利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

46 条记录 (耗时 0.025 秒)

    2-Benzoyl-4-nitroanilides and their use as medicaments
    31.
    发明授权
    2-Benzoyl-4-nitroanilides and their use as medicaments 失效
    2-苯甲酰基-4-硝基酰苯胺及其作为药物的用途

    公开(公告)号：US4289770A

    公开(公告)日：1981-09-15

    申请号：US159070

    申请日：1980-06-13

    申请人： Henri Cousse ,  Gilbert Mouzin

    发明人： Henri Cousse ,  Gilbert Mouzin

    IPC分类号： C07D295/15 ,  A61K31/535 ,  A61K31/16 ,  C07C103/183 ,  C07D295/14

    CPC分类号： C07D295/15

    摘要： New derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicaments.The new chemical derivatives of the invention have the general formula ##STR1## in which R represents a linear or branched alkyl group, an alkenyl group, a cycloalkyl group or a benzyl group,R.sub.1 represents a hydrogen atom, an alkyl group or a hydroxy alkyl group,R.sub.2 represents a hydroxy-alkyl, alkenyl or alkynyl group, possibly substituted one or more times by an alkyl radical, or a cycloalkyl group having three to six carbon atoms;R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are attached, a nitrogen heterocycle containing possibly a second heteroatom selected from among oxygen and nitrogen;under the condition, however, that when R.sub.2 represents a hydroxy-alkyl group R.sub.1 may not be a hydrogen atom.Use as hypnotic agents for the treatment of insomnia.

    摘要翻译： 2-苯甲酰基-4-硝基苯胺的新衍生物，其制备及其作为药物的用途。 本发明的新化学衍生物具有通式“IMAGE”，其中R表示直链或支链烷基，烯基，环烷基或苄基，R1表示氢原子，烷基或羟基烷基 基团，R 2表示羟基 - 烷基，烯基或炔基，可能被烷基或具有3-6个碳原子的环烷基取代一次或多次; R1和R2可以与它们所连接的氮原子形成含有可能含有选自氧和氮的第二杂原子的氮杂环; 然而，在这种条件下，当R 2表示羟基 - 烷基时，R 1可以不是氢原子。 用作催眠药物治疗失眠。

    Analgesic (3-micotinamido-N(quinolyl) anthranilates and method of use
    34.
    发明授权
    Analgesic (3-micotinamido-N(quinolyl) anthranilates and method of use 失效
    止痛剂（3-吡啶甲酰氨基-N（喹啉基）邻氨基苯甲酸酯及其使用方法

    公开(公告)号：US4122181A

    公开(公告)日：1978-10-24

    申请号：US749230

    申请日：1976-12-10

    申请人： Henri Cousse ,  Gilbert Mouzin

    发明人： Henri Cousse ,  Gilbert Mouzin

    IPC分类号： C07D213/82 ,  A61K31/47 ,  C07D215/44

    CPC分类号： C07D213/82

    摘要： The invention concerns new chemical compounds which can be used as medicaments, their preparation, and pharmaceutical compositions, and method of treating therewith.The new chemical compounds have the general formula ##STR1## in which X, which is in 7 position, represents a halogen atom or a trifluoromethyl group.The medicaments containing these active principles may be used in the treatment of various pains, i.e., as analgesics.

    摘要翻译： 本发明涉及可用作药物的新化合物，其制备方法和药物组合物及其处理方法。

    Aromatic keto acids and derivatives having analgetic, antiinflammatory, and hypocholesterolemizing action
    35.
    发明授权
    Aromatic keto acids and derivatives having analgetic, antiinflammatory, and hypocholesterolemizing action 失效
    具有止痛，抗炎和低胆固醇作用的芳香酮酸和衍生物

    公开(公告)号：US4058558A

    公开(公告)日：1977-11-15

    申请号：US560946

    申请日：1975-03-21

    申请人： Henri Cousse ,  Gilbert Mouzin ,  Jean-Pierre Rieu

    发明人： Henri Cousse ,  Gilbert Mouzin ,  Jean-Pierre Rieu

    IPC分类号： C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C59/90 ,  C07D295/185 ,  C07C63/33 ,  A61K31/19

    CPC分类号： C07D295/185 ,  C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C59/90

    摘要： This invention relates to new chemical compounds useful as drugs, as well as to pharmaceutical compositions containing the same.The new products are aromatic keto acid compounds with antiinflammatory as well as analgetic and hypocholesteremic activity and having the general formula ##STR1## wherein R.sub.1 is hydrogen, halogen, phenyl, halophenyl, phenoxy, or substituted phenoxy.R.sub.2 is hydrogen or alkoxy.R.sub.1 and R.sub.2 may form a ring, for instance: phenyl or cyclohexyl.R.sub.3 is always other than hydrogen, being either methyl (CH.sub.3) or methylene. When R.sub.3 is CH.sub.3, a double bond is present between the A and B carbons. When R.sub.3 is a methylene connected by a double bond to the B carbon, there can be only a single bond between the A and B carbons. The remaining valences of the A carbon atom are satisfied by hydrogen atoms.R.sub.4 may be OH, alkoxy, ##STR2##The drugs containing these active principles are useful in the prevention and treatment of inflammatory syndromes, pain, and conditions involving excess cholresterol.

    摘要翻译： 本发明涉及可用作药物的新化合物，以及含有该化合物的药物组合物。

    Method of reducing cholesterol using certain aromatic keto acids
    36.
    发明授权
    Method of reducing cholesterol using certain aromatic keto acids 失效
    使用某些芳香族酮酸降低胆固醇的方法

    公开(公告)号：US4008323A

    公开(公告)日：1977-02-15

    申请号：US560344

    申请日：1975-03-21

    申请人： Henri Cousse ,  Gilbert Mouzin ,  Jean-Pierre Rieu ,  Andre Delhon

    发明人： Henri Cousse ,  Gilbert Mouzin ,  Jean-Pierre Rieu ,  Andre Delhon

    IPC分类号： C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C59/90 ,  C07D295/185 ,  A61K31/495 ,  A61K31/19 ,  A61K31/205 ,  A61K31/235

    CPC分类号： C07D295/185 ,  C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C59/90

    摘要： This invention relates to new chemical compounds useful as drugs, as well as to pharmaceutical compositions containing the same. This application claims their hypocholesterolemic use.The new products are aromatic keto acid compounds with antiinflammatory as well as analgetic and hypocholesteremic acitvity and having the general formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, phenyl, halophenyl, alkyl, phenoxy, or substituted phenoxy.R.sub.2 is hydrogen or alkoxy. R.sub.1 and R.sub.2 may form a ring, for instance: phenyl or cyclohexyl. R.sub.3 is always other than hydrogen, being either methyl (CH.sub.3) or methylene.When R.sub.3 is CH.sub.3, a double bond is present between the A and B carbons. When R.sub.3 is a methylene connected by a double bond to the B carbon, there can be only a single bond between the A and B carbons. The remaining valences of the A carbon atom are satisfied by hydrogen atoms.R.sub.4 may be OH, alkoxy, ##STR2## The drugs containing these active principles are useful in the prevention and treatment of inflammatory syndromes, pain, and conditions involving excess chloresterol.

    摘要翻译： 本发明涉及可用作药物的新化合物，以及含有该化合物的药物组合物。 本申请要求其低胆固醇血症用途。

    Medicaments having psychotropic properties (antitussives)
    37.
    发明授权
    Medicaments having psychotropic properties (antitussives) 失效
    具有精神药性的药物（镇咳药）

    公开(公告)号：US3958002A

    公开(公告)日：1976-05-18

    申请号：US538754

    申请日：1975-01-06

    申请人： Antoine Stenger ,  Henri Cousse ,  Gilbert Mouzin

    发明人： Antoine Stenger ,  Henri Cousse ,  Gilbert Mouzin

    IPC分类号： C07D295/13 ,  C07D307/68 ,  C07D207/08

    CPC分类号： C07D295/13 ,  C07D307/68

    摘要： 5-Bromo-N-(N.sup.1 -pyrrolidino-alkyl)-ortho-cresotamides having 2 to 5 carbon atoms in the alkyl moiety and therapeutically acceptable salts thereof, compositions containing such compounds useful as antitussives, and a method of suppressing of a cough in a host by administering an effective amount of such a compound with a pharmaceutically acceptable excipient. 5-Bromo-ortho-cresotamide may also be named 5-bromo-2-hydroxy-3-methyl-benzamide.

    摘要翻译： 在烷基部分具有2-5个碳原子的5-溴-N-（N-氨基 - 吡咯烷基 - 烷基） - 对 - 甲酚酰胺及其治疗上可接受的盐，含有用作镇咳药的化合物的组合物，以及抑制咳嗽的方法 通过将有效量的这种化合物与药学上可接受的赋形剂一起给予宿主。 5-溴 - 邻甲酚酰胺也可以称为5-溴-2-羟基-3-甲基 - 苯甲酰胺。

    Use of a Serenoa repens extract for the production of a medicament to treat prostate cancer
    39.
    发明授权
    Use of a Serenoa repens extract for the production of a medicament to treat prostate cancer 有权
    使用Serenoa repens提取物生产用于治疗前列腺癌的药物

    公开(公告)号：US06599540B1

    公开(公告)日：2003-07-29

    申请号：US09937676

    申请日：2001-09-28

    申请人： Pierre Fabre ,  Jean-Pierre Raynaud ,  Henri Cousse

    发明人： Pierre Fabre ,  Jean-Pierre Raynaud ,  Henri Cousse

    IPC分类号： A61K3578

    CPC分类号： A61K36/889 ,  A61K2300/00

    摘要： The invention relates to the use of a lipido-sterolic Serenoa repens extract for the production of a medicament which is administered in an isolated manner or in an associated manner, in a simultaneous, separated or staggered manner, with prostatectomy, radiotherapy and/or hormonotherapy in order to prevent and/or treat prostate cancer.

    摘要翻译： 本发明涉及使用脂质 - 甾体Serenoa repens提取物来生产药物，其以前列腺切除术，放射治疗和/或激素治疗以同时，分离或交错的方式以孤立的方式或以相关联的方式施用 以预防和/或治疗前列腺癌。

    Derivatives of phenoxy isobutyric acid having hypolipemizing and hypocholesterolemizing action
    40.
    发明授权
    Derivatives of phenoxy isobutyric acid having hypolipemizing and hypocholesterolemizing action 失效
    具有高效和高脂肪氧化活性的苯氧基异丁酸的衍生物

    公开(公告)号：US3987175A

    公开(公告)日：1976-10-19

    申请号：US577402

    申请日：1975-05-14

    申请人： Henri Cousse

    发明人： Henri Cousse

    IPC分类号： C07D213/82 ,  C07D213/89 ,  C07D213/56 ,  A61K31/455 ,  C07D213/90

    CPC分类号： C07D213/82 ,  C07D213/89

    摘要： The present invention relates to new chemical products which are useful as hypolipemizing and hypocholesterolemizing agents.The new compounds are derivatives of phenoxy isobutyric acid of the general formula ##EQU1## wherein: A is a lower-alkylene bridge of 2 to 6 carbon atoms, either linear or branched,X is a halogen atom,R = h or lower-alkyl,The N of the pyridyl ring can be replaced by an N-oxide, or the compounds can be in the form of their pharmaceutically-acceptable acid addition salts.Pharmaceutical compositions containing these active principles are useful for hypolipemizing and hypocholesterolemizing purposes, e.g., in the prevention and treatment of atherosclerosis and its consequences.