公开(公告)号：US12297508B2

公开(公告)日：2025-05-13

申请号：US17960026

申请日：2022-10-04

Applicant: Personalis, Inc.

Inventor： John West ,  Laurie Goodman ,  Richard Chen

IPC: C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6874 ,  G16B30/10 ,  G16H10/40

Abstract: The present disclosure provides methods and systems for personalized genetic testing of disease in a subject, in particular for identifying and tracking genetic mutations identified in an individual subject to monitor for cancer or for the spread or recurrence of the disease. In some embodiments, custom assays, including custom panels designed to target sequence data corresponding to both subject-specific loci and other loci known for cancer-causing or therapy resistance mutations, are designed based upon the sequencing of a screening biopsy sample. Such custom assays are then run on subsequently obtained tissue samples, such as tissue obtained from a surgical resection of a primary or metastatic tumor or from a lymph node biopsy. The subsequently obtained tissue samples can be taken from the subject at various time points after an initial screening biopsy to further allow for extended monitoring of the subject for spread or recurrence of the disease.

公开(公告)号：US20240200136A1

公开(公告)日：2024-06-20

申请号：US18593406

申请日：2024-03-01

Applicant: Personalis, Inc.

Inventor： John West ,  Christian Haudenschild ,  Richard Chen

IPC: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B20/00 ,  G16B30/00 ,  G16B35/00 ,  G16B99/00 ,  G16C20/60

CPC classification number: C12Q1/6874 ,  C12Q1/6806 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  C12Q1/6869 ,  G16B35/00 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US11952625B2

公开(公告)日：2024-04-09

申请号：US18179582

申请日：2023-03-07

Applicant: Personalis, Inc.

Inventor： John West ,  Christian Haudenschild ,  Richard Chen

IPC: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B20/00 ,  G16B30/00 ,  G16B35/00 ,  G16B99/00 ,  G16C20/60

CPC classification number: C12Q1/6874 ,  C12Q1/6806 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  C12Q1/6869 ,  G16B35/00 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US11591653B2

公开(公告)日：2023-02-28

申请号：US17744205

申请日：2022-05-13

Applicant: Personalis, Inc.

Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Shujun Luo ,  Mark R. Pratt ,  John West

IPC: C12Q1/6874 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  G16B20/10 ,  G16B20/20 ,  G16B35/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B35/00 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US11408033B2

公开(公告)日：2022-08-09

申请号：US17078857

申请日：2020-10-23

Applicant: Personalis, Inc.

Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Shujun Luo ,  Mark R. Pratt ,  John West

IPC: C12Q1/6874 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  G16B20/10 ,  G16B20/20 ,  G16B35/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B35/00 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US11384394B2

公开(公告)日：2022-07-12

申请号：US17548379

申请日：2021-12-10

Applicant: Personalis, Inc.

Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Shujun Luo ,  Mark R. Pratt ,  John West

IPC: C12Q1/6874 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  G16B20/10 ,  G16B20/20 ,  G16B35/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B35/00 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US20210238677A1

公开(公告)日：2021-08-05

申请号：US17235776

申请日：2021-04-20

Applicant: Personalis, Inc.

Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Shujun Luo ,  Mark R. Pratt ,  John West

IPC: C12Q1/6874 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  C12Q1/6806

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US20210054452A1

公开(公告)日：2021-02-25

申请号：US17032959

申请日：2020-09-25

Applicant: Personalis, Inc.

Inventor： John West ,  Richard Chen ,  Christian Haudenschild ,  Gabor Bartha ,  Shujun Luo

IPC: C12Q1/6874 ,  C12Q1/6886 ,  C12Q1/689 ,  C12Q1/70

Abstract: Provided herein are compositions, methods, and systems for sample processing and/or data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample from a human, non-human, and combinations thereof.

公开(公告)号：US10266890B2

公开(公告)日：2019-04-23

申请号：US14810337

申请日：2015-07-27

Applicant: Personalis, Inc.

Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Shujun Luo ,  Mark R. Pratt ,  John West

IPC: C12Q1/68 ,  G06F19/10 ,  G06F19/18 ,  G06F19/22 ,  C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6869 ,  C40B50/02

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US20180051338A1

公开(公告)日：2018-02-22

申请号：US15793845

申请日：2017-10-25

Applicant: Personalis, Inc.

Inventor： John West ,  Christian Haudenschild ,  Richard Chen

IPC: C12Q1/68 ,  G06F19/22

CPC classification number: C12Q1/6883 ,  C12Q1/68 ,  C12Q1/6853 ,  C12Q1/6869 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00

Abstract: The present disclosure provides methods and systems for personalized genetic testing of a subject. In some embodiments, a sequencing assay is performed on a biological sample from the subject, which then leads to genetic information related to the subject. Next, nucleic acid molecules are array-synthesized or selected based on the genetic information derived from data of the sequencing assay. At least some of the nucleic acid molecules may then be used in an assay which may provide additional information on one or more biological samples from the subject or a biological relative of the subject.