公开(公告)号：US20050171114A1

公开(公告)日：2005-08-04

申请号：US11047259

申请日：2005-01-31

申请人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stephane Leonce ,  Bruno Pfeiffer ,  Pierre Renard

发明人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stephane Leonce ,  Bruno Pfeiffer ,  Pierre Renard

IPC分类号： C07D491/147 ,  A61K31/4375 ,  A61K31/4985 ,  A61P35/00 ,  C07B61/00 ,  C07D491/14 ,  C07D491/22 ,  A61K31/498 ,  A61K31/4745

CPC分类号： C07D491/14

摘要： A compound selected from those of formula (I): wherein: B1, B2 represent carbon or nitrogen, X, Y, X1 and Y1 represent a group selected from hydrogen, halogen, hydroxy, alkoxy, nitro, cyano, trihaloalkyl and NRaRb wherein Ra and Rb are as defined in the description, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —OR″a, —NR′aR′b, —O-Ta-OR″a, —NR″a-Ta-NR′aR′b, NR″a—C(O)-TaH, —O—C(O)-TaH, —O-Ta-NRa′Rb′, —NR″a-Ta-OR″a, —NR″a-Ta-CO2R″a and —NR″a—C(O)-Ta-NR′aR′b wherein R′a, R′b, R″a and Ta are as defined in the description, R3, R4 represent hydrogen or alkyl, A represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH—, —C(O)—CH(R8)— or —CH(R8)—C(O)— wherein R5, R6, R7 and R8 are as defined in the description, its isomers, N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

公开(公告)号：US06642248B2

公开(公告)日：2003-11-04

申请号：US10205566

申请日：2002-07-25

申请人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  Elisabeth Seguin ,  Abdelhakim El Omri ,  John Hickman ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

发明人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  Elisabeth Seguin ,  Abdelhakim El Omri ,  John Hickman ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

IPC分类号： A61K314741

CPC分类号： C07D491/04

摘要： A compound selected from those of formula (I): wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa, —NRaRb, —NRa—C(O)—T1, —O—C(O)—T1, —O—T2-NRaRb, —O—T2-ORa, —NRa—T2-NRaRb, —NRa—T2-ORa and —NRa—T2-CO2Ra wherein Ra, Rb, T1, T2 are as defined in the description, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, —ORa, —NRaRb, —NRa—C(O)—T1, —O—C(O)—T1, —O—T2-NRaRb, —O—T2-ORa, —NRa—T2-NRaRb, —NRa—T2-ORa and —NRa—T2-CO2Ra wherein Ra, Rb, T1 and T2 are as defined hereinbefore, R3 and R4 represent hydrogen or alkyl, W represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH— or —C(O)—CH(R8)— wherein R5, R6, R7 and R8 are as defined in the description, their isomers and N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

摘要翻译： 选自式（I）的化合物：其中：X和Y表示选自氢，卤素，巯基，氰基，硝基，烷基，三卤代烷基，三卤代烷基羰基氨基，-OR a，-NR a R b，-NR a -C（O） - T1，-OC（O）-T1，-O-T2-NRaRb，-O-T2-ORa，-NRa-T2-NRaRb，-NRa-T2-ORa和-NRa-T2-CO2Ra，其中Ra，Rb，T1 ，T 2如说明书中所定义，R 1表示氢或烷基，R 2表示选自氢，-OR a，-NR a R b，-NR a -C（O）-T1，-OC（O）-T1，-O- R2-NRaRb，-O-T2-ORa，-NRa-T2-NRaRb，-NRa-T2-ORa和-NRa-T2-CO2Ra，其中Ra，Rb，T1和T2如上所定义，R3和R4代表氢或 烷基，W表示式-CH（R 5）-CH（R 6） - ， - CH = C（R 7） - ， - C（R 7）= CH-或-C（O）-CH（R 8） R5，R6，R7和R8如说明书中所定义，它们的异构体和N-氧化物及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物，可用于治疗癌症。

公开(公告)号：US06509345B2

公开(公告)日：2003-01-21

申请号：US10010380

申请日：2001-11-05

申请人： Gilbert Lavielle ,  Patrick Hautefaye ,  Alain Pierre ,  Ghanem Atassi ,  John Hickman ,  Bernard Cimetiere

发明人： Gilbert Lavielle ,  Patrick Hautefaye ,  Alain Pierre ,  Ghanem Atassi ,  John Hickman ,  Bernard Cimetiere

IPC分类号： C07D47114

CPC分类号： C07D471/14 ,  A61K31/4745 ,  Y02P20/55

摘要： Compound of formula (I): wherein: n is 0, 1 or 2, R1, R2, R3, R4 and R5 are selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyloxy, carboxy, nitro, cyano, aminocarbonyl (optionally substituted), and the groups (CH2)p—NRaRb and —O—C(O)—N—RaRb, with p, Ra and Rb being as defined in the description, or two adjacent groups R2, R3, R4 and R5 together form a group —O—(CH2)t—O, t being an integer from 1 to 3, R60, R70n, R80 and R90 represent a hydrogen atom, a hydroxy group, an alkoxy group, or an O—(CO)—X or O—(CO)—NXW group as defined in the description, R61, R71n, R81 and R91 represent a hydrogen atom, alkyl, alkenyl or alkynyl, or taken in pairs together form a bond or an oxirane group, or two groups together form an oxo group. and medicinal products containing the same are useful for the treatment of cancerous diseases.

摘要翻译： 式（I）化合物：其中：n为0,1或2，R1，R2，R3，R4和R5选自氢，卤素，烷基，烯基，炔基，全卤代烷基，环烷基，环烷基烷基，羟基，羟烷基，烷氧基 ，烷氧基烷基，烷氧基羰基，酰氧基，羧基，硝基，氰基，氨基羰基（任选取代的）和基团（CH 2）p -NR a R b和-OC（O）-NR a R b，其中p，R a和R b如 描述或两个相邻基团R 2，R 3，R 4和R 5一起形成基团-O-（CH 2）t O，t为1至3的整数，R 60，R 70n，R 80和R 90表示氢原子，羟基， 烷氧基或描述中定义的O-（CO）-X或O-（CO）-NXW基团，R61，R71n，R81和R91表示氢原子，烷基，烯基或炔基，或成对取代 一起形成键或环氧乙烷基团，或两个基团一起形成氧代基，并且含有该氧基的药物可用于治疗癌性疾病。

公开(公告)号：US5885669A

公开(公告)日：1999-03-23

申请号：US907471

申请日：1997-08-08

申请人： David Evan Bryan Morgans ,  John Hickman

发明人： David Evan Bryan Morgans ,  John Hickman

IPC分类号： G02F1/1339 ,  G02F1/13 ,  G02F1/1335

CPC分类号： G02F1/133512 ,  Y10T428/1036 ,  Y10T428/1064

摘要： A liquid crystal display device having a liquid crystal layer interposed between a pair of substrates, said substrates being coupled to each other through an insulative sealing material at the peripheral portions thereof, one of said pair of substrates being a transparent front substrate through which viewing of the display device occurs, and a graphite containing matrix coating on an inside surface of the front substrate, said coating having a matrix of apertures therein, said coating being applied by application of a composition comprising in weight percent, about 1% to about 30% colloidal graphite, about 0.1% to about 20% binder material for the coating, and about 10% to about 98% of a fluid carrier, said applied coating having a thickness of less than about 20 microns.

摘要翻译： 一种液晶显示装置，其具有插入在一对基板之间的液晶层，所述基板通过绝缘密封材料在其周边部分彼此连接，所述一对基板中的一个基板是透明的前基板， 发生显示装置，并且在前基板的内表面上具有含石墨的基质涂层，所述涂层具有其中的孔基体，所述涂层通过施用包含重量百分比为约1％至约30％ 胶体石墨，用于涂层的约0.1％至约20％的粘合剂材料和约10％至约98％的流体载体，所述涂覆的涂层具有小于约20微米的厚度。

公开(公告)号：US08133889B2

公开(公告)日：2012-03-13

申请号：US12806045

申请日：2010-08-04

申请人： Jean-Claude Ortuno ,  Alexis Cordi ,  Jean-Michel Lacoste ,  Vincent Lacoste, legal representative ,  Pauline Lacoste, legal representative ,  Imre Fejes ,  Michael Burbridge ,  John Hickman ,  Alain Pierre

发明人： Jean-Claude Ortuno ,  Alexis Cordi ,  Jean-Michel Lacoste ,  Imre Fejes ,  Michael Burbridge ,  John Hickman ,  Alain Pierre

IPC分类号： A61K31/5377 ,  A61K31/422 ,  A61K31/496 ,  A61K31/454 ,  C07D413/14 ,  A61P35/00

CPC分类号： C07D417/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14

摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.

摘要翻译： 式（I）化合物：其中：m和n表示1或2，A表示吡咯基，X表示C（O），S（O）或SO 2基团，R 1和R 2表示烷基， 与它们携带的氮原子一起形成杂环基，R3和R4与携带它们的原子一起形成杂环基，R 5表示氢原子或烷基，R 6表示氢原子或卤素原子。 含有该药物的药物可用于治疗癌症。

公开(公告)号：US20060138004A1

公开(公告)日：2006-06-29

申请号：US11360063

申请日：2006-02-23

申请人： Robert Anthony ,  Daniel Guyton ,  Douglas Evans ,  John Hickman

发明人： Robert Anthony ,  Daniel Guyton ,  Douglas Evans ,  John Hickman

IPC分类号： B65D83/10

CPC分类号： A61B50/362 ,  A61B17/06133 ,  A61B17/062 ,  A61B17/3215 ,  A61B50/3001 ,  A61B50/33 ,  A61B2017/06147 ,  A61B2050/0059 ,  A61B2050/21

摘要： The invention relates to a multipurpose device for the safe handling of sharp surgical implements and comprises a molded thermoplastic body that includes a container portion and a scalpel holder section. Magnetic material in the container holds scalpel blades and/or needles after use and magnetic material on the holder section presents a needle for pick-up by a needle holder. The scalpel holder section supports a scalpel or scalpels in cantilever fashion for convenient gripping and withdrawal by a surgeon. The body has a shape and surface characteristics that assures a secure hand grip even in wet conditions.

公开(公告)号：US20060080319A1

公开(公告)日：2006-04-13

申请号：US10963086

申请日：2004-10-12

申请人： John Hickman ,  Kesavaprasath Ranganathan ,  Michael Schmidt ,  Steven Van Gundy

发明人： John Hickman ,  Kesavaprasath Ranganathan ,  Michael Schmidt ,  Steven Van Gundy

IPC分类号： G06F17/30

CPC分类号： H04L67/104 ,  G06F11/2023 ,  G06F11/2069 ,  H04L67/1002 ,  H04L67/1029 ,  H04L67/1031 ,  H04L67/1034 ,  H04L67/1059 ,  H04L67/1093 ,  H04L67/1097

摘要： An apparatus, system, and method are provided for facilitating storage management through organization of storage resources. The present invention includes a configuration module that configures a first logical entity and a second logical entity to interact with each other in a peer-to-peer domain such that each logical entity mirrors operations of, and is in direct communication with, the other logical entity. An information module exposes local resources of the first logical entity and local resources of the second logical entity to a management node such that the local resources are available as target resources of a management command from the management node. An address module selectively addresses a management command from the management node towards a local resource of the first logical entity and/or a local resource of the second logical entity as determined by the type of management command.

摘要翻译： 提供了一种装置，系统和方法，用于通过组织存储资源来促进存储管理。 本发明包括配置模块，其配置第一逻辑实体和第二逻辑实体以在对等域中彼此交互，使得每个逻辑实体反映其他逻辑的操作并与其直接通信 实体。 信息模块将第一逻辑实体的本地资源和第二逻辑实体的本地资源公开给管理节点，使得本地资源可用作来自管理节点的管理命令的目标资源。 地址模块从管理节点向管理命令的类型确定的第一逻辑实体的本地资源和/或第二逻辑实体的本地资源选择性地寻址管理命令。

公开(公告)号：US20060040930A1

公开(公告)日：2006-02-23

申请号：US10531393

申请日：2003-10-17

申请人： Gerard Coudert ,  Nathalie Ayerbe ,  Franck Lepiere ,  Sylvain Routier ,  Daniel-Henri Caignard ,  Pierre Renard ,  John Hickman ,  Alain Pierre ,  Stephane Leonce

发明人： Gerard Coudert ,  Nathalie Ayerbe ,  Franck Lepiere ,  Sylvain Routier ,  Daniel-Henri Caignard ,  Pierre Renard ,  John Hickman ,  Alain Pierre ,  Stephane Leonce

IPC分类号： A61K31/5383 ,  A61K31/4745 ,  C07D491/14 ,  C07D471/14

CPC分类号： C07D471/14 ,  C07D487/04 ,  C07D491/14

摘要： Compounds of formula (I): wherein: A is as defined in the description, Y represents a group selected from an oxygen atom and a methylene group, R2 represents a hydrogen atom and in that case: R3 represents a group selected from a hydrogen atom and the groups linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl (in which the alkyl moiety is linear or branched) and SO2CF3, or R2 and R3 form a bond, R1 represents a group selected from a hydrogen atom and the groups linear or branched (C1-C6)alkyl, aryl and aryl-(C1-C6)alkyl (in which the alkyl moiety is linear or branched) or a linear or branched (C1-C6)alkylene chain, Z1 and Z2 each represent a hydrogen atom or Z1 and Z2, together with the carbon atoms carrying them, form a phenyl group. Medicaments.

摘要翻译： 式（I）的化合物：其中：A如说明书中所定义，Y表示选自氧原子和亚甲基的基团，R 2表示氢原子，在这种情况下：R 3 表示选自氢原子和直链或支链（C 1 -C 6 -C 6）烷基，芳基，芳基 - （ C 1 -C 6 -C 6烷基（其中烷基部分是直链或支链的）和SO 2 -C 3 C 3 >或R 2和R 3'形成键，R 1表示选自氢原子和直链或支链基团的基团（ C 1 -C 6 -C 6烷基，芳基和芳基 - （C 1 -C 6 -C 6）烷基（在 其中烷基部分是直链或支链的）或直链或支链（C 1 -C 6 -C 6）亚烷基链，Z 1和Z 2， 各自表示氢原子或Z 1和Z 2，以及带有它们的碳原子形成苯基。 药剂

公开(公告)号：US06699876B2

公开(公告)日：2004-03-02

申请号：US10300330

申请日：2002-11-20

申请人： Gilbert Lavielle ,  Patrick Hautefaye ,  Alain Pierre ,  Ghanem Atassi ,  John Hickman ,  Bernard Cimetiere

发明人： Gilbert Lavielle ,  Patrick Hautefaye ,  Alain Pierre ,  Ghanem Atassi ,  John Hickman ,  Bernard Cimetiere

IPC分类号： A61K314375

CPC分类号： C07D471/14 ,  A61K31/4745

摘要： Compound of formula (I): wherein: n is 0, 1 or 2, R1 represents (C3-C11)cycloalkyl or (C3-C11)cycloalkylalkyl, R2, R3, R4 and R5 are selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyloxy, carboxy, nitro, cyano, aminocarbonyl (optionally substituted), and the groups (CH2)p—NaRb and —O—C(O)—N—RaRb, with p, Ra and Rb being as defined in the description, or two adjacent groups R2, R3, R4 and R5 together form a group —O—(CH2)t—O, t being integer from 1 to 3, R60, R70n, R80 and R90 represent a hydrogen atom, a hydroxy group, an alkoxy group, or an O—(CO)—X or O—(CO)—NXW group as defined in the description, R61, R71n, R81, and R91 represent a hydrogen atom, alkyl, alkenyl or alkynyl, or taken in pairs together form a bond or an oxirane group, or two groups together form an oxo group. and medicinal products containing the same are useful for the treatment of cancerous disesases.

摘要翻译： 式（I）化合物：其中：n为0,1或2，R1代表（C3-C11）环烷基或（C3-C11）环烷基烷基，R2，R3，R4和R5选自氢，卤素，烷基，烯基 ，炔基，全卤代烷基，环烷基，环烷基烷基，羟基，羟基烷基，烷氧基，烷氧基烷基，烷氧基羰基，酰氧基，羧基，硝基，氰基，氨基羰基（任选取代的）和基团（CH 2）p-NaRb和-OC（O） -RaRb，其中p，Ra和Rb如说明书中所定义，或两个相邻基团R 2，R 3，R 4和R 5一起形成基团-O-（CH 2）t O，t为1至3的整数，R 60，R 70n R 80和R 90表示如说明书中定义的氢原子，羟基，烷氧基或O-（CO）-X或O-（CO）-NXW基团，R61，R71n，R81和R91表示 氢原子，烷基，烯基或炔基，或成对取成一起形成键或环氧乙烷基，或两个基团一起形成氧代基，并且含有该氧基的药物可用于治疗癌性疾病。

公开(公告)号：US06627650B2

公开(公告)日：2003-09-30

申请号：US10171191

申请日：2002-06-13

申请人： Michel Wierzbicki ,  Marie-Françoise Boussard ,  Anne Rousseau ,  Ghanem Atassi ,  John Hickman ,  Alain Pierre ,  Stéphane Leonce ,  Nicolas Guilbaut ,  Laurence Kraus-Berthier

发明人： Michel Wierzbicki ,  Marie-Françoise Boussard ,  Anne Rousseau ,  Ghanem Atassi ,  John Hickman ,  Alain Pierre ,  Stéphane Leonce ,  Nicolas Guilbaut ,  Laurence Kraus-Berthier

IPC分类号： A61K3140

CPC分类号： C07D401/12 ,  C07D209/94 ,  C07D405/12 ,  C07D409/12 ,  C07D491/04

摘要： A compound of formula (I): wherein: R represents hydrogen, optionally substituted alkyl or alkenyl, R1 to R8, which may be identical or different, each represents hydrogen, optionally substituted alkyl, hydroxy, acyloxy, optionally substituted amino, carboxy, optionally substituted alkoxy, or alkenyloxy, or one of R1 to R8 forms, with another of R1 to R8 that is adjacent, an alkylenedioxy group, X represents oxygen or NR16 wherein R16 represents hydrogen, alkyl, aryl or arylalkyl, R9 represents hydrogen, aryl, heteroaryl, or optionally substituted, saturated or unsaturated alkyl, an isomer thereof, or an addition salt thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.

摘要翻译： 式（I）的化合物：其中：R表示氢，任选取代的烷基或烯基，可以相同或不同的R 1至R 8各自表示氢，任选取代的烷基，羟基，酰氧基，任选取代的氨基，羧基，任选地 取代的烷氧基或烯氧基，或R 1至R 8中的一个与相邻的R 1至R 8中的另一个相邻，亚烷基二氧基，X表示氧或NR 16，其中R16表示氢，烷基，芳基或芳烷基，R9表示氢， 杂芳基或任选取代的饱和或不饱和的烷基，其异构体或其加成盐与药学上可接受的酸或碱的混合物。含有该化合物的药物可用作抗癌剂。