Process for producing 1-bromo-4-phenylbutane
    31.
    发明授权
    Process for producing 1-bromo-4-phenylbutane 失效
    1-溴-4-苯基丁烷的制备方法

    公开(公告)号:US6037509A

    公开(公告)日:2000-03-14

    申请号:US289385

    申请日:1999-04-12

    CPC分类号: C07C17/35 C07C22/04 C07C45/46

    摘要: A process for producing 1-bromo-4-phenylbutane of the formula (1): ##STR1## which is characterized by the steps of; reacting 4-bromobutyryl halide of the formula (2): ##STR2## where X is a halogen atom, with benzene in the presence of a Lewis acid to give a 4-bromobutyrophenone of the formula (3): ##STR3## and reacting 4-bromobutyrophenone compound of the formula (3) with hydrogen in the presence of a metal catalyst.

    摘要翻译: 一种制备式(1)的1-溴-4-苯基丁烷的方法:其特征在于以下步骤: 使式(2)的4-溴丁酰卤(其中X是卤素原子)与苯在路易斯酸存在下反应,得到式(3)的4-溴丁酰苯:并使式(4)的4-溴丁酰苯化合物与式 (3)与氢气在金属催化剂存在下反应。

    Process for producing hexahydrothieno[3,4-D]imidazole-2,4-diones
    32.
    发明授权
    Process for producing hexahydrothieno[3,4-D]imidazole-2,4-diones 失效
    六氢噻吩并[3,4-D]咪唑-2,4-二酮的制备方法

    公开(公告)号:US5969149A

    公开(公告)日:1999-10-19

    申请号:US161226

    申请日:1998-09-28

    IPC分类号: C07D495/04 C07D235/26

    CPC分类号: C07D495/04

    摘要: There is disclosed a process for producing hexahydrothieno[3,4-d]imidazole-2,4-diones of the formula (1): wherein R is the same or different and represents a lower alkyl group, an alkenyl group, an aryl group or an aralkyl group all of which may be substituted, which is characterized by the step of reacting hexahydrofuro[3,4-d]imidazole-2,4-diones of the formula (2): ##STR1## wherein R has the same meaning as described above with hydrogen sulfide in the presence of a basic compound and sulfur.

    摘要翻译: 公开了制备式(1)的六氢噻吩并[3,4-d]咪唑-2,4-二酮的方法:其中R相同或不同,表示低级烷基,烯基,芳基 或其所有可以被取代的芳烷基,其特征在于使式(2)的六氢呋喃并[3,4-d]咪唑-2,4-二酮的反应步骤:其中R具有与上述相同的含义 在碱性化合物和硫的存在下使用硫化氢。

    Process for producing aminonitropyridines
    33.
    发明授权
    Process for producing aminonitropyridines 失效
    制备氨基硝基吡啶的方法

    公开(公告)号:US5648496A

    公开(公告)日:1997-07-15

    申请号:US623039

    申请日:1996-03-28

    摘要: A process for producing an aminonitropyridine represented by the general formula [1], which comprises reacting a nitropyridine represented by the general formula [2] (wherein X.sup.1, X.sup.2 and X.sup.3 indicate a hydrogen atom, a halogen atom, a nitro group, a cyano group, an aryl group, an aromatic heterocycle or an alkyl group, etc.; Y is an oxygen atom; and n is 0 or 1) with an O-substituted hydroxylamine represented by the general formula [3] (wherein R.sup.4 is a hydrogen atom, an alkyl group, a cycloalkyl group or an aralkyl group; and R.sup.5 is an alkyl group or an aralkyl group) or a salt thereof in the presence of a base and a metal catalyst. ##STR1##

    摘要翻译: 一种制备由通式[1]表示的氨基硝基吡啶的方法,其包括使由通式[2]表示的硝基吡啶与其反应(其中X 1,X 2和X 3表示氢原子,卤素原子,硝基,氰基 基团,芳基,芳族杂环或烷基等; Y是氧原子; n是0或1)与通式[3]表示的O-取代羟胺(其中R 4是氢 原子,烷基,环烷基或芳烷基; R 5为烷基或芳烷基)或其盐在碱和金属催化剂存在下反应。

    METHOD FOR NITRATING ISOUREA
    34.
    发明申请
    METHOD FOR NITRATING ISOUREA 审中-公开
    用于制造ISOUREA的方法

    公开(公告)号:US20090018364A1

    公开(公告)日:2009-01-15

    申请号:US12282479

    申请日:2007-03-15

    IPC分类号: C07C273/18

    摘要: An object of the present invention is to industrially advantageously produce N-nitroisoureas or a salt thereof which is useful as a synthetic intermediate for pharmaceuticals and pesticides. The present invention relates to a process for producing a compound represented by the formula (2): wherein R1, R2 and R3 are as defined below, or a salt thereof, which comprises reacting a compound represented by the formula (1): wherein R1 represents an optionally substituted straight-chain or branched C1 to C6 alkyl group, R2 and R3 are the same or different and represent an optionally substituted straight-chain or branched C1 to C6 alkyl group, a cycloalkyl group or a substituted aryl group, or R2 and R3 simultaneously represent a hydrogen atom, or a salt thereof with a nitrating agent in the presence of sulfur trioxide.

    摘要翻译: 本发明的目的是在工业上有利地生产N-硝基异脲或其盐,其可用作药物和农药的合成中间体。 本发明涉及由式(2)表示的化合物的制备方法:其中R1,R2和R3如下所定义,或其盐,其包括使式(1)表示的化合物:其中R1 表示任选取代的直链或支链C1至C6烷基,R2和R3相同或不同,表示任选取代的直链或支链C1至C6烷基,环烷基或取代的芳基或R2 和R3同时在三氧化硫的存在下与硝化剂一起代表氢原子或其盐。

    Process for producing retinal and intermediates for producing the same
    38.
    发明授权
    Process for producing retinal and intermediates for producing the same 失效
    用于生产视网膜和中间体的方法

    公开(公告)号:US06288283B1

    公开(公告)日:2001-09-11

    申请号:US09584354

    申请日:2000-06-01

    IPC分类号: C07C4711

    摘要: There are disclosed: a hydroxyaldehyde derivative of formula (1): wherein the wavy line depicted by indicates a single bond and the compound having a double bond to which said single bond is attached represents E or Z isomer or a mixture thereof, a methoxy alcohol derivative of formula (2): wherein the wavy line depicted by indicates a single bond and the compound having a double bond to which said single bond is attached represents E or Z isomer or a mixture thereof, processes for producing the same, and a process for producing a retinal using the same.

    摘要翻译: 公开了式(1)的羟基醛衍生物:其中由所示的波浪线表示单键,并且 具有所述单键的双键的化合物表示E或Z异构体或其混合物,式(2)的甲氧基醇衍生物:其中由

    Method for producing arylvinylsulfone
    39.
    发明授权
    Method for producing arylvinylsulfone 失效
    芳基乙烯基砜的制备方法

    公开(公告)号:US5902905A

    公开(公告)日:1999-05-11

    申请号:US968306

    申请日:1997-11-12

    IPC分类号: C07C315/04 C07C317/14

    CPC分类号: C07C315/04

    摘要: There is provided a method for producing arylvinylsulfone of the formula: ##STR1## wherein, R.sup.1 and R.sup.2 denote each independently a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group,a nitro group, an amino group, a lower alkylamino group anda lower di(alkylamino) group,which comprises reacting .beta.-haloethylarylsulfone of the formula: ##STR2## wherein, R.sup.1 and R.sup.2 are as defined above and X denotes a halogen atom, with an alkali metal carbonate or an alkali metal hydrogencarbonate in the presence of a catalytic amount of an amine or its inorganic acid salt or a quaternary ammonium salt.

    摘要翻译: 提供了下式的芳基乙烯基砜的制备方法:其中,R1和R2各自独立地表示氢原子,卤素原子,低级烷基,低级烷氧基,硝基,氨基,低级烷基氨基 和低级二(烷基氨基)基团,其包括使下式的β-卤代乙基芳基砜反应:其中,R1和R2如上所定义,X表示卤素原子,与碱金属碳酸盐或碱金属碳酸氢盐在 催化量的胺或其无机酸盐或季铵盐。