公开(公告)号：US20060154949A1

公开(公告)日：2006-07-13

申请号：US11042281

申请日：2005-01-24

Applicant: Geoffrey Heintzelman ,  Kristin Averill ,  John Dodd ,  Keith Demarest ,  Yuting Tang ,  Paul Jackson

Inventor： Geoffrey Heintzelman ,  Kristin Averill ,  John Dodd ,  Keith Demarest ,  Yuting Tang ,  Paul Jackson

IPC: A61K31/473

CPC classification number: C07D221/16 ,  A61K31/473 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D491/04

Abstract: This invention provides novel arylindenopyridines of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing Adensine A2a receptors or reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

Abstract translation: 本发明提供了新颖的具有下列结构式的Ar 3吲哚并吡啶：和包含该化合物的药物组合物，其可用于治疗通过拮抗Adensine A2a受体或降低适当细胞中PDE活性而改善的病症。 本发明还提供了使用本发明的药物组合物的治疗和预防方法。

公开(公告)号：US20060094581A1

公开(公告)日：2006-05-04

申请号：US10975903

申请日：2004-10-28

Applicant: Paul Jackson

Inventor： Paul Jackson

IPC: B31B1/86

CPC classification number: B65D33/1658 ,  B31B70/004 ,  B65D33/08

Abstract: A bag for granular products, made of heat sealable film, having an integral handle within the top sealed portion of the bag that fits into and is secured within an opening in the bottom sealed portion of the bag, whereby the bag can be securely re-closed after opening by folding the top portion of the bag over toward the bottom portion of the bag, and securing the integral handle within the opening.

Abstract translation: 一种由热封膜制成的颗粒状产品袋，在袋的顶部密封部分内具有一体的手柄，该袋子装配并固定在袋的底部密封部分的开口内，从而可以牢固地重新包装袋子， 通过将袋的顶部部分折叠到袋子的底部部分，并将整体手柄固定在开口内，打开后关闭。

公开(公告)号：US20050171065A1

公开(公告)日：2005-08-04

申请号：US11051188

申请日：2005-02-07

Applicant: Paul Jackson ,  Takashi Tsukamoto ,  Barbara Slusher ,  Eric Wang

Inventor： Paul Jackson ,  Takashi Tsukamoto ,  Barbara Slusher ,  Eric Wang

IPC: A61P13/08 ,  A61P21/00 ,  A61P27/06 ,  C07C63/307 ,  C07C63/68 ,  C07C65/05 ,  C07C65/40 ,  C07C229/38 ,  C07C229/60 ,  C07C235/80 ,  C07C259/06 ,  C07C259/10 ,  C07C317/44 ,  C07C323/12 ,  C07C323/56 ,  C07C323/62 ,  C07D231/06 ,  C07D307/52 ,  C07F9/38 ,  C07F9/28 ,  A61K31/195 ,  A61K31/4152 ,  A61K31/66 ,  C07C237/20

CPC classification number: C07D231/06 ,  C07C63/307 ,  C07C63/68 ,  C07C65/05 ,  C07C65/40 ,  C07C229/38 ,  C07C229/60 ,  C07C235/80 ,  C07C259/06 ,  C07C259/10 ,  C07C317/44 ,  C07C323/12 ,  C07C323/56 ,  C07C323/62 ,  C07D307/52 ,  C07F9/3834 ,  C07F9/3882

Abstract: New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnostic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.