-
公开(公告)号：US4749691A
公开(公告)日：1988-06-07
申请号：US37470
申请日：1987-04-13
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
CPC分类号： C07C243/00 , C07K5/0215 , C07K5/06017 , C07K5/06026 , C07K5/06052 , C07K5/06078 , C07K5/06104 , C07K9/005 , C12R1/465 , A61K38/00 , Y02P20/55
摘要： The invention relates to novel peptides of enhanced pharmacological activity of the formula: ##STR1## wherein R.sup.1 is hydroxyalkanoyl,R.sup.2 and R.sup.q are each hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy, R.sup. 2 is hydrogen or lower alkyl; R.sup.p is hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy or a group of the formula: ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above; R.sup.r is hydrogen or amino protective group; m is an integer 1 to 3;or its pharmaceutically acceptable salt.
摘要翻译： 本发明涉及增强的药理活性的新肽，其具有下式：其中R 1是羟基烷酰基，R 2和R q各自是氢，羧基，被保护的羧基或下式的基团：其中Ra 2是单 - 或 二羧基（或被保护的羧基）低级烷基或芳基部分可以被羟基取代的芳（羧基或被保护的羧基）低级烷基，R 2是氢或低级烷基; Rp是氢，羧基，受保护的羧基，条件是当R 2和R q中的一个是氢时，另一个是羧基或保护的羧基或下式的基团：其中Ra2和Rb2各自如上所定义; Rr为氢或氨基保护基; m为整数1〜3; 或其药学上可接受的盐。
-
公开(公告)号：US4605559A
公开(公告)日：1986-08-12
申请号：US646090
申请日：1984-08-31
CPC分类号： C12P1/06 , H05K1/0298
摘要： The invention relates to a new compound, FR-900447, and pharmaceutically acceptable salts thereof having antimicrobial and antitumor activity, to a pharmaceutically composition thereof, and to a process for production thereof by culturing Streptomyces rubropurpureus FERM BP-584 in nutrient medium under aerobic condition.
摘要翻译： 本发明涉及一种具有抗微生物和抗肿瘤活性的新化合物FR-900447及其药学上可接受的盐及其药物组合物，以及通过在需氧条件下在营养培养基中培养罗氏假单胞菌FERM BP-584的方法 。
-
公开(公告)号：US4539155A
公开(公告)日：1985-09-03
申请号：US515590
申请日：1983-07-21
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
IPC分类号： A61K38/00 , C07K5/02 , C07K7/02 , C07K9/00 , C07C103/52 , C07C69/74 , C07C101/20 , C07C101/30
CPC分类号： C07C243/00 , C07K5/0215 , C07K9/005 , C12R1/465 , A61K38/00
摘要： The invention relates to compounds and salts of compounds which are diaminopimelyl peptides, N-acetoxypropionyl or N-t-butoxycarbonyl-amino-acid - (.alpha.-OBzl) glutamic acid peptides or N-acylated derivatives of (.alpha.-OBzl) glytamic acid or of (.alpha.-OBzl) aminoadipic acid.The compounds and their salts are starting materials for the preparation of pharmacologically active peptides.
摘要翻译： 本发明涉及化合物和化合物的盐，它们是二氨基辛基肽，N-乙酰氧基丙酰基或N-叔丁氧基羰基 - 氨基酸 - （α-Boc z）谷氨酸肽或（α-Boc z）谷氨酸的N-酰化衍生物或（ α-OBzl）氨基己二酸。 化合物及其盐是制备药理活性肽的起始原料。
-
34.发明授权
公开(公告)号：US4479942A
公开(公告)日：1984-10-30
申请号：US403117
申请日：1982-07-29
申请人： Michio Yamashita , Tadaaki Komori , Junji Hosoda , Yoshio Kawai , Itsuo Uchida , Masanobu Kohsaka , Hiroshi Imanaka , Kazuo Sakane , Hiroyuki Setoi , Tsutomu Teraji
发明人： Michio Yamashita , Tadaaki Komori , Junji Hosoda , Yoshio Kawai , Itsuo Uchida , Masanobu Kohsaka , Hiroshi Imanaka , Kazuo Sakane , Hiroyuki Setoi , Tsutomu Teraji
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P31/04 , C07H19/16 , C12P19/40 , C07H17/00 , C07H19/06
摘要： This invention relates to tetrahydrofuran-carboxylic acid derivatives, of antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,R.sup.2 is amino or acylamino andR.sup.3 is carboxy or a protected carboxy groupor a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及抗微生物活性的四氢呋喃 - 羧酸衍生物，其具有下式：其中R1是氨基或被保护的氨基，R2是氨基或酰基氨基，R3是羧基或被保护的羧基或药学上可接受的盐 其中。
-
公开(公告)号：US4458078A
公开(公告)日：1984-07-03
申请号：US377841
申请日：1982-05-13
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
CPC分类号： C07C243/00 , C07K5/0215 , C07K9/005 , C12R1/465 , A61K38/00 , Y02P20/55 , Y10S930/19
摘要： The invention relates to novel intermediates for the preparation of peptides of pharmacological activity, said intermediates being of the formulas: ##STR1## wherein R.sub.2.sup.r is amino protective group andY is hydrogen or amino protective group; and : ##STR2##
摘要翻译： 本发明涉及用于制备药理学活性肽的新型中间体，所述中间体具有下式：其中R2r为氨基保护基，Y为氢或氨基保护基; 和：
-
公开(公告)号：US4178210A
公开(公告)日：1979-12-11
申请号：US880036
申请日：1978-03-17
申请人： Arnold L. Demain , Masanobu Kohsaka
发明人： Arnold L. Demain , Masanobu Kohsaka
IPC分类号： C07D501/10 , C12P35/00 , C12D9/00
CPC分类号： C12P35/00 , Y10S435/926
摘要： A cephalosporin antibiotic is produced from a precursor comprising the five membered thiazolidine ring and the .beta. lactam moiety characteristics of penicillins by contacting the precursor with a cell-free extract of Cephalosporium acremonium in the presence of ATP under conditions favoring high oxygen transfer. Preferably, an ATP regeneration system comprising a phosphate donor and a phosphotransferase enzyme is included in the reaction.
摘要翻译： 通过在有利于高氧转移的条件下，在ATP存在下使前体与顶头孢霉的无细胞提取物接触，由包含五元噻唑烷环的前体和β-内酰胺部分特征产生头孢菌素抗生素。 优选地，包含磷酸供体和磷酸转移酶的ATP再生系统包括在反应中。
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.046 秒)
