公开(公告)号：US20070274995A1

公开(公告)日：2007-11-29

申请号：US11537537

申请日：2006-09-29

申请人： David Botstein ,  Audrey Goddard ,  David Lawrence ,  Diane Pennica ,  Margaret Roy ,  William Wood

发明人： David Botstein ,  Audrey Goddard ,  David Lawrence ,  Diane Pennica ,  Margaret Roy ,  William Wood

IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C12N1/21 ,  C12N1/18 ,  C12N5/06 ,  C07K16/30 ,  C07K14/82

CPC分类号： C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/52 ,  C07K16/18 ,  C07K16/24 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N2333/52 ,  G01N2500/00

摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.

摘要翻译： 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的心肌营养因子-1基因的鉴定。 预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。 因此，被扩增的基因编码的心肌营养因子-1多肽被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。

公开(公告)号：US20070160618A1

公开(公告)日：2007-07-12

申请号：US11535254

申请日：2006-09-26

申请人： David Botstein ,  Audrey Goddard ,  David Lawrence ,  Diane Pennica ,  Margaret Roy ,  William Wood

发明人： David Botstein ,  Audrey Goddard ,  David Lawrence ,  Diane Pennica ,  Margaret Roy ,  William Wood

IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC分类号： C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/52 ,  C07K16/18 ,  C07K16/24 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N2333/52 ,  G01N2500/00

摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.

公开(公告)号：US20050042699A1

公开(公告)日：2005-02-24

申请号：US10895545

申请日：2004-07-21

申请人： David Botstein ,  Audrey Goddard ,  David Lawrence ,  Diane Pennica ,  Margaret Roy ,  William Wood

发明人： David Botstein ,  Audrey Goddard ,  David Lawrence ,  Diane Pennica ,  Margaret Roy ,  William Wood

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/52 ,  C07K16/18 ,  C07K16/24 ,  C12Q1/68 ,  A61K39/395 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/52 ,  C07K16/18 ,  C07K16/24 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N2333/52 ,  G01N2500/00

摘要： The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Acordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.

摘要翻译： 本发明涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的复合和方法。 本发明基于在肿瘤细胞基因组中扩增的心肌营养因子-1基因的鉴定。 预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。 因此，由扩增的基因编码的心肌营养因子-1多肽被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。

公开(公告)号：US20050014225A1

公开(公告)日：2005-01-20

申请号：US10858981

申请日：2004-06-01

申请人： David Botstein ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Margaret Roy ,  William Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Margaret Roy ,  William Wood

IPC分类号： C07H21/04 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/1709

摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20050176104A1

公开(公告)日：2005-08-11

申请号：US11052503

申请日：2005-02-04

申请人： Audrey Goddard ,  Paul Godowski ,  Austin Gurney ,  James Pan ,  Margaret Roy ,  William Wood

发明人： Audrey Goddard ,  Paul Godowski ,  Austin Gurney ,  James Pan ,  Margaret Roy ,  William Wood

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K14/82 ,  C07K16/30 ,  C07K16/40 ,  C12N5/06 ,  C12N5/16 ,  C12N15/00 ,  C12P21/02 ,  C12P21/04

CPC分类号： C07K16/30

摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。 预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。