公开(公告)号：US20160291458A1

公开(公告)日：2016-10-06

申请号：US14753192

申请日：2015-06-29

申请人： Daquan He ,  Fang Wei ,  Jun Zhu ,  Yukun Lv ,  Xusheng Zhang

发明人： Daquan He ,  Fang Wei ,  Jun Zhu ,  Yukun Lv ,  Xusheng Zhang

IPC分类号： G03F1/36 ,  G06F17/50

CPC分类号： G03F1/36

摘要： A method integrating target optimization and optical proximity correction including: fragmenting sides of a target pattern in the metal layer to form a plurality of fragments; simulating the target pattern and calculating image log slope of each fragment; calculating a target pattern optimal parameter for each fragment which is a product of three parameters including the image log slope, overlap ratio of the target pattern and a via pattern in a via layer, and critical dimension; optimizing the target pattern based on the target pattern optimal parameter; preforming optical proximity correction to the optimized target pattern; determining whether the corrected target pattern meets requirements; if yes, ending the target optimization and optical proximity correction; otherwise, using the corrected target pattern as a current target pattern and iterate from the step of simulating the target pattern and calculating image log slope of each fragment.

摘要翻译： 一种集成目标优化和光学邻近校正的方法，包括：金属层中的目标图案的碎裂边以形成多个碎片; 模拟目标模式并计算每个片段的图像对数斜率; 计算每个片段的目标图案最优参数，该三个参数的乘积包括图像对数斜率，目标图案的重叠率和通孔层中的通孔图案以及临界尺寸; 基于目标模式优化参数优化目标模式; 对优化的目标图案进行光学邻近校正; 确定校正的目标模式是否满足要求; 如果是，结束目标优化和光学邻近校正; 否则，使用校正的目标图案作为当前目标图案，并且从模拟目标图案的步骤并且计算每个片段的图像对数斜率来迭代。

公开(公告)号：US08996101B2

公开(公告)日：2015-03-31

申请号：US13457983

申请日：2012-04-27

申请人： Xusheng Zhang ,  Teresa A. Whitman ,  Paul J. DeGroot ,  Mark L. Brown ,  Jeffrey M. Gillberg

发明人： Xusheng Zhang ,  Teresa A. Whitman ,  Paul J. DeGroot ,  Mark L. Brown ,  Jeffrey M. Gillberg

IPC分类号： A61B5/0464 ,  A61B5/00 ,  A61N1/365 ,  A61N1/362 ,  A61B5/046

CPC分类号： A61B5/7221 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/686 ,  A61B5/6869 ,  A61B5/7264 ,  A61B5/7285 ,  A61B7/00 ,  A61N1/3621 ,  A61N1/36514 ,  G06F19/00

摘要： A method and device for detecting a cardiac event that includes sensing cardiac electrical signals representative of electrical activity of a heart of a patient, detecting the cardiac event in response to the sensed cardiac signals, determining an indication of signal reliability corresponding to the sensed cardiac signals as being one of a reliable signal and a not reliable signal, and switching operation of the device between a first mode of determining whether the sensed signal is one of treatable and not treatable and a second mode of determining whether the sensed signal is one of treatable and not treatable in response to the determined indication of signal reliability.

摘要翻译： 一种用于检测心脏事件的方法和装置，其包括感测表示患者心脏的电活动的心脏电信号，响应于感测到的心脏信号检测心脏事件，确定与所感测的心脏信号相对应的信号可靠度的指示 作为可靠信号和不可靠信号之一，以及在确定感测信号是可治疗和不可治疗的第一模式之间的装置的切换操作以及确定感测信号是否是可治疗的信号之一的第二模式 并且不能响应于所确定的信号可靠性指示而被处理。

公开(公告)号：US20130289640A1

公开(公告)日：2013-10-31

申请号：US13458009

申请日：2012-04-27

申请人： Xusheng Zhang ,  Jeffrey M. Gillberg

发明人： Xusheng Zhang ,  Jeffrey M. Gillberg

IPC分类号： A61N1/365

CPC分类号： A61N1/36578 ,  A61N1/3686

摘要： A system and method for generating a pacing vector selection table senses a heart sound signal generated by a heart sound sensor and representing sounds generated by the heart of the patient. A processor controls the sequential selection of a pacing electrode vectors from electrodes positioned along a heart chamber. Pacing pulses are delivered via the sequentially selected plurality of pacing electrode vectors. The processor receives the heart sound signal, determines a plurality of different pacing responses using the heart sound signal for each of the of pacing electrode vectors, and generates a pacing vector selection table listing the plurality of different pacing responses for each of the plurality of pacing electrode vectors.

摘要翻译： 用于产生起搏矢量选择表的系统和方法感测由心音传感器产生的心音信号，并且表示由患者心脏产生的声音。 处理器控制来自位于心室的电极的起搏电极向量的顺序选择。 经由顺序选择的多个起搏电极载体递送起搏脉冲。 处理器接收心音信号，使用针对起搏电极矢量中的每一个的心音信号来确定多个不同的起搏响应，并且生成起搏矢量选择表，其列出多个起搏响应中的每一个起搏响应 电极向量。

公开(公告)号：US08437842B2

公开(公告)日：2013-05-07

申请号：US12768917

申请日：2010-04-28

申请人： Xusheng Zhang ,  Robert W. Stadler ,  Saul E. Greenhut ,  Mark L. Brown ,  Troy E. Jackson ,  Teresa A. Whitman

发明人： Xusheng Zhang ,  Robert W. Stadler ,  Saul E. Greenhut ,  Mark L. Brown ,  Troy E. Jackson ,  Teresa A. Whitman

IPC分类号： A61B5/04

CPC分类号： A61B5/0452 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/7203 ,  A61N1/3621

摘要： A medical device and associated method obtaining cardiac event intervals corresponding to a tachycardia interval. Evidence of a rhythm breaking point is obtained in response to sensing a cardiac event having a morphology corresponding to a supraventricular beat. A non-treatable rhythm is detected in response to the plurality of cardiac event intervals and the evidence of the rhythm breaking point.

摘要翻译： 获得对应于心动过速间隔的心脏事件间隔的医疗装置和相关方法。 响应于感测具有对应于室上搏动的形态的心脏事件而获得节律断点的证据。 响应于多个心脏事件间隔和节律断点的证据来检测不可治疗的节律。

公开(公告)号：US20120101393A1

公开(公告)日：2012-04-26

申请号：US12912217

申请日：2010-10-26

申请人： Xusheng Zhang ,  Jeffrey M. Gillberg

发明人： Xusheng Zhang ,  Jeffrey M. Gillberg

IPC分类号： A61B5/0205

CPC分类号： A61B5/0452 ,  A61B5/0816 ,  A61B5/7239 ,  A61B5/7278 ,  A61B5/7282

摘要： A method and apparatus for monitoring respiration in a patient sense a cardiac electrical signal and detect signal peaks from the cardiac electrical signal. A peak amplitude waveform is generated from the signal peaks. a first derivative of the peak amplitude waveform is computed. Inspiration pulses are derived from the first derivative signal, and a respiration metric can be computed using the inspiration pulses derived from the cardiac electrical signal.

摘要翻译： 用于监测患者呼吸的方法和装置感测心电信号并检测心电信号的信号峰值。 从信号峰值产生峰值振幅波形。 计算峰值幅度波形的一阶导数。 启发脉冲从一阶导数信号导出，并且可以使用从心电信号导出的吸气脉冲来计算呼吸度量。

公开(公告)号：US20120101392A1

公开(公告)日：2012-04-26

申请号：US12912111

申请日：2010-10-26

申请人： Sourav K. Bhunia ,  Xusheng Zhang

发明人： Sourav K. Bhunia ,  Xusheng Zhang

IPC分类号： A61B5/0205

CPC分类号： A61N1/3621 ,  A61N1/36542 ,  A61N1/3702

摘要： An implantable medical device is configured to perform a method for detecting cardiac events by sensing a patient activity signal and determining a patient activity trend in response to the activity signal. A cardiac event detection threshold is set in response to the patient activity trend. The device senses a cardiac signal and detects a cardiac event in response to the cardiac signal and the detection threshold.

摘要翻译： 可植入医疗装置被配置为通过感测患者活动信号并且响应于活动信号确定患者活动趋势来执行用于检测心脏事件的方法。 响应于患者活动趋势设置心脏事件检测阈值。 该装置感测心脏信号，并根据心脏信号和检测阈值检测心脏事件。

公开(公告)号：US08160684B2

公开(公告)日：2012-04-17

申请号：US11380837

申请日：2006-04-28

申请人： Raja N. Ghanem ,  Robert W. Stadler ,  Xusheng Zhang

发明人： Raja N. Ghanem ,  Robert W. Stadler ,  Xusheng Zhang

IPC分类号： A61B5/0452 ,  A61N1/368

CPC分类号： A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7239 ,  A61N1/05 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3956 ,  Y10S128/901 ,  Y10S128/902

摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, and determining whether the sensing of cardiac signals along the first sensing vector and along the second sensing vector is corrupted by noise. If the cardiac signals sensed along both the first sensing vector and the second sensing vector are not corrupted by noise, a determination is made as to whether the cardiac signals sensed along the first sensing vector and along the second sensing vector are one of a first cardiac event and a second cardiac event. The determination of whether the cardiac signals sensed along the first sensing vector and along the second sensing vector are one of a first cardiac event and a second cardiac event is then confirmed.

摘要翻译： 一种检测医疗装置中的心脏事件的方法，包括：感测来自形成第一感测向量和第二感测向量的多个电极的心脏信号，以及确定沿着第一感测向量并沿着第二感测的心脏信号的感测 矢量被噪音破坏了。 如果沿着第一感测向量和第二感测矢量两者感测的心脏信号不被噪声破坏，则确定沿着第一感测向量和沿着第二感测向量感测的心脏信号是否是第一心脏 事件和第二次心脏事件。 然后确定沿着第一感测向量和沿着第二感测向量感测的心脏信号是否是第一心脏事件和第二心脏事件之一的确定。

公开(公告)号：US08068901B2

公开(公告)日：2011-11-29

申请号：US11742625

申请日：2007-05-01

申请人： Raja N. Ghanem ,  Robert W. Stadler ,  Xusheng Zhang ,  Karen J. Kleckner ,  Paul G. Krause

发明人： Raja N. Ghanem ,  Robert W. Stadler ,  Xusheng Zhang ,  Karen J. Kleckner ,  Paul G. Krause

IPC分类号： A61B5/0402

CPC分类号： A61N1/3704 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/7239 ,  A61N1/3925

摘要： A method and apparatus of updating a sensing parameter in a medical device that includes sensing cardiac signals, determining intervals in response to the sensed cardiac signals, determining interval patterns associated with the determined intervals, and updating the sensing parameter in response to the determined interval patterns.

摘要翻译： 一种更新医疗设备中的感测参数的方法和装置，包括感测心脏信号，响应于感测的心脏信号确定间隔，确定与所确定的间隔相关联的间隔模式，以及响应于所确定的间隔模式来更新感测参数 。

公开(公告)号：US20110270103A1

公开(公告)日：2011-11-03

申请号：US12768807

申请日：2010-04-28

申请人： Xusheng Zhang ,  Robert W. Stadler ,  Jeffrey M. Gillberg

发明人： Xusheng Zhang ,  Robert W. Stadler ,  Jeffrey M. Gillberg

IPC分类号： A61B5/0464 ,  A61B5/0452

CPC分类号： A61B5/0464 ,  A61B5/0245 ,  A61B5/7203 ,  A61N1/3622 ,  A61N1/3962

摘要： A medical device and associated method for discriminating cardiac events includes determining whether a first match score is within a first match zone having a first correlation with a non-treatable cardiac event, a second match zone having a second correlation with the non-treatable cardiac event less than the first correlation with the non-treatable event, a third match zone having a first correlation with a treatable cardiac event, and a fourth match zone having a second correlation with the treatable cardiac event greater than the first correlation with the treatable cardiac event. A determination is made as to whether a second match score and a third match score are within the first match zone, the second match zone, the third match zone and the fourth match zone to generate a first adjusting factor, and cardiac event evidence is accumulated in response to the first adjusting factor for discriminating cardiac events.

摘要翻译： 用于鉴别心脏事件的医疗装置和相关联的方法包括确定第一匹配得分是否在与不可治疗心脏事件具有第一相关性的第一匹配区域内，与不可治疗心脏事件具有第二相关性的第二匹配区域 小于与不可治疗事件的第一相关性，具有与可治疗心脏事件的第一相关性的第三匹配区，以及与可治疗心脏事件具有大于与可治疗心脏事件的第一相关性的第二相关性的第四匹配区 。 确定第二匹配分数和第三匹配分数是否在第一匹配区域，第二匹配区域，第三匹配区域和第四匹配区域内，以产生第一调整因子，并且累积心脏事件证据 响应于用于区分心脏事件的第一调整因子。

公开(公告)号：US20110270102A1

公开(公告)日：2011-11-03

申请号：US12768773

申请日：2010-04-28

申请人： Xusheng Zhang ,  Robert W. Stadler ,  Jeffrey M. Gillberg

发明人： Xusheng Zhang ,  Robert W. Stadler ,  Jeffrey M. Gillberg

IPC分类号： A61B5/0464 ,  A61B5/0452

CPC分类号： A61N1/36514 ,  A61B5/02405 ,  A61B5/04525 ,  A61B5/7203 ,  A61N1/3621 ,  A61N1/3962

摘要： A medical device and associated method for discriminating cardiac events includes sensing a cardiac signal spatially located across approximately a full duration of a predetermined sensing window. A match score is determined corresponding to the sensed cardiac signal. A beat feature of multiple beat features across less than the full duration of the sensing window is determined, the beat feature being selected from the multiple beat features in response to the match score. Cardiac event evidence is accumulated in response to the match score and the determined beat feature, and cardiac events are discriminated in response to the accumulated cardiac evidence.

摘要翻译： 用于鉴别心脏事件的医疗装置和相关联的方法包括感测在预定感测窗口的大约整个持续时间上空间定位的心脏信号。 根据感测的心脏信号确定匹配分数。 确定在小于感测窗口的整个持续时间的多个拍子特征的拍子特征，响应于匹配分数，从多拍特征中选择节拍特征。 响应于匹配得分和确定的搏动特征累积心脏事件证据，并且响应于累积的心脏证据来区分心脏事件。