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154 条记录 (耗时 0.051 秒)

    Human P24 vesicle proteins
    31.
    发明授权
    Human P24 vesicle proteins 失效
    人类P24囊泡蛋白

    公开(公告)号：US6130325A

    公开(公告)日：2000-10-10

    申请号：US801740

    申请日：1997-02-14

    申请人： Surya K. Goli ,  Olga Bandman

    发明人： Surya K. Goli ,  Olga Bandman

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P35/00 ,  A61P43/00 ,  C07K14/705 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/63

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention provides two human p24 vesicle trafficking proteins (designated individually as Hp24-1 and Hp24-2 and collectively as Hp24) and polynucleotides which identify and encode Hp24. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Hp24 and a method for producing Hp24. The invention also provides for agonists, antibodies, or antagonists specifically binding Hp24, and their use, in the prevention and treatment of diseases associated with expression of Hp24. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Hp24 for the treatment of diseases associated with the expression of Hp24. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Hp24.

    摘要翻译： 本发明提供了两种人p24小泡运输蛋白（分别命名为Hp24-1和Hp24-2，统称为Hp24）和鉴定和编码Hp24的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码Hp24的核酸序列和生产Hp24的方法。 本发明还提供了特异性结合Hp24的激动剂，抗体或拮抗剂及其在预防和治疗与Hp24表达相关的疾病中的用途。 另外，本发明提供了将反义分子用于编码Hp24的多核苷酸用于治疗与Hp24表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合Hp24的抗体的诊断测定法。

    DNA hybridizing to a human cystatin-like protein (CSTIN)
    32.
    发明授权
    DNA hybridizing to a human cystatin-like protein (CSTIN) 失效
    与人类半胱氨酸蛋白酶抑制蛋白样蛋白（CSTIN）杂交的DNA

    公开(公告)号：US6110686A

    公开(公告)日：2000-08-29

    申请号：US314777

    申请日：1999-05-19

    申请人： Olga Bandman ,  Surya K. Goli

    发明人： Olga Bandman ,  Surya K. Goli

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/55 ,  A61K45/00 ,  A61P25/00 ,  A61P35/00 ,  C07K14/81 ,  C07K16/40 ,  C12N1/21 ,  C12N5/10 ,  C12N15/15 ,  C12P21/02 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C07K14/8139 ,  C07K16/40 ,  A61K38/00

    摘要： The present invention provides a human cystatin-like protein (CSTIN) and polynucleotides which identify and encode CSTIN. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding CSTIN and a method for producing CSTIN. The invention also provides for agonists, antibodies, or antagonists specifically binding CSTIN, and their use, in the prevention and treatment of diseases associated with expression of CSTIN. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding CSTIN for the treatment of diseases associated with the expression of CSTIN. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding CSTIN.

    摘要翻译： 本发明提供了人半胱氨酸蛋白酶抑制蛋白样蛋白（CSTIN）和识别和编码CSTIN的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码CSTIN的核酸序列和用于产生CSTIN的方法。 本发明还提供了特异性结合CSTIN的激动剂，抗体或拮抗剂及其在预防和治疗与CSTIN表达相关的疾病中的用途。 另外，本发明提供反义分子用于编码CSTIN的多核苷酸用于治疗与表达CSTIN相关的疾病。 本发明还提供利用多核苷酸或其片段或其互补体和特异性结合CSTIN的抗体的诊断测定法。

    Human pathogenesis-related protein
    33.
    发明授权
    Human pathogenesis-related protein 失效
    人类发病相关蛋白

    公开(公告)号：US6071874A

    公开(公告)日：2000-06-06

    申请号：US199887

    申请日：1998-11-24

    申请人： Olga Bandman ,  Surya K. Goli

    发明人： Olga Bandman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/435 ,  A61K38/17

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention provides a human pathogenesis-related protein (HPRP) and polynucleotides which identify and encode HPRP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPRP and a method for producing HPRP. The invention also provides for agonists, antibodies, or antagonists specifically binding HPRP, and their use, in the prevention and treatment of diseases associated with expression of HPRP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPRP for the treatment of diseases associated with the expression of HPRP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPRP.

    摘要翻译： 本发明提供鉴定和编码HPRP的人发病相关蛋白（HPRP）和多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HPRP的核酸序列和产生HPRP的方法。 本发明还提供了特异性结合HPRP的激动剂，抗体或拮抗剂及其在预防和治疗与HPRP表达相关的疾病中的用途。 另外，本发明提供了反义分子用于编码HPRP的多核苷酸用于治疗与HPRP表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HPRP的抗体的诊断测定法。

    ATP synthase subunits
    34.
    发明授权
    ATP synthase subunits 失效

    公开(公告)号：US6020474A

    公开(公告)日：2000-02-01

    申请号：US783974

    申请日：1997-01-15

    申请人： Olga Bandman ,  Jennifer L. Hillman ,  Surya K. Goli

    发明人： Olga Bandman ,  Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C12N1/21 ,  C12N9/14 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N9/14 ,  A61K38/00

    摘要： The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.

    Tumor-associated kazal inhibitor-like polypeptides and encoding polynucleotides
    35.
    发明授权
    Tumor-associated kazal inhibitor-like polypeptides and encoding polynucleotides 失效
    肿瘤相关的kazal抑制剂样多肽和编码多核苷酸

    公开(公告)号：US5858710A

    公开(公告)日：1999-01-12

    申请号：US744670

    申请日：1996-11-06

    申请人： Olga Bandman ,  Surya K. Goli ,  Lynn E. Murry

    发明人： Olga Bandman ,  Surya K. Goli ,  Lynn E. Murry

    IPC分类号： G01N33/574 ,  A61K38/00 ,  A61K38/55 ,  A61K39/395 ,  A61P1/00 ,  A61P35/00 ,  C07K14/81 ,  C07K16/38 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/15 ,  C12Q1/68 ,  C07K14/435 ,  C12N15/70 ,  C12N15/79

    CPC分类号： C07K14/8135 ,  A61K38/00

    摘要： The present invention provides a human tumor-associated Kazal inhibitor (TAKI) and polynucleotides which identify and encode TAKI. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TAKI and a method for producing TAKI. The invention also provides for agonists, antibodies, or antagonists specifically binding TAKI, and their use, in the prevention and treatment of intestinal diseases including cancer. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TAKI for the treatment of diseases associated with the expression of TAKI. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TAKI.

    摘要翻译： 本发明提供了一种人肿瘤相关的卡马尔抑制剂（TAKI）和鉴定和编码TAKI的多核苷酸。 本发明还提供了基因工程表达载体和宿主细胞，其包含编码TAKI的核酸序列和产生TAKI的方法。 本发明还提供了特异性结合TAKI的激动剂，抗体或拮抗剂及其在预防和治疗包括癌症的肠道疾病中的用途。 另外，本发明提供反义分子用于编码TAKI的多核苷酸用于治疗与TAKI表达相关的疾病。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合TAKI的抗体的诊断测定法。

    Human chloride channel
    36.
    发明授权
    Human chloride channel 失效
    人体氯化物通道

    公开(公告)号：US5854411A

    公开(公告)日：1998-12-29

    申请号：US781560

    申请日：1997-01-09

    申请人： Surya K. Goli ,  Olga Bandman

    发明人： Surya K. Goli ,  Olga Bandman

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K45/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/566 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention provides a novel human chloride channel (HCCP) and polynucleotides which identify and encode HCCP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HCCP and a method for producing HCCP. The invention also provides for agonists, antibodies, or antagonists specifically binding HCCP, and their use, in the prevention and treatment of diseases associated with expression of HCCP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HCCP for the treatment of diseases associated with the expression of HCCP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HCCP.

    摘要翻译： 本发明提供一种新型人氯通道（HCCP）和鉴定和编码HCCP的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HCCP的核酸序列和生产HCCP的方法。 本发明还提供特异性结合HCCP的激动剂，抗体或拮抗剂及其在预防和治疗与HCCP表达相关的疾病中的用途。 另外，本发明提供了反义分子用于编码HCCP的多核苷酸用于治疗与HCCP表达有关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HCCP的抗体的诊断测定法。

    Human proteasome subunit proteins
    38.
    发明授权
    Human proteasome subunit proteins 失效

    公开(公告)号：US5843715A

    公开(公告)日：1998-12-01

    申请号：US701935

    申请日：1996-08-23

    申请人： Olga Bandman ,  Janice Au-Young ,  Jennifer L. Hillman ,  Surya K. Goli

    发明人： Olga Bandman ,  Janice Au-Young ,  Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C12N1/21 ,  C12N9/64 ,  C12N15/00 ,  C07H21/04 ,  C12N15/85

    CPC分类号： C12N9/6421 ,  C12Y304/25001 ,  A61K38/00

    摘要： The present invention provides polynucleotides which identify and encode novel human proteasome subunit proteins. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PSUB. The invention also provides for the use of substantially purified PSUB, antagonists, and in pharmaceutical compositions for the treatment of diseases associated with the expression of PSUB. Additionally, the invention provides for the use of antisense molecules to PSUB in pharmaceutical compositions for treatment of diseases associated with the expression of PSUB. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding PSUB or anti-PSUB antibodies which specifically bind to PSUB.

    Polynucleotides encoding a novel prostate-specific kallikrein
    39.
    发明授权
    Polynucleotides encoding a novel prostate-specific kallikrein 失效
    编码新型前列腺特异性激肽释放酶的多核苷酸

    公开(公告)号：US5786148A

    公开(公告)日：1998-07-28

    申请号：US744026

    申请日：1996-11-05

    申请人： Olga Bandman ,  Surya K. Goli

    发明人： Olga Bandman ,  Surya K. Goli

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K45/00 ,  A61P35/00 ,  C07K16/40 ,  C12N1/21 ,  C12N9/64 ,  C12N15/57 ,  C12Q1/68 ,  C12R1/19 ,  C12P21/02 ,  C07H21/04 ,  C12N15/63

    CPC分类号： C12N9/6445 ,  A61K38/00 ,  Y10S435/971

    摘要： The present invention provides a human prostate-specific kallikrein (HPSK) and polynucleotides which identify and encode HPSK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPSK and a method for producing HPSK. The invention also provides for agonists, antibodies, or antagonists specifically binding HPSK, and their use, in the prevention and treatment of diseases associated with expression of HPSK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPSK for the treatment of diseases associated with the expression of HPSK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPSK.

    摘要翻译： 本发明提供了人前列腺特异性激肽释放酶（HPSK）和识别和编码HPSK的多核苷酸。 本发明还提供了包含编码HPSK的核酸序列的基因工程表达载体和宿主细胞以及用于产生HPSK的方法。 本发明还提供特异性结合HPSK的激动剂，抗体或拮抗剂及其在预防和治疗与HPSK表达相关的疾病中的用途。 另外，本发明提供反义分子用于编码HPSK的多核苷酸用于治疗与HPSK表达相关的疾病。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HPSK的抗体的诊断测定法。

    ATP synthase subunits
    40.
    发明授权
    ATP synthase subunits 失效
    ATP合酶亚基

    公开(公告)号：US06531575B1

    公开(公告)日：2003-03-11

    申请号：US09546306

    申请日：2000-04-10

    申请人： Olga Bandman ,  Jennifer L. Hillman ,  Surya K. Goli

    发明人： Olga Bandman ,  Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： C07K100

    CPC分类号： C12N9/14 ,  A61K38/00

    摘要： The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.

    摘要翻译： 本发明提供两个ATP合成酶亚单位（分别命名为Asy-1和Asy-2，统称为Asy）和识别和编码Asy的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码Asy的核酸序列和产生Asy的方法。 本发明还提供了用于预防和治疗与Asy表达相关的疾病的Asy和特异性结合Asy的激动剂，抗体或拮抗剂。 另外，本发明提供反义分子用于编码Asy的多核苷酸用于治疗与Asy表达相关的疾病。 本发明还提供利用多核苷酸或其片段或其互补体和特异性结合Asy的抗体的诊断测定法。