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61 条记录 (耗时 0.044 秒)

    4′-O-substituted tylosin analogs
    1.
    发明授权
    4′-O-substituted tylosin analogs 失效
    4'-O-取代的泰乐菌素类似物

    公开(公告)号：US06576615B2

    公开(公告)日：2003-06-10

    申请号：US10007744

    申请日：2001-11-08

    申请人： Ly Tam Phan ,  Tianying Jian ,  Yao-Ling Qiu ,  Yat Sun Or

    发明人： Ly Tam Phan ,  Tianying Jian ,  Yao-Ling Qiu ,  Yat Sun Or

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： There are described novel 4′ substituted tylosin analogs and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

    摘要翻译： 描述了新颖的4'取代的泰乐菌素类似物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了一种通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物及其制备方法来治疗细菌感染的方法。

    23-O-substituted 5-O-mycaminosyltylonide derivatives
    2.
    发明授权
    23-O-substituted 5-O-mycaminosyltylonide derivatives 失效
    23-O-取代的5-O-碳霉糖基海藻衍生物

    公开(公告)号：US06753415B2

    公开(公告)日：2004-06-22

    申请号：US10126076

    申请日：2002-04-19

    申请人： Ly Tam Phan ,  Yao-Ling Qiu ,  Yat Sun Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina Busuyek

    发明人： Ly Tam Phan ,  Yao-Ling Qiu ,  Yat Sun Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina Busuyek

    IPC分类号： A61K317048

    CPC分类号： C07H17/08

    摘要： There are described novel 5-O-mycaminosyltylonide (OMT) analogs possessing increased antibacterial activity toward Gram positive and Gram negative bacteria as well as macrolide resistant Gram positives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a patient a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds

    摘要翻译： 描述了具有对革兰氏阳性和革兰氏阴性细菌以及大环内酯抗性革兰氏阳性和药学上可接受的组合物具有增加的抗细菌活性的新型5-O-碳霉糖基托伦（OMT）类似物，其包含治疗有效量的本发明化合物与 药学上可接受的载体。 还描述了通过向患者施用含有治疗有效量的本发明化合物的药物组合物和用于制备这些化合物的方法来治疗细菌感染的方法

    Bicyclic 9a-azalide derivatives
    4.
    发明授权
    Bicyclic 9a-azalide derivatives 失效
    双环9a-azalide衍生物

    公开(公告)号：US07402568B2

    公开(公告)日：2008-07-22

    申请号：US11236043

    申请日：2005-09-27

    申请人： Yat Sun Or ,  Yao-Ling Qiu ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

    发明人： Yat Sun Or ,  Yao-Ling Qiu ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I和II的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    Bicyclic macrolide derivatives
    5.
    发明授权
    Bicyclic macrolide derivatives 失效
    双环大环内酯衍生物

    公开(公告)号：US06790835B1

    公开(公告)日：2004-09-14

    申请号：US10455219

    申请日：2003-06-05

    申请人： Yao-Ling Qiu ,  Ly Tam Phan ,  Tongzhu Liu ,  Zhigang Chen ,  Yat Sun Or

    发明人： Yao-Ling Qiu ,  Ly Tam Phan ,  Tongzhu Liu ,  Zhigang Chen ,  Yat Sun Or

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    6-11 Bridged Oxime Erythromycin Derivatives
    6.
    发明申请
    6-11 Bridged Oxime Erythromycin Derivatives 审中-公开
    6-11桥接肟红霉素衍生物

    公开(公告)号：US20100041618A1

    公开(公告)日：2010-02-18

    申请号：US12543155

    申请日：2009-08-18

    申请人： Guoqiang Wang ,  Ly Tam Phan ,  Yat Sun Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

    发明人： Guoqiang Wang ,  Ly Tam Phan ,  Yat Sun Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

    IPC分类号： A61K31/7048 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    C-9 ALKENYLIDINE BRIDGED MACROLIDES
    7.
    发明申请
    C-9 ALKENYLIDINE BRIDGED MACROLIDES 有权
    C-9烯丙基嵌段共聚物

    公开(公告)号：US20080119418A1

    公开(公告)日：2008-05-22

    申请号：US11940766

    申请日：2007-11-15

    申请人： Ly Tam Phan ,  Yao-Ling Qiu ,  Yat Sun Or

    发明人： Ly Tam Phan ,  Yao-Ling Qiu ,  Yat Sun Or

    IPC分类号： A61K31/7052 ,  C07H17/08

    CPC分类号： C07D493/08 ,  C07D498/18

    摘要： The present invention discloses compounds of formulae (I), (II) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了具有抗菌性能的式（I），（II）或其药学上可接受的盐，酯或前药的化合物。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    6-O-substituted bicyclic ketolides
    9.
    发明授权
    6-O-substituted bicyclic ketolides 失效
    6-O-取代的双环酮内酯

    公开(公告)号：US06774115B1

    公开(公告)日：2004-08-10

    申请号：US10454865

    申请日：2003-06-05

    申请人： Yao-Ling Qiu ,  Ly Tam Phan ,  Yat Sun Or

    发明人： Yao-Ling Qiu ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。