公开(公告)号：US20240361243A1

公开(公告)日：2024-10-31

申请号：US18626595

申请日：2024-04-04

Applicant: PHOTOTHERMAL SPECTROSCOPY CORP.

Inventor： Craig Prater

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  G01N21/6486 ,  G01N2201/062 ,  G01N2201/0636

Abstract: Methods and systems described herein detect autofluorescence of a sample. These methods and systems obviate the need for addition of fluorophores to samples to create IR absorption

公开(公告)号：US20240044782A1

公开(公告)日：2024-02-08

申请号：US18452023

申请日：2023-08-18

Applicant: Photothermal Spectroscopy Corp.

Inventor： Craig Prater ,  David Grigg ,  Derek Decker

IPC: G01N21/35 ,  G02B21/00 ,  G01J3/45

CPC classification number: G01N21/35 ,  G02B21/002 ,  G01J3/45

Abstract: Asymmetric interferometry is used with various embodiments of Optical Photothermal Infrared (OPTIR) systems to enhance the signal strength indicating the photothermal effect on a sample.

公开(公告)号：US11885745B2

公开(公告)日：2024-01-30

申请号：US17872418

申请日：2022-07-25

Applicant: Photothermal Spectroscopy Corp.

Inventor： Craig Prater

IPC: G01N21/64 ,  G01N21/359 ,  G01J3/02 ,  G01N21/3563 ,  G01N21/35

CPC classification number: G01N21/645 ,  G01J3/0227 ,  G01N21/359 ,  G01N21/3563 ,  G01N21/6428 ,  G01N21/6456 ,  G01N2021/3595 ,  G01N2021/6439 ,  G01N2021/6471

Abstract: Embodiments disclosed include methods and apparatus for Fluorescent Enhanced Photothermal Infrared (FE-PTIR) spectroscopy and chemical imaging, which enables high sensitivity and high spatial resolution measurements of IR absorption with simultaneous confocal fluorescence imaging. In various embodiments, the FE-PTIR technique utilizes combined/simultaneous OPTIR and fluorescence imaging that provides significant improvements and benefits compared to previous work by simultaneous detection of both IR absorption and confocal fluorescence using the same optical detector at the same time.

公开(公告)号：US20240011830A1

公开(公告)日：2024-01-11

申请号：US18311748

申请日：2023-05-03

Applicant: Photothermal Spectroscopy Corp

Inventor： Derek Decker ,  Craig Prater

IPC: G01J3/02 ,  G01J3/10

CPC classification number: G01J3/0297 ,  G01J3/0216 ,  G01J3/0229 ,  G01J3/108 ,  G01J2003/102

Abstract: Apparatuses and methods for microscopic analysis of a sample using spatial light manipulation to increase signal to noise ratio are described herein.

公开(公告)号：US11774354B2

公开(公告)日：2023-10-03

申请号：US17955131

申请日：2022-09-28

Applicant: Photothermal Spectroscopy Corp

Inventor： Craig Prater ,  David Grigg ,  Derek Decker

IPC: G01J3/45 ,  G01N21/35 ,  G02B21/00

CPC classification number: G01N21/35 ,  G01J3/45 ,  G02B21/002

Abstract: Asymmetric interferometry is used with various embodiments of Optical Photothermal Infrared (OPTIR) systems to enhance the signal strength indicating the photothermal effect on a sample.

公开(公告)号：US20230236118A1

公开(公告)日：2023-07-27

申请号：US17955131

申请日：2022-09-28

Applicant: Photothermal Spectroscopy Corp

Inventor： Craig Prater ,  David Grigg ,  Derek Decker

IPC: G01N21/35 ,  G02B21/00 ,  G01J3/45

CPC classification number: G01N21/35 ,  G02B21/002 ,  G01J3/45

Abstract: Asymmetric interferometry is used with various embodiments of Optical Photothermal Infrared (OPTIR) systems to enhance the signal strength indicating the photothermal effect on a sample.

公开(公告)号：US20230131208A1

公开(公告)日：2023-04-27

申请号：US17955122

申请日：2022-09-28

Applicant: Photothermal Spectroscopy Corp.

Inventor： Derek Decker ,  Craig Prater

IPC: G01J3/02 ,  G01J3/10

Abstract: Apparatuses and methods for microscopic analysis of a sample using spatial light manipulation to increase signal to noise ratio are described herein.

公开(公告)号：US20220357275A1

公开(公告)日：2022-11-10

申请号：US17872418

申请日：2022-07-25

Applicant: Photothermal Spectroscopy Corp.

Inventor： Craig Prater

IPC: G01N21/64 ,  G01N21/359 ,  G01J3/02

Abstract: Embodiments disclosed include methods and apparatus for Fluorescent Enhanced Photothermal Infrared (FE-PTIR) spectroscopy and chemical imaging, which enables high sensitivity and high spatial resolution measurements of IR absorption with simultaneous confocal fluorescence imaging. In various embodiments, the FE-PTIR technique utilizes combined/simultaneous OPTIR and fluorescence imaging that provides significant improvements and benefits compared to previous work by simultaneous detection of both IR absorption and confocal fluorescence using the same optical detector at the same time.

公开(公告)号：US20220018773A1

公开(公告)日：2022-01-20

申请号：US17381021

申请日：2021-07-20

Applicant: Photothermal Spectroscopy Corp.

Inventor： Craig Prater

IPC: G01N21/64 ,  G01N21/359 ,  G01J3/02

Abstract: Embodiments disclosed include methods and apparatus for Fluorescent Enhanced Photothermal Infrared (FE-PTIR) spectroscopy and chemical imaging, which enables high sensitivity and high spatial resolution measurements of IR absorption with simultaneous confocal fluorescence imaging. In various embodiments, the FE-PTIR technique utilizes combined/simultaneous OPTIR and fluorescence imaging that provides significant improvements and benefits compared to previous work by simultaneous detection of both IR absorption and confocal fluorescence using the same optical detector at the same time.