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公开(公告)号：US20060258666A1
公开(公告)日：2006-11-16
申请号：US11407605
申请日：2006-04-20
申请人： Mark Player , Nand Baindur , Benjamin Brandt , Naresh Chadha , Raymond Patch , Davoud Asgari , Taxiarchis Georgiadis
发明人： Mark Player , Nand Baindur , Benjamin Brandt , Naresh Chadha , Raymond Patch , Davoud Asgari , Taxiarchis Georgiadis
IPC分类号： A61K31/501 , A61K31/454 , A61K31/4439 , A61K31/4172 , C07D403/02
CPC分类号： C07D405/12 , C07D307/68 , C07D409/12
摘要： The invention is directed to compounds of Formula II: wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.
摘要翻译： 本发明涉及式II的化合物：其中A，R 1，R 2，R 3，R 4， 说明书中列出了X，Y和W，以及其抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体或其药学上可接受的盐。
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公开(公告)号：US07101907B2
公开(公告)日：2006-09-05
申请号：US10652159
申请日：2003-08-29
申请人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo , Gregory R. Mundy
发明人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo , Gregory R. Mundy
IPC分类号： A61K31/335
CPC分类号： C07D215/14 , A23L33/10 , A61K31/00 , A61K31/192 , A61K31/22 , A61K31/225 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/505 , A61K45/06 , A61K2300/00
摘要： The topical administration of statins for the treatment of bone disorders is disclosed.
摘要翻译： 公开了用于治疗骨骼疾病的他汀类药物的局部给药。
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公开(公告)号：US20050245615A1
公开(公告)日：2005-11-03
申请号：US11062481
申请日：2005-02-23
申请人： Mark Burns , Gerard Graminski , Nand Baindur , Reitha Weeks
发明人： Mark Burns , Gerard Graminski , Nand Baindur , Reitha Weeks
IPC分类号： C07C237/10 , C07C237/22 , C07C255/24 , C07C311/06 , C07C311/19 , C07C311/42 , C07D233/61 , C07D307/68 , C07D333/34 , A61K31/16
CPC分类号： C07C237/10 , C07C237/22 , C07C255/24 , C07C311/06 , C07C311/19 , C07C311/42 , C07C2601/04 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D307/68 , C07D333/34
摘要： Proliferative cutaneous disease states or conditions are treated by administering a polyamine transport inhibitor R-X-L-polyamine wherein R is a straight or branched C10-50 saturated or unsaturated aliphatic, carboxyalkyl, carbalkoxyalkyl, or alkoxy; a C1-8 alicyclic; a single or multiring aryl substituted or unsubstituted aliphatic; and aliphatic-substituted or unsubstituted single or multiring aromatic; a single or multiring heterocyclic; a single or multiring heterocyclic aliphatic; an aryl sulfonyl; X is —CO—, —SO2—, or —CH2—; and L is a covalent bond or a naturally occurring amino acid, lysine, ornithine, 2,4-diaminobutyric acid, or pharmaceutically acceptable salts thereof or prodrug thereof, and a polyamine biosynthesis inhibitor.
摘要翻译： 通过施用多胺转运抑制剂<？in-line-formula description =“In-Line Formulas”end =“lead”→> RXL-多胺<？in-line-formula description =“In”来治疗增生性皮肤疾病状态或病症 其中R是直链或支链的C10-50饱和或不饱和脂族，羧基烷基，烷氧基烷基或烷氧基; C1-8脂环族 单或多芳基取代或未取代的脂族基; 和脂族取代或未取代的单或多芳族芳族; 单一或多重杂环; 单一或多重杂环脂肪族; 芳基磺酰基; X是-CO - ， - SO 2 - 或-CH 2 - 。 L是共价键或天然存在的氨基酸，赖氨酸，鸟氨酸，2,4-二氨基丁酸或其药学上可接受的盐或其前药，以及多胺生物合成抑制剂。
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公开(公告)号：US06762044B2
公开(公告)日：2004-07-13
申请号：US10177308
申请日：2002-06-21
申请人： Paul O. Sheppard , Nand Baindur , Paul D. Bishop
发明人： Paul O. Sheppard , Nand Baindur , Paul D. Bishop
IPC分类号： C12N948
CPC分类号： C12N9/6489 , A61K38/00
摘要： The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for MAPP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the MAPP polypeptides.
摘要翻译： 本发明涉及针对MAPP的多核苷酸和多肽分子及其变体，其是解聚酶蛋白酶的新成员。 多肽和编码它们的多核苷酸是细胞 - 细胞相互作用调控，可用于递送和治疗。 本发明还包括针对MAPP多肽的抗体。
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公开(公告)号：US06576755B1
公开(公告)日：2003-06-10
申请号：US09636399
申请日：2000-08-10
IPC分类号： C12N1512
CPC分类号： C07K14/4723 , A61K38/00 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the &bgr;-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
摘要翻译： 本发明涉及zamp1的多核苷酸和多肽分子，其是β-防御素家族的新成员。 多肽和编码它们的多核苷酸表现出抗微生物活性，并可用于微生物感染的研究或治疗。 本发明还包括针对zamp1多肽的抗体。
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公开(公告)号：US06420154B1
公开(公告)日：2002-07-16
申请号：US09632098
申请日：2000-08-02
申请人： Paul O. Sheppard , Nand Baindur , Paul D. Bishop
发明人： Paul O. Sheppard , Nand Baindur , Paul D. Bishop
IPC分类号： C12N948
CPC分类号： C12N9/6489 , A61K38/00
摘要： The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for MAPP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the MAPP polypeptides.
摘要翻译： 本发明涉及针对MAPP的多核苷酸和多肽分子及其变体，其是解聚酶蛋白酶的新成员。 多肽和编码它们的多核苷酸是细胞 - 细胞相互作用调控，可用于递送和治疗。 本发明还包括针对MAPP多肽的抗体。
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公开(公告)号：US6008208A
公开(公告)日：1999-12-28
申请号：US878868
申请日：1997-06-19
申请人： Charles Petrie , Mark W. Orme , Nand Baindur , Kirk G. Robbins , Scott M. Harris , Maria Kontoyianni , Gregory R. Mundy
发明人： Charles Petrie , Mark W. Orme , Nand Baindur , Kirk G. Robbins , Scott M. Harris , Maria Kontoyianni , Gregory R. Mundy
IPC分类号： A61K31/47 , A61K31/549 , A61K31/655 , A61K31/35 , A61K31/495
CPC分类号： A61K31/47 , A61K31/549 , A61K31/655
摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.
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公开(公告)号：US5948776A
公开(公告)日：1999-09-07
申请号：US808739
申请日：1997-02-28
IPC分类号： A61K31/196 , A61K31/4184 , A61K31/428 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/53 , A61K31/655 , A61K31/165 , A61K31/215 , A61K31/33
CPC分类号： A61K31/655 , A61K31/196 , A61K31/4184 , A61K31/428 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/53
摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15.ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.
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39.发明授权Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis 有权用于合成烷基喹啉和烷基喹唑啉激酶调节剂的中间体及其相关合成方法公开(公告)号：US07825244B2
公开(公告)日：2010-11-02
申请号：US11422352
申请日：2006-06-06
IPC分类号： C07D239/88 , C07D239/94 , C07D215/12 , C07D215/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14
摘要： The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: wherein R1, R2, R99, and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
摘要翻译： 本发明涉及式C的烷基喹啉和烷基喹唑啉化合物：其中R1，R2，R99和X如本文所定义，这些化合物在合成蛋白酪氨酸激酶抑制剂，特别是FLT3和/或c- 套件和/或TrkB。
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公开(公告)号：US07432302B2
公开(公告)日：2008-10-07
申请号：US11062481
申请日：2005-02-23
IPC分类号： A61K31/65
CPC分类号： C07C237/10 , C07C237/22 , C07C255/24 , C07C311/06 , C07C311/19 , C07C311/42 , C07C2601/04 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D307/68 , C07D333/34
摘要： Proliferative cutaneous disease states or conditions are treated by administering a polyamine transport inhibitor R-X-L-polyamine wherein R is a straight or branched C10-50 saturated or unsaturated aliphatic, carboxyalkyl, carbalkoxyalkyl, or alkoxy; a C1-8 alicyclic; a single or multiring aryl substituted or unsubstituted aliphatic; and aliphatic-substituted or unsubstituted single or multiring aromatic; a single or multiring heterocyclic; a single or multiring heterocyclic aliphatic; an aryl sulfonyl; X is —CO—, —SO2—, or —CH2—; and L is a covalent bond or a naturally occurring amino acid, lysine, ornithine, 2,4-diaminobutyric acid, or pharmaceutically acceptable salts thereof or prodrug thereof, and a polyamine biosynthesis inhibitor.
摘要翻译： 通过施用多胺转运抑制剂<？in-line-formula description =“In-Line Formulas”end =“lead”→> RXL-多胺<？in-line-formula description =“In”来治疗增生性皮肤疾病状态或病症 其中R是直链或支链的C10-50饱和或不饱和脂族，羧基烷基，烷氧基烷基或烷氧基; C1-8脂环族 单或多芳基取代或未取代的脂族基; 和脂族取代或未取代的单或多芳族芳族; 单一或多重杂环; 单一或多重杂环脂肪族; 芳基磺酰基; X是-CO - ， - SO 2 - 或-CH 2 - 。 L是共价键或天然存在的氨基酸，赖氨酸，鸟氨酸，2,4-二氨基丁酸或其药学上可接受的盐或其前药，以及多胺生物合成抑制剂。
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