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61 条记录 (耗时 0.038 秒)

    6,11-4-Carbon bridged ketolides
    31.
    发明授权
    6,11-4-Carbon bridged ketolides 失效
    6,11-4-碳桥式酮内酯

    公开(公告)号：US07049417B2

    公开(公告)日：2006-05-23

    申请号：US10841206

    申请日：2004-05-07

    申请人： Yat Sun Or ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

    发明人： Yat Sun Or ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

    IPC分类号： C07H1/00

    CPC分类号： C07H17/08

    摘要： Novel 6,11-4-carbon bridged ketolides, pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.

    摘要翻译： 描述了包含治疗有效量的本发明化合物与药学上可接受的载体的新颖的6,11-4-碳桥连酮内酯，药学上可接受的组合物。 还描述了通过向动物施用含有治疗有效量的本发明化合物和制备这些化合物的方法的药物组合物来治疗细菌感染的方法。

    6-O-substituted bicyclic ketolides
    32.
    发明授权
    6-O-substituted bicyclic ketolides 失效
    6-O-取代的双环酮内酯

    公开(公告)号：US06774115B1

    公开(公告)日：2004-08-10

    申请号：US10454865

    申请日：2003-06-05

    申请人： Yao-Ling Qiu ,  Ly Tam Phan ,  Yat Sun Or

    发明人： Yao-Ling Qiu ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    4′-O-substituted tylosin analogs
    33.
    发明授权
    4′-O-substituted tylosin analogs 失效
    4'-O-取代的泰乐菌素类似物

    公开(公告)号：US06576615B2

    公开(公告)日：2003-06-10

    申请号：US10007744

    申请日：2001-11-08

    申请人： Ly Tam Phan ,  Tianying Jian ,  Yao-Ling Qiu ,  Yat Sun Or

    发明人： Ly Tam Phan ,  Tianying Jian ,  Yao-Ling Qiu ,  Yat Sun Or

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： There are described novel 4′ substituted tylosin analogs and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

    摘要翻译： 描述了新颖的4'取代的泰乐菌素类似物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了一种通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物及其制备方法来治疗细菌感染的方法。

    PROCESSES FOR THE PREPARATION OF O-[5-(4-AMINO-THIAZOL-2-YL)-PYRIDIN-2-YLMETHYL]-HYDROXYLAMINE
    34.
    发明申请
    PROCESSES FOR THE PREPARATION OF O-[5-(4-AMINO-THIAZOL-2-YL)-PYRIDIN-2-YLMETHYL]-HYDROXYLAMINE 有权
    制备O- [5-（4-氨基 - 噻唑-2-基） - 吡啶-2-基]甲基] - 羟基甲酰胺的方法

    公开(公告)号：US20090281324A1

    公开(公告)日：2009-11-12

    申请号：US12437636

    申请日：2009-05-08

    申请人： Datong Tang ,  Yinglin Han ,  Yanhe Huang ,  Ly Tam Phan ,  Yat Sun Or ,  Zhe Wang

    发明人： Datong Tang ,  Yinglin Han ,  Yanhe Huang ,  Ly Tam Phan ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： C07D417/04

    CPC分类号： C07D417/04

    摘要： The present invention relates generally to novel methods for the synthesis of O-[5-(4-amino-thiazol-2-yl)-pyridin-2-ylmethyl]-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):

    摘要翻译： 本发明一般涉及合成O- [5-（4-氨基 - 噻唑-2-基） - 吡啶-2-基甲基] - 羟胺的新方法，其是合成桥接的 红霉素衍生物及其各自的药学上可接受的盐在PCT申请WO 03/097659 A1中。 特别地，本发明涉及制备式（Ia）化合物的方法和中间体：

    ANTI-BACTERIAL ACTIVITY OF 9-HYDROXY DERIVATIVES OF 6,11-BICYCLOLIDES
    36.
    发明申请
    ANTI-BACTERIAL ACTIVITY OF 9-HYDROXY DERIVATIVES OF 6,11-BICYCLOLIDES 有权
    6,11-双酚的9-羟基衍生物的抗细菌活性

    公开(公告)号：US20090281050A1

    公开(公告)日：2009-11-12

    申请号：US12437616

    申请日：2009-05-08

    申请人： Rajesh Iyengar ,  Yanchun Wang ,  Ly Tam Phan ,  Yat Sun Or

    发明人： Rajesh Iyengar ,  Yanchun Wang ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K31/7048 ,  C07H17/08 ,  A61P31/04

    CPC分类号： A61K31/706 ,  A61K31/7056 ,  C07H17/08

    摘要： The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit superior antibacterial properties, particularly against Haemophilus influenzae. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其表现出优异的抗菌性，特别是抗流感嗜血杆菌。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    9a, 11-3C-bicyclic 9a-azalide derivatives
    37.
    发明授权
    9a, 11-3C-bicyclic 9a-azalide derivatives 有权
    9a，11-3C-双环9a-氮杂衍生物

    公开(公告)号：US07276487B2

    公开(公告)日：2007-10-02

    申请号：US10946339

    申请日：2004-09-21

    申请人： Guoqiang Wang ,  Yulin Peng ,  Yanchun Wang ,  Ly Tam Phan ,  Yat Sun Or

    发明人： Guoqiang Wang ,  Yulin Peng ,  Yanchun Wang ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    11-C-substituted erythromycin derivatives
    38.
    发明授权
    11-C-substituted erythromycin derivatives 有权
    11-C-取代的红霉素衍生物

    公开(公告)号：US06953782B2

    公开(公告)日：2005-10-11

    申请号：US10745856

    申请日：2003-12-24

    申请人： Ly Tam Phan ,  Yat Sun Or ,  Jay Judson Farmer

    发明人： Ly Tam Phan ,  Yat Sun Or ,  Jay Judson Farmer

    IPC分类号： A61K31/365 ,  A61K31/70 ,  A61K31/7048 ,  C07D313/00 ,  C07D313/06 ,  C07D313/20 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulae I, II, III or IV or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I，II，III或IV的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    11-C-substituted derivatives of clarithromycin
    39.
    发明授权
    11-C-substituted derivatives of clarithromycin 失效
    克拉霉素的11-C-取代衍生物

    公开(公告)号：US06812216B2

    公开(公告)日：2004-11-02

    申请号：US10178991

    申请日：2002-06-25

    申请人： Ly Tam Phan ,  Jay Judson Farmer ,  Yat Sun Or

    发明人： Ly Tam Phan ,  Jay Judson Farmer ,  Yat Sun Or

    IPC分类号： A61K3170

    CPC分类号： C07H17/08 ,  A61K31/70

    摘要： There are described 11-C-substituted derivatives of clarithromycin and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

    摘要翻译： 描述了克拉霉素的11-C-取代衍生物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了一种通过向动物施用含有治疗有效量的本发明化合物的药物组合物和这些化合物的制备方法来治疗细菌感染的方法。

    6-O-substituted bicyclic macrolides
    40.
    发明授权
    6-O-substituted bicyclic macrolides 有权
    6-O-取代的双环大环内酯类

    公开(公告)号：US06716820B1

    公开(公告)日：2004-04-06

    申请号：US10455001

    申请日：2003-06-05

    申请人： Yao-Ling Qiu ,  Ly Tam Phan ,  Yat Sun Or

    发明人： Yao-Ling Qiu ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。