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    METHOD OF PRODUCING PARTIALLY PURIFIED EXTRACELLULAR METABOLITE PRODUCTS FROM BACILLUS COAGULANS AND BIOLOGICAL APPLICATIONS THEREOF
    33.
    发明申请
    METHOD OF PRODUCING PARTIALLY PURIFIED EXTRACELLULAR METABOLITE PRODUCTS FROM BACILLUS COAGULANS AND BIOLOGICAL APPLICATIONS THEREOF 有权
    生产部分纯化的细菌性代谢产物的方法及其生物应用

    公开(公告)号：US20150173374A1

    公开(公告)日：2015-06-25

    申请号：US14576411

    申请日：2014-12-19

    申请人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivakumar Arumugam ,  Furqan Ali

    发明人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivakumar Arumugam ,  Furqan Ali

    IPC分类号： A01N63/02 ,  C12N1/20

    CPC分类号： A01N63/02 ,  A01N31/08 ,  A01N37/12 ,  C12N1/20 ,  C12R1/07 ,  C12R1/085 ,  C12R1/19 ,  C12R1/385 ,  C12R1/42 ,  C12R1/445 ,  C12R1/45 ,  C12R1/46 ,  A01N65/08

    摘要： Disclosed is a method for producing partially purified extracellular metabolite preparation from the probiotic bacterial strain Bacillus coagulans SBC-37 (Deposited in the Microbial Type Culture Collection and Gene Bank as strain number MTCC 5856) exhibiting 99% genetic homology with the known bacterial strains Bacillus coagulans ATCC 31284, Bacillus coagulans NBRC 3887 and Bacillus coagulans ATCC 7050. Also disclosed is the anti-microbial profile of said extracellular metabolite preparation against a panel of microbial pathogens, including synergistic anti-microbial effects of preparation when combined with a synergistic preservative blend comprising from about 61% w/w of thymol, about 38% of monolaurin and about 1% w/w of magnolol obtained from supercritical fluid extracts of Magnolia officinalis. The extracellular metabolite preparation alone or the combination of said extracellular metabolite preparation and preservative blend also inhibits microbial biofilm formation in a synergistic manner.

    摘要翻译： 公开了一种从已知菌株凝结芽孢杆菌（Bacillus coagulans）显示出99％的遗传同源性的益生菌菌株凝结芽孢杆菌凝结芽孢杆菌SBC-37（沉积在微生物型培养物收集和基因库中的菌株号MTCC 5856）的部分纯化细胞外代谢物制剂的方法。 ATCC 31284，凝结芽孢杆菌NBRC 3887和凝结芽孢杆菌ATCC 7050.还公开了所述细胞外代谢产物针对一组微生物病原体的抗微生物特征，包括与协同防腐混合物组合时的制备的协同抗微生物作用， 约61％w / w的百里酚，约38％的单月桂酸和约1％w / w的从木兰超临界流体提取物获得的厚朴酚。 单独的胞外代谢物制剂或所述细胞外代谢物制剂和防腐剂混合物的组合也以协同方式抑制微生物生物膜形成。