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46 条记录 (耗时 0.02 秒)

    Aromatic keto acids and derivatives having analgetic, antiinflammatory, and hypocholesterolemizing action
    3.
    发明授权
    Aromatic keto acids and derivatives having analgetic, antiinflammatory, and hypocholesterolemizing action 失效
    具有止痛，抗炎和低胆固醇作用的芳香酮酸和衍生物

    公开(公告)号：US4058558A

    公开(公告)日：1977-11-15

    申请号：US560946

    申请日：1975-03-21

    申请人： Henri Cousse ,  Gilbert Mouzin ,  Jean-Pierre Rieu

    发明人： Henri Cousse ,  Gilbert Mouzin ,  Jean-Pierre Rieu

    IPC分类号： C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C59/90 ,  C07D295/185 ,  C07C63/33 ,  A61K31/19

    CPC分类号： C07D295/185 ,  C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C59/90

    摘要： This invention relates to new chemical compounds useful as drugs, as well as to pharmaceutical compositions containing the same.The new products are aromatic keto acid compounds with antiinflammatory as well as analgetic and hypocholesteremic activity and having the general formula ##STR1## wherein R.sub.1 is hydrogen, halogen, phenyl, halophenyl, phenoxy, or substituted phenoxy.R.sub.2 is hydrogen or alkoxy.R.sub.1 and R.sub.2 may form a ring, for instance: phenyl or cyclohexyl.R.sub.3 is always other than hydrogen, being either methyl (CH.sub.3) or methylene. When R.sub.3 is CH.sub.3, a double bond is present between the A and B carbons. When R.sub.3 is a methylene connected by a double bond to the B carbon, there can be only a single bond between the A and B carbons. The remaining valences of the A carbon atom are satisfied by hydrogen atoms.R.sub.4 may be OH, alkoxy, ##STR2##The drugs containing these active principles are useful in the prevention and treatment of inflammatory syndromes, pain, and conditions involving excess cholresterol.

    摘要翻译： 本发明涉及可用作药物的新化合物，以及含有该化合物的药物组合物。

    Method of reducing cholesterol using certain aromatic keto acids
    4.
    发明授权
    Method of reducing cholesterol using certain aromatic keto acids 失效
    使用某些芳香族酮酸降低胆固醇的方法

    公开(公告)号：US4008323A

    公开(公告)日：1977-02-15

    申请号：US560344

    申请日：1975-03-21

    申请人： Henri Cousse ,  Gilbert Mouzin ,  Jean-Pierre Rieu ,  Andre Delhon

    发明人： Henri Cousse ,  Gilbert Mouzin ,  Jean-Pierre Rieu ,  Andre Delhon

    IPC分类号： C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C59/90 ,  C07D295/185 ,  A61K31/495 ,  A61K31/19 ,  A61K31/205 ,  A61K31/235

    CPC分类号： C07D295/185 ,  C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C59/90

    摘要： This invention relates to new chemical compounds useful as drugs, as well as to pharmaceutical compositions containing the same. This application claims their hypocholesterolemic use.The new products are aromatic keto acid compounds with antiinflammatory as well as analgetic and hypocholesteremic acitvity and having the general formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, phenyl, halophenyl, alkyl, phenoxy, or substituted phenoxy.R.sub.2 is hydrogen or alkoxy. R.sub.1 and R.sub.2 may form a ring, for instance: phenyl or cyclohexyl. R.sub.3 is always other than hydrogen, being either methyl (CH.sub.3) or methylene.When R.sub.3 is CH.sub.3, a double bond is present between the A and B carbons. When R.sub.3 is a methylene connected by a double bond to the B carbon, there can be only a single bond between the A and B carbons. The remaining valences of the A carbon atom are satisfied by hydrogen atoms.R.sub.4 may be OH, alkoxy, ##STR2## The drugs containing these active principles are useful in the prevention and treatment of inflammatory syndromes, pain, and conditions involving excess chloresterol.

    摘要翻译： 本发明涉及可用作药物的新化合物，以及含有该化合物的药物组合物。 本申请要求其低胆固醇血症用途。

    2'-(Orthochlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and use as medicaments
    7.
    发明授权
    2'-(Orthochlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and use as medicaments 失效
    2' - （邻氯苯甲酰基）-4'-氯草酰酰苯胺及其组合物，并用作药物

    公开(公告)号：US4382930A

    公开(公告)日：1983-05-10

    申请号：US220514

    申请日：1980-12-29

    申请人： Gilbert Mouzin ,  Henri Cousse ,  Antoine Stenger

    发明人： Gilbert Mouzin ,  Henri Cousse ,  Antoine Stenger

    IPC分类号： A61K31/165 ,  A61K31/535 ,  A61P21/02 ,  A61P25/18 ,  A61P25/20 ,  C07C231/12 ,  C07C237/04 ,  C07C237/06 ,  C07C275/38 ,  C07D295/15 ,  C07D295/14

    CPC分类号： C07D295/15 ,  Y10S514/96 ,  Y10S514/962 ,  Y10S514/966

    摘要： The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.

    摘要翻译： 本发明涉及2' - （邻氯苯甲酰基）-4'-氯草酰苯胺，其组合物及其作为药物的用途，例如作为抗焦虑剂。 本发明的化合物具有通式I（I）其中R表示氢或烷基，R 1和R 2可以相同或不同，并且选自氢，烷基，羟基烷基，烯基和炔基，可能被 烷基和具有3至6个成员的环烷基，可能被烷基取代，条件是当R 1和R 2之一表示氢时，另一个不是低级烷基或羟烷基; 并且进一步的条件是R 1和R 2可以不同时表示氢或低级烷基。 R1和R2可以与它们所连接的氮原子形成可能含有选自氧和氮的第二杂原子的氮杂环。

    .beta.-Nicotinamido-ethyl anthranilate
    8.
    发明授权
    .beta.-Nicotinamido-ethyl anthranilate 失效
    乙酰氨基苯甲酸乙酯

    公开(公告)号：US4152521A

    公开(公告)日：1979-05-01

    申请号：US931488

    申请日：1978-08-07

    申请人： Henri Cousse ,  Gilbert Mouzin

    发明人： Henri Cousse ,  Gilbert Mouzin

    IPC分类号： C07D213/82 ,  C07D213/56

    CPC分类号： C07D213/82

    摘要： The invention concerns new chemical compounds which can be used as medicaments, their preparation, and pharmaceutical compositions, and method of treating therewith.The new chemical compounds have the general formula ##STR1## in which X, which is in 7 position, represents a halogen atom or a trifluoromethyl group.The medicaments containing these active principles may be used in the treatment of various pains, i.e., as analgesics.

    摘要翻译： 本发明涉及可用作药物的新化合物，其制备方法和药物组合物及其处理方法。