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42 条记录 (耗时 0.027 秒)

    Camptothecin analogue compounds
    1.
    发明授权
    Camptothecin analogue compounds 失效
    喜树碱类似物

    公开(公告)号：US06509345B2

    公开(公告)日：2003-01-21

    申请号：US10010380

    申请日：2001-11-05

    申请人： Gilbert Lavielle ,  Patrick Hautefaye ,  Alain Pierre ,  Ghanem Atassi ,  John Hickman ,  Bernard Cimetiere

    发明人： Gilbert Lavielle ,  Patrick Hautefaye ,  Alain Pierre ,  Ghanem Atassi ,  John Hickman ,  Bernard Cimetiere

    IPC分类号： C07D47114

    CPC分类号： C07D471/14 ,  A61K31/4745 ,  Y02P20/55

    摘要： Compound of formula (I): wherein: n is 0, 1 or 2, R1, R2, R3, R4 and R5 are selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyloxy, carboxy, nitro, cyano, aminocarbonyl (optionally substituted), and the groups (CH2)p—NRaRb and —O—C(O)—N—RaRb, with p, Ra and Rb being as defined in the description, or two adjacent groups R2, R3, R4 and R5 together form a group —O—(CH2)t—O, t being an integer from 1 to 3, R60, R70n, R80 and R90 represent a hydrogen atom, a hydroxy group, an alkoxy group, or an O—(CO)—X or O—(CO)—NXW group as defined in the description, R61, R71n, R81 and R91 represent a hydrogen atom, alkyl, alkenyl or alkynyl, or taken in pairs together form a bond or an oxirane group, or two groups together form an oxo group. and medicinal products containing the same are useful for the treatment of cancerous diseases.

    摘要翻译： 式（I）化合物：其中：n为0,1或2，R1，R2，R3，R4和R5选自氢，卤素，烷基，烯基，炔基，全卤代烷基，环烷基，环烷基烷基，羟基，羟烷基，烷氧基 ，烷氧基烷基，烷氧基羰基，酰氧基，羧基，硝基，氰基，氨基羰基（任选取代的）和基团（CH 2）p -NR a R b和-OC（O）-NR a R b，其中p，R a和R b如 描述或两个相邻基团R 2，R 3，R 4和R 5一起形成基团-O-（CH 2）t O，t为1至3的整数，R 60，R 70n，R 80和R 90表示氢原子，羟基， 烷氧基或描述中定义的O-（CO）-X或O-（CO）-NXW基团，R61，R71n，R81和R91表示氢原子，烷基，烯基或炔基，或成对取代 一起形成键或环氧乙烷基团，或两个基团一起形成氧代基，并且含有该氧基的药物可用于治疗癌性疾病。

    Camptothecin analogue compounds
    2.
    发明授权
    Camptothecin analogue compounds 失效
    喜树碱类似物

    公开(公告)号：US06699876B2

    公开(公告)日：2004-03-02

    申请号：US10300330

    申请日：2002-11-20

    申请人： Gilbert Lavielle ,  Patrick Hautefaye ,  Alain Pierre ,  Ghanem Atassi ,  John Hickman ,  Bernard Cimetiere

    发明人： Gilbert Lavielle ,  Patrick Hautefaye ,  Alain Pierre ,  Ghanem Atassi ,  John Hickman ,  Bernard Cimetiere

    IPC分类号： A61K314375

    CPC分类号： C07D471/14 ,  A61K31/4745

    摘要： Compound of formula (I): wherein: n is 0, 1 or 2, R1 represents (C3-C11)cycloalkyl or (C3-C11)cycloalkylalkyl, R2, R3, R4 and R5 are selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyloxy, carboxy, nitro, cyano, aminocarbonyl (optionally substituted), and the groups (CH2)p—NaRb and —O—C(O)—N—RaRb, with p, Ra and Rb being as defined in the description, or two adjacent groups R2, R3, R4 and R5 together form a group —O—(CH2)t—O, t being integer from 1 to 3, R60, R70n, R80 and R90 represent a hydrogen atom, a hydroxy group, an alkoxy group, or an O—(CO)—X or O—(CO)—NXW group as defined in the description, R61, R71n, R81, and R91 represent a hydrogen atom, alkyl, alkenyl or alkynyl, or taken in pairs together form a bond or an oxirane group, or two groups together form an oxo group. and medicinal products containing the same are useful for the treatment of cancerous disesases.

    摘要翻译： 式（I）化合物：其中：n为0,1或2，R1代表（C3-C11）环烷基或（C3-C11）环烷基烷基，R2，R3，R4和R5选自氢，卤素，烷基，烯基 ，炔基，全卤代烷基，环烷基，环烷基烷基，羟基，羟基烷基，烷氧基，烷氧基烷基，烷氧基羰基，酰氧基，羧基，硝基，氰基，氨基羰基（任选取代的）和基团（CH 2）p-NaRb和-OC（O） -RaRb，其中p，Ra和Rb如说明书中所定义，或两个相邻基团R 2，R 3，R 4和R 5一起形成基团-O-（CH 2）t O，t为1至3的整数，R 60，R 70n R 80和R 90表示如说明书中定义的氢原子，羟基，烷氧基或O-（CO）-X或O-（CO）-NXW基团，R61，R71n，R81和R91表示 氢原子，烷基，烯基或炔基，或成对取成一起形成键或环氧乙烷基，或两个基团一起形成氧代基，并且含有该氧基的药物可用于治疗癌性疾病。

    Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them
    5.
    发明授权
    Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them 失效
    氨基甲酸酯和硫代氨基甲酸酯鬼臼毒素衍生物，制备方法和含有它们的药物组合物

    公开(公告)号：US06878746B2

    公开(公告)日：2005-04-12

    申请号：US10312175

    申请日：2001-06-19

    申请人： Claude Monneret ,  Emmanuel Bertounesque ,  Philippe Meresse ,  Ghanem Atassi ,  Alain Pierre ,  John Hickman ,  Bruno Pfeiffer ,  Pierre Renard

    发明人： Claude Monneret ,  Emmanuel Bertounesque ,  Philippe Meresse ,  Ghanem Atassi ,  Alain Pierre ,  John Hickman ,  Bruno Pfeiffer ,  Pierre Renard

    IPC分类号： A61K31/36 ,  A61P35/00 ,  C07D493/04 ,  A61K31/365

    CPC分类号： C07D493/04 ,  Y02P20/55

    摘要： A compound selected from these of formula (I): wherein: R1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl or phosphono, R2 represents oxygen or sulphur, R3 represents hydrogen or alkyl, cycloalkyl or arylalkyl, X represents linear or branched (C1-C6)alkylene, R4 represents a group selected from amino optionally substituted by one or two groups, —N(R3)—X1—OR5 wherein R3, X1 and R5 are as defined in the description, —N(R3)—X1—NR6R7 wherein R3, X1, R6 and R7 are as defined in the description, hydroxy, alkoxy, aryloxy, —O—X1—OR5 wherein R5 and X1 are as defined in the description, and —O—X1—NR6R7 wherein R6, R7 and X1 are as defined in the description, its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base, and medical products containing the same which are useful in the treatment of cancer.

    摘要翻译： 选自这些式（I）的化合物：其中：R1表示氢，烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基或膦酰基，R2表示氧或硫，R3 表示氢或烷基，环烷基或芳基烷基，X表示直链或支链（C1-C6）亚烷基，R4表示选自任选被一个或两个基团取代的氨基的基团-N（R3）-X1-OR5，其中R3，X1和 R 5如说明书中所定义，-N（R3）-X1-NR6R7，其中R3，X1，R6和R7如说明书中所定义，羟基，烷氧基，芳氧基，-O-X1-OR5，其中R5和X1为 和-O-X 1 -NR 6 R 7，其中R 6，R 7和X 1如说明书中所定义，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有它们的医药产品可用 在治疗癌症。

    Benzo[b]pyrano[3,2-h]acridin-7-one compounds
    8.
    发明授权
    Benzo[b]pyrano[3,2-h]acridin-7-one compounds 失效

    公开(公告)号：US07056929B2

    公开(公告)日：2006-06-06

    申请号：US10627463

    申请日：2003-07-26

    申请人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  Elisabeth Seguin ,  Abdelhakim El Omri ,  John Hickman ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

    发明人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  Elisabeth Seguin ,  Abdelhakim El Omri ,  John Hickman ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

    IPC分类号： A61K31/44

    CPC分类号： C07D491/04

    摘要： A method for treating a living body afflicted with a cancer selected from lung and ovarian carcinoma, comprising the step of administering to the living animal body an amount of a compound selected from those of formula (I): wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa, —NRaRb, —NRa—C(O)-T1, —O—C(O)-T1, —O-T2-NRaRb, —O-T2-ORa, —NRa-T2-NRaRb, —NRa-T2-ORa and —NRa-T2-CO2Ra wherein Ra, Rb, T1, T2 are as defined in the description, or X and Y together form a methylenedioxy or ethylenedioxy, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, —ORa, —NRaRb, —NRa—C(O)-T1, —O—C(O)-T1, —O-T2-NRaRb, —O-T2-ORa, —NRa-T2-NRaRb, —NRa-T2-ORa and —NRa-T2-CO2Ra wherein Ra, Rb, T1 and T2 are as defined hereinbefore, R3 and R4 represent hydrogen or alkyl, W represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH— or —C(O)—CH(R8)— wherein R5, R6, R7 and R8 are as defined in the description, their isomers and N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful in the treatment of cancer.