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公开(公告)号：US08852605B2
公开(公告)日：2014-10-07
申请号：US11695735
申请日：2007-04-03
IPC分类号： A61K39/00 , A61K39/38 , A61K39/40 , A61K39/385 , A61K39/116 , A61K39/02 , A61K39/106 , A61K38/00 , A61K38/16 , A61K39/395 , A61K31/415 , A01N43/46
CPC分类号： A61K39/107 , A61K47/646
摘要： The disclosure pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These conjugates are useful as pharmaceutical compositions and/or vaccines to induce serum antibodies which have bactericidal (vibriocidal) activity against V. cholerae, in particular V. cholerae O139, and are useful to prevent, treat and/or reduce the severity of disease caused by V. cholerae infection, such as cholera. The present disclosure also relates to diagnostic tests for V. cholerae infection, and/or cholera caused by V. cholerae infection, using one or more of the oligo- or poly-saccharide-carrier conjugates or antibodies described above.
摘要翻译： 本公开涉及霍乱弧菌O139的荚膜多糖或结构和/或免疫相关的寡糖或多糖和载体的缀合物。 这些缀合物可用作药物组合物和/或疫苗以诱导对霍乱弧菌（特别是霍乱弧菌O139）具有杀菌（弧菌）活性）的血清抗体，并且可用于预防，治疗和/或降低引起的疾病的严重性 霍乱弧菌感染，如霍乱。 本公开还涉及使用一种或多种上述寡糖或多糖 - 载体缀合物或抗体的霍乱弧菌感染和/或由霍乱弧菌感染引起的霍乱的诊断测试。
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公开(公告)号：US06797275B1
公开(公告)日：2004-09-28
申请号：US09653433
申请日：2000-09-01
IPC分类号： A61K39112
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies againt S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
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公开(公告)号：US06207157B1
公开(公告)日：2001-03-27
申请号：US08842409
申请日：1997-04-23
申请人： Xin-Xing Gu , Chao-Ming Tsai , David J. Lim , John B. Robbins
发明人： Xin-Xing Gu , Chao-Ming Tsai , David J. Lim , John B. Robbins
IPC分类号： A61K3900
CPC分类号： A61K39/102 , A61K2039/6037 , Y10S435/851
摘要： A conjugate vaccine for Nontypeable Haemophilus influenzae comprising lipooligosaccharide from which esterified fatty acids have been removed conjugated to an immunogenic carrier. The vaccine is useful for prevention of otitis media and respiratory infections in mammals.
摘要翻译： 用于不可分型流感嗜血杆菌的结合疫苗，其包含已除去已酯化脂肪酸的脂寡糖，与免疫原性载体结合。 该疫苗可用于预防中耳炎和哺乳动物的呼吸道感染。
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公开(公告)号：US20090243122A1
公开(公告)日：2009-10-01
申请号：US12185003
申请日：2008-08-01
IPC分类号： H01L23/544 , H01L21/76
CPC分类号： H01L23/544 , H01L2223/54426 , H01L2223/54453 , H01L2223/5448 , H01L2924/0002 , H01L2924/00
摘要： An IC alignment mark in a contact metal layer for use under an opaque layer, and a process for forming the alignment mark, are disclosed. The alignment mark includes contact metal fields, each several microns wide, with an array of PMD pillars in the interior, formed during contact etch, contact metal deposition and selective contact metal removal processes. The pillars are arrayed such that all exposed surfaces of the contact metal are planar. One configuration is a rectangular array in which every other row is laterally offset by one-half of the column spacing. Horizontal dimensions of the pillars are selected to maximize the contact metal fill factor, while providing sufficient adhesion to the underlying substrate during processing. The contact metal is at least 15 nanometers lower than the PMD layer surrounding the alignment mark, as a result of the contact metal removal process.
摘要翻译： 公开了在不透明层下使用的接触金属层中的IC对准标记和用于形成对准标记的工艺。 对准标记包括几微米宽的接触金属场，在接触蚀刻期间形成的PMD柱阵列，接触金属沉积和选择性接触金属去除过程。 柱子被排列成使得接触金属的所有暴露表面是平面的。 一个配置是矩形阵列，其中每隔一行被横向偏移列间距的一半。 选择柱的水平尺寸以使接触金属填充因子最大化，同时在处理期间向下面的基底提供足够的粘附。 作为接触金属去除过程的结果，接触金属比围绕对准标记的PMD层低至少15纳米。
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公开(公告)号：US07527797B1
公开(公告)日：2009-05-05
申请号：US10363618
申请日：2000-09-01
IPC分类号： A61K39/00 , A61K39/38 , A61K39/40 , A61K39/385 , A61K39/116 , A61K39/02 , A61K39/106 , A61K38/00 , A61K38/16 , A01N37/18 , C12P21/08 , C08H1/00 , C07K16/00
CPC分类号： A61K39/107 , A61K47/646
摘要： The invention pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These conjugates are useful as pharmaceutical compositions and/or vaccines to induce serum antibodies which have bactericidal (vibriocidal) activity against V. cholerae, in particular V. cholerae O139, and are useful to prevent, treat and/or reduce the severity of disease caused by V. cholerae infection, such as cholera. The present invention also relates to diagnostic tests for V. cholerae infection, and/or cholera caused by V. cholerae infection, using one or more of the oligo- or poly-saccharide-carrier conjugates or antibodies described above.
摘要翻译： 本发明涉及霍乱弧菌O139的荚膜多糖或结构和/或免疫相关的寡糖或多糖和载体的缀合物。 这些缀合物可用作药物组合物和/或疫苗以诱导对霍乱弧菌（特别是霍乱弧菌O139）具有杀菌（弧菌）活性）的血清抗体，并且可用于预防，治疗和/或降低引起的疾病的严重性 霍乱弧菌感染，如霍乱。 本发明还涉及使用一种或多种上述寡糖或多糖 - 载体缀合物或抗体的霍乱弧菌感染和/或由霍乱弧菌感染引起的霍乱的诊断测试。
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公开(公告)号：US07247307B2
公开(公告)日：2007-07-24
申请号：US11015436
申请日：2004-12-16
申请人： Shousun Chen Szu , John B. Robbins , Edward Konadu, deceased , Yvonne Ageyman Konadu, legal representative
发明人： Shousun Chen Szu , John B. Robbins , Edward Konadu, deceased , Yvonne Ageyman Konadu, legal representative
IPC分类号： A61K39/108 , A61K39/385
CPC分类号： A61K39/0258 , A61K2039/6037 , Y02A50/474
摘要： This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity of, bacterial infections. More particularly it relates to the use of polysaccharides containing the tetrasaccharide repeat unit: (→3)-α-DGalpNAc-(1→2)-α-D-PerpNAc-(1→3)-α-L-Fucp-(1→4)-β-D-Glcp-(1→), and conjugates thereof, to induce serum antibodies having bactericidal (killing) activity against hemolytic-uremic syndrome (HUS) causing E. coli, in particular E. coli O157. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies which have bactericidal or bacteriostatic activity against E. coli, in particular E. coli O157, and are useful to prevent and/or treat illnesses caused by E. coli O157.The invention further relates to the antibodies which immunoreact with the O-specific polysaccharide of E. coli O157 and/or the carrier, that are induced by these conjugates and/or compositions thereof. The invention also relates to methods and kits using one or more of the polysaccharides, conjugates or antibodies described above.
摘要翻译： 本发明涉及大肠杆菌O157的O-特异性多糖与载体及其组合物的缀合物，以及这些缀合物和/或其组合物在哺乳动物中引发免疫原性应答的方法，包括提供保护的应答 反对或减轻细菌感染的严重性。 更具体地说，涉及使用含有四糖重复单元的多糖：（→3）-alpha-DGalpNAc-（1-> 2）-alpha-D-PerpNAc-（1-> 3）-alpha-L-Fucp - （1-> 4）-β-D-Glcp-（1->）及其缀合物，以诱导对引起大肠杆菌的溶血性尿毒综合征（HUS）具有杀菌（杀伤）活性的血清抗体，特别是E 大肠杆菌O157。 缀合物及其组合物可用作诱导对大肠杆菌特别是大肠杆菌O157具有杀菌或抑菌活性的血清抗体的疫苗，并且可用于预防和/或治疗由大肠杆菌O157引起的疾病。 本发明还涉及与这些缀合物和/或其组合物诱导的大肠杆菌O157和/或载体的O-特异性多糖免疫反应的抗体。 本发明还涉及使用上述一种或多种多糖，缀合物或抗体的方法和试剂盒。
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公开(公告)号：US06607725B2
公开(公告)日：2003-08-19
申请号：US09789017
申请日：2001-02-20
申请人： Xin-Xing Gu , Chao-Ming Tsai , David J. Lim , John B. Robbins
发明人： Xin-Xing Gu , Chao-Ming Tsai , David J. Lim , John B. Robbins
IPC分类号： A61K39395
CPC分类号： A61K39/102 , A61K2039/6037 , Y10S435/851
摘要： A conjugate vaccine for Nontypeable Haemophilus influenzae comprising lipooligosaccharide from which esterified fatty acids have been removed conjugated to an immunogenic carrier. The vaccine is useful for prevention of otitis media and respiratory infections in mammals.
摘要翻译： 用于不可分型流感嗜血杆菌的结合疫苗，其包含已除去已酯化脂肪酸的脂寡糖，与免疫原性载体结合。 该疫苗可用于预防中耳炎和哺乳动物的呼吸道感染。
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公开(公告)号：US4935064A
公开(公告)日：1990-06-19
申请号：US173837
申请日：1988-03-28
CPC分类号： C02F1/50 , C02F1/766 , C02F2103/04
摘要： Trace quantities of elemental iodine are added to deionized water used in the manufacture of semiconductor materials and devices in order to sterilize the water and the delivery system of microscopic life forms, and to leave the iodine in the flow all the way through processing except for those process steps where iodine may be detrimental to the process step.
摘要翻译： 在制造半导体材料和器件的去离子水中加入痕量的元素碘，以便对水和微生物形式的输送系统进行消毒，并将碘在流中一直通过加工，除了那些 碘可能对工艺步骤有害的工艺步骤。
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公开(公告)号：US08324742B2
公开(公告)日：2012-12-04
申请号：US12185003
申请日：2008-08-01
IPC分类号： H01L23/544 , H01L21/76
CPC分类号： H01L23/544 , H01L2223/54426 , H01L2223/54453 , H01L2223/5448 , H01L2924/0002 , H01L2924/00
摘要： An IC alignment mark in a contact metal layer for use under an opaque layer, and a process for forming the alignment mark, are disclosed. The alignment mark includes contact metal fields, each several microns wide, with an array of PMD pillars in the interior, formed during contact etch, contact metal deposition and selective contact metal removal processes. The pillars are arrayed such that all exposed surfaces of the contact metal are planar. One configuration is a rectangular array in which every other row is laterally offset by one-half of the column spacing. Horizontal dimensions of the pillars are selected to maximize the contact metal fill factor, while providing sufficient adhesion to the underlying substrate during processing. The contact metal is at least 15 nanometers lower than the PMD layer surrounding the alignment mark, as a result of the contact metal removal process.
摘要翻译： 公开了在不透明层下使用的接触金属层中的IC对准标记和用于形成对准标记的工艺。 对准标记包括几微米宽的接触金属场，在接触蚀刻期间形成的PMD柱阵列，接触金属沉积和选择性接触金属去除过程。 柱子被排列成使得接触金属的所有暴露表面是平面的。 一个配置是矩形阵列，其中每隔一行被横向偏移列间距的一半。 选择柱的水平尺寸以使接触金属填充因子最大化，同时在处理期间向下面的基底提供足够的粘附。 作为接触金属去除过程的结果，接触金属比围绕对准标记的PMD层低至少15纳米。
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40.发明授权Lipooligosaccharide based vaccine for prevention of moraxella (branhamella)catarrhalis infections in humans 失效基于低聚糖的疫苗，用于预防人体中的莫拉氏菌（布氏菌）卡他氏菌感染公开(公告)号：US06685949B1
公开(公告)日：2004-02-03
申请号：US09610034
申请日：2000-07-05
申请人： Xin-Xing Gu , John B. Robbins
发明人： Xin-Xing Gu , John B. Robbins
IPC分类号： A61K3902
CPC分类号： C12P19/04 , A61K39/1045 , A61K2039/5555 , A61K2039/55572 , A61K2039/6037
摘要： A conjugate vaccine for Moraxella (Branhamella) catarrhalis comprising isolated lipooligosaccharide from which esterified fatty acids have been removed, to produce a detoxified lipooligosaccharide (dLOS), or from which lipid A has been removed, to produce a detoxified oligosaccharide (OS), which is linked to an immunogenic carrier. The vaccine is useful for preventing otitis media and respiratory infections caused by M. catarrhalis in mammals, including humans.
摘要翻译： 包含分离出的脂多糖的莫拉沙氏菌（Branhamella）卡他氏菌共轭疫苗，其中除去了酯化的脂肪酸，产生脱脂脂寡糖（dLOS），或从其中除去脂质A，产生解毒的寡糖（OS） 与免疫原性载体连接。 该疫苗可用于预防由哺乳动物包括人在内的卡他莫拉菌引起的中耳炎和呼吸道感染。
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