公开(公告)号：US20160361542A1

公开(公告)日：2016-12-15

申请号：US15043794

申请日：2016-02-15

Applicant: Nuvectra Corporation

Inventor： Norbert Kaula ,  Yohannes Iyassu

IPC: A61N1/36 ,  G06F19/00 ,  A61N1/372

CPC classification number: A61N1/36132 ,  A61N1/36007 ,  A61N1/36014 ,  A61N1/3605 ,  A61N1/36107 ,  A61N1/36185 ,  A61N1/37247 ,  A61N1/37264 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63

Abstract: A non-zero starting value for ramping up a stimulation parameter for an electrical stimulation to be delivered to a patient is determined. The non-zero starting value is customized to the patient. A pulse generator is caused to generate the electrical stimulation, which is delivered to the patient via an implanted lead. The pulse generator is caused to ramp up, from the determined non-zero starting value and toward a predefined maximum limit value, the stimulation parameter for a plurality of electrode contacts on the lead. Feedback is received from the patient in response to the ramping up. The feedback is received via an electronic patient feedback device. Based on the ramping up and the received feedback from the patient, a perception threshold is determined for each of the plurality of electrode contacts. The perception threshold is a value of the stimulation parameter that corresponds to the patient feeling the electrical stimulation.

Abstract translation: 确定用于递增用于递送给患者的电刺激的刺激参数的非零起始值。 非零起始值是针对患者定制的。 引起脉冲发生器以产生电刺激，其通过植入引线输送给患者。 引起脉冲发生器从确定的非零起始值向预定义的最大极限值斜坡上升，引导线上的多个电极触点的刺激参数。 从病人的反应中收到反馈，以应对飙升。 通过电子病人反馈装置接收反馈。 基于患者的上升和接收到的反馈，确定多个电极接触中的每一个的感知阈值。 感知阈值是对应于感觉电刺激的患者的刺激参数的值。

公开(公告)号：US09504830B2

公开(公告)日：2016-11-29

申请号：US14537235

申请日：2014-11-10

Applicant: Nuvectra Corporation

Inventor： Norbert Kaula ,  Yohannes Iyassu ,  Steven Siegel ,  Michele Spinelli

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372

CPC classification number: A61N1/0558 ,  A61N1/05 ,  A61N1/0512 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/3606 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/37235 ,  A61N1/37247

Abstract: The present disclosure involves a method of measuring a physiological feedback from a patient in response to electrical stimulation. A stimulation parameter of a sacral nerve stimulation therapy is ramped up. The sacral nerve stimulation therapy includes electrical pulses generated by a pulse generator based on programming instructions received from an electronic programmer. The electrical pulses are delivered to a patient via a stimulation lead that is implanted in the patient. Via an anal electrode device that is at least partially inserted inside an anal canal of the patient, a compound motor action potential (CMAP) is measured from an anal sphincter of the patient while the stimulation parameter of the sacral nerve stimulation therapy is being ramped up. A stimulation threshold is determined based on the measured CMAP.

Abstract translation: 本公开涉及一种响应于电刺激来测量来自患者的生理反馈的方法。 骶神经刺激治疗的刺激参数升高。 骶神经刺激治疗包括基于从电子编程器接收的编程指令由脉冲发生器产生的电脉冲。 通过植入患者的刺激引线将电脉冲输送给患者。 通过至少部分插入患者肛管内的肛门电极装置，在骶神经刺激治疗的刺激参数正在上升的同时，从患者的肛门括约肌测​​量复合运动动作电位（CMAP） 。 基于测量的CMAP确定刺激阈值。

公开(公告)号：US20190054301A1

公开(公告)日：2019-02-21

申请号：US16166659

申请日：2018-10-22

Applicant: Nuvectra Corporation

Inventor： Norbert Kaula ,  Yohannes Iyassu

IPC: A61N1/36 ,  G06F19/00 ,  G16H40/67 ,  G16H40/63 ,  A61N1/372 ,  G16H20/40

Abstract: Feedback regarding electrical stimulation is provided to a patient. Electrical stimulation is applied to the patient. The electrical stimulation is applied by varying an electrical stimulation parameter. A signal is communicated to the patient via an electronic device. The signal is correlated with the electrical stimulation parameter such that the signal varies in association with the varying of the electrical stimulation parameter. The communicating is performed while the electrical stimulation is applied. Feedback is received from the patient in response to the electrical stimulation. Based on the received feedback from the patient, the electrical stimulation is adjusted.

公开(公告)号：US09872988B2

公开(公告)日：2018-01-23

申请号：US15043954

申请日：2016-02-15

Applicant: Nuvectra Corporation

Inventor： Norbert Kaula ,  Yohannes Iyassu

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A61N1/08 ,  A61N1/372 ,  A61B5/11 ,  A61B5/22

CPC classification number: A61N1/36135 ,  A61B5/11 ,  A61B5/225 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/36057 ,  A61N1/36132 ,  A61N1/36142 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37282 ,  A61N1/37288

Abstract: A pulse generator is programmed to generate electrical stimulation to target a sacral nerve or a pudendal nerve of the patient. The electrical stimulation being delivered at least in part via a lead. The electrical stimulation is applied by ramping up a stimulation parameter over time. A first, a second, and a third physiological response are detected from the patient as a result of the electrical stimulation. A first value, a second value, and a third value of the stimulation parameter associated with the first, second, and third physiological response are measured, respectively. A placement of the lead inside the patient is evaluated based on at least one of: a chronological sequence in which the first, second, and third physiological responses occurred, a comparison of the first value with a predetermined threshold, or respective deviations of the second value or the third value from the first value.

公开(公告)号：US20170266437A1

公开(公告)日：2017-09-21

申请号：US15610898

申请日：2017-06-01

Applicant: Nuvectra Corporation

Inventor： Norbert Kaula ,  Yohannes Iyassu ,  Michael Labbe

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/372

CPC classification number: A61N1/0558 ,  A61N1/05 ,  A61N1/0512 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/3606 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/37235 ,  A61N1/37247

Abstract: A pulse generator is configured to generate electrical pulses of an electrical stimulation therapy. The pulse generator includes an N number of output channels and a microcontroller configured to generate instructions. The pulse generator is configured to generate different stimulation waveforms simultaneously for the output channels. The different waveforms have different waveform characteristics. A mesh electrode array includes an M number of electrodes. Each of the electrodes is configured to deliver the electrical pulses of the electrical stimulation therapy. M is at least several times greater than N. A solid state relay contains a plurality of controllable switches that is each configured to be turned on or off in response to the instructions received from the microcontroller, such that the solid state relay routes the output channels of the pulse generator to different subset of the electrodes of the mesh electrode array at different points in time.

公开(公告)号：US09669227B2

公开(公告)日：2017-06-06

申请号：US14932130

申请日：2015-11-04

Applicant: Nuvectra Corporation

Inventor： Norbert Kaula ,  Yohannes Iyassu

IPC: A61N1/00 ,  A61N1/372 ,  G06F19/00 ,  A61N1/36

CPC classification number: A61N1/37247 ,  A61N1/3605 ,  A61N1/36057 ,  A61N1/36132 ,  A61N1/36135 ,  A61N1/36142 ,  A61N1/37264 ,  G16H40/63

Abstract: Electrical stimulation therapy is provided for a patient. A user is informed that a user-supplied electrical stimulation waveform can be entered into an electronic programmer. At least in part via a user interface of the electronic programmer, it is detected that the user-supplied electrical stimulation waveform has been received by the electronic programmer. A determination is made to whether the user-supplied electrical stimulation waveform is compliant with a set of predetermined restrictions. In response to a determination that the user-supplied electrical stimulation waveform is compliant with the set of predetermined restrictions, a pulse generator is instructed to generate electrical stimulation pulses based on the user-supplied electrical stimulation waveform.

公开(公告)号：US20170050034A1

公开(公告)日：2017-02-23

申请号：US15256149

申请日：2016-09-02

Applicant: Nuvectra Corporation

Inventor： Norbert Kaula ,  Yohannes Iyassu

IPC: A61N1/372 ,  G06F19/00 ,  A61N1/36

CPC classification number: A61N1/37247 ,  A61N1/36185 ,  G06F3/0482 ,  G06F3/0484 ,  G06F3/04842 ,  G06F3/04847 ,  G06F3/0485 ,  G06F19/00 ,  G06F19/3481 ,  G16H20/30 ,  G16H40/63 ,  G16H50/50

Abstract: A first fraction of an electrical stimulation is allocated to a first electrode. In response to user input, the first fraction of the electrical stimulation is fixed to the first electrode such that the first fraction is user-adjustable but cannot be automatically changed. In response to the first fraction being fixed to the first electrode, a respective second fraction of the electrical stimulation is automatically allocated to a plurality of second electrodes. The second fraction is a function of the first fraction and a total number of the second electrodes. Thereafter, a new electrode is added to, or deleting from, the second electrodes, while the first fraction is still fixed to the first electrode. The respective second fractions are automatically adjusted in response to the adding or the deleting, without affecting the first fraction of the electrical stimulation that has been fixed to the first electrode.

Abstract translation: 电刺激的第一部分被分配给第一电极。 响应于用户输入，电刺激的第一部分固定到第一电极，使得第一部分是用户可调节的，但不能自动改变。 响应于第一部分被固定到第一电极，电刺激的相应的第二部分被自动分配给多个第二电极。 第二部分是第一部分和第二电极的总数的函数。 此后，当第一部分仍然固定到第一电极时，新的电极被添加到第二电极或从第二电极删除。 相应的第二部分根据添加或删除而自动调整，而不影响固定到第一电极的电刺激的第一部分。

公开(公告)号：US09433790B2

公开(公告)日：2016-09-06

申请号：US14536863

申请日：2014-11-10

Applicant: Nuvectra Corporation

Inventor： Norbert Kaula ,  Yohannes Iyassu

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372

CPC classification number: A61N1/0558 ,  A61N1/05 ,  A61N1/0512 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/3606 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/37235 ,  A61N1/37247

Abstract: In response to input from a patient who is being treated by a sacral nerve stimulation therapy, an electronic diary is generated that includes a plurality of voiding responses of the patient over a period of time. The sacral nerve stimulation therapy includes electrical pulses delivered to the patient according to a first stimulation program and via a first subset of electrode contacts on a lead that is implanted in the patient. The lead has a plurality of electrode contacts that include the first subset. Based on the voiding responses in the electronic diary, a loss of efficacy of the sacral nerve stimulation therapy is detected. The sacral nerve stimulation therapy is automatically adjusted in response to the detected loss of efficacy. The automatically adjustment of the sacral nerve stimulation therapy may include either a program-based sweep or a contact-based sweep.

Abstract translation: 响应于通过骶神经刺激疗法治疗的患者的输入，产生包括患者在一段时间内的多个排尿反应的电子日记。 骶神经刺激治疗包括根据第一刺激程序传送给患者的电脉冲，并且经由植入患者的引线上的电极接触的第一子集。 引线具有包括第一子集的多个电极接触。 根据电子日记中的排尿反应，检测到骶神经刺激疗法的功效丧失。 响应于检测到的功效丧失，自动调整骶神经刺激疗法。 骶神经刺激治疗的自动调整可以包括基于程序的扫描或基于接触的扫描。

公开(公告)号：US09427584B2

公开(公告)日：2016-08-30

申请号：US14537293

申请日：2014-11-10

Applicant: Nuvectra Corporation

Inventor： Norbert Kaula ,  Yohannes Iyassu ,  Michael Labbe

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A61N1/372

CPC classification number: A61N1/0558 ,  A61N1/05 ,  A61N1/0512 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/3606 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/37235 ,  A61N1/37247

Abstract: The present disclosure involves a method of generating different stimulation waveforms as a part of sacral nerve stimulation therapy. A first stimulation waveform having a first stimulation waveform characteristic is generated. The first stimulation waveform is delivered to a first body part of a patient at least in part via a first channel. A second stimulation waveform having a second stimulation waveform characteristic is generated. The second stimulation waveform characteristic is different from the first stimulation waveform characteristic. The second stimulation waveform is delivered to a second body part of the patient at least in part via a second channel that is separate and independent from the first channel. The first body part and second body part correspond to different organs or different types of nerves.

Abstract translation: 本公开涉及一种产生不同刺激波形作为骶神经刺激治疗的一部分的方法。 产生具有第一刺激波形特性的第一刺激波形。 第一刺激波形至少部分地经由第一通道被输送到患者的第一身体部分。 产生具有第二刺激波形特性的第二刺激波形。 第二刺激波形特性与第一刺激波形特性不同。 至少部分地经由与第一通道分开且独立的第二通道将第二刺激波形输送到患者的第二身体部分。 第一体部分和第二体部分对应于不同的器官或不同类型的神经。

公开(公告)号：US10347381B2

公开(公告)日：2019-07-09

申请号：US16197091

申请日：2018-11-20

Applicant: Nuvectra Corporation

Inventor： Norbert Kaula ,  Yohannes Iyassu

IPC: G16H50/50 ,  G06F19/00 ,  G16H40/63 ,  A61N1/36 ,  A61N1/372 ,  A61N1/05

Abstract: The present disclosure involves a medical system that includes one or more implantable medical devices configured to deliver a medical therapy to a patient. The medical system also includes a portable electronic device on which a touch-sensitive user interface is implemented. The user interface is configured to provide a visual representation of the medical therapy through a hierarchy. The hierarchy includes a lower level representation of the medical therapy that corresponds to a stimulation program that includes a plurality of configurable stimulation parameters. The hierarchy includes a middle level representation of the medical therapy that corresponds to a stimulation program-set that includes a plurality of different stimulation programs. The hierarchy includes an upper level representation of the medical therapy that corresponds to a scrollable collection of stimulation program-sets that are represented by a plurality of digital cards, respectively.