公开(公告)号：US08715215B2

公开(公告)日：2014-05-06

申请号：US12733702

申请日：2008-08-26

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61M37/00 ,  C02F1/44

CPC classification number: A61M1/342 ,  A61M1/3639 ,  A61M1/3672 ,  A61M5/1452 ,  A61M5/16859 ,  A61M2205/14 ,  A61M2205/3331

Abstract: A method of checking and/or monitoring the correct operation of an adding device of a medical apparatus includes detecting a characteristic signal course being generated by the adding device. The medical apparatus includes an extracorporeal circuit with which the adding device is connected such that an agent can be introduced into the extracorporeal circuit via the adding device. The pressure loss in the extracorporeal circuit is measured and evaluated for checking and/or monitoring the correct operation of the adding device. The adding device for this purpose generates an oscillating pressure course.

Abstract translation: 检查和/或监视医疗装置的添加装置的正确操作的方法包括检测由加法装置产生的特征信号路线。 该医疗装置包括与添加装置连接的体外回路，使得能够通过加法装置将药剂引入体外回路。 对体外电路中的压力损失进行测量和评估，以检查和/或监视加法装置的正确操作。 用于此目的的添加装置产生振荡压力进程。

公开(公告)号：US08574183B2

公开(公告)日：2013-11-05

申请号：US12598250

申请日：2008-04-29

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61M37/00

CPC classification number: A61M1/342 ,  A61M1/3403 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3635 ,  A61M1/3639 ,  A61M2205/3331 ,  A61M2205/707

Abstract: The present invention relates to a method and a device for monitoring a blood treatment unit, subdivided by a semipermeable membrane into a blood chamber and a dialysis liquid chamber, of an extra-corporeal blood treatment device, which comprises an extra-corporeal blood circuit having an arterial branch leading to the blood chamber of the blood treatment unit, a venous branch, which extends away from the blood chamber, and a dialysis fluid system, in which the dialysis liquid chamber is arranged. The method according to the present invention and the device according to the present invention are based on the idea that the change of the flow resistance of the dialysis machine is determined based on two measurements, wherein an oscillating pressure signal in the extra-corporeal blood circuit or in the dialysis fluid system is measured before and after the change of the substitution rate and/or ultrafiltration rate, with which the substitute is applied to, or ultrafiltrate is removed from, the blood flowing in the blood circulation system. Preferably, the supply of substitute is interrupted temporarily.

Abstract translation: 本发明涉及一种用于监测血液处理单元的方法和装置，所述血液处理单元由半透膜分隔成血液腔和透析液室，所述血液处理单元包括体外血液回路，所述体外血液回路具有 通向血液处理单元的血液室的动脉分支，远离血液室延伸的静脉分支，以及配置有透析液室的透析液体系统。 根据本发明的方法和根据本发明的装置是基于以下思想：基于两次测量来确定透析机的流动阻力的变化，其中在体外血液回路中的振荡压力信号 或在血液循环系统中流动的血液中替代替代物和/或超滤速率改变之前或之后，或透析液体系中的血液循环系统中流出的血液中除去超滤液。 优选地，替代品的供应暂时中断。

公开(公告)号：US08500671B2

公开(公告)日：2013-08-06

申请号：US13122220

申请日：2009-09-29

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61M37/00

CPC classification number: A61M1/30 ,  A61M1/1006 ,  A61M1/1039 ,  A61M1/1086 ,  A61M1/302 ,  A61M1/308 ,  A61M1/3603 ,  A61M2205/3334

Abstract: A device for the extracorporal blood treatment in a single-needle operating mode includes means for delivering blood into, and means for delivering blood out of means for collecting blood, and a controller for setting the respective delivery rates of the means for the delivery of blood. The operating mode of the means for delivering blood is continually switched between an arterial and a venous phase by the controller, wherein during the arterial phase the delivery rate Qb of the means for delivering blood is greater than the delivery rate Qsn of the means for delivering blood such that blood may be withdrawn from the patient during the arterial phase, and during the venous phase the delivery rate Qb is smaller than the delivery rate Qsn such that blood may be administered to the patient during the venous phase.

Abstract translation: 用于以单针操作模式进行体外血液处理的装置包括用于将血液输送到用于收集血液的装置中的装置和用于输送血液的装置，以及用于设定用于输送血液的装置的各自输送速率的控制器 。 用于输送血液的装置的操作模式由控制器在动脉和静脉期之间连续切换，其中在动脉期期间，用于输送血液的装置的输送速率Qb大于用于输送的装置的输送速率Qsn 血液，使得血液可以在动脉期期间从患者中取出，并且在静脉期期间，输送速率Qb小于输送速率Qsn，使得可以在静脉期期间向患者施用血液。

公开(公告)号：US20130193039A1

公开(公告)日：2013-08-01

申请号：US13813490

申请日：2011-07-29

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61M1/36 ,  G01P13/02

CPC classification number: A61M1/3663 ,  A61M1/16 ,  A61M1/1617 ,  A61M1/367 ,  A61M2205/18 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/702 ,  G01P13/02

Abstract: The present invention relates to a device and a method for detecting the direction of the fluid flow through a dialyzer, as well as an extracorporeal blood treatment apparatus which comprises a device for detecting the direction of the fluid flow through the dialyzer. The devices and methods according to the present invention are based on the change in a physical and/or chemical property, for example the substance concentration or the temperature, of a fluid flowing into the one chamber of the dialyzer and the measurement of the change in the physical and/or chemical property of the fluid flowing out of the one chamber of the dialyzer.

Abstract translation: 本发明涉及一种用于检测通过透析器的流体流动的方向的装置和方法，以及包括用于检测通过透析器的流体流动的方向的装置的体外血液处理装置。 根据本发明的装置和方法基于物理和/或化学特性的变化，例如流入透析器的一个室的流体的物质浓度或温度的变化，以及 从透析器的一个腔室流出的流体的物理和/或化学性质。

公开(公告)号：US08430834B2

公开(公告)日：2013-04-30

申请号：US12443000

申请日：2007-09-25

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61M37/00

CPC classification number: A61M1/3626 ,  A61M1/3639 ,  A61M5/365

Abstract: The present invention relates to a method and to a device for detecting the entry of air in a fluid system, in particular in an extracorporeal blood circuit of a blood treatment device comprising an arterial branch leading to the blood treatment unit and a venous branch leading from said blood treatment unit. Periodic fluctuations in the fluid system, in particular in the arterial tube, are measured upstream of the blood pump arranged in said arterial tube. The measured periodic pressure signal is analyzed spectrally in a system of functions, in particular a system of orthogonal functions, for example sine and cosine functions and the entry of air is deduced if at least one of the coefficients of the functions exceeds or falls below predefined threshold values.

Abstract translation: 本发明涉及一种用于检测流体系统中特别是在血液处理装置的体外血液循环中进入空气的方法和装置，该血液处理装置包括通向血液处理单元的动脉分支和从 说血液处理单位。 流体系统中特别是在动脉管中的周期性波动在布置在所述动脉管中的血液泵的上游被测量。 测量的周期性压力信号在功能系统，特别是正交函数系统（例如正弦和余弦函数）中进行频谱分析，并且如果功能的系数中的至少一个超过或低于预定义的范围，则推断空气的输入 阈值。

公开(公告)号：US20120199526A1

公开(公告)日：2012-08-09

申请号：US13500930

申请日：2010-10-01

Applicant: Pascal Kopperschmidt ,  Christoph Bocklet

Inventor： Pascal Kopperschmidt ,  Christoph Bocklet

IPC: A61M1/16 ,  G01N27/02 ,  G06F19/00

CPC classification number: B01D65/102 ,  A61M1/1656 ,  A61M1/1672 ,  A61M2205/3317 ,  A61M2205/705 ,  B01D61/22 ,  B01D65/10 ,  B01D65/104 ,  B01D2311/243

Abstract: The present invention relates to devices and methods for inspecting filters for extracorporeal blood treatment devices, e.g., filters for filtering dialysis fluid. The inspection of the filter according to the present invention is based on the measurement of the flow potential before and after changing the fluid flow of an electrolytic fluid between a transversal flow through the semi-permeable membrane of the filter and a longitudinal flow along the semi-permeable membrane of the filter, or vice versa. Changing the flow direction of the electrolytic fluid results in a change to the conductivity proceeding from a base value P to a higher value P2 or a lower value P1, wherein the conductivity readjusts to the base value P after a certain time interval T1, T2. An improper state of the filter is determined on the basis of the change in conductivity after changing the flow direction of the electrolytic fluid.

Abstract translation: 本发明涉及用于检查用于体外血液处理装置的过滤器的装置和方法，例如用于过滤透析液的过滤器。 根据本发明的过滤器的检查是基于在通过过滤器的半透膜的横向流动和沿半过滤器的纵向流动改变电解液的流体流动之前和之后的流量的测量 过滤器的不透水膜，反之亦然。 改变电解液的流动方向导致从基值P向较高值P2或较低值P1开始的电导率的变化，其中在一定时间间隔T1，T2之后，电导率重新调整到基值P. 基于改变电解液流动方向后的电导率变化来确定过滤器的不正确状态。

公开(公告)号：US08043076B2

公开(公告)日：2011-10-25

申请号：US12282544

申请日：2007-03-01

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: F04B43/12

CPC classification number: A61M1/16 ,  F04B43/0081 ,  F04B43/12 ,  F04B51/00 ,  F04B2201/1203 ,  F04B2207/70

Abstract: The invention relates to a method and to a device for operating an electric peristaltic hose pump, in particular a hose pump for transporting fluids in medical-technical devices, in particular extracorporeal blood treatment devices. In order to monitor the regular operation of a hose pump, the power consumption of the pump or a physical variable in correlation with the power consumption, in particular the pump flow, is monitored. The pump flow includes a periodically non-altering direct component which is superimposed on a periodically altering alternating component. In order to monitor the regular operation of the hose pump, the alternating component of the power consumption in relation to the direct component of the power consumption is monitored as whether it increases and/or decreases during blood treatment.

Abstract translation: 本发明涉及一种用于操作电动蠕动软管泵的方法和装置，特别是用于在医疗技术装置中输送流体的软管泵，特别是体外血液处理装置。 为了监测软管泵的常规操作，监测泵的功率消耗或与功率消耗特别是泵流量相关的物理变量。 泵流包括周期性地不改变的直接分量，其被叠加在周期性变化的交替分量上。 为了监视软管泵的常规操作，监测与功耗的直接分量相关的功率消耗的交替分量，以及在血液处理期间是否增加和/或减少。

公开(公告)号：US20110034814A1

公开(公告)日：2011-02-10

申请号：US12933466

申请日：2009-03-24

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61B5/021

CPC classification number: A61M1/3656 ,  A61M1/3639 ,  A61M1/3653 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3344 ,  A61M2205/52

Abstract: The invention relates to a method and a device for monitoring a vascular access during an extracorporeal blood treatment. The method and the device according to the invention are based on the monitoring of the difference between the venous pressure measured by a venous pressure sensor and the arterial pressure measured by an arterial pressure sensor (in the extracorporeal blood circuit. According to the method and the device according to the invention, a test function describing disturbances in the extracorporeal blood circuit is determined. Said test function is used to determine a noise-free differential pressure from the measured venous and arterial pressure, said differential pressure being evaluated in an arithmetic and evaluation unit to identify a defective vascular access.

Abstract translation: 本发明涉及用于在体外血液处理期间监测血管通路的方法和装置。 根据本发明的方法和装置是基于监测由静脉压力传感器测量的静脉压与由动脉压传感器测量的动脉压之间的差异（在体外血液回路中），根据该方法和 根据本发明的装置，确定描述体外血液循环中的紊乱的测试功能，所述测试功能用于根据测得的静脉和动脉压来确定无噪音压差，所述差压在算术和评估中进行评估 识别血管通路有缺陷的单位。

公开(公告)号：US20100137777A1

公开(公告)日：2010-06-03

申请号：US12598250

申请日：2008-04-29

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61M1/34

CPC classification number: A61M1/342 ,  A61M1/3403 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3635 ,  A61M1/3639 ,  A61M2205/3331 ,  A61M2205/707

Abstract: The present invention relates to a method and a device for monitoring a blood treatment unit, subdivided by a semipermeable membrane into a blood chamber and a dialysis liquid chamber, of an extra-corporeal blood treatment device, which comprises an extra-corporeal blood circuit having an arterial branch leading to the blood chamber of the blood treatment unit, a venous branch, which extends away from the blood chamber, and a dialysis fluid system, in which the dialysis liquid chamber is arranged. The method according to the present invention and the device according to the present invention are based on the idea that the change of the flow resistance of the dialysis machine is determined based on two measurements, wherein an oscillating pressure signal in the extra-corporeal blood circuit or in the dialysis fluid system is measured before and after the change of the substitution rate and/or ultrafiltration rate, with which the substitute is applied to, or ultrafiltrate is removed from, the blood flowing in the blood circulation system. Preferably, the supply of substitute is interrupted temporarily.

Abstract translation: 本发明涉及一种用于监测血液处理单元的方法和装置，所述血液处理单元由半透膜分隔成血液腔和透析液室，所述血液处理单元包括体外血液回路，所述体外血液回路具有 通向血液处理单元的血液室的动脉分支，远离血液室延伸的静脉分支，以及配置有透析液室的透析液体系统。 根据本发明的方法和根据本发明的装置是基于以下思想：基于两次测量来确定透析机的流动阻力的变化，其中在体外血液回路中的振荡压力信号 或在血液循环系统中流动的血液中替代替代物和/或超滤速率改变之前或之后，或透析液体系中的血液循环系统中流出的血液中除去超滤液。 优选地，替代品的供应暂时中断。

公开(公告)号：US20090247926A1

公开(公告)日：2009-10-01

申请号：US12443000

申请日：2007-09-25

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: G01M3/04 ,  A61M1/14

CPC classification number: A61M1/3626 ,  A61M1/3639 ,  A61M5/365

Abstract: The present invention relates to a method and to a device for detecting the entry of air in a fluid system, in particular in an extracorporeal blood circuit of a blood treatment device comprising an arterial branch leading to the blood treatment unit and a venous branch leading from said blood treatment unit. Periodic fluctuations in the fluid system, in particular in the arterial tube, are measured upstream of the blood pump arranged in said arterial tube. The measured periodic pressure signal is analyzed spectrally in a system of functions, in particular a system of orthogonal functions, for example sine and cosine functions and the entry of air is deduced if at least one of the coefficients of the functions exceeds or falls below predefined threshold values.

Abstract translation: 本发明涉及一种用于检测流体系统中特别是在血液处理装置的体外血液循环中进入空气的方法和装置，该血液处理装置包括通向血液处理单元的动脉分支和从 说血液处理单位。 流体系统中特别是在动脉管中的周期性波动在布置在所述动脉管中的血液泵的上游被测量。 测量的周期性压力信号在功能系统，特别是正交函数系统（例如正弦和余弦函数）中进行频谱分析，并且如果功能的系数中的至少一个超过或低于预定义的范围，则推断空气的输入 阈值。