公开(公告)号：US09750449B2

公开(公告)日：2017-09-05

申请号：US10735188

申请日：2003-12-12

申请人： Georgios Stamatas ,  Nikiforos Kollias

发明人： Georgios Stamatas ,  Nikiforos Kollias

IPC分类号： A61B5/05 ,  A61B5/00 ,  G01N21/64 ,  G01N33/50

CPC分类号： A61B5/442 ,  A61B5/0071 ,  G01N21/64 ,  G01N33/5091

摘要： The present invention relates to a method of determining skin health of an area of skin by exposing the area of skin to a first exposure radiation to induce the area of skin to emit a first fluorescent emission, measuring the intensity of the first fluorescent emission, exposing the area of skin to a second exposure radiation to induce the area of skin to emit a second fluorescent emission, measuring the intensity of the second fluorescent emission, calculating a ratio of these intensities, and comparing the ratio to a control ratio.

公开(公告)号：US08666844B2

公开(公告)日：2014-03-04

申请号：US12820844

申请日：2010-06-22

申请人： Steven A. Shaya ,  Neal Matheson ,  John Anthony Singarayar ,  Nikiforos Kollias ,  Jeffrey Adam Bloom

发明人： Steven A. Shaya ,  Neal Matheson ,  John Anthony Singarayar ,  Nikiforos Kollias ,  Jeffrey Adam Bloom

IPC分类号： G06Q30/00

CPC分类号： G06Q30/0631 ,  G06Q30/02 ,  G06Q30/0202 ,  G06Q30/0254 ,  G06Q30/0282 ,  G06Q30/0641

摘要： Systems and methods of utilizing communications networks and multivariate analysis to predict or recommend optimal products from a predefined population of commercially available products are disclosed. The recommendations are based on intelligence contained in processing elements and subjective and/or objective product information received from consumers or input to the systems as part of their initial setup. The output of the systems comprise sets of products that they predict the consumer will prefer and/or perform well for the problem or concern identified by the consumer. The performance and preference predictions are a function of consumer problems and product responsiveness patterns. Objective product information is generally obtained with diagnostic instruments. Data measured with the diagnostic instruments may be communicated to the data processing portions of the invention via the Internet. The outputs of the data processing portion of the system may be presented to consumers via the Internet as well.

摘要翻译： 公开了利用通信网络和多变量分析来预测或推荐来自预定义的市售产品群体的最佳产品的系统和方法。 这些建议是基于处理要素中包含的智能，以及从消费者收到的主观和/或客观的产品信息，或作为其初始设置的一部分输入到系统。 系统的输出包括他们预测消费者将更喜欢和/或对于消费者所识别的问题或关切而表现良好的产品集合。 性能和偏好预测是消费者问题和产品响应模式的函数。 客观的产品信息通常用诊断仪器获得。 用诊断仪器测量的数据可以经由因特网传送到本发明的数据处理部分。 系统的数据处理部分的输出也可以经由因特网向消费者呈现。

公开(公告)号：US08026942B2

公开(公告)日：2011-09-27

申请号：US11169813

申请日：2005-06-29

申请人： Gregory Payonk ,  Georgios Stamatas ,  Nikiforos Kollias

发明人： Gregory Payonk ,  Georgios Stamatas ,  Nikiforos Kollias

IPC分类号： H04N7/18 ,  A61B5/00

CPC分类号： A61B5/445 ,  A61B5/0064 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/441 ,  A61B5/442 ,  A61B5/443 ,  A61B5/444 ,  G06F19/00 ,  H04N5/23209 ,  H04N5/2354 ,  Y02A90/26

摘要： A skin testing and imaging station and corresponding method for capturing, displaying and analyzing images of a person and for testing the skin using a variety of probes includes a digital camera, a light source capable of providing at least two different wavelengths of light, a plurality of probes for conducting skin tests, a touch-screen display and a computer for controlling the components of the station. The apparatus selectively captures and displays a plurality of digital images using different wavelengths of illuminating light, e.g., using a plurality of flashes and filters, some of which may be adjustable to adjust the angle of incidence of the illuminating light on the subject. In video mode, the camera displays a real time image on the display facilitating a user to position a probe for testing any specific area of the skin. Preferably, the apparatus is self-serve, allowing any person to capture, review and analyze the images and skin data. Verbal and/or graphic instructions to a user aid in use of the station. An intuitive graphic user interface with thumbnail images is employed. Focus control, zoom and synchronized side-by side comparison of images are available.

摘要翻译： 使用各种探针拍摄，显示和分析人的图像和测试皮肤的皮肤测试和成像站以及相应的方法包括数字照相机，能够提供至少两种不同波长的光的光源，多个 用于进行皮肤测试的探针，触摸屏显示器和用于控制电台部件的计算机。 该装置使用不同波长的照明光选择性地捕获和显示多个数字图像，例如使用多个闪光和滤光器，其中一些可以是可调节的，以调节被摄体上的照明光的入射角。 在视频模式下，相机在显示屏上显示实时图像，便于用户定位用于测试皮肤特定区域的探针。 优选地，该装置是自助的，允许任何人捕获，审查和分析图像和皮肤数据。 对用户的口头和/或图形指令有助于使用该站。 使用具有缩略图的直观的图形用户界面。 焦点控制，缩放和同步并排比较图像可用。

公开(公告)号：US07558416B2

公开(公告)日：2009-07-07

申请号：US11863328

申请日：2007-09-28

申请人： Gregory Payonk ,  Nikiforos Kollias ,  Gabriela Oana Cula

发明人： Gregory Payonk ,  Nikiforos Kollias ,  Gabriela Oana Cula

IPC分类号： G06K11/00

CPC分类号： A61B5/0059 ,  A61B5/442 ,  G01J3/50

摘要： An apparatus and method for assessing photodamage has a digital imaging system for recording blue light imagining and in particular the green signal response intensity of the skin of a person, which is indicative of elastotic material and photodamage. Because the image data has a numerical intensity value, which may be expressed in RGB or L*a*b* colorspace, the image data taken from one image can be numerically compared to that of one or more other images and the image data is amenable to numerical and statistical analysis. Comparison to population profiles/image data permits an individual's image data to be characterized numerically, such as by a relative score or percentile rating. The image data can also be used to ascertain the degree of variation over a surface such as the face, with wider variation being indicative of greater photodamage.

摘要翻译： 用于评估光损伤的装置和方法具有用于记录蓝光想象的数字成像系统，特别是用于指示弹性材料和光损伤的人的皮肤的绿色信号响应强度。 由于图像数据具有可以以RGB或L * a * b *颜色空间表示的数值强度值，所以从一个图像获取的图像数据可以与一个或多个其他图像的图像数据进行数值比较，并且图像数据是可接受的 进行数值和统计分析。 与人口概况/图像数据的比较允许个人的图像数据以数字表示，例如通过相对评分或百分位数评级。 图像数据也可以用于确定诸如面部之类的表面上的变化程度，更广泛的变化指示更大的光损伤。

公开(公告)号：US07507228B2

公开(公告)日：2009-03-24

申请号：US10609708

申请日：2003-06-30

申请人： Ying Sun ,  Jue-Chen Liu ,  Jeffrey M. Wu ,  Nikiforos Kollias

发明人： Ying Sun ,  Jue-Chen Liu ,  Jeffrey M. Wu ,  Nikiforos Kollias

IPC分类号： A61M31/00

CPC分类号： A61N1/0428 ,  A61N1/044 ,  A61N1/0448

摘要： The present invention features a device having a barrier membrane contacting surface, the device containing: a power source; a first conductive electrode; a second conductive electrode; a first light emitting diode; and a carrier containing an active agent; wherein the power source is in electric communication with the first conductive electrode, the second conductive electrode, and the light emitting diode, and wherein the device is arranged such that light from the first light emitting diode and the carrier are in communication with the barrier membrane contacting surface.

摘要翻译： 本发明的特征在于具有阻挡膜接触表面的装置，该装置包括：电源; 第一导电电极; 第二导电电极; 第一发光二极管; 和含有活性剂的载体; 其中所述电源与所述第一导电电极，所述第二导电电极和所述发光二极管电连通，并且其中所述装置被布置成使得来自所述第一发光二极管和所述载体的光与所述阻挡膜连通 接触面。

公开(公告)号：US20090059028A1

公开(公告)日：2009-03-05

申请号：US12201044

申请日：2008-08-29

申请人： Nikiforos Kollias ,  Jeffrey Pote ,  Gregory Payonk

发明人： Nikiforos Kollias ,  Jeffrey Pote ,  Gregory Payonk

IPC分类号： H04N5/228 ,  H04N17/00

CPC分类号： A61B5/441 ,  A61B5/0071 ,  A61B2560/0233 ,  G03B15/06 ,  G06K9/00255 ,  G06K9/2018

摘要： A standard used to test imaging systems is imaged by a digital camera which expresses the image of the standard as a plurality of pixels having associated intensities. A computer automatically finds the image of the standard in the image and quantitatively compares intensities of pixels of a subsequent image of the standard to the first image to discern changes indicative of malfunction. A set of images of the standard may be collected and compiled to develop standard data, such as average of median values, that can be used to test imaging apparatus. The standard may be provided with a plurality of types of imaging standards occupying sub-areas that produce a different photoresponse to a plurality of different light sources. A fluorescent standard may be included that has a plurality of different fluorescence levels. Multiple sub-areas of the same type may be distributed over the surface area of the standard to measure the photoresponse in several areas and also to facilitate locating all sub-areas of the standard, e.g., multiple white squares may be distributed over the standard that may be identified by thresholding. The results of testing via the standard may be graphically displayed.

摘要翻译： 用于测试成像系统的标准由数字照相机成像，数字照相机将标准的图像表示为具有相关联的强度的多个像素。 计算机自动找到图像中的标准图像，并且定量地比较标准的后续图像的像素强度与第一图像，以辨别指示故障的变化。 可以收集和编辑一组标准的图像以开发可用于测试成像装置的标准数据，例如中值的平均值。 该标准可以设置有多种类型的成像标准，占据对多个不同光源产生不同光响应的子区域。 可以包括具有多个不同荧光水平的荧光标准。 相同类型的多个子区域可以分布在标准的表面区域上以测量几个区域中的光响应，并且还有助于定位标准的所有子区域，例如，可以在标准上分布多个白色正方形 可以通过阈值来识别。 可以图形显示通过标准测试的结果。

公开(公告)号：US20080132793A1

公开(公告)日：2008-06-05

申请号：US11018387

申请日：2004-12-20

申请人： Nikiforos Kollias ,  Wei Dong Tian ,  Jenny E. Freeman

发明人： Nikiforos Kollias ,  Wei Dong Tian ,  Jenny E. Freeman

IPC分类号： A61B6/00

CPC分类号： A61B5/14532 ,  A61B5/0071 ,  A61B5/1455

摘要： Instruments and methods for performing non-invasive measurements of analyte concentrations and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.

摘要翻译： 用于进行非侵入性测量分析物浓度并监测，分析和调节组织状态（如组织葡萄糖水平）的仪器和方法。

公开(公告)号：US20080080766A1

公开(公告)日：2008-04-03

申请号：US11863333

申请日：2007-09-28

申请人： Gregory Payonk ,  Nikiforos Kollias ,  Dick Jackson

发明人： Gregory Payonk ,  Nikiforos Kollias ,  Dick Jackson

IPC分类号： G06K9/00

CPC分类号： A45D44/005 ,  A45D2044/007 ,  G06T7/90

摘要： An imaging system and method has digital image capture and analysis capability. The digital images may be taken in a variety of illumination conditions, with the skin response indicating skin condition. The digital images may be converted from RGB format to L*a*b* format and analyzed quantitatively to assess color and brightness. The color/brightness information from the digital images may be used to assess skin condition and changes thereof, as well as selecting cosmetics provided in a range of colors. The color information gleaned from the digital images of a population may be utilized to identify a palette of colors for cosmetics or to aid in conducting clinical studies.

摘要翻译： 成像系统和方法具有数字图像捕获和分析功能。 数字图像可以在各种照明条件下拍摄，皮肤响应指示皮肤状况。 数字图像可以从RGB格式转换为L * a * b *格式并定量分析以评估颜色和亮度。 来自数字图像的颜色/亮度信息可用于评估皮肤状况及其变化，以及选择在一系列颜色中提供的化妆品。 从群体的数字图像中收集的颜色信息可以用于识别用于化妆品的调色板或用于辅助进行临床研究。

公开(公告)号：US20070053940A1

公开(公告)日：2007-03-08

申请号：US11556322

申请日：2006-11-03

申请人： Kelly Huang ,  Nikiforos Kollias ,  Ellen Kurtz ,  Katharine Martin ,  Florence Natter ,  Arthur Pellegrino

发明人： Kelly Huang ,  Nikiforos Kollias ,  Ellen Kurtz ,  Katharine Martin ,  Florence Natter ,  Arthur Pellegrino

IPC分类号： A61K8/02

CPC分类号： A61B5/442 ,  A61B5/0077 ,  G06T7/0012 ,  G06T2207/30004

摘要： The present invention includes a method of measuring the efficacy of a skin treatment program on human skin. The method comprises: a. accessing a multiplicity of photographic images of human faces, each image having associated with it a chronological age of the human whose likeness it captures; b. assessing the multiplicity of photographic images of human faces for a facial parameter; c. scoring the facial parameter on each image according to a scoring system to create a parameter score for each image; d. correlating the parameter scores to the chronological ages to obtain an age-parameter correlation; e. scoring an untreated subject human face for the facial parameter to obtain a subject baseline parameter score; f. treating the subject human face with a skin treatment program; g. scoring the treated subject human face for the facial parameter to obtain a subject treatment parameter score; h. determining the difference between the subject baseline parameter score and the subject treatment parameter score to obtain a treatment score difference; and i. comparing the treatment score difference with the age-parameter correlation to determine a constructive age change of the human face effected by treatment of the human face with the skin treatment program.

摘要翻译： 本发明包括测量皮肤处理程序对人体皮肤的功效的方法。 该方法包括：a。 访问人脸的多个摄影图像，每个图像与其相关联的是与其相似的人的时间年龄; b。 评估面部参数人脸摄影图像的多样性; C。 根据评分系统对每个图像上的面部参数进行评分，以创建每个图像的参数分数; d。 将参数分数与时间年龄相关联以获得年龄参数相关性; e。 为面部参数评分未经处理的受试者人脸以获得受试者基线参数得分; F。 用皮肤治疗方案治疗受试者的人脸; G。 对面部参数的受检对象人脸进行评分以获得受试者治疗参数得分; H。 确定受试者基准参数得分和受试者治疗参数得分之间的差异以获得治疗分数差; 和我。 将治疗分数差异与年龄参数相关性进行比较，以确定通过用皮肤治疗程序治疗人脸而实现的人脸的建构性年龄变化。

公开(公告)号：US20060092315A1

公开(公告)日：2006-05-04

申请号：US11169813

申请日：2005-06-29

申请人： Gregory Payonk ,  Georgios Stamatas ,  Nikiforos Kollias

发明人： Gregory Payonk ,  Georgios Stamatas ,  Nikiforos Kollias

IPC分类号： H04N5/222

CPC分类号： A61B5/445 ,  A61B5/0064 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/441 ,  A61B5/442 ,  A61B5/443 ,  A61B5/444 ,  G06F19/00 ,  H04N5/23209 ,  H04N5/2354 ,  Y02A90/26

摘要： A skin testing and imaging station and corresponding method for capturing, displaying and analyzing images of a person and for testing the skin using a variety of probes includes a digital camera, a light source capable of providing at least two different wavelengths of light, a plurality of probes for conducting skin tests, a touch-screen display and a computer for controlling the components of the station. The apparatus selectively captures and displays a plurality of digital images using different wavelengths of illuminating light, e.g., using a plurality of flashes and filters, some of which may be adjustable to adjust the angle of incidence of the illuminating light on the subject. In video mode, the camera displays a real time image on the display facilitating a user to position a probe for testing any specific area of the skin. Preferably, the apparatus is self-serve, allowing any person to capture, review and analyze the images and skin data. Verbal and/or graphic instructions to a user aid in use of the station. An intuitive graphic user interface with thumbnail images is employed. Focus control, zoom and synchronized side-by side comparison of images are available.

摘要翻译： 使用各种探针拍摄，显示和分析人的图像和测试皮肤的皮肤测试和成像站以及相应的方法包括数字照相机，能够提供至少两种不同波长的光的光源，多个 用于进行皮肤测试的探针，触摸屏显示器和用于控制电台部件的计算机。 该装置使用不同波长的照明光选择性地捕获和显示多个数字图像，例如使用多个闪光和滤光器，其中一些可以是可调节的，以调节被摄体上的照明光的入射角。 在视频模式下，相机在显示屏上显示实时图像，便于用户定位用于测试皮肤特定区域的探针。 优选地，该装置是自助的，允许任何人捕获，审查和分析图像和皮肤数据。 对用户的口头和/或图形指令有助于使用该站。 使用具有缩略图的直观的图形用户界面。 焦点控制，缩放和同步并排比较图像可用。