or eliminating the potential for generation of immune responses against the phage. The incapacitated bacterial pathogen is then removed by the normal defense systems such as phagocytes and macrophages.
摘要翻译： 本发明的特征在于溶酶蛋白（“Lys减”噬菌体）中缺乏的治疗性噬菌体。 Lys minus噬菌体不能促进细菌宿主的有效溶解，因为需要噬菌体溶素的酶活性来分解细菌细胞壁的肽聚糖层。 Lys减去噬菌体在其适当的细菌宿主的侵入中保留活性，破坏细菌基因组和复制，其足以抑制细菌生长和复制。 因此，治疗性Lys-噬菌体阻止了细菌病原体感染的扩散，而不会破坏细菌。 这种方法是有吸引力的，因为它也可以防止噬菌体后代的释放，从而减少或消除针对噬菌体产生免疫应答的可能性。 然后通过正常的防御系统如吞噬细胞和巨噬细胞去除失能的细菌病原体。
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32.发明申请Method, computer program product, and system of optimized data translation from relational data storage to hierarchical structure 失效方法，计算机程序产品和从关系数据存储到分层结构的优化数据转换系统公开(公告)号：US20050138073A1
公开(公告)日：2005-06-23
申请号：US10744424
申请日：2003-12-22
CPC分类号： G06F17/30595 , Y10S707/99934 , Y10S707/99945 , Y10S707/99948
摘要： A tagging tree that defines a hierarchical output data structure and relational database query operations that retrieve the data to be included in each hierarchical section is accepted and processed. A query optimizer analyzes the tagging tree to determine database query operations that can be combined into a single query command. An outer-union query command is generated to allow efficient combination of multiple query commands, some of which are predicates to others. The tagging tree is modified to replace the database queries that were combined into the outer-union query to extract data from the results set produced by the outer-union query as opposed to submitting queries to the database manager. The optimized queries can be reused an arbitrary number of times to leverage the optimizing resources that were used in their creation.
摘要翻译： 定义分层输出数据结构的标记树和检索要包含在每个分层部分中的数据的关系数据库查询操作被接受和处理。 查询优化器分析标记树以确定可以组合成单个查询命令的数据库查询操作。 生成一个外联合查询命令，以允许多个查询命令的有效组合，其中一些查询命令是其他命令的谓词。 标记树被修改为将组合到外联合查询中的数据库查询替换为从外联合查询生成的结果集中提取数据，而不是向数据库管理器提交查询。 优化的查询可以重复使用任意次数，以利用其创建中使用的优化资源。
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33.发明申请Method, system and recording medium for maintaining the order of nodes in a heirarchical document 有权方法，系统和记录介质，用于维护阴性文件中节点的顺序公开(公告)号：US20050028091A1
公开(公告)日：2005-02-03
申请号：US10629744
申请日：2003-07-30
申请人： Rajesh Bordawekar , Yi Chen , George Mihaila , Sriram Padmanabhan
发明人： Rajesh Bordawekar , Yi Chen , George Mihaila , Sriram Padmanabhan
CPC分类号： G06Q10/10 , Y10S707/99942
摘要： A method, a system and recording medium for maintaining the order of nodes in a hierarchical document. The method may select the maximum and the minimum number of children for each node, build an auxiliary ordered tree having at least as many leaves as atoms within the hierarchical document based upon the selected maximum and minimum number of children for each node, attach the atoms to the leaves of the auxiliary ordered tree, and label each of the nodes in the auxiliary ordered tree.
摘要翻译： 一种用于维护分级文档中节点顺序的方法，系统和记录介质。 该方法可以基于每个节点的所选择的最大和最小子数，来选择每个节点的最大和最小子数，构建具有至少与分层文档中的原子一样多的叶的辅助有序树，附加原子 到辅助有序树的叶子，并标记辅助有序树中的每个节点。
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公开(公告)号：US20220351102A1
公开(公告)日：2022-11-03
申请号：US16491817
申请日：2019-08-20
IPC分类号： G06Q10/06
摘要： A system for community monitoring is disclosed. The system includes a community processing subsystem. The community processing subsystem includes an entity control module, configured to control each of plurality of tasks corresponding to one of a plurality of entities. The community processing subsystem also includes a task monitoring module, configured to monitor each of the plurality of tasks corresponding to one of the plurality of entities by entity associated techniques. The community processing subsystem also includes an information exchange module, configured to exchange information within the plurality of entities. A community memory subsystem is configured to store details regarding monitored plurality of tasks corresponding to one of the plurality of entities in real time. Present disclosure enables proper monitoring of every possible entity in a society through a common platform.
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35.发明授权Incapacitated whole-cell immunogenic bacterial compositions produced by recombinant expression 有权通过重组表达产生的无效的全细胞免疫原性细菌组合物公开(公告)号：US09289481B2
公开(公告)日：2016-03-22
申请号：US12560321
申请日：2009-09-15
IPC分类号： A61K39/02 , A61P37/04 , C12N15/74 , A61K39/108 , A61K39/00
CPC分类号： A61K39/02 , A61K39/0258 , A61K2039/522 , C12N15/70 , Y02A50/474
摘要： The present invention features incapacitated whole-cell bacterial immunogenic compositions and methods of their production, which compositions are useful to deliver antigens in a manner resembling the live infectious organism in terms of elicitation of a robust immune response, but with reduced risk or no risk of disease. The compositions of the invention are produced by rendering a bacterium bacteriostatic through expression of a recombinant promoter in the bacterial cell, which promoter can be operably linked to a polynucleotide encoding a recombinant gene product. In one embodiment, where the bacterium is a gram negative host, the recombinant gene product provides for reduced toxicity of LPS. In one embodiment, the gene product is a bacteriophage protein, such as endolysin, holin, or ndd.
摘要翻译： 本发明具有丧失能力的全细胞细菌免疫原性组合物及其生产方法，该组合物可用于以类似于活的感染性生物体的方式递送抗原，以引发强大的免疫应答，但具有降低的风险或没有风险 疾病。 本发明的组合物通过使细菌抑菌细菌通过在细菌细胞中表达重组启动子而产生，该启动子可以与编码重组基因产物的多核苷酸可操作地连接。 在一个实施方案中，当细菌是革兰氏阴性宿主时，重组基因产物提供LPS的毒性降低。 在一个实施方案中，基因产物是噬菌体蛋白，例如细胞内溶素，蛋白质或ndd。
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公开(公告)号：US08748150B2
公开(公告)日：2014-06-10
申请号：US13476750
申请日：2012-05-21
CPC分类号： A01N63/02 , A61K38/50 , C07K14/00 , C07K2319/00 , C07K2319/035 , C07K2319/33 , C12N1/20 , C12N9/2462 , C12N9/78
摘要： The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
摘要翻译： 本发明提供了减少微生物菌落生长的方法和组合物，包括感染，并且包括治疗组合物，用于治疗感染的方法以及用于鉴定另外的这种组合物的方法。
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37.发明申请公开(公告)号：US20130117217A1
公开(公告)日：2013-05-09
申请号：US13618282
申请日：2012-09-14
IPC分类号： G06F17/30
CPC分类号： G06F17/30563 , G06F17/30589 , G06F17/30592
摘要： A computer-implemented method, computer program product and a system for supporting star and snowflake data schemas for use with an Extract, Transform, Load (ETL) process, comprising selecting a data source comprising dimensional data, where the dimensional data comprises at least one source table comprising at least one source column, importing a data model for the dimensional data into a data integration system, analyzing the imported data model to select a star or snowflake target data schema comprising target dimensions and target facts, generating a meta-model representation by mapping at least one source table or source column to each target fact and target dimension, automatically converting the meta-model representation into one or more ETL jobs, and executing the ETL jobs to extract the dimensional data from the data source and loading the dimensional data into the selected target data schema in a target data system.
摘要翻译： 一种计算机实现的方法，计算机程序产品和用于支持用于与提取，变换，加载（ETL）过程一起使用的星形和雪花数据模式的系统，包括选择包括尺寸数据的数据源，其中所述维数据包括至少一个 源表包括至少一个源列，将维数据的数据模型导入数据集成系统，分析导入的数据模型以选择包括目标维度和目标事实的星形或雪花目标数据模式，生成元模型表示 通过将至少一个源表或源列映射到每个目标事实和目标维度，将元模型表示自动转换为一个或多个ETL作业，以及执行ETL作业以从数据源提取尺寸数据并加载维度 数据到目标数据系统中的所选目标数据模式。
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公开(公告)号：US20130117216A1
公开(公告)日：2013-05-09
申请号：US13292234
申请日：2011-11-09
CPC分类号： G06F17/30563 , G06F17/30589 , G06F17/30592
摘要： A computer-implemented method, computer program product and a system for supporting star and snowflake data schemas for use with an Extract, Transform, Load (ETL) process, comprising selecting a data source comprising dimensional data, where the dimensional data comprises at least one source table comprising at least one source column, importing a data model for the dimensional data into a data integration system, analyzing the imported data model to select a star or snowflake target data schema comprising target dimensions and target facts, generating a meta-model representation by mapping at least one source table or source column to each target fact and target dimension, automatically converting the meta-model representation into one or more ETL jobs, and executing the ETL jobs to extract the dimensional data from the data source and loading the dimensional data into the selected target data schema in a target data system.
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公开(公告)号：US20110165583A1
公开(公告)日：2011-07-07
申请号：US13061640
申请日：2009-09-02
摘要： A modified vector comprising a reporter gene having a STOP codon upstream of the multiple cloning site of the vector which is characterized in that the recombinant clones show fluoresce or show color in presence of inducer. A method for identification and selection of recombinant clones comprising the modified vector wherein the recombinant clones florescence or show color in a suitable suppressor strain of the STOP codon associated with the gene of interest. A method of preparation of recombinant clone comprising gene of interest and modified vector comprising amplification of gene of interest using specific primers containing STOP codon different from STOP codon used with reporter gene; cloning the amplified gene of interest in the modified vector; transformation of cloned modified vector in the STOP codon suppressor host cell wherein the STOP codon suppressor host cell is specific for STOP codon used with the gene of interest wherein the recombinant clones either fluorescence or show color depending upon the reporter gene used.
摘要翻译： 包含在载体的多克隆位点上游具有一个末端密码子的报道基因的修饰载体，其特征在于重组克隆在诱导物存在下显示出荧光或显示出颜色。 用于鉴定和选择包含修饰载体的重组克隆的方法，其中所述重组克隆在与所关心的基因相关的STOP密码子的合适的抑制菌株中荧光或显示颜色。 包含目的基因和修饰载体的重组克隆的制备方法，其包括使用与报告基因使用的不同于STOP密码子的不同密码子的特异性引物扩增目标基因; 在经修饰的载体中克隆所扩增的目的基因; 克隆的修饰载体在STOP密码子抑制基因宿主细胞中的转化，其中所述的停止密码子抑制基因宿主细胞对于与感兴趣的基因一起使用的终止密码子是特异性的，其中所述重组克隆根据所使用的报道基因是荧光或显示颜色。
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40.发明申请Parallel Processing of ETL Jobs Involving Extensible Markup Language Documents 有权涉及可扩展标记语言文档的ETL作业的并行处理公开(公告)号：US20110072319A1
公开(公告)日：2011-03-24
申请号：US12566255
申请日：2009-09-24
申请人： Manoj K. Agarwal , Manish A. Bhide , Srilakshmi Kotwal , Srinivas Kiran Mittapalli , Sriram Padmanabhan
发明人： Manoj K. Agarwal , Manish A. Bhide , Srilakshmi Kotwal , Srinivas Kiran Mittapalli , Sriram Padmanabhan
CPC分类号： G06F11/3604 , G06F17/30917
摘要： Techniques for running an Extract Transform Load (ETL) job in parallel on one or more processors wherein the ETL job comprises use of an extensible markup language (XML) document are provided. The techniques include receiving an XML document input, identifying a node in the XML document at which partitioning of the XML document is to begin, sending partition information to each respective processor, performing a shallow parsing of the XML document in parallel on the one or more processors, wherein each processor performs shallow parsing using the identified partition node until it reaches its identified partition, using the shallow parsing to generate the partition of the input XML document, wherein each processor generates a different partition of the same XML document, and sending each partition in streaming format to an ETL job instance.
摘要翻译： 提供了在一个或多个处理器上并行运行提取变换加载（ETL）作业的技术，其中ETL作业包括使用可扩展标记语言（XML）文档。 这些技术包括接收XML文档输入，识别XML文档中开始分割XML文档的节点，向每个相应处理器发送分区信息，在一个或多个文件上并行执行XML文档的浅析解 处理器，其中每个处理器使用所识别的分区节点执行浅解析，直到其到达其识别的分区，使用浅解析来生成输入XML文档的分区，其中每个处理器生成相同XML文档的不同分区，并且发送每个 以流格式分区到ETL作业实例。
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